Gordon Research Conferences
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Conference Program
 
Stress Proteins in Growth, Development & Disease
July 17-22, 2011
Renaissance Tuscany Il Ciocco Resort
Lucca (Barga), Italy
Chair:
Lea Sistonen

Vice Chair:
Judith Frydman

The cellular proteome is constantly exposed to a wide variety of toxic stresses. These include external stresses, such as elevated temperatures and radiation damage as well as physiological stresses encountered during cellular proliferation and differentiation, such as oxidative stress generated by metabolic reactions. The proteome is also stressed by a large number of common stimuli, such as pharmacological agents, infection, and inflammation. In all organisms, induction of the stress response is essential for the maintenance of protein homeostasis in response to proteotoxic stress. A hallmark of stressed cells and organisms is the increased synthesis of molecular chaperones that aid in the folding of nascent polypeptides and prevent protein misfolding and aggregation. They are also important for protein degradation and translocation across membranes as well as for the correct formation of macromolecular assembles. The protein quality control and stress protection machineries require strict signaling modalities and transcriptional programs, which are altered in a number of disease states, including cancer, cardiovascular disease, metabolic disease (e.g. diabetes), and liver disease. Modulation of the stress response also plays a critical role in lifespan regulation and aging-related diseases such as Alzheimer’s, Parkinson’s, Huntington’s, and prion-based disease.

The 2011 Gordon Conference “Stress Proteins in Growth, Development & Disease” will highlight the most recent advances in stress biology and biomedical research of stress-related diseases. Special emphasis is on a multitude of model systems that are being used to investigate stress sensing, signaling and regulation of gene expression, including epigenetic mechanisms. Post-translational modifications of stress proteins and their involvement in the key enzymatic pathways, leading to these modifications, are of major interest. The recent discoveries in the chemical modulation of stress pathways and the role of stress proteins as integrators of cell stress, development and lifespan will be presented. The Conference’s collegial and scholarly environment encourages vigorous discussions of exciting developments related to several areas of stress research. The meeting provides also excellent opportunities for graduate students, postdoctoral fellows and junior group leaders to present their work either in posters or short talks. The formal scientific program together with more informal discussions will enhance the dissemination of new information and the formation of new collaborations, which are invaluable for deeper understanding of the versatile roles of stress proteins in human health, aging, and disease.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmProtein Quality Control and Transcription in Stress and Disease
Discussion Leader: Lea Sistonen (Åbo Akademi University)
7:40 pm - 8:20 pm Peter Walter (University of California, San Francisco)
"The Unfolded Protein Response in health and disease"
8:20 pm - 8:35 pm Discussion
8:35 pm - 9:15 pm John Lis (Cornell University)
"Heat Shock Factor and its targets: a model for understanding both transcription regulation and cancer enabling networks"
9:15 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmProtective Mechanisms Against Protein Misfolding
Discussion Leader: Rick Morimoto (Northwestern University)
9:00 am - 9:20 am Ulrich Hartl (Max Planck Institute of Biochemistry, Martinsried)
"Proteostasis capacity and the toxicity of beta-aggregation"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Elizabeth Craig (University of Wisconsin, Madison)
"Specificity of Hsp70 molecular machineries"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break / Group Photo
10:30 am - 10:50 am Bernd Bukau (University of Heidelberg)
"Cellular strategies fighting protein aggregation"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Harm Kampinga (University of Groningen)
"Heat Shock Proteins and their role in different facets of protein quality control"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am Jeffrey Brodsky (University of Pittsburgh)
"Molecular chaperone and small molecule modifiers of large T antigen, an oncogenic viral protein"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pm Anne Bertolotti (MRC Laboratory of Molecular Biology)
"Correcting protein folding defects by fine-tuning translation in stressed cells"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session 1 (odd-numbered presenters)
5:30 pm - 7:30 pmStressing the Ubiquitin-Proteasome Pathway
Discussion Leader: Linda Hendershot (St. Jude Children's Research Hospital)
5:30 pm - 5:50 pm Dan Finley (Harvard Medical School)
"Regulation of the proteasome by ubiquitin chain editing"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pm Nico Dantuma (Karolinska Institute)
"Stabilization signals: How to resist proteasomal degradation"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:50 pm Pia Roos-Mattjus (Åbo Akademi University)
"Connecting Heat Shock Factors to the cell cycle"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:10 pm Naoki Hayashida (Yamaguchi University School of Medicine)
"Loss of HSF2 function accelerates the accumulation of misfolded proteins upon proteotoxic stress"
7:10 pm - 7:15 pm Discussion
7:15 pm - 7:20 pm Shu-Bing Qian (Cornell University)
"Early pausing of translating ribosomes in response to ubiquitin-proteasome stress"
7:20 pm - 7:25 pm Discussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmProtein Homeostasis in the Secretory Pathway
Discussion Leader: Jeffrey Brodsky (University of Pittsburgh)
9:00 am - 9:20 am David Ron (University of Cambridge)
"Protein folding homeostasis in the ER"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Kazuhiro Nagata (Kyoto Sangyo University)
"Protein quality control in the ER and the nucleus"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 am Linda Hendershot (St. Jude Children's Research Hospital)
"J walking through the ER"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Kenji Kohno (Nara Institute of Science and Technology)
"A novel translational regulation in the unfolded proteins response"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am Ze'ev Ronai (Sanford-Burnham Medical Research Institute)
"Linking ER stress with cell cycle control"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Maho Niwa (University of California, San Diego)
"Dissecting of Ire1 Rnase via action of novel Ire1 inhibitor"
12:10 pm - 12:15 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session 1 (odd-numbered presenters)
5:30 pm - 7:30 pmProtein Homeostasis in the Cytoplasm
Discussion Leader: Ana Maria Cuervo (Albert Einstein College of Medicine)
5:30 pm - 5:50 pm Judith Frydman (Stanford University)
"Chaperone networks maintaining protein homeostasis"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pm Kevin Morano (University of Texas Medical School)
"The cytosolic Hsp70 chaperone Ssa1 is a sensor for activation of HSF1 by thiol-reactive compounds"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:50 pm Ursula Jakob (University of Michigan)
"Inducing oxidative protein unfolding - a host-mediated antimicrobial strategy"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:10 pm James Shorter (University of Pennsylvania School of Medicine)
"Hsp104: a weapon to combat diverse protein-misfoling disorders"
7:10 pm - 7:15 pm Discussion
7:15 pm - 7:25 pm Pierre Goloubinoff (University of Lausanne)
"The mechanism of Hsp70 chaperones as ATP-fuelled olypeptide unfoldases"
7:25 pm - 7:30 pm Discussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStress-Activated Transcription in Aging, Development and Disease
Discussion Leader: John Lis (Cornell University)
9:00 am - 9:20 am Jason Brickner (Northwestern University)
"DNA zip codes confer precise subnuclear targeting in stress-inducible genes"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Gabriella Santoro (University of Rome Tor Vergata)
"Inflammatory signaling under stress: role of HSF1"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 am Akira Nakai (Yamaguchi University School of Medicine)
"A new mechanism of mammalian HSF1-mediated chromatin opening"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Valérie Mezger (University Paris Diderot)
"Novel roles of Heat Shock Factors in Fetal Alcohol Syndrome"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 am Evgeny Nudler (New York University School of Medicine)
"The central role of eEF1A1 in the heat shock response"
11:40 am - 11:45 am Discussion
11:45 am - 12:05 pm Elisabeth Christians (University of Utah, School of Medicine)
"Stress and mammalian early embryos: update on old findings and some recent questions"
12:05 pm - 12:15 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session 2 (even-numbered presenters)
5:30 pm - 7:30 pmStress Responses as Regulators of Longevity and Aging
Discussion Leader: Ursula Jakob (University of Michigan)
5:30 pm - 5:50 pm Ana Maria Cuervo (Albert Einstein College of Medicine)
"Selective autophagy in the cellular response to stress"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pm Rick Morimoto (Northwestern University)
"Cell non-autonomous control of the heat shock response and proteostasis networks"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:50 pm Andy Dillin (The Salk Institute for Biological Studies)
"Proteostasis in aging and stem cells"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:10 pm Anat Ben-Zvi (Ben-Gurion University of the Negev)
"Proteostasis collapse in somatic tissues is regulated by germline stem cells"
7:10 pm - 7:15 pm Discussion
7:15 pm - 7:25 pm Mikael Molin (University of Gothenburg)
"Caloric restriction requires the peroxiredoxin Tsa1 for enhanced H2O2 resistance and life span extension in Saccharomyces cerevisiae"
7:25 pm - 7:30 pm Discussion
7:30 pm - 8:00 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSignaling Pathways Regulating Stress Responses and Life Span
Discussion Leader: Andy Dillin (The Salk Institute for Biological Studies)
9:00 am - 9:20 am Ivor Benjamin (University of Utah, School of Medicine)
"Redox signaling networks underlying protein-induced diseases in flies and mice"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Dirk Bohmann (University of Rochester Medical Center)
"Nrf2 signaling in Drosophila aging and stress defense"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 am Brian Freeman (University of Illinois, Urbana-Champaign)
"The p23 molecular chaperone and GCN5 acetyltransferase cooperatively modulate transcription pathways"
10:50 am - 11:20 am Daniel Neef (Duke University)
"Modulating human HSF1 activity in protein misfolding"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 am Onn Brandman (University of California, San Francisco)
"Comprehensive characterization of cytosolic stress network through an HSF1-based genetic interaction map"
11:40 am - 11:45 am Discussion
11:45 am - 11:55 am Boaz Tirosh (Hebrew University of Jerusalem)
"Functional overlap between the mTOR and the unfolded protein response in the generation of mucosal plasma cells"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Paul Chang (Koch Institute, MIT)
"PARP-16 is required for the unfolded protein response"
12:10 pm - 12:15 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session 2 (even-numbered presenters)
5:30 pm - 7:30 pmPharmacological Interventions Targeting Stress Proteins
Discussion Leader: Harm Kampinga (University of Groningen)
5:30 pm - 5:50 pm Jason Gestwicki (University of Michigan)
"Assembly and disassembly of Hsp70 chaperone complexes using small molecules"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:10 pm Benjamin Vincent (Whitehead Institute, MIT)
"Exploring and exploiting the role of stress responses in antifungal drug resistance"
6:10 pm - 6:15 pm Discussion
6:15 pm - 6:25 pm John Hulleman (The Scripps Research Institute)
"Adapting proteostasis to ameliorate loss- and gain-of-function misfolding diseases"
6:25 pm - 6:30 pm Discussion
6:30 pm - 6:50 pm William Balch (The Scripps Research Institute)
"Reprogramming biological folding and trafficking to manage human health"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:15 pm Judith Frydman (Stanford University)
"Closing Remarks"
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13AG040824-01 from the National Institute of Mental Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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