The 2012 Cardiac Regulatory Mechanisms Gordon Research Conference is one of the premier meetings for scientists interested in cellular and molecular mechanisms regulating the normal and diseased heart. In addition to the role of Ca in excitation/contraction coupling and contractility that formed the original basis for this meeting, the 2012 meeting will integrate studies at the nexus of Ca, ion channels, redox and kinase signaling, and mitochondria in regulating cardiac cell function and diseases such as sudden arrhythmias, hypertrophy and heart failure. Emerging data has shown an important role for redox and kinase regulation of ion channels and transporters. Compelling data also show cross-talk between kinase and redox signaling. Mitochondria are involved in ion signaling, redox regulation, metabolism and cell death and play an important role in regulating excitation contraction coupling and cardiac function. The meeting will report on mechanisms by which these pathways function and interact. Topics include novel models for studying cardiovascular disease, new mechanisms and targets for redox signaling, signaling via contractile proteins, the intersection of calcium, signaling and hypertrophy, mitochondrial regulation of Ca signaling and cardiac function, the importance of location in signaling, ion channels and arrhythmias and novels aspects of Ca dynamics. The meeting will cover basic mechanism as well as perspectives on translating these findings into a better understanding of disease mechanisms, diagnosis, prevention and treatment. The goal of the meeting is to bring together scientists who can critically evaluate developments at the forefront of cardiovascular research. This is accomplished by including established as well as early career research scientists from the fields of physiology, pharmacology, molecular biology, biochemistry, biophysics and bioengineering, along with physician/scientists with an appreciation for the therapeutic implications of cardiovascular research. Based on past experience, we can guarantee an atmosphere of intense and lively discussions where all participants contribute and learn.