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Stem Cells and Cancer
Gordon Research Conference

Dates

February 20-25, 2011

Location

Ventura Beach Marriott
Ventura, CA

Organizers

Chair:
Catriona Jamieson

Vice Chair:
Andreas Trumpp

Meeting Description

The 2011 Gordon Conference on Stem cells and Cancer will present cutting-edge research on the cellular and molecular mechanisms controlling self-renewal and differentiation of both normal and cancer stem cells. Cumulative evidence indicates that cancer stem cells are responsible for the growth and spread of tumors. Expansion of normal stem cells is under tight genetic and epigenetic control. Cancer stem cells have escaped these limitations resulting in expansion of the self-renewing cell populations. The goals of this meeting are to present the most current research into the cellular and molecular biology of normal and cancer stem cells. Topics that will be explored in this meeting are cancer stem cell microenvironmental interactions, self-renewal regulation in normal and malignant stem cells, cellular reprogramming mechanisms, new markers for stem cells and cancer stem cells and cancer stem cells as therapeutic targets. The conference will bring together key investigators at the forefront of stem cell research and will provide opportunities for postdocs and graduate students to present their work in poster sessions and in a selected set of short talks. There will be ample opportunity for discussions and informal interactions to help promote cross-disciplinary interactions and foster collaborations between stem cell researchers world-wide.

Conference Organizers: Catriona Jamieson, MD, PhD and Andreas Trumpp, PhD

Contributors

Meeting Program

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Lectures
Discussion Leader: Catriona Jamieson, MD, PhD (UCSD)
7:40 pm - 7:50 pmIntroduction
7:50 pm - 8:05 pmAndreas Trumpp, PhD (DKFZ)
"Dormancy in normal and malignant stem cells"
8:05 pm - 8:15 pm Discussion
8:15 pm - 9:15 pmKeynote Lecture: John Dick, PhD (UHN)
"Modeling the human leukemogenic process"
9:15 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSelf-Renewal and Cancer
Discussion Leader: Tannistha Reya, PhD (Duke)
9:00 am - 9:10 amIntroduction
9:10 am - 9:45 am Hanna Mikkola, MD, PhD (UCLA)
"Specification and self-renewal of hematopoietic stem cells"
9:45 am - 10:00 am Discussion
10:00 am - 10:30 am Group Photo / Coffee Break
10:30 am - 11:10 am Tannistha Reya, PhD (Duke)
"Developmental Signaling in Stem Cells and Cancer"
11:10 am - 11:30 am Discussion
11:30 am - 12:10 pmRoel Nusse, PhD (Stanford)
"Wnt signaling in tissue generation and regeneration"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmHemapoietic Stem Cells and Leukemia
Discussion Leader: Camilla Forberg, PhD (UCSC)
7:30 pm - 7:40 pmIntroduction
7:40 pm - 8:10 pm Ioannis Aifantis, PhD (NYU)
"The Ubiquitome and its role in blood stem cell differentiation and leukemia"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:45 pmDavid Traver, PhD (UCSD)
"Development of the hematopoietic system"
8:45 pm - 8:50 pm Discussion
8:50 pm - 9:20 pmEmmanuelle Passegue, PhD (UCSF)
"HSC function in normal and diseased hematopoiesis"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmReprogramming and Cancer
Discussion Leader: Jean C.Y. Wang, PhD (U Toronto)
9:00 am - 9:10 amIntroduction
9:10 am - 9:50 am Robert Wechsler-Reya, PhD (Duke)
"The Road to Ruin: Transforming Stem Cells into Brain Tumors"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 11:10 am Tom Look, MD (Harvard)
"MET activation in leukemia initiating cells induced by aberrant autocrine expression"
11:10 am - 11:30 am Discussion
11:30 am - 12:10 pmMaarten Van Lohuizen, PhD (Netherlands Cancer Institute)
"Role of Polycomb repressors in stem cells and cancer"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSolid Tissue Stem Cells and Cancer
Discussion Leader: Irv Weissman, MD (Stanford)
7:30 pm - 7:40 pmIntroduction
7:40 pm - 8:10 pmIrv Weissman, MD (Stanford)
"Normal and neoplastic stem cells"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:45 pm Hong Wu, PhD (UCLA)
"PTEN, Stem Cells and Prostate Cancer Stem Cells"
8:45 pm - 8:50 pm Discussion
8:50 pm - 9:20 pmJane Visvader, MD (Walter + Eliza Hall Institute of Medical Research)
"The mammary epithelial hierarchy and its implications for oncogenesis"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStem Cell Profiling and (Epi)genomics
Discussion Leader: Bing Ren, PhD (UCSD)
9:00 am - 9:10 amIntroduction
9:10 am - 9:35 amConnie Eaves, PhD (BC Cancer Agency, Terry Fox Laboratory, Vancouver)
"Manipulating CML Stem Cell Self-renewal"
9:35 am - 9:45 am Discussion
9:45 am - 10:10 am Kelly Frazer, PhD (UCSD)
10:10 am am - 10:20 am Discussion
10:20 am Coffee Break
10:55 am - 11:20 am Alysson Muotri (UCSD)
"Mobilization of L1 retrotransposons during stem cell differentiation"
11:20 am - 11:30 am Discussion
11:30 am - 12:10 pmLeonard Zon, MD (Harvard)
"Stem Cell Fate and Self-Renewal"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmLate Breaking Abstracts
Discussion Leader: Barbara Marte, PhD (Nature Journal)
7:30 pm - 7:40 pmIntroduction
7:40 pm - 8:10 pm Bill Matsui, PhD (Johns Hopkins)
"Pancreatic cancer stem cell targeting via the tumor microenvironment"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:50 pm Peter Dirks, PhD (U Toronto)
8:50 pm - 8:55 pm Discussion
8:55 pm - 9:20 pmAlan Trounson, PhD (CIRM)
"Accelerating translation of discoveries in cancer stem cell related research to the clinic"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNiche Signaling and Stem Cell Control
Discussion Leader: Lawrence Goldstein
9:00 am - 9:10 amIntroduction
9:10 am - 9:50 am Hans Clevers, MD, PhD (Hubrecht Institute)
"Wnt signaling, Lgr5 stem cells and cancer"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 11:10 amToshio Suda, MD, PhD (Keio U)
"Quiescence of stem cells in the hypoxic niche"
11:10 am - 11:30 am Discussion
11:30 am - 12:10 pmAmy Wagers, PhD (Harvard)
"Myogenic and mesenchymal precursors in muscle regeneration, aging, and tumorigenesis"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTherapeutics Against Cancer Stem Cells
Discussion Leader: Neil Gibson, PhD (Pfizer)
7:30 pm - 7:40 pmIntroduction
7:40 pm - 8:10 pmCraig Jordan, PhD (Rochester)
"Therapeutic Targeting of Leukemia Stem Cells"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:45 pm Dennis Carson, MD (UCSD)
"Application of Cancer Stem Cells in Drug Development"
8:45 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Jeremy Rich, MD (Lerner Research Institute)
"Brain Tumor Stem Cells in Therapy"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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