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Conference Program
 
Salivary Glands & Exocrine Biology
February 6-11, 2011
Hotel Galvez
Galveston, TX

The eighth Salivary Gland and Exocrine Biology Gordon Research Conference is the preeminent multi-disciplinary conference in these fields. It will continue the highly successful conference series that has brought together investigators at the forefront of salivary, lacrimal, pancreas and exocrine gland research, including basic, translational, and clinical researchers, with promising young scientists and experts from associated fields. We aim to bring together a diverse group of leading scientists into a single forum to present and discuss their latest unpublished results. A major goal is to prioritize future research directions in all aspects of the biology and pathobiology of exocrine glands and their secretions, along with related diagnostic and therapeutic advances.

This meeting will facilitate collaborations between groups with different strengths, but with intimately related interests. The program will highlight current research issues and state-of-the-art scientific approaches relevant for all investigators engaged in salivary gland and exocrine biology research. To these ends, the program will include researchers using a number of model systems to investigate the molecular mechanisms involved in glandular development and exocrine function. These include signal transduction, gene regulation, proliferation and apoptosis, protein and fluid secretion, and the control and regulation of secretion. The role these processes play in the initiation and progression of "exocrineopathies", such as Sjogrens syndrome, dry eye, and pancreatitis, will be included, as well as the immunology and genetics of Sjogrens syndrome. We also plan to include presentations on exocrine gland tumor biology and rare diseases of exocrine glands. Importantly, the therapeutic regeneration of exocrine tissue using gene therapy and stem/progenitor and iPS cells will be addressed. Additionally, the program will include researchers using a systems biology approach to investigate exocrine biology and glandular secretions, including advances in genomic, proteomic, and other “-omics”.

A few abstracts will be selected for shorter oral presentation in the weeks preceding the conference to ensure that the oral program includes exciting new advances. To encourage the participation of young investigators we will award a number of travel fellowships for students and postdoctoral fellows based on their submitted abstracts. To be considered for a travel award, abstracts must be submitted by Jan 16, 2011.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
Welcome from Masataka Murakami and Matthew Hoffman
7:40 pm - 9:30 pmSalivary, Pancreas, and Lacrimal Keynote Presentations
7:40 pm - 7:45 pm Discussion Leader: Maria A. Kukuruzinska (Boston University)
"Introduction"
7:45 pm - 8:10 pm Kenneth M. Yamada (NIDCR, National Institutes of Health)
"Cell and tissue dynamics"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:45 pm Ray J. MacDonald (University of Texas Southwestern)
"Development of the acinar pancreas; transcriptional control and ChIP-Seq analysis"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Darlene A. Dartt (Harvard University)
"P2X receptors in lacrimal gland: Role in secretion and disease"
9:20 pm - 9:30Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmMolecular mechanisms of Exocrine Secretion
Discussion Leader: Mary E. Reyland (University of Colorado Health Sciences Center)
9:00 am - 9:20 am Roberto Weigert (NIDCR, National Institutes of Health)
"A role for the acto-myosin complex in regulated exocytosis revealed by intravital microscopy"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Sarah F. Hamm-Alvarez (University of Southern California)
"Cross talk between transcytotic and exocytotic membrane trafficking in lacrimal gland acinar cells
9:50 am - 10:00 am Discussion
10:00 am - 10:10 am Miwako Matsuki-Fukushima (School of Dentistry at Matsudo, Japan)
"Aquaporin-6 is involved in osmoregulation of rat parotid secretory granules"
10:10 am - 10:15 am Discussion
10:15 am - 10:45 am Coffee Break
10:45 am - 11:05 am Debbie J. Andrew (Johns Hopkins University)
"Gene regulation in the early Drosophila salivary gland: Morphogenesis, secretion and cell-type specialization"
11:05 am - 11:15 am Discussion
11:15 am - 11:35 am Shmuel Muallem (University of Texas Southwestern)
"HCO3-secretion"
11:35 am - 11:45 am Discussion
11:45 am - 11:55 am Rebecca M. Fox (Johns Hopkins University)
"The CrebA/Creb3-like transcription factors are required to boost the secretory capacity of specialized secretory organs"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Lorena B. De Souza (São Paulo University, Brazil)
"PLD is involved in the formation of golgi associated clathrin coated vesicles in intercalated duct cells of parotid gland"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Sumit Bhattacharya (Univerity of Toledo)
"Differential effects of P2X4 and P2X7 receptor activations on Ca2+ signaling and exocytosis in mouse parotid acinar cells"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session (Odd numbered posters presented)
6:00 pmDinner
7:30 pm - 9:30 pmTumor Biology, Diseases, and Diagnostics
Discussion Leader: David T. Wong (UCLA School of Dentistry)
7:30 pm - 7:50 pm Kirsten H. Limesand (University of Arizona)
"Signaling pathways involved in radiation-induced salivary gland dysfunction"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm V.P. Eswarakumar (Yale University)
"Molecular mechanisms of salivary gland hypoplasia"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm John McDevitt (Rice University)
"Next generation diagnostic devices based on bio-nano-chips"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:10 pm Jieping Yang (University of California Los Angeles)
"Mechanism underlying salivary diagnostics for systemic diseases: the contribution of disease-derived exosomes"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Anne M. Rowzee (NIDCR, National Institutes of Health)
"Salivary glands are useful target organs for gene therapy of diabetes mellitus"
9:25 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSystems Biology
Discussion Leader: Melinda Larsen (University at Albany)
9:00 am - 9:20 am James Sneyd (Auckland University, New Zealand)
"Modelling saliva secretion at multiple scales"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Yoshiro Sohma (Keio University School of Medicine, Japan)
"Direct measurement and simulation of water movement: a novel approach to water transport physiology"
9:50 am - 10:00 am Discussion
10:00 am - 10:10 am Markus Hardt (Boston Biomedical Research Institute)
"Absolute quantification of endogenous salivary peptides using high resolution selected reaction monitoring mass spectrometry"
10:10 am - 10:15 am Discussion
10:15 am - 10:45 am Coffee Break
10:45 am - 11:05 am Ivan T. Rebustini (NIDCR, National Institutes of Health)
"MicroRNAs regulate proliferation and cell fate decisions"
11:05 am - 11:15 am Discussion
11:15 am - 11:35 am Kasia A. Rejniak (Moffitt Cancer Center)
"Intrinsic and extrinsic mechanisms in epithelial gland formation: an integrated model"
11:35 am - 11:45 am Discussion
11:45 am - 12:05 pm Steve Horvath (University of California Los Angeles)
"Studying gene co-expression modules related to Sjogrens syndrome"
12:05 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Melissa A. Metzler (University of Louisville)
"MicroRNA changes in parotid gland acinar differentiation"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session (Even numbered posters presented)
6:00 pmDinner
7:30 pm - 9:30 pmExocrine Glycobiology
Discussion Leader: Sarah M. Knox (NIDCR, National Institutes of Health)
7:30 pm - 7:50 pm Maria A. Kukuruzinska (Boston University)
"Interplay among protein N-glycosylation, Wnt signaling, and E-cadherin-mediated cell-cell adhesion"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Kelly TenHagen (NIDCR, National Institutes of Health)
"Protein O-glycosylation in developmentally regulated cell adhesion and organogenesis"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm J. Michael Pierce (University of Georgia)
"Application of technologies for the glycomics of stem and cancer cells to identify biomarkers"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Steven Leach (Johns Hopkins University)
"Finding the center: Centroacinar progenitors in mouse and zebrafish pancreas"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmInflammation and Autoimmunity
Discussion Leader: Darlene Dartt
9:00 am - 9:20 am Ilias Alevizos (NIDCR, National Institutes of Health)
"MicroRNAs as biomarkers of inflammation and salivary gland dysfunction in Sjögren's syndrome"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Hiroshi Ishiguro (Nagoya University Japan)
"Pancreatic duct dysfunction and pancreatitis"
9:50 am - 10:00 am Discussion
10:00 am - 10:10 am Sreedevi Chinthamani (University of Buffalo)
"Lipoxin inhibits immune cell adherence and rolling in salivary epithelium and vascular endothelium"
10:10 am - 10:15 am Discussion
10:15 am - 10:45 am Coffee Break
10:45 am - 11:05 am Gary Weisman (University of Missouri)
"P2 nucleotide receptors: balancing salivary gland inflammation and regeneration"
11:05 am - 11:15 am Discussion
11:15 am - 11:35 am Seunghee Cha (University of Florida)
"Innate immunity and secretory dysfunction in Sjögren's syndrome"
11:35 am - 11:45 am Discussion
11:45 am - 11:55 am Kwong Tai Oscar Cheng (NIDCR, National Institutes of Health)
"Targeted deletion STIM1 and STIM2 in T lymphocytes leads to Sjögren's Syndrome-like salivary gland autoimmune disease"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Olutayo A. Odusanwo (University of Buffalo)
"D series Resolvins (RvDs) prevent TNF α-mediated disruption of monolayer formation in salivary epithelium"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Julian L. Ambrus (Buffalo General Hospital)
"Use of IL14α transgenic mice in the study of Sjogren's disease"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session (General poster viewing)
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmEpithelial Progenitor Cell Biology
Discussion Leader: Isabelle M.A. Lombaert (NIDCR, National Institutes of Health)
7:30 pm - 7:50 pm Sarah M. Knox (NIDCR, National Institutes of Health)
"A little bit nervous? Parasympathetic innervation regulates epithelial progenitor cells"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Fei Liu (Texas A&M Health Sciences Center)
"Modulating Wnt and hedgehog pathways for functional restoration of salivary glands"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Catherine E. Ovitt (University of Rochester)
"Ascl3 as a marker of adult progenitor cells"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:10 pm Abigail S. Tucker (Kings College London, UK) "Epithelial-mesenchymal interactions during salivary gland initiation"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Jeff C. Hsu (NIDCR, National Institutes of Health) "Development of complementary approaches to probe epithelial plasticity in developing mouse salivary glands"
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSignal Transduction and Exocrine Gland Function
Discussion Leader: David Yule (University of Rochester)
9:00 am - 9:20 am James W. Putney (NIEHS, National Institutes of Health)
"Physiological function of store-operated calcium channels in epithelia and other non-excitable cells"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Lily Jan (University of California San Francisco)
"Getting to know the TMEM16 family"
9:50 am - 10:00 am Discussion
10:00 am - 10:10 am Stephen P. Soltoff (Harvard University)
"Regulation and identification of the Na,K-ATPase alpha 1 subunit phosphorylation in rat parotid acinar cells"
10:10 am - 10:15 am Discussion
10:15 am - 10:45 am Coffee Break
10:45 am - 11:05 am Hiroshi Sugiya (Nihon University, Japan)
"cAMP-dependent exocytosis in parotid acinar cells"
11:05 am - 11:15 am Discussion
11:15 am - 11:35 am Akihiko Tanimura (Health Sciences University of Hokkaido, Japan)
"Roles of purinergic receptors on the spontaneous and agonist-induced Ca2+ responses in rat salivary ducts"
11:35 am - 11:45 am Discussion
11:45 am - 11:55 am Fei Wei (National Institute for Natural Sciences, Japan)
"Salivary fluid secretion induced by Chinese herb, DanShen"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Marit H. Aure (University of Oslo, Norway)
"Aquaporins in the mouse sublingual salivary gland"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Nataliya V. Fedirko (Bogomoletz Institute of Physiology, Ukraine)
"CB1 and CB2 receptors in submandibular acinar cells: functional coupling between basal fluid and electrolytes secretion and Ca2+ signaling"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session (General poster viewing)
6:00 pmDinner
7:30 pm - 9:30 pmRegeneration and iPS Cells
Discussion Leader: Indu S. Ambudkar (NIDCR, National Institutes of Health)
7:30 pm - 7:50 pm Tetsuya Kawakita (Keio University, Japan)
"Lacrimal gland regeneration"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Ana Cotrim (NIDCR, National Institutes of Health)
"Transfer of human aquaporin-1 cDNA to correct radiation-induced salivary hypofunction"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:40 pm Sharon J. Sequeira (University at Albany)
"Nanoscale topography of 3D artificial scaffolds regulates salivary gland epithelial cell morphology and focal adhesion complex formation"
8:40 pm - 8:45 pm Discussion
8:45 pm - 8:55 pm Kazuo Komiyama (Nihon University, Japan)
"Epiregulin regulates acinar cell regeneration process in mouse submandibular gland"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Rob P. Coppes (University of Groningen, Netherlands)
"The development of stem cell therapy to reduce radiation-induced hyposalivation"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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