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Conference Program
 
Staphylococcal Diseases
July 24-29, 2011
Renaissance Tuscany Il Ciocco Resort
Lucca (Barga), Italy

The 12th Gordon Conference on Staphylococcal Diseases 2011 will present cutting-edge research on the important pathogens S. aureus and coagulase-negative staphylococci. Topics at this meeting will include: host interaction, immune evasion, evolution, physiology, cell surfaces, therapeutics and patient management. Invited speakers from academia and industry who are at the forefront of their subject will be presenting their latest unpublished research. All attendees will have the opportunity to present posters and exchange ideas with leaders in the staphylococcal field. As in previous years, the best posters from younger researchers will be selected for short oral presentations. The collegial atmosphere of this Conference, with organized discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an ideal setting for scientists from different disciplines to exchange ideas, brainstorm and foster cross-disciplinary collaborations.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmThe Host Pathogen Interface
Discussion Leader: Fritz Götz (University of Tuebingen)
7:40 pm - 8:25 pm Tim Foster (Trinity College, Dublin)
"Evasion of Host Defences by Surface Proteins"
8:25 pm - 8:40 pm Discussion
8:40 pm - 9:15 pm Andreas Peschel (University of Tuebingen)
"Sorting the Good from the Bad - The Human Formyl-Peptide Receptor 2 in Staphylococcal Infections"
9:15 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBacterial Adaptation and Evolution
Discussion Leader: Wolfgang Witte (Robert Koch Institute)
9:10 am - 9:45 am Jose Penades (CSIC, Spain)
"Phage dUTPases Induce Transfer of Pathogenicity Islands by an Oncogenic G-Protein Like Mechanism"
9:45 am - 10:00 am Discussion
10:00 am Coffee Break / Group Photo
10:40 am - 11:15 am Jodi Lindsay (St George's, University of London)
"Is a Flexible S. aureus Genome a Successful S. aureus Genome?"
11:15 am - 11:30 am Discussion
11:30 am - 11:38 am Sunhee Ahn (Duke University Medical Center)
"Role of common genetic variants in the acquisition and severity of Staphylococcus aureus bacteremia"
11:38 am - 11:40 am Discussion
11:40 am - 12:15 pm Jacques Schrenzel (Geneva University Hospital)
"Barriers to Horizontal Gene Transfer"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmStrategic Sequencing - Beyond the Initial Genomes
Discussion Leader: Ed Feil (University of Bath)
5:40 pm - 6:15 pm Sharon Peacock (University of Cambridge)
"MRSA transmission: time to remove the blindfold"
6:15 pm - 6:30 pmDiscussion
6:30 pm - 6:38 pmLaura Spoor (University of Edinburgh)
"Evidence for large scale recombination among distinct ruminant-adapted Staphylococcus aureus lineages"
6:38 pm - 6:40 pm Discussion
6:40 pm - 7:15 pm Ulrich Nübel (Robert Koch Institute)
"Reconstructing Clonal Expansions and Spatial Spread"
7:15 pm - 7:30 pm Discussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmThe Dynamic Cell Wall
Discussion Leader: Magnus Höök (Texas A&M)
9:10 am - 9:40 am Simon Foster (University of Sheffield)
"Cell Wall Architecture and Dynamics"
9:40 am - 9:55 am Discussion
9:55 am Coffee Break
10:20 am - 10:50 am Mariana Pinho (ITQB, Portugal)
"Temporal and Spatial Regulation of Cell Wall Synthesis in S. aureus"
10:50 am - 11:05 am Discussion
11:05 am - 11:35 am Olaf Schneewind (University of Chicago)
"Protein Targetting in Staphylococci v Bacilli"
11:35 am - 11:50 am Discussion
11.50 am - 12:20 pm Steven Lower (The Ohio State University)
"Nanoscale Bonds at the Heart of Staphylococcus aureus Biofilms on Cardiac Prostheses
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmProspects for Future Disease Management
Discussion Leader: Steve Projan (MedImmune)
5:40 pm - 6:15 pm Annaliesa Anderson (Pfizer)
"Can We Beat S. aureus at Its Own Game? Insights into the Design and Evaluation of a Novel Investigational Vaccine for the Prevention of S. aureus Invasive Disease"
6:15 pm - 6:30 pm Discussion
6:30 pm - 6:38 pm Mark Shirtliff (University of Maryland)
"Staphylococcus aureus biofilm infections: Immune response, diagnostics, and vaccine development"
6:38 pm - 6:40 pm Discussion
6:40 pm - 7:15 pm Bret Sellman (MedImmune)
"Characterization of potent inhibitory anti-alpha toxin mAbs: Correlation between affinity and activity"
7:15 pm - 7:30 pm Discussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmThe Metabolic Engine and Gene Regulation
Discussion Leader: Greg Somerville (University of Nebraska-Lincoln)
9:10 am - 9:40 am Tony Richardson (University of North Carolina)
"Polyamine Metabolism and Staphylococcus aureus Infections"
9:40 am - 9:55 am Discussion
9:55 am Coffee Break
10:20 am - 10:50 am Christiane Wolz (University of Tuebingen)
"Stringent Control in S. aureus"
10:50 am - 11:05 am Discussion
11:05 am - 11:35 am Brice Felden (Université Rennes)
"An overlapping RNA pair expressed by S. aureus with a dual function: one encodes a membrane polypeptide and the other is a regulator"
11:35 am - 11:50 am Discussion
11:50 am - 12:20 pm Angelika Grundling (Imperial College London)
"How Staphylococcus aureus Synthesizes Lipoteichoic Acid and How It Can Survive Without It"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmChanging Patterns of Staphylococcal Disease and Colonisation
Discussion Leader: Sharon Peacock (University of Cambridge)
5:40 pm - 6:10 pm James Chen (Chang Gung Children's Hospital, Taiwan)
"CA-MRSA Infection and Colonization: from Clinical to Bench Research"
6:10 pm - 6:25 pm Discussion
6:25 pm - 6:33 pm Thippeswamy Sannasiddappa (University of Reading)
"The influence of Staphylococcus aureus on gut microbial ecology in an in vitro continuous culture human colonic model system"
6:33 pm - 6:35 pm Discussion
6:35 pm - 6:43 pm Mark Holmes (University of Cambridge)
"Emergence of a novel mecA homologue in MRSA from human and bovine populations in the UK and Denmark"
6:43 pm - 6:45 pm Discussion
6:45 pm - 7:15 pm Christopher Montgomery (University of Chicago)
"The Pathophysiology of USA300, Secrets of a Successful Clone"
7:15 pm - 7:30 pm Discussion
7:30 pm - 8:00 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmImmunity and Evasion
Discussion Leader: Jos van Strijp (UMC Utrecht)
9:10 am - 9:40 am Jos van Strijp (UMC Utrecht)
"Staphylococcal Immune Evasion and Implications in Vaccination"
9:40 am - 9:55 am Discussion
9:55 am Coffee Break
10:20 am - 10:50 am John Fraser (University of Auckland)
"The Staphylococcal Superantigen-Like (SSL) Proteins in the Defence Againt Innate Immunity"
10:50 am - 11:05 am Discussion
11:05 am - 11:35 am David Underhill (Cedars Sinai Medical Center)
"The Role of Phagocytosis in Macrophage Inflammatory Responses to S. aureus"
11:35 am - 11:50 am Discussion
11:50 am - 12:20 pm Paul Kubes (University of Calgary)
"Imaging Bacterial Clearance in the Vasculature and Tissues"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 6:30 pmHot Topics - Correlates of Protection: Antibodies or T Cells?
Discussion Leader: Jean Lee (Harvard Medical School)
5:30 pm - 5:50 pm Tessie McNeely (Merck)
"IsdB, an Investigational Vaccine for Staphylococcus aureus, induces Efficacious Humoral and Cellular Immunity in Preclinical Models of Infection"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pm Fabio Bagnoli (Novartis)
"Dissecting the immune responses generated by protein-based vaccines against Staphylococcus aureus"
6:20 pm - 6:30 pm Discussion
6:30 pm - 7:30 pmPoster Review
Discussion Leaders: Vance Fowler (Duke) and Mark Smeltzer (UAMS)
(6 speakers TBA)
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13A1096460-01 from the National Institute of Mental Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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