Gordon Research Conferences
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Conference Program
 
Antibody Biology & Engineering
March 25-30, 2012
Hotel Galvez
Galveston, TX
Chairs:
Derry Roopenian & Paul Carter

Vice Chair:
Jenny Woof

Antibodies epitomize the remarkable adaptability and exquisite molecular specificity of the host immune response. Substantial progress is being made towards unraveling the dauntingly complex mechanisms by which a successful antibody response develops and is maintained. As impressive progress is being made toward the exploitation of antibodies as a platform for the development of biodiagnostics and biotherapeutics that will have an ever-increasing impact on virtually all areas of biomedical science and disease treatment. For these reasons, this is an exciting time to bring together scientists working at the cutting edges of basic mechanisms of the antibody response, antibody biochemistry and structure, advanced antibody engineering technologies, and clinical applications to share their new results, cross-fertilize, and synthesize bold new concepts to guide the field.

This second Antibody Biology & Engineering GRC will provide this opportunity in a collegial and highly interactive environment that typifies the Gordon Research Conferences. Leading experts and thought leaders both from academia and industry will share their most recent findings on topics of broad interest to the attendees. Investigators and trainees at all levels will have many opportunities for presenting of their new, exciting results in poster sessions and selected oral presentations, with ample time for discussion, networking and brainstorming.

The conference will be held in the Hotel Galvez and Spa located on the beachfront in historic Galveston, Texas and affording numerous recreational activities. All attendees are urged to stay for the duration of the meeting.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmFROM B CELLS TO THERAPEUTIC ANTIBODIES
Discussion Leader: J. Donald Capra (Oklahoma Medical Research Foundation)
7:40 pm - 7:50 pm Don Capra (Oklahoma Medical Research Foundation)
"Opening remarks"
7:50 pm - 8:30 pm Gregory Winter (Medical Research Council)
"From Antibodies to Bicycles"
8:30 pm - 8:40 pm Discussion
8:40 pm - 9:20 pm Gary Nabel (NIAID, NIH)
"Rational design and delivery of optimized broadly neutralizing Abs to HIV"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmNATURAL AND SYNTHETIC EVOLUTION OF THE ANTIBODY RESPONSE
Discussion Leader: Max Cooper (Emory University)
9:00 am - 9:10 am Max Cooper (Emory University)
"Opening remarks"
9:10 am - 9:35 am Andreas Plückthun (University of Zurich)
"DARPins in tumor targeting"
9:35 am - 9:45 am Discussion
9:45 am - 10:10 am Michael Feldhaus (Adimab)
"Cell based selections using a yeast based antibody discovery platform"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 am Coffee Break
10:50 am - 11:15 am Brantley Herrin (Emory University)
"Naturally occurring Leucine-rich repeat-based antibodies in lampreys"
11:15 am - 11:25 am Discussion
11:25 am - 11:35 am Laird Bloom (Pfizer)
"Fundamental characteristics of the immunoglobulin Vh repertoire of chickens in comparison to those of humans, mice and camelids"
11:35 am - 11:40 am Discussion
11:40 am - 11:50 am John Lofblom (Royal Institute of Technology - KTH)
"Generation and in vitro characterization of HER3-specific Affibody molecules"
11:50 am - 11:55 am Discussion
11:55 am - 12:05 pm David King (AnaptysBio)
"Reproducing somatic hypermutation in vitro enables isolation and maturation of antibodies for therapy"
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:20 pm Gabriel Cheung (Cell Signaling Technology)
"A proteomics approach for the identification and cloning of monoclonal antibodies from serum"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmTHE ANTIBODY REPERTOIRE - DEVELOPMENT AND CHARACTERIZATION
Discussion Leader: Herbert Morse III (NIAID)
7:30 pm - 7:40 pm Herbert Morse III (NIAID)
"Opening remarks"
7:40 pm - 8:05 pm Ann Feeney (Scripps)
"Epigenetic and 3-dimensional regulation of antibody repertoire formation"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:40 pm Rafael Casellas (NIAMS)
"Genomic targets of AID and RPA in B lymphocytes"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm George Georgiou (University of Texas Austin)
"High throughput sequencing of B cell repertoires in normal and diseased individuals"
9:15 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmB CELL RESPONSE - DRIVERS AND CONTROLLERS
Discussion Leader: Hideki Ueno (Baylor Institute for Immunology Research)
9:00 am - 9:10 am Hideki Ueno (Baylor Institute for Immunology Research)
"Opening remarks"
9:10 am - 9:35 am Carola Vinuesa (John Curtin School of Medical Research)
"Follicular helper, follicular regulatory and follicular NK T cells"
9:35 am - 9:45 am Discussion
9:45 am - 10:10 am Andrea Cerutti (Mount Sinai School of Medicine)
"Regulation of B cell differentiation and antibody production"
10:10 am - 10:20 am Discussion
10:20 am - 10:50 am Coffee Break
10:50 am - 11:15 am Stuart Tangye (Garvan Institute)
"Human B cell drivers"
11:15 am - 11:25 am Discussion
11:25 am - 11:50 am Harvey Cantor (Harvard Medical School)
"Control of germinal center responses by CD8+ regulatory T cells"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Alejo Chorny (Mount Sinai School of Medicine)
"The soluble pattern recognition receptor PTX3 delivers B cell stimulating signals"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm John Schrader (The Biomedical Research Centre, UBC)
"Genetic and functional analysis of pathogenic human monoclonal auto-antibodies"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmTHE ANTIBODY RESPONSE IN INFECTIOUS DISEASES
Discussion Leader: John Schrader (The Biomedical Research Centre, UBC)
7:30 pm - 7:55 pm Wayne Marasco (Dana Farber Cancer Institute)
"Challenges to a universal Influenza vaccine"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:30 pm Patrick Wilson (University of Chicago)
"Antibody response to influenza"
8:30 pm - 8:40 pm Discussion
8:40 pm - 8:50 pm Xiaoti Guo (NIAID, NIH)
"Triggering a CD4-binding site antibody, VRC01, and its germline precursor on B cells"
8:50 pm - 8:55 pm Discussion
8:55 pm - 9:10 pm Jonathan Lai (Albert Einstein College of Medicine)
"Intermediates in the Ebola virus membrane fusion pathway targeted synthetic antibodies"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Hwan Keun Kim (University of Chicago)
"Monoclonal antibodies against nontoxigenic protein A prevent S. aureus abscess formation in mice"
9:25 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBIOLOGY AND EXPLOITATION OF FC RECEPTORS
Discussion Leader: Richard Blumberg (Harvard Medical School)
9:00 am - 9:10 am Richard Blumberg (Harvard Medical School)
"Opening remarks"
9:10 am - 9:35 am Sally Ward (UTSW)
"Targeting FcRn for therapy"
9:35 am - 9:45 am Discussion
9:45 am - 10:10 am John Desjarlais (Xencor)
"Creation of novel antibody properties and activities with Fc engineering"
10:10 am - 10:20 am Discussion
10:20 am - 10:50 am Coffee Break
10:50 am - 11:15 am Leo James (MRC)
"TRIM21 mediated intracellular antibody neutralization"
11:15 am - 11:25 am Discussion
11:25 am - 11:35 am Kristi Baker (Brigham & Woman's/Harvard)
"The neonatal Fc receptor for IgG, FcRn, regulates homeostatic CD8+ T cell activation in non-inflamed mucosal sites"
11:35 am - 11:40 am Discussion
11:40 am - 11:50 am Jan Terje Andersen (Oslo University Hospital/University)
"Extending the half-life of scFv-fragments using super albumin variants"
11:50 am - 11:55 am Discussion
11:55 am - 12:05 pm Omid Vafa (Janssen Research and Development)
"Anti-CD20 Ig2sigma demonstrates in vivo B-cell depletion independent of immune effector functions"
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:20 pm Thomas Spreter Von Kreudenstein (Zymeworks, Inc.)
"Optimized Fc heterodimers for improved purity and stability in the development of bispecific antibodies"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pmTARGETED DELIVERY OF ANTIBODIES et al
Discussion Leader: Davinder Gill (Hilleman Laboratories)
7:30 pm - 7:40 pm Davinder Gill (Hilleman Laboratories)
"Opening remarks"
7:40 pm - 8:05 pm Mark Dennis (Genentech)
"Transfer'rin antibodies into the brain"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:40 pm Jan Schnitzer (Proteogenomics Research Institute for Systems Medicine)
"Overcoming the endothelial cell barrier to penetrate solid tumors"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm Carlos Barbas (Scripps)
"From bi to pentaspecific antibodies: Zybodies as a practical approach to multispecificity and exceptional therapeutics"
9:15 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
9:00 am - 12:30 pmNEXT GEN ANTIBODY-BASED THERAPEUTICS - DESIGN TO APPLICATION
Discussion Leader: Paul Carter (Genentech)
9:00 am - 9:10 am Paul Carter (Genentech)
"Opening remarks"
9:10 am - 9:35 am Jonathan Drachman (Seattle Genetics)
"SGN-35 and other auristatin-based antibody-drug conjugates"
9:35 am - 9:45 am Discussion
9:45 am - 10:10 am Ellen Filvaroff (Genentech)
"Development and activity of MetMAb"
10:10 am - 10:20 am Discussion
10:20 am - 10:50 am Coffee Break
10:50 am - 11:15 am Janine Schuurman (GenMab)
"Efficient post-production generation of bispecific IgG1 via controlled Fab-arm exchange"
11:15 am - 11:25 am Discussion
11:25 am - 11:35 am Ykelien Boersma (CSIRO)
"EGFR-specific DARPins as potential cancer therapeutics"
11:35 am - 11:40 am Discussion
11:40 am - 11:50 am Jijie Gu (Abbott Bioresearch Center)
"DVD - Ig molecules reveal novel receptor biology and potentially novel therapeutic modality"
11:50 am - 11:55 am Discussion
11:55 am - 12:05 pm Phillip Bardwell (Abbott)
"A Novel Monovalent Format to Target T Cells to Tumor Cells using Dual Variable Domain-Immunoglobulins (DVD-IgTM)"
12:05 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 8:30 pmMICE and COMPUTERS FOR MAKING THERAPEUTIC ANTIBODIES
Discussion Leaders: Derry Roopenian (The Jackson Laboratory) and Davinder Gill (Hilleman Laboratories)
7:30 pm - 7:40 pm Glenn Friedrich (Kymab)
"Robust mouse ES technology used to generate megabase human immunoglobin transgenics"
7:40 pm - 7:50 pm Discussion
7:50 pm - 8:00 pm Andrew Murphy (Regeneron Pharmaceuticals)
"Engineering mouse antigen receptor genes at the megabase scale"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:20 pm Sandeep Kumar (Pfizer)
"Understanding aggregation and immunogenicity in therapeutic mAbs via biopharmaceutical informatics"
8:20 pm - 8:30 pm Discussion
8:30 pm - 9:30 pmAD HOC PANEL: LESSONS, CHALLENGES and OPPORTUNITIES
(Moderator and Discussants to be selected at the meeting)
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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