| SUNDAY |
| 4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| Kathryn Sandberg (Georgetown University, Washington, DC) |
| 7:40 pm - 9:30 pm | PARADIGM SHIFTS IN THE RAS |
| 7:40 pm - 7:50 pm | Discussion Leader: Louis J. Dell'Italia (University of Alabama, Birmingham, AL) |
| 7:50 pm - 8:30 pm | Pierre Corvol (Collége de France, Paris, France)
"Can we improve upon current RAS therapies?" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:20 pm | Kenneth Bernstein (Cedars-Sinai Medical Center, Los Angeles, CA)
"RAS: past lessons, current trends, future possibilities" |
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 10:00 am | YOUNG INVESTIGATOR SESSION |
| Discussion Leader: Kathy Griendling (Emory University, Atlanta, GA) |
| 9:00 am - 9:10 am | Ulrike Maschke (Charité Universitätsmedizin, Berlin & Max-Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany)
"Deletion of (Pro)renin receptor impairs T cell development" |
| 9:10 am - 9:15 am | Discussion |
| 9:15 am - 9:25 am | Sean Thatcher (University of Kentucky, Kentucky)
"Distinct mechanisms of ACE2 deficiency to promote AngII-induced atherosclerosis versus abdominal aortic aneurysms" |
| 9:25 am - 9:30 am | Discussion |
| 9:30 am - 9:40 am | Johannes Stegbauer (Heinrich-Heine University, Düsseldorf, Germany & Duke University, Durham, NC)
"Cell-specific deletion of the type 1a (AT1a) angiotensin receptor from collecting duct exaggerates Angiotensin II - dependent hypertension" |
| 9:40 am - 9:45 am | Discussion |
| 9:45 am - 9:55 am | Lajos Marko (Charité Universitätsmedizin, Berlin & Max-Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany)
"Bcl10 deficiency attenuates angiotensin (Ang) II-induced organ damage but not albuminuria" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:30 am | Coffee Break |
| 10:30 am - 10:50 am | GORDON RESEARCH SEMINAR YOUNG INVESTIGATOR HIGHLIGHTS |
| 10:30 am - 10:35 am | Discussion Leader: Johannes Stegbauer (Heinrich-Heine University, Düsseldorf, Germany) |
| 10:35 am - 10:50 am | TBA (young Investigators selected from GRS poster sessions) |
| 10:50 am - 12:30 pm | WHAT'S THE ANG DOING IN ANGIOGENESIS? |
| 10:50 am - 11:00 am | Discussion Leader: Susan C. Fagan (University of Georgia, Augusta, GA) |
| 11:00 am - 11:20 am | Micheline M. Resende (Texas Heart Institute, Houston, TX)
"Role of the RAS on bone marrow-derived progenitor cell function and its impact on skeletal muscle angiogenesis" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Patric Garcia (Universitätsklinikum des Saarlandes, Homburg, Germany)
"ACE inhibition stimulates fracture healing and periosteal callus formation" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Azza El-Remessy (University of Georgia, Augusta, GA)
"ARBs in diabetic retinopathy: the latest news" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | ARBs, ACEi & CANCER RISK: CAN WE HANDLE THE TRUTH? |
| 7:30 pm - 7:40 pm | Discussion Leader: Rhian Touyz (University of Glasgow, Glasgow, Scotland) |
| 7:40 pm - 8:00 pm | Volker Fendrich (Philipps-Universität Marburg, Marburg, Germany)
"ACE inhibitors and the progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:30 pm | Sripal Bangalore (New York University, New York City, NY)
"RAAS blockers and risk of cancer" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:00 pm | James Fang (Harrington-McLaughlin Heart & Vascular Institute, Cleveland, OH)
"ARBs and cancer risk" |
| 9:00 pm - 9:10 pm | Discussion |
| Discussants (late breaking research) |
| 9:10 pm - 9:15 pm | Kirsty Pringle (University of Newcastle, Newcastle, NSW, Australia)
"The RAS in an endometrial cancer cell line: evidence for positive feedback in a tissue renin-angiotensin system?" |
| 9:15 pm - 9:20 pm | Discussion |
| 9:20 pm - 9:25 pm | Arndt Manzel (Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, Germany)
"RAS regulation of autoimmune inflammation of the CNS" |
| 9:25 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 10:35 am | NOVEL APPROACHES OPEN NEW WINDOWS INTO RAS FUNCTION |
| 9:00 am - 9:10 am | Discussion Leader: Satoru Eguchi (Temple University, Philadelphia, PA) |
| 9:10 am - 9:30 am | Julia L. Cook (Ochsner Clinic Foundation, New Orleans, LA)
"Novel insights from transgenic mice expressing intracellular fluorescent angiotensin II" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:00 am | Matthew C. Zimmerman (Nebraska Medical Center, Omaha, NE)
"Modulating angiotensin II intra-neuronal signaling using nanoformulated antioxidants" |
| 10:00 am - 10:10 am | Discussion |
| Discussants (late breaking research) |
| 10:10 am - 10:15 am | Eugen Brailoiu (Temple University, Philadelphia, PA)
"Proangiotensin 12: More than an Ang II precursor?" |
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 10:35 am | Coffee Break |
| 10:35 am - 12:30 pm | RAS STRUCTURAL BIOLOGY: GROOVY TURN ONS AND OFFS |
| 10:35 am - 10:45 am | Discussion Leader: Wally Thomas (University of Queensland, Brisbane, Australia) |
| 10:45 am - 11:05 am | Zsolt Böcskei (Sanofi-Aventis, Strasbourg, France)
"Structural biology insights into prorenin activation and renin inhibition" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:35 am | Robin W. Carrell (Cambridge Institute for Medical Research, Cambridge, UK)
"The angiotensinogen-renin complex and the modulation of angiotensin release" |
| 11:35 am - 11:45 am | Discussion |
| 11:45 am - 12:05 pm | Emanuel Escher (University of Sherbrooke, Sherbrooke, QC, Canada)
"Structure and activation mechanisms of the human angiotensin type 1 receptor" |
| 12:05 pm - 12:15 pm | Discussion |
| Discussant (late breaking research) |
| 12:15 pm - 12:25 pm | Andras Balla (Semmelweis University, Budapest, Hungary)
"Molecular dynamics of angiotensin type 1 receptor activation" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | CAN YOU HEAR ME NOW? ADDITIONAL RAS SIGNALING MECHANISMS |
| 7:30 pm - 7:40 pm | Discussion Leader: Genevieve Nguyen (College de France, Paris, France) |
| 7:40 pm - 8:00 pm | Linda McAllister-Lucas (University of Michigan, Ann Arbor, MI)
"CBM signalosome: The missing link between angiotensin, GPCRs and inflammation" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:30 pm | Ariel R. Gomez (University of Virginia, Charlottesville, VA)
"Differentiation and plasticity of renin cells" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:00 pm | Tobias Hermle (University of Freiburg, Freiburg, Germany)
"The role of PRR in endocytosis and planar cell polarity" |
| 9:00 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Cristina-Maria Sirrenberg-Cruciat (Deutsches Krebsforschungszentrum, Heidelberg, Germany)
"Wnt signaling and the (pro)renin receptor" |
| 9:25 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 10:55 am | OVERLAPPING, INTERACTING, CROSSREACTING: THE IMMUNE AND RENIN ANGIOTENSIN SYSTEMS |
| 9:00 am - 9:10 am | Discussion Leader: David L. Mattson (Medical College of Wisconsin, Milwaukee, WI) |
| 9:10 am - 9:30 am | David Harrison (Vanderbilt University, Nashville, TN)
"T cell subtypes in angiotensin II-dependent hypertension" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:00 am | Khalid Matrougui (Tulane University, New Orleans, LA)
"T regulatory cells and vascular endothelial dysfunction" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:30 am | Ulrich Blank (Institut National de la Sante et de la Recherche Medicale, Paris, France)
"Mouse mast cell protease-4-dependent intrarenal angiotensin II formation contributes to inflammation and fibrosis in immune complex-mediated glomerulonephritis" |
| 10:30 am - 10:40 am | Discussion |
| 10:40 am - 10:55 am | Coffee Break |
| 10:55 am - 12:30 pm | IN THE BEGINNING THERE WAS THE RAS (AND STEM CELLS) |
| 10:55 am - 11:05 am | Discussion Leader: Maria Mirotsou (Duke University, Durham, NC) |
| 11:05 am - 11:25 am | Anton Roks (Erasmus Medical Center, Rotterdam, The Netherlands)
"Novel targets and drugs for RAS intervention: stem cells and stabilized angiotensins" |
| 11:25 am - 11:35 am | Discussion |
| 11:35 am - 11:55 am | Asrar B. Malik (University of Illinois, Chicago, IL)
"Vascular regeneration potential of ACE expressing endothelial progenitor cells" |
| 11:55 am - 12:05 pm | Discussion |
| Discussants (late breaking research) |
| 12:05 pm - 12:15 pm | Xiao Z. Shen (Cedars-Sinai Medical Center, Los Angeles, CA)
"How ACE regulates hematopoiesis" |
| 12:15 pm - 12:20 pm | Discussion |
| 12:20 pm - 12:25 pm | Zhiying Shan (University of Florida, Gainesville, FL)
"Paradoxical action of the NTS AT1 receptor on Inflammation and hypertension" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
| 7:30 pm - 9:30 pm | DISTINCT RAS MECHANISMS IN DIVERSE AORTIC PATHOLOGIES |
| 7:30 pm - 7:40 pm | Discussion Leader: Chris Tikellis (Baker Institute, Melbourne, Australia) |
| 7:40 pm - 8:00 pm | Alvin H. Schmaier (Case Western Reserve University, Cleveland, OH)
"Prolylcarboxypeptidase: Modulators of blood pressure, thrombosis risk and vascular homeostasis" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:30 pm | Lisa Cassis (University of Kentucky, Lexington, KY)
"Sexual dimorphism of aortic pathologies" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:00 pm | Jefferson Doyle (Johns Hopkins University, Baltimore, MD)
"Ying-Yang of angiotensin receptors in aortic aneurysms" |
| 9:00 pm - 9:10 pm | Discussion |
| Discussants (late breaking research) |
| 9:10 pm - 9:15 pm | Matthew Sparks (Duke University, Durham, NC)
"Angiotensin II type 1A receptors in vascular smooth muscle cells contribute to blood pressure control, salt sensitivity and hypertension"
|
| 9:15 pm - 9:20 pm | Discussion |
| 9:20 pm - 9:25 pm | Jacqueline R. Kemp (Cleveland Clinic, Cleveland, OH)
"Influence of angiotensin II/AT1R-regulated miRNA on phenotypic modulation of vascular cells"
|
| 9:25 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 10:55 am | BREAKING NEWS IN THE CARDIO-RENAL RAS: FOCUS ON CHYMASE AND MAST CELLS |
| 9:00 am - 9:10 am | Discussion Leader: Helmy M. Siragy (University of Virginia, Charlottesville, VA) |
| 9:10 am - 9:30 am | Lisa Harrison-Bernard (Louisiana State University, New Orleans, LA)
"Targeting renal chymase in diabetic nephropathy - why ACE inhibition is not enough" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:00 am | Ahsan Husain (Emory University, Atlanta, GA)
"Mast cell chymase limits the cardiac efficacy of ACEi therapy" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:30 am | Roberto Levi (Weill Cornell Medical College, New York City, NY)
"Cardiac mast cell renin in severe arrhythmic dysfunction" |
| 10:30 am - 10:40 am | Discussion |
| 10:40 am - 10:55 am | Coffee Break |
| 10:55 am - 12:30 pm | NEW TARGETS FOR OLD ARROWS |
| 10:55 am - 11:05 am | Discussion Leader: Robert C. Speth (NOVA Southeastern University, Ft Lauderdale, FL) |
| 11:05 am - 11:25 am | Alan Sved (University of Pittsburgh, Pittsburgh, PA)
"Will ARBs become the next antidepressant?" |
| 11:25 am - 11:35 am | Discussion |
| 11:35 am - 12:05 pm | Lawrence Steinman (Stanford University, Palo Alto, CA)
"Promising use of ACEi in multiple sclerosis" |
| 12:05 pm - 12:15 pm | Discussion |
| Discussants (late breaking research) |
| 12:15 pm - 12:20 pm | Patrick Kehoe (University of Bristol, Bristol, UK)
"Angiotensins in Alzheimer's disease: friend or foe?" |
| 12:20 pm - 12:22 pm | Discussion |
| 12:22 pm - 12:27 pm | Colin Sumners (University of Florida, Gainesville, FL)
"The good side of the RAS in stroke" |
| 12:27 pm - 12:29 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | HIDDEN TREASURES OF THE RAS |
| 7:30 pm - 7:38 pm | Discussion Leader: A.H. Jan Danser (Erasmus Medical Center, Rotterdam, The Netherlands) |
| 7:38 pm - 7:58 pm | John Osborn (University of Minnesota, Minneapolis, MN)
"Obligatory role of dietary sodium in angiotensin II hypertension: Neurogenic mechanisms" |
| 7:58 pm - 8:08 pm | Discussion |
| 8:08 pm - 8:28 pm | Catherine Llorens-Cortes (Collége de France, Paris, France)
"Blocking the brain RAS with orally active aminopeptidase A inhibitors: A new strategy for treating hypertension" |
| 8:28 pm - 8:38 pm | Discussion |
| 8:38 pm - 8:58 pm | Robson Santos (Federal University of Minas Gerais, Belo Horizonte, Brazil)
"Signaling and translational aspects of angiotensin (1-7)" |
| 8:58 pm - 9:08 pm | Discussion |
| Discussants (late breaking research) |
| 9:08 pm - 9:14 pm | Uwe Klein (Theravance Inc., San Francisco, CA)
"TD-0212, a first-in-class single molecule ARNI compound" |
| 9:14 pm - 9:19 pm | Discussion |
| 9:19 pm - 9:25 pm | Marko Poglitsch (Apeiron Biologics, Vienna, Austria)
"RAS-Fingerprinting: A powerful tool for drug development and personalized medicine" |
| 9:25 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |