Gordon Research Conferences
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Conference Program
 
Craniofacial Morphogenesis & Tissue Regeneration
March 18-23, 2012
Four Points Sheraton / Holiday Inn Express
Ventura, CA
Chair:
Robert Maxson

Vice Chair:
Andrea Streit

Related Meeting Information
The Craniofacial Morphogenesis & Tissue Regeneration Gordon Research Conference was held in conjunction with the Craniofacial Morphogenesis & Tissue Regeneration Gordon Research Seminar. Please refer to the Craniofacial Morphogenesis & Tissue Regeneration GRS web page for more information.

The 2012 Gordon Conference on Craniofacial Morphogenesis and Tissue Regeneration will focus on the molecular and genetic underpinnings of craniofacial development in an evolutionary context. It will feature a range of topics, including the early migration and specification of neural crest and mesodermal populations that compose the head, the patterned growth and signaling events that produce the major craniofacial organs, and the evolution of developmental mechanisms that give rise to the diversity of craniofacial form in vertebrates. The Conference will also cover disorders that affect craniofacial development, and animal models used to investigate their pathophysiology. A major theme will be the function of stem cells in basic developmental mechanisms and as tools in tissue engineering approaches to the treatment of craniofacial disease.

The Conference will bring together an array of investigators who are at the forefront of their fields within craniofacial biology. It will provide unique opportunities for junior investigators and graduate students to present their work in poster format and interact with leaders in the field. In addition, a group of poster presenters will be selected to give brief oral presentations. The collegial and interdisciplinary atmosphere of this Conference, with formal discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, will provide an excellent venue for investigators from different disciplines in craniofacial biology to brainstorm and to develop collaborations across fields.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Presentations
Discussion Leader: Paul Trainor (Stowers Institute, Kansas City, USA)
7:40 pm - 8:20 pmPatrick Tam (University of Sydney, Sydney, AUS)
"Head formation in the mouse embryo: signals and genetic switches"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmLauri McCauley (University of Michigan, Ann Arbor, USA)
"Parathyroid hormone: Understanding basic mechanisms fosters a clinical application in craniofacial regeneration"
9:15 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmNeural crest and placodes
Discussion Leader: Patrick Tam (University of Sydney, Sydney, AUS)
9:00 am - 9:25 amAngela Nieto (Instituto de Neurociencias, Alicante, Spain)
"The ins and outs of the epithelial to mesenchymal transition"
9:25 am - 9:30 amDiscussion
9:30 am - 9:55 amTatiana Hochgreb (California Institute of Technology, Pasadena, USA)
"Switching on bone: a novel molecular mechanism that modulates timing of jaw ossification"
9:55 am - 10:05 amDiscussion
10:05 am - 10:20 amRuchi Bajpai (University of Southern California, Los Angeles, USA)
"The delaminating crest provide insights into craniofacial defects and tumor metastasis"
10:20 am - 10:25 amDiscussion
10:25 am - 10:45 amCoffee Break
10:45 am - 11:10 amDavid Raible (University of Washington, Seattle, USA)
"Regulation of sensory neurogenesis in zebrafish neural crest"
11:10 am - 11:20 amDiscussion
11:20 am - 11:45 amAndy Groves (Baylor College of Medicine, Houston, USA)
"Hear-Say: The role of the Foxi3 transcription factor in otic placode induction and craniofacial development"
11:45 am - 11:55 amDiscussion
11:55 am - 12:10 pmBerta Alsina (Universitat Pompeu Fabra, Barcelona, Spain)
"Role of Retinoic Acid in Inner Ear Development and Regeneration"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPlanar Cell Polarity in Craniofacial Morphogenesis
Discussion Leader: Andrea Streit (King's College London, UK)
7:30 pm - 7:55 pmJohn Wallingford (University of Texas, Austin USA)
"Planar cell polarity: from cell biology to human disease"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmPhilip Beales (University College London, UK)
"Cilia, Complement and Crest in Craniofacial Morphogenesis"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmTom Schilling (University of California Irvine, Irvine, USA)
"The Fat pathway regulates cartilage patterning and polarity"
9:15 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStem Cells
Discussion Leader: Yang Chai (University of Southern California, Los Angeles, USA)
9:00 am - 9:25 amJoanna Wysocka (Stanford University, Palo Alto, USA)
"What epigenomics can teach us about craniofacial development"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 amOphir Klein (UCSF, San Francisco, USA)
"Genetic and epigenetic regulation of epithelial stem cells in the rodent incisor"
10:05 am - 10:20 amDiscussion
10:20 am - 10:35 amCoffee Break
10:35 am - 10:50 amHu Zhao (University of Southern California, Los Angeles, USA)
"Arterioles provide a niche for the quiescent dental mesenchymal stem cell"
10:50 am - 11:00 amDiscussion
11:00 am - 11:25 amSongtao Shi (University of Southern, Los Angeles, USA)
"Orofacial Bone Regeneration: From Clinics to Bench-top and Back"
11:25 am - 11:40 amDiscussion
11:40 am - 12:05 pmPaul Sharpe (Kings College, London UK)
"Mouse incisor MSC niches in growth and repair"
12:05 pm - 12:20 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMorphogenesis and Patterned Growth
Discussion Leader: Paul Sharpe (Kings College, London UK)
7:30 pm - 7:55 pmHazel Sive (MIT, Boston, USA)
"Regulation of vertebrate mouth formation"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:15 pmLicia Selleri (Cornell University, New York, USA)
"A Conserved Pbx-Wnt-p63-Irf6 Regulatory Module Controls Face Morphogenesis by Promoting Epithelial Apoptosis"
8:15 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmIrma Thesleff (University of Helsinki, FI)
"Mechanisms of tooth renewal"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:10 pmYi-ping Chen (Tulane University, New Orleans, USA)
"BMP signaling regulates palate patterning and development"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmDavid Clouthier (University of Colorado-Denver, USA)
"Nkx2.5 is a central mediator of lower jaw morphogenesis"
9:25 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHuman Genetics and Disease Models
Discussion Leader: Richard Maas (Harvard University, Boston, USA)
9:00 am - 9:25 amJeff Murray (University of Iowa, USA)
"GWAS and beyond: New mutations/genes/pathways for human cleft lip/palate"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amPhilippe Soriano (Mt Sinai, New York, USA)
"PDGF Signaling and Craniofacial Development"
10:00 am - 10:10 amDiscussion
10:10 am - 10:25 amCoffee Break
10:25 am - 10:40 amAmy Merrill (University of Southern California, Los Angeles, USA)
"Intranuclear FGFR2 signaling in craniofacial development"
10:40 am - 10:50 amDiscussion
10:50 am - 11:15 amPaul Trainor (Stowers Institute, Kansas City, USA)
"Ribosome Biogenesis and DNA Damage - Global Processes but Local Effects on Craniofacial Development and Disease"
11:15 am - 11:25 amDiscussion
11:25 am - 11:50 amJoan Richtsmeir (Penn St, University Park, USA)
"The role of fibroblast growth factor receptors in craniofacial variation, disease and evolution"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:15 pmJames Martin (Baylor College of Medicine, Houston, USA)
"MicroRnas in Orofacial Clefting"
12:20 pm - 12:25 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmSignaling and Disease
Discussion Leader: Irma Thesleff (University of Helsinki, FI)
7:30 pm - 7:55 pmScott Fraser (Caltech, Pasadena, USA)
"Multimodal imaging of craniofacial patterning"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmYang Chai (University of Southern California, Los Angeles, USA)
"Alternative TGF-beta signaling mechanism and craniofacial malformations"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmKaren Liu (King's College London, UK)
"Signal integration in craniofacial morphogenesis"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmJeremy Green (King's College London, UK)
"Periodic stripe formation by a Turing-mechanism operating at growth zones in the mammalian palate"
9:25 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEvolution
Discussion Leader: Joan Richtsmeier (Penn State University, University Park, USA)
9:00 am - 9:25 amMatthew Harris (Harvard Medical School, Boston, USA)
"Comparative genetics as a means to understand capacity and constraint in craniofacial development"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 amJeffery Streelman (Georgia Tech, Atlanta, USA)
"Developmental Genetics of Diversity in Regenerating Dentitions"
10:05 am - 10:20 amDiscussion
10:20 am - 10:35 amCoffee Break
10:35 am - 10:50 amClare Baker (University of Cambridge, UK)
"The development and evolution of vertebrate electroreceptors: a 'sixth sense'"
10:50 am - 11:00 amDiscussion
11:00 am - 11:25 amBenedikt Hallgrimsson (University of Calgary, Calgary CA)
"The Phenogenomics of Variation in Craniofacial Form"
11:25 am - 11:40 amDiscussion
11:40 am - 12:05 pmRichard Schneider (UCSF, San Francisco, USA)
"Regulation of Jaw Size during Development and Evolution"
12:05 pm - 12:20 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTissue Engineering
Discussion Leader: Songtao Shi (University of Southern California, Los Angeles, USA)
7:30 pm - 7:55 pmStephen Murray (The Jackson Laboratory, Bar Harbor, USA)
"KOMP2 and the International Mouse Phenotyping Consortium: Opportunities and resources for the craniofacial research community"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmRichard Maas (Harvard University, Boston, USA)
"Gene regulatory networks in early tooth development"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmPaul H. Krebsbach (University of Michigan)
"Pluripotent stem cells: opening another avenue for craniofacial regeneration"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmMichael Longaker (Stanford University, Palo Alto, USA)
"Skeletal tissue engineering using adipose derived cells"
9:25 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13DE022501-01from the National Institutes of Dental and Craniofacial Research. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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