Gordon Research Conferences
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Conference Program
 
Signal Transduction within the Nucleus
February 27 - March 4, 2011
Four Points Sheraton / Holiday Inn Express
Ventura, CA

The Gordon Conference on Signal Transduction within the Nucleus will be the fourth one of a series held every other year. This conference provides an outstanding forum to present and discuss new findings for how signaling pathways participate in the regulation of nuclear processes. The synergies fueled by the diverse and interdisciplinary approaches taken by participants of past meetings drive unique perspectives in connecting signaling pathways to nuclear functions. This momentum will be strengthened and enhanced in the 2011 meeting. Elucidating the mechanisms by which nuclear enzymes, chromatin and its modifications and nuclear machineries contribute to the abilities of cells and organisms to respond and survive in dynamic environments will be essential to gain a full understanding of the nuclear dysfunctions that contribute directly to disease processes, including cancer biology and genetic disorders.

The meeting will convene approximately 35 invited speakers representing key areas of nuclear signal transduction, with a total of 140 participants. The program will consist of morning and evening sessions that broadly address cutting-edge issues in the following areas: nucleo-cytoplasmic signaling, the physiology of stress responses, nuclear lipid signaling, nuclear receptor signaling, agonist-induced nuclear lipid and carbohydrate metabolism, chromatin composition and functional role, DNA damage/repair pathways, nuclear organization and spatial architecture, nuclear membrane dynamics, RNA processing and export, and control of nuclear division. Small, intensive poster sessions will be convened in the later afternoons, allowing all participants to contribute to and learn about these topics. Informal discussions among established and junior principal investigators, postdoctoral fellows, and students will be stimulated during early-afternoon and late-evening breaks. This conference will offer a timely and highly topical program allowing the investigators to connect the newly discovered signaling pathways and nuclear functions.

Note: The Chair has created a flyer to advertise the GRC, which can be downloaded by clicking here (PDF Format, right-click and "Save As" to download).


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 7:50 pm Welcome / Introductory Comments by Conference Co-Chairs
7:50 pm - 8:35 pmThe Unfolded Protein Response
Discussion Leader: Vytas A. Bankaitis (University of North Carolina School of Medicine)
7:40 pm - 8:20 pmKeynote Speaker: Peter Walter (University of California, San Francisco and HHMI)
"The Unfolded Protein Response in Health and Disease"
8:20 pm - 8:35 pm Discussion
8:35 pm - 9:30 pm Informal Poster Session
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmStress Signaling
Discussion Leader: Vytas A. Bankaitis (University of North Carolina School of Medicine)
9:00 am - 9:25 amRandal Kaufman (University of Michigan Medical Center)
"Protein misfolding in the ER and oxidative stress"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 amChristopher Nicchitta (Duke University School of Medicine)
"Partitioning the mRNA transcriptome: Bimodal regulation of mRNA localization to the endoplasmic reticulum"
10:00 am - 10:10 am Discussion
10:10 am - 10:40 am Coffee Break
10:40 am - 11:05 amJairaj Acharya (National Cancer Institute, USA)
"Cellular addiction on Ceramide Flux - A CERT'nty"
11:05 am - 11:10 am Discussion
11:10 am - 11:35 amAnne Brunet (Stanford University)
"FoxO transcription factors in aging and longevity"
11:35 am - 11:45 am Discussion
11:45 am - 12:10 pm Gregory D. Davis (Sigma-Aldrich, ZFN Group)
"Modulation of endogenous kinase activity in human cells via codon editing using zinc finger nucleases"
12:10 pm - 12:20 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 8:30 pmTranscriptional Regulation by RNA Polymerase II and Chromatin
Discussion Leader: Ali Shilatifard (Stowers Institute)
7:30 pm - 8:10 pmKeynote Speaker: Danny Reinberg (Howard Hughes Medical Institute, NYU School of Medicine)
"Chromatin and Its Impact on Gene Expression and Cellular Memory"
8:10 pm - 8:30 pm Discussion
8:30 pm - 9:30 pm Informal Poster Session
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNuclear Inositide and Lipid Signaling
Discussion Leader: John York (Duke University School of Medicine and HHMI)
9:00 am - 9:25 amSusan Wente (Vanderbilt University School of Medicine)
"Regulation of nucleocytoplasmic transport"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 amNullin Divecha (CRUK Inositide Laboratory, University of Manchester)
"Regulation and function of nuclear phosphatidylinositol-5-phosphate"
10:00 am - 10:10 am Discussion
10:10 am - 10:40 am Coffee Break
10:40 am - 11:05 amLucio Cocco (University of Bologna School of Medicine)
"Physiology and pathology of nuclear inositide signalling"
11:05 am - 11:10 am Discussion
11:10 am - 11:35 amJulie Saba (Children’s Hospital Oakland Research Institute)
"Sphingosine-1-phosphate lyase regulates DNA damage responses"
11:35 am - 11:45 am Discussion
11:45 am - 12:00 pmHitoshi Yagisawa (University of Hyogo Graduate School of Life Science)
"Mechanisms of nucleocytoplasmic transport of phospholipase C-delta1 and its role in cellular function"
12:00 pm - 12:05 pm Discussion
12:05 pm - 12:20 pm Raymond Blind (University 0f California at San Francisco)
"The nuclear receptor SF-1/PIP complex is a unique substrate for IPMK and phospholipid metabolic enzymes, regulating transcription"
12:20 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:15 pmNuclear Organization
Discussion Leader: Michael Rout (Rockefeller University)
7:30 pm - 7:55 pmTom Misteli (National Cancer Institute, NIH)
"Epigenetic regulation of alternative splicing"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:30 pmKatherine Borden (University of Montreal)
"Understanding the nuclear functions of eIF4E in mRNA export: from cells to the clinic"
8:30 pm - 8:40 pm Discussion
8:40 pm - 9:05 pmSiegfried Musser (Texas A&M Health Science Center)
"Transport complex assembly and disassembly during nucleocytoplasmic transport visualized by single molecule FRET"
9:05 pm - 9:15 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRNA, Chromatin, and Nuclear Signaling
Discussion Leader: Ramin Shiekhattar (Wistar)
9:00 am - 9:25 amRamin Shiekhattar (Wistar)
"Long Noncoding RNAs with Enhancer-like Function in Human Cells"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 amDanesh Moazed (HHMI/Harvard)
"Control of chromosome organization and stability by inner nuclear membrane proteins"
10:00 am - 10:10 am Discussion
10:10 am - 10:40 am Coffee Break
10:40 am - 11:05 amRobert Goldman (Northwestern University Feinberg School of Medicine)
"A multitude of mutations in the human lamin A gene are providing new insights into the functional organization of the nucleus"
11:05 am - 11:10 am Discussion
11:10 am - 11:35 am Hans Martin Herz (Stowers Institute for Medical Research)
"Jarid2, a gene-specific and context-dependent modulator of Polycomb repressive complex-2 in Drosophila"
11:35 am - 11:45 am Discussion
11:45 am - 12:00 pm Michael R. Huebner (Cold Spring Harbor Laboratory)
"Dynamics and function of the H3K27 demethylase JMJD3"
12:00 pm - 12:05 pm Discussion
12:05 pm - 12:20 pm Mark Biggin (Lawrence Berkeley National Lab)
"Chromatin accessibility directs the widespread, overlapping patterns of animal transcription factor binding in vivo"
12:20 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:15 pmChromatin and the Regulation of Gene Expression
Discussion Leader: Sue Jaspersen (Stowers Institute)
7:30 pm - 7:55 pmSue Jaspersen (Stowers Institute)
"The function of spindle pole body proteins in nuclear chromosome dynamics"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:30 pmShelley Berger (U Penn)
"Chromatin and aging"
8:30 pm - 8:40 pm Discussion
8:40 pm - 9:05 pmJerry Workman (Stowers Institute)
"Map kinases and histone modifications"
9:05 pm - 9:15 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSignaling to the Nucleus
Discussion Leader: Pascale Zimmermann (K.U.Leuven School of Medicine)
9:00 am - 9:25 amAlan Hinnebusch (Laboratory of Gene Regulation and Development NICHD, NIH)
"Transcriptional control by endosomal sorting factors in yeast"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 amBrenda Andrews (University of Toronto)
"Using yeast functional genomics to map transcriptional regulatory networks and pathways"
10:00 am - 10:10 am Discussion
10:10 am - 10:40 am Coffee Break
10:40 am - 11:05 amShinya Kuroda (University of Tokyo)
"Temporal coding of AKT and ERK signaling networks"
11:05 am - 11:10 am Discussion
11:10 am - 11:25 amFabio Stossi (University of Illinois)
"ERK2 acts directly on chromatin to drive macrophage-dependent loss of estrogen receptor alpha expression in breast cancer cells"
11:25 am - 11:30 am Discussion
11:30 am - 11:45 amFrank Alber (University of Southern California)
"Higher order genome organization from population based structure calculations"
11:45 am - 11:50 am Discussion
11:50 am - 12:15 pm Primal De Lanerolle (University of Illinois at Chicago)
"Molecular motors in the nucleus: Life without filaments"
12:15 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmThe RNA Polymerase II, Chromatin and Cancer
Discussion Leader: Andreas Ladurner (EMBL)
7:30 pm - 7:55 pmAndreas Ladurner (EMBL)
"PARP1-dependent responses in the function and localization of chromatin regulators"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:30 pmJames Goodrich (University of Colorado)
"Regulation of mRNA transcription by non-coding RNAs"
8:30 pm - 8:40 pm Discussion
8:40 pm - 9:05 pmBing Ren (UCSD)
"Comprehensive analysis of a cancer epigenome"
9:05 pm - 9:15 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1 R13 GM097728-01 from the National Institute of General Medical Sciences. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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