Gordon Research Conferences
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Conference Program
 
Nitric Oxide
Understanding the Biology and Chemistry of Its Formation, Action and Signaling
February 13-18, 2011
Four Points Sheraton / Holiday Inn Express
Ventura, CA
Chair:
Martin Feelisch

Vice Chair:
Jon Lundberg

Nitric oxide (NO) is a pluripotent signaling and effector molecule which serves important regulatory roles in mammalian cell biology. Every two years since its inception in 1995, the Gordon Research Conference (GRC) on Nitric Oxide offers the opportunity to discuss select themes at the interface of NO biology, chemistry and medicine. What distinguishes this conference series from other meetings in the field is the emphasis on mechanistic aspects of NO signaling and action, its truly multi-disciplinary approach, and a special format that ensures ample time for discussion and fosters stimulating scientific interaction between participants of all levels of seniority. Invited speakers and poster presenters, along with attendees planning on contributing to the “hot topic” session, are encouraged to present their latest findings, to actively participate in discussions and to not shy away from including preliminary data of speculative nature suited to challenge established concepts and/or push research frontiers.

Three decades after the discovery of “endothelium-derived relaxing factor”, a multitude of prestigious prizes and more than 100,000 publications later a molecular understanding as to how exactly NO acts and signals has yet to emerge. While much progress has been made in recent years, with the emergence of “redox signalling” and new roles for the oxidative breakdown products of NO, nitrite and nitrate, many important questions remain unanswered. The program of the upcoming NO-GRC will attempt to cover some relatively under-researched but important areas of investigation, e.g. the regulation of intermediary metabolism by NO, its role in the cellular/bodily ability to cope with situations of relative oxygen scarcity, the significance of oxygen and metals for the fate of NO, as well as exciting new developments in the field. Coverage of the latest research in established areas will be complemented by discussions on questions for which we do not have an answer yet. A cross-disciplinary approach will be sought throughout, with investigators at the forefront of research in molecular and structural biology, biochemistry, chemistry, and medicine, together with experts in microbial, plant and animal/human biology to address topics of mutual interest. The open and relaxed atmosphere of the GRC will make this meeting an ideal forum for the exchange of ideas and thought-provoking discussions between senior investigators and junior colleagues. If there was one important conference in 2011 you plan on attending, look no further – you found it.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:35 pmWelcome Comments by GRC Site Staff
7:35 pm - 7:45 pm Introductory Comments by Conference Chair, Martin Feelisch
7:45 pm - 9:30 pmMaking NO: Comparing the Bacterial, Plant and Mammalian Toolkit
Discussion Leader: William C. Sessa (Yale University, New Haven, CT)
7:45 pm - 8:10 pmBrian R. Crane (Cornell University, Ithaca, NY)
"The Chemistry and Biology of Nitric Oxide Synthases from Microbes and Men"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:45 pmDennis Stuehr (Cleveland Clinic Foundation, Cleveland, OH)
"Key Catalytic Features that Distinguish the Eukaryotic and Prokaryotic NO Synthases"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:20 pmWerner M. Kaiser (University of Würzburg, Würzburg, Germany)
"How Do Plants Make NO, and Does Fluorescence Imaging Tell Us the Truth?"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmCoping with Oxygen Shortage: HIF, Mitochondria, and Altitude Physiology
Discussion Leader: Serpil Erzurum (Cleveland Clinic Foundation, Cleveland, OH)
9:00 am - 9:25 amBernhard Bruene (Goehte University, Frankfurt, Germany)
"HIF and the NO-Output System in Macrophage Biology"
9:25 am - 9:40 am Discussion
9:40 am - 10:05 amPaul T. Schumacker (Northwestern University, Chicago, IL)
"Mitochondrial Oxidants Signal Cellular Stress Responses"
10:05 am - 10:20 am Discussion
10:20 am - 10:50 am Coffee Break
10:50 am - 11:15 amMichael P.W. Grocott (University College London, London, England)
"NO Formation on Ascent to Mt. Everest"
11:15 am - 11:30 am Discussion
11:30 am - 11:55 amCynthia M. Beall (Case Western Reserve University, Cleveland, OH)
"Recent Human Evolution and Adaptation to Oxygen Shortage"
11:55 am - 12:10 pm Discussion
12:10 pm - 12:25 pm Chair's Choice: Jessica E Dada (Wales Heart Research Institute, Cardiff, UK)
"Oxygen mediates red blood cell-induced hypoxic vasorelaxation"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session (Session Moderators: Timothy R. Billiar (University of Pittsburgh), Steven S. Gross (Cornell University), Mark Gladwin (University of Pittsburgh))
6:00 pmDinner
7:30 pm - 9:30 pmChemical Biology: Storage, Transport and Nitrogen Oxide Cycling
Discussion Leader: Jay L. Zweier (Ohio State University, Columbus, OH)
7:30 pm - 7:55 pmJack R. Lancaster (University of Alabama at Birmingham, Birmingham, AL)
"New Effects of NO Interactions with Cellular Non-Heme Iron"
7:55 pm - 8:10 pm Discussion
8:10 pm - 8:35 pmJon O. Lundberg (Karolinska Institutet, Stockholm, Sweden)
"Inorganic Nitrate, eNOS and the Metabolic Syndrome"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:15 pmRichard Weller (University of Edinburgh, Edinburgh, Scotland)
"Sun, Skin and the Heart - Is NO the Link between Sunlight and Cardiovascular Health?"
9:15 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSubstrate Utilization, Intermediary Metabolism and Mechanisms of Resistance
Discussion Leader: Andrew J. Gow (Rutgers University, Piscataway, NJ)
9:00 am - 9:45 amKeynote Lecture: Carl Nathan (Weill Cornell Medical College, New York, NY)
"Toward New Therapies for Infectious Disease: Inhibiting Pathogens’ Resistance to Host Immune Chemistry"
9:45 am - 10:00 am Discussion
10:00 am - 10:30 am Coffee Break
10:30 am - 10:55 am Joerg Durner (Helmholtz Zentrum Muenchen, Munich, Germany)
"Nitric Oxide Signalling in Plant Defence"
10:55 am - 11:10 am Discussion
11:10 am - 11:35 amDean P. Jones (Emory University, Atlanta, GA)
"Redox Compartmentalization of the Cysteine Proteome"
11:35 am - 11:50 am Discussion
11:50 am - 12:05 pmChair's Choice: Jay R Laver (University of Sheffield Medical School, Sheffield, UK)
"Bacterial nitric oxide detoxification prevents the formation of host cell S-nitrosothiol"
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:30 pm General Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session (Session Moderators: Timothy R. Billiar (University of Pittsburgh), Steven S. Gross (Cornell University), Mark Gladwin (University of Pittsburgh))
6:00 pmDinner
7:30 pm - 9:30 pmThiol/Redox Signaling
Discussion Leader: William R. Montfort (University of Arizona, Tucson, AZ)
7:30 pm - 7:55 pmJonathan S. Stamler (Case Western Reserve University, Cleveland, OH)
"Protein S-Nitrosylation Updated"
7:55 pm - 8:10 pm Discussion
8:10 pm - 8:35 pmMichael P. Murphy (MRC Mitochondrial Biology Unit, Cambridge, UK)
"Using Mitochondria Targeted-NO Donors to Investigate Mitochondrial NO Metabolism"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:15 pmHarry Ischiropolous (University of Pennsylvania, Philadelphia, PA)
"Probing for Factors that Influence Formation and Selectivity of Protein S-Nitrosylation"
9:15 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFrom Bedside to Bench and Back - What’s New on the Therapeutic Horizon?
Discussion Leader: Malte Kelm (Heinrich Heine University, Düsseldorf, Germany)
9:00 am - 9:25 amAmrita Ahluwalia (Barts and the London School of Medicine and Dentistry, London, England)
"Dietary Nitrate and Hypertension: Therapeutic Potential Realized"
9:25 am - 9:40 am Discussion
9:40 am - 10:05 amEddie Weitzberg (Karolinska Institutet, Stockholm, Sweden)
"Dietary Nitrate and Mitochondrial Function"
10:05 am - 10:20 am Discussion
10:20 am - 10:50 am Coffee Break
10:50 am - 11:15 amJohn Pernow (Karolinska Insitutet, Stockholm, Sweden)
"Regulation of NO Availability and Cardiovascular Function by Arginase"
11:15 am - 11:30 am Discussion
11:30 am - 11:55 amWarren M. Zapol (Massachusetts General Hospital, Boston, MA)
"Inhaled NO for the Prevention of Vasoconstriction by Infused Hemoglobin or Blood Substitutes"
11:55 am - 12:10 pm Discussion
12:10 pm - 12:25 pm Chair's Choice: Tienush Rassaf (Division of Cardiology, Pulmonology and Angiology, University of Duesseldorf, Germany)
"Nitrite and globins- new avenues for old molecules"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session (Session Moderators: Timothy R. Billiar (University of Pittsburgh), Steven S. Gross (Cornell University), Mark Gladwin (University of Pittsburgh))
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmCurrent Controversies and Late Breaking Findings / Hot Topics
Discussion Leaders: Jon O. Lundberg (Karolinska Institutet, Stockholm) and Mark T. Gladwin (University of Pittsburgh, Pittsburgh, PA)
7:30 pm - 7:45 pm Jay Zweier (Ohio State University Medical Center, Columbus, OH)
"Uncoupling of eNOS by S-glutathionylation"
7:45 pm - 7:53 pm Discussion
7:53 pm - 8:08 pm An L. Moens (Maastricht University Medical Centre, Maastricht, The Netherlands)
"Reversal of eNOS uncoupling by folic acid"
8:08 pm - 8:15 pm Discussion
8:15 pm - 8:30 pm Harold Raat (Erasmus Medical Center, Rotterdam, The Netherlands)
"Nitric oxide and the red cell storage lesion"
8:30 pm - 8:38 pm Discussion
8:38 pm - 8:53 pm Emily J. Tsai (Temple University School of Medicine, Philadelphia)
"NO-cGMP Signaling and Dynamic sGC Localization in the Stressed Heart"
8:53 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Hot Topics (5 min talks, selected from submitted abstracts and on site):
  • Massimo Delledonne (University of Verona, Italy)
    "Identification of candidate genes involved in NO signaling during cell death in plants"
  • Jeffrey S. Isenberg (University of Pittsburgh, USA)
    "TSP1-CD47 upregulates NOX-derived ROS in VSMCs and arteria to limit NO signaling and vasodilation"
  • Jason R. Hickok (University of Illinois Chicoago, USA)
    "Dinitrosyliron complexes are the most abundant NO-derived cellular adducts"
  • Milos Filipovic (University of Erlangen-Nuremberg, Germany)
    "Chemical insight into physiological effects of hydrogen sulfide: Reaction with ONOO- and formation of a new NO donor"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNO-cGMP Signal Transduction
Discussion Leader: John Garthwaite (University College of London, London, England)
9:00 am - 9:25 amWilliam R. Montfort (University of Arizona, Tucson, AZ)
"Soluble Guanylyl Cyclase: From Moth to Man"
9:25 am - 9:40 am Discussion
9:40 am - 10:05 amDoris Koesling (Ruhr University-Bochum, Bochum, Germany)
"The Role of NO/cGMP Signaling in Synaptic Transmission"
John Garthwaite (Wolfson Biomedical Research Institute, University College London, London, UK)
"Neuronal NO release recorded using highly sensitive detector cells"
10:05 am - 10:20 am Discussion
10:20 am - 10:50 am Coffee Break
10:50 am - 11:15 amHarald HHW Schmidt (Universiteit Maastricht, Maastricht, The Netherlands)
"ROS versus NOS"
11:15 am - 11:30 am Discussion
11:30 am - 11:55 amTakaaki Akaike (Kumamoto University, Kumamoto, Japan)
"Cellular Signaling by Nitrated Cyclic Nucleotides and Regulation of its Biological Effects"
11:55 am - 12:10 pm Discussion
12:10 pm - 12:25 pm Chair's Choice: Ah-Lim Tsai (Hematology and Internal Medicine, University of Texas Medical Center, Houston, TX)
"A Sliding-Rule Principle" for Gas Selectivity by Heme Proteins Sensors"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmHeme-NOx Interactions and Nitroxyl
Discussion Leader: Peter C. Ford (University of California, Santa Barbara, Santa Barbara, CA)
7:30 pm - 7:55 pmDavid A. Wink (National Cancer Institute, Bethesda, CA)
"On the Chemistry of Heme-Derived NO/HNO Formation"
7:55 pm - 8:10 pm Discussion
8:10 pm - 8:35 pmGeorge B. Richer-Addo (University of Oklahoma, Norman, OK)
"Is That Supposed to Be Green? Unraveling the Hb-Nitrite Interaction"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:15 pmS. Bruce King (Wake Forest University, Winston-Salem, NC)
"Organophosphorus Chemistry for Nitroxyl Detection"
9:15 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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