Gordon Research Conferences
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Conference Program
 
Cell Death
July 15-20, 2012
Renaissance Tuscany Il Ciocco Resort
Lucca (Barga), Italy
Chair:
John M. Abrams

Vice Chair:
Eric H. Baehrecke

Cell death is a fundamental biological process, universally required for normal development and firmly established in the etiology, pathogenesis and treatment of many diseases. This Gordon Conference will explore the frontiers of Cell Death research, with themes that focus on newly discovered molecules, pathways and mechanisms that specify active forms of cell death in health and disease. The Conference will feature talks and poster presentations on a wide range of topics that span apoptotic signaling networks (e.g. caspase control, Bcl-2 family proteins, mitochondrial dynamics) and non-canonical cell death pathways, including necrosis and autophagy. Invited speakers are recruited from a variety of scientific disciplines, including biochemistry, genetics, structural biology, cell biology, developmental biology, neuroscience and immunology. The Conference will gather established experts who are leaders in the field together with junior scientists, postdocs and graduate students to share discoveries and exchange ideas. Some poster presenters will be selected for short talks. The intimate format and collegial atmosphere of this Conference is designed to enable brainstorming and promote collaborations.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session
Discussion Leader: Guido Kroemer (INSERM)
7:40 pm - 8:20 pmMartin Raff (University College London)
"Reminiscence on a diversion into cell death"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmRichard Youle (NINDS)
"Bcl-2 family proteins: location, relocation, translocation"
9:15 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBcl2 Proteins and the Mitochondriome
Discussion Leader: Doug Green (St. Jude Children's Research Hospital)
9:00 am - 9:20 amJean-Claude Martinou (Université de Genève)
"Bax and Mcl-1: functions beyond control of mitochondrial outer membrane integrity"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amDavid Andrews (McMaster University)
"Distinct Interactions of Bcl-2 family proteins at the endoplasmic reticulum and mitochondria measured in live cells"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amGroup Photo / Coffee Break
10:30 am - 10:50 amXuejun Jiang (Memorial Sloan-Kettering Cancer Center)
"Small Molecule Modulators of Apoptosis Identified by High-Throughput Screening"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amLoren Walensky (Dana-Farber Cancer Institute)
"Dissecting and Targeting the Activation Pathway of Pro-Apoptotic BAX"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amEmily Cheng (Memorial Sloan-Kettering Cancer Center)
"Molecular control of the mitochondrion-dependent cell death program by the BCL-2 family"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmStefan Glaser (Walter + Eliza Hall Institute Of Medical Research)
"Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia"
12:10 pm - 12:15 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmDeath Pathways and Networks
Discussion Leader: Peter Vandenabeele (Ghent University / Vib)
5:30 pm - 5:50 pmSally Kornbluth (Duke University School of Medicine)
"Kinase signaling and control of the apoptosome"
5:50 pm - 6:00 pmDiscussion
6:00 pm - 6:20 pmSeamus Martin (Trinity College)
"Surprising Outcomes from Cell Death Signals"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmVishva Dixit (Genentech, Inc.)
"Why so many ways to die? The role of caspases, kinases and magic potions"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmDoug Green (St. Jude Children's Research Hospital)
"DOA: RIPK3 is the weapon in C8/FADD KO mice; who is the killer?"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCells Getting Rip'd
Discussion Leader: Marcus Peter (Northwestern University Feinberg School of Med.)
9:00 am - 9:20 amJunying Yuan (Harvard University)
"Programmed cell death: from apoptosis to necroptosis"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amEd Mocarski (Emory University)
"Rip'd off by Viruses via Pattern Recognition"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amDomagoj Vucic (Genentech, Inc.)
"Ubiquitination of c-IAP1 and RIP1 dictates cell death decisions"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amPascal Meier (Institute of Cancer Research)
"IAPs: Guardians of RIPs"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amFrancis Chan (University Of Massachusetts Medical School)
"Rip'd by a sliver: new insight into necrosome activation"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmGerry Melino (University Of Leicester)
"Involvement of p73 in mitochondrial metabolism and senescence"
12:10 pm - 12:15 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmDeath Effectors and Effective Engineering
Discussion Leader: Loren Walensky (Dana-Farber Cancer Institute)
5:30 pm - 5:50 pmClaudio A Hetz (University Of Chile)
"BAX-Inhibitor 1 (TMBIM) family of proteins: Ancestral regulators of cell death"
5:50 pm - 6:00 pmDiscussion
6:00 pm - 6:20 pmGuy Salvesen (Sanford-Burnham Medical Research Institute)
"Survival, Death, Caspases and Paracaspase"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmJames Wells (University of California, San Francisco)
"Engineering Cells to Death"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmPeter Vandenabeele (Ghent University)
"In vivo role of RIPK kinases in cell death and inflammation"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmOncogenic Connections
Discussion Leader: Gerry Melino (University of Leicester)
9:00 am - 9:20 amKaren Vousden (The Beatson Institute for Cancer Research)
"Regulation of cell survival through the p53 pathway"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amAndreas Villunger (Innsbruck Medical University)
"A1/BFl-1 in leukocyte development and function"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amMarcus Peter (Northwestern University Feinberg School of Medicine)
"CD95/Fas protects cancer cells against necrotic cell death"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amLaura Attardi (Stanford University School of Medicine)
"Deconstructing p53 transcriptional networks in tumor suppression"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amGuido Kroemer (INSERM)
"Fighting the immortal: cell death induction by anticancer chemotherapy"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmJan Paul Medema (Academic Medical Center)
"Lipid metabolism, a perfect target for anti-tumor therapy?"
12:10 pm - 12:15 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmDisease Mechanisms
Discussion Leader: Sally Kornbluth (Duke University School of Medicine)
5:30 pm - 5:50 pmAndreas Strasser (The Walter and Eliza Hall Institute of Medical Research)
"The role of pro-survival Bcl-2 family members in tumorigenesis and cancer therapy"
5:50 pm - 6:00 pmDiscussion
6:00 pm - 6:20 pmMaya Saleh (McGill Life Sciences Complex)
"Novel functions of apoptosis effectors in innate immunity"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmWill Wood (University Of Bath)
"Damage, Death and Development; Signal Integration in Drosophila macrophages"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmJ. Marie Hardwick (Johns Hopkins University Schools of Public Health and Medicine)
"Yeast cell death model system identifies new human disease genes"
7:20 pm - 7:30 pmDiscussion
7:30 pm - 8:00 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNoncanonical Death Pathways
Discussion Leader: J. Marie Hardwick (Johns Hopkins School of Medicine)
9:00 am - 9:20 amBeth Levine (UT Southwestern Medical Center)
"Deregulated Beclin 1 function: a mediator of bona fide autophagic cell death?"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amMichael Overholtzer (Memorial Sloan-Kettering Cancer Center)
"Alternative paths to engulfment and death"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amValina Dawson (Johns Hopkins University School of Medicine)
"Parthanatos"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amChristine Watson (University of Cambridge)
"Stat3 regulates a lysosomal pathway of cell death in vivo in mammary gland"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amEli Arama (Weizmann Institute of Science)
"Restriction of Caspase Activation During Spermatid Terminal Differentiation in Drosophila"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmKatherine Ralston (University Of Virginia)
"Chew your food: trogocytosis plays a role in activating non-apoptotic host cell killing by the parasite Entamoeba histolytica"
12:10 pm - 12:15 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmTranslation and Therapeutics
Discussion Leader: Huseyin Mehmet (Merck Research Laboratories)
5:30 pm - 5:50 pmAvi Ashkenazi (Genentech, Inc.)
"Control of death receptor-mediated caspase activation by the ubiquitin system"
5:50 pm - 6:00 pmDiscussion
6:00 pm - 6:20 pmHenning Walczak (Imperial College London)
"Linear ubiquitination in cell death and innate immune signalling"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmSharad Kumar (Centre For Cancer Biology)
"Non-apoptotic functions of an 'apoptotic' caspase"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmKevin Ryan (Beatson Institute for Cancer Research)
"Starved to death - metabolic cell death priming downstream of p53"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 2R13CA153310-02 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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