Gordon Research Conferences
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Conference Program
 
Viruses & Cells
May 29 - June 3, 2011
Renaissance Tuscany Il Ciocco Resort
Lucca (Barga), Italy
Chair:
Terence S. Dermody

Vice Chair:
Paula Traktman

The 2011 Viruses and Cells Gordon Research Conference, the premier conference in the field of virology, will focus on the cell biology of virus infection, mechanisms of virus-host interactions, viral emergence and evolution, and development of antiviral therapeutics and vaccines. The 2011 meeting will be held at Il Ciocco, the beautiful GRC conference site in Barga, Italy, from May 29 to June 3, 2011.

Invited speakers will present new findings on the dynamic interactions of viruses with host cells and organisms, mechanisms of viral evasion and antagonism of host immune responses to infection, and the ecology of viruses and virus transmission. Topics will include: pathogenesis and immune responses; virus discovery, evolution, and fitness; receptors and signaling; entry and assembly; translational control; regulation of nuclear functions; virus-induced organelles; antivirals and vaccines; and structure and catalysis. Session conveners, who are experts in the topics covered in each session, will lead lively discussions following each presentation. In addition to the invited speakers, shorter talks will be chosen at the time of registration from the abstracts submitted for the poster sessions. Selections will be made to highlight exciting new developments in virology research with an emphasis on younger scientists. The evening poster sessions are a prominent part of this conference and will provide an important opportunity for participants to present and discuss their research findings in a congenial atmosphere. The conference will bring together investigators at the forefront of the field, young investigators launching independent research careers, postdoctoral fellows and graduate students, and investigators from industry to discuss new ideas and foster collaborations.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:35 pmWelcome / Introductory Comments by GRC Site Staff
7:35 pm - 9:30 pmPathogenesis and Immune Responses
Discussion Leaders: Lynn Enquist (Princeton University) and Don Ganem (Novartis Institutes for Biomedical Research)
7:35 pm - 7:55 pm Keynote Presentation: Charles Rice (Rockefeller University)
"Antiviral actions of type I interferon-stimulated genes"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:25 pm Michael Diamond (Washington University School of Medicine)
"Mechanisms of innate immune control of West Nile virus"
8:25 pm - 8:35 pm Discussion
8:35 pm - 8:55 pm Klaus Früh (Oregon Health & Science University)
"Immune evasion by cytomegalovirus: Challenges and opportunities for vaccine development"
8:55 pm - 9:05 pm Discussion
9:05 pm - 9:25 pm Ashley Haase (University of Minnesota)
"The paradoxical ill effects of the immune response in HIV and SIV infections"
9:25 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmVirus Discovery, Evolution, and Fitness
Discussion Leaders: Ann Palmenberg (University of Wisconsin, Madison) and Julie Pfeiffer (UT Southwestern)
9:00 am - 9:20 am David Wang (Washington University School of Medicine)
"Metagenomic approaches to viral discovery"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Sara Sawyer (University of Texas, Austin)
"Probing the genetic barriers that prevent animal viruses from infecting humans"
9:50 am - 10:00 am Discussion
10:00 am - 10:30 am Coffee Break / Group Photo
10:30 am - 10:50 am Mark Denison (Vanderbilt University)
"Evidence for an RNA virus proofreading machine: Replication infidelity of coronavirus exonuclease mutants"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Raul Andino (UCSF)
"Poliovirus: Diversity, mutational robustness, and evolvability"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 am Oren Kobiler (Princeton University)
"A limited number of alpha herpesviruses genomes initiates replication in distinct nuclear compartments"
11:40 am - 11:45 am Discussion
11:45 am - 11:55 am Deborah Lenschow (Washington University School of Medicine)
"ISG15, independent of UbE1L-mediated conjugation, is critical in the control of Chikungunya virus infection"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Erik Barton (Wake Forest University)
"Subversive cooperation between an oncogenic gammaherpesvirus and interferon regulatory factor 2 promotes latency and controls viral reactivation"
12:10 pm - 12:15 pm Discussion
12:30 pmLunch
1:30 pm - 5:30 pmFree Time
5:30 pm - 7:30 pmReceptors and Signaling
Discussion Leaders: Ari Helenius (ETH Zurich) and Thilo Stehle (Universität Tübingen, Germany)
5:30 pm - 5:50 pm Ten Feizi (Imperial College London)
"The impact of carbohydrate microarrays on the molecular dissection of pathogen-host interactions"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pm Carolyn Coyne (University of Pittsburgh)
"The signaling orchestra elicited by picornavirus cell entry"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:50 pm Bala Chandran (Chicago Medical School, Rosalind Franklin University of Medicine and Science)
"Temporal interactions of Kaposi's sarcoma associated herpesvirus with functionally related cell surface molecules - platform for signal induction"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:20 pm Lucas Pelkmans (ETH Zurich and 3V Biosciences, East Palo Alto, CA)
"Signaling induced by simian virus 40 reveals a new pathway to achieve transient uncoupling of cortical actin with the plasma membrane"
7:20 pm - 7:30 pm Discussion
8:00 pmDinner
9:30 pmPoster Session A
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEntry and Assembly
Discussion Leaders: Margaret Kielian (Albert Einstein College of Medcine) and Robert Lamb (Northwestern University)
9:00 am - 9:20 am Felix Rey (Institut Pasteur, Paris)
"Class II viral fusion proteins: Insights into their activation mechanism"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Gary Nabel (NIH-NIAID)
"Conserved structures required for HIV-1 entry: The key to an AIDS vaccine"
9:50 am - 10:00 am Discussion
10:00 am - 10:30 am Coffee Break
10:30 am - 10:50 am Judith White (University of Virginia)
"Ebolavirus entry into cells"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Billy Tsai (University of Michigan)
"How polyomaviruses enter and penetrate host membranes to cause disease"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am Winfried Weissenhorn (Grenoble University, France)
"Getting in and out: New insights for HIV-1"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Emily Bruce (University of Cambridge, United Kingdom)
"The cellular Rab11 pathway is involved in late stages of influenza virus assembly and budding"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Kartik Chandran (Albert Einstein College of Medcine)
"The Niemann-Pick C1 protein is a critical endosomal host factor for filovirus entry"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 5:30 pmFree Time
5:30 pm - 7:30 pmTranslational Control
Discussion Leaders: James Alwine (University of Pennsylvania) and Ian Mohr (New York University)
5:30 pm - 5:50 pm Sunnie Thompson (University of Alabama at Birmingham)
"Mechanisms of viral IRES-mediated translation"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pm Lyubov Ryabova (Université de Strasbourg, France)
"Polycistronic translation in cauliflower mosaic virus"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:50 pm Felicia Goodrum (University of Arizona)
"Translational regulation of CMV gene expression"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:20 pm Yolanda Revilla (Universidad Autónoma de Madrid-CSIC, Spain)
"African swine fever virus and control of host translation"
7:20 pm - 7:30 pm Discussion
8:00 pmDinner
9:30 pmPoster Session B
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRegulation of Nuclear Functions
Discussion Leaders: Michael Imperiale (University of Michigan) and Thomas Stamminger (Universität Erlangen-Nürnberg, Erlangen, Germany)
9:00 am - 9:20 am Thorsten Wolff (Robert Koch Institute, Berlin, Germany)
"Exploitation of nuclear host functions by influenza viruses"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Laimonis Laimins (Northwestern University Feinberg School of Medicine)
"Human papillomavirus and the ATM DNA Damage Response"
9:50 am - 10:00 am Discussion
10:00 am - 10:30 am Coffee Break
10:30 am - 10:50 am Phil Branton (McGill University, Montreal)
"Adenovirus control of the cell cycle"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Rozanne Sandri-Goldin (University of California, Irvine)
"ICP27, a pivotal player in regulating HSV-1 gene expression"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 am Alessandro Marcello (International Center for Genetic Engineering and Biotechnology, Trieste, Italy)
"Spatial and temporal dynamics of RNA virus replication in live cells"
11:40 am - 11:45 am Discussion
11:45 am - 11:55 am Greg Sowd (Vanderbilt University)
"A role for Bloom syndrome complex, BTR, in SV40 replication?"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Micah Luftig (Duke University Medical Center)
"An ATM/Chk2-mediated DNA damage responsive signaling pathway suppresses Epstein-Barr virus transformation of primary human B cells"
12:10 pm - 12:15 pm Discussion
12:30 pmLunch
1:30 pm - 5:30 pmFree Time
5:30 pm - 7:30 pmVirus-Induced Organelles
Discussion Leaders: Cristina Risco (Centro Nacional de Biotecnologia, Spain) and Sean Whelan (Harvard Medical School)
5:30 pm - 5:50 pm Paul Ahlquist (University of Wisconsin, Madison)
"Structure, assembly, and function of viral RNA replication compartments"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pm Tero Ahola (University of Helsinki, Finland)
"Formation and intracellular transport of alphavirus replication vesicles"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:50 pm Jacomine Krijnse-Locker (University of Heidelberg, Germany)
"Ultra-structural analysis of membranes modified by large DNA viruses"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:20 pm Abraham Minsky (Weizmann Institute of Science, Rehovot, Israel)
"The mimivirus factory: Functional and structural aspects"
7:20 pm - 7:30 pm Discussion
8:00 pmDinner
9:30 pmPoster Session C
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAntivirals and Vaccines
Discussion Leaders: Teresa Compton (Biogen IDEC) and Diane Griffin (Johns Hopkins University)
9:00 am - 9:20 am Michael Farzan (Harvard Medical School)
"A family of interferon-inducible transmembrane proteins restrict viral entry"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Benhur Lee (UCLA)
"Broad spectrum antiviral approaches"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 am Coffee Break
10:20 am - 10:40 amBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
10:40 am - 11:00 am Katya Heldwein (Tufts University)
"Structural insights into herpesvirus cell entry"
11:00 am - 11:10 am Discussion
11:10 am - 11:30 am Phil Dormitzer (Novartis Vaccines and Diagnostics)
"Optimizing vaccine antigens based on viral glycoprotein structures"
11:30 am - 11:40 am Discussion
11:40 am - 11:50 am Christiane Wobus (University of Michigan)
"The role of cellular deubiquitinases during norovirus infection"
11:50 am - 11:55 am Discussion
11:55 am - 12:05 pm Peter White (Boehringer-Ingelheim Canada)
"Evaluation of the lipid kinase PI4KIIIalpha as an anti-HCV drug target"
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:20 pm Benjamin tenOever (Mount Sinai School of Medicine)
"Engineering viral tools through the exploitation of microRNAs"
12:20 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 5:30 pmFree Time
5:30 pm - 7:30 pmVirus Nanomachines: Structure and Catalysis
Discussion Leaders: Craig Cameron (Pennsylvania State University) and Stephen Harrison (Harvard Medical School)
5:30 pm - 5:50 pm Keynote Presentation: Angela Belcher (MIT)
"Viruses and nanotechnology"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pm Antoine van Oijen (Groningen University, The Netherlands)
"Single-particle fluorescence studies of influenza viral fusion"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:50 pm John Patton (NIH-NIAID)
"Some assembly required: Mechanism of rotavirus genome packaging and replication"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:20 pm Hong Zhou (UCLA)
"CryoEM model of the human adenovirus"
7:20 pm - 7:30 pm Discussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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