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Cyclic Nucleotide Phosphodiesterases
A Molecular Exploration of Cyclic-Nucleotide Action
May 20-25, 2012
Renaissance Tuscany Il Ciocco Resort
Lucca (Barga), Italy
Chairs:
Kjetil Tasken & John D. Scott

Vice Chairs:
Manuela Zaccolo & Nickolas J . Brandon

The cyclic-nucleotides cAMP and cGMP are intracellular chemical signals that control most aspects of cellular behavior. These so-called "second messenger" responsive pathways have long been considered therapeutic targets for the treatment of cardiovascular and inflammatory airway diseases and neuropsychiatric disorders. The 2012 Gordon Conference on Cyclic Nucleotide Phosphodiesterases will convene in Il Ciocco Italy from May 20-25, 2012. This 8th meeting in the series will provide a forum for investigators from academia and industry to present cutting-edge research and ponder the latest concepts in molecular and cellular cyclic nucleotide metabolism and cell signaling. The opening session of the meeting will set the scene with lectures from three renowned experts in cyclic nucleotide signaling. Pharmacological intervention of second messenger responses as therapies for a variety of pathophysiological disorders will be a featured topic of discussion. The scientific program will also feature a range of lectures that explore the structural biology of phosphodiesterases, the spatial organization of cAMP/cGMP effector molecules, genetic manipulation of phosphodiesterases and the pathophysiolgical implications of defective cyclic nucleotide signaling. The keynote lecture will be delivered by Dr. Johannes L. Bos on the interface of cAMP and cancer signaling pathways. The organizers encourage junior scientists and graduate students to attend. Delegates should submit an abstract of their research for poster presentation and selected individuals will be invited to give short talks on emerging aspects of cyclic nucleotide research. The collegial atmosphere of this conference, with discussion sessions and informal gatherings in the afternoons and evenings, creates an optimal environment for scientists from different disciplines to interact.

Contributors
SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmCyclic Nucleotide Signaling Pathways: From Impulse to Target
Discussion Leader: Joseph Beavo (University of Washington, Seattle, WA)
7:45 pm - 8:10 pmCarmen Dessauer (University of Texas Medical School, Houston, TX)
"Facilitation of cAMP Signaling by Anchored Adenylyl Cyclase Complexes"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmSusan Taylor (University of California San Diego, CA)
"Dynamic Regulation and Localization of PKA"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmManuela Zaccolo (University of Oxford, UK)
"PDEs and local control of cAMP signal in cardiac myocytes"
9:20 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmThe Physiology of Cyclic Nucleotide Action
Discussion Leader: Nicholas Brandon (Psychiatry Research at Pfizer, Cambridge, MA)
9:05 am - 9:30 amMarco Conti (UCSF, San Francisco, CA)
"PDE4 and regulation of beta adrenergic signaling"
9:30 am - 9:40 amDiscussion
9:40 am - 9:50 amShort Talk: Xiaodong Cheng (University of Texas Medical Branch, Galveston, TX)
"Isoform-specific antagonists of exchange proteins directly activated by cAMP"
9:50 am - 9:55 amDiscussion
9:55 am - 10:20 amStanley C. Froehner (University of Washington, Seattle, WA)
"Compartmentalized Nitric Oxide-cGMP Signaling in Skeletal and Cardiac Muscle"
10:20 am - 10:30 amDiscussion
10:30 amGroup Photo / Coffee Break
11:00 am - 11:25 amAlexander Pfeifer (University of Bonn, DE)
"Differential roles of cGMP and cAMP in fat"
11:25 am - 11:35 amDiscussion
11:35 am - 11:45 amShort Talk: Wito Richter (University of California San Francisco, CA)
"PDE4s are critical regulators of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) in primary human bronchial epithelial cells (HBEs)"
11:45 am - 11:50 amDiscussion
11:50 am - 12:15 pmJoseph Beavo (University of Washington, Seattle, WA)
"Roles for PDE8 in regulation of cellular function"
12:15 pm - 12:25 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmTherapeutic Intervention of Phosphodiesterase Signaling 1
Discussion Leader: Miles Houslay (Kings College, London, UK)
5:35 pm - 6:00 pmRick H. Cote (University of New Hampshire, Durham, NH)
"Mapping the interaction surface of PDE6 with its binding partners"
6:00 pm - 6:10 pmDiscussion
6:10 pm - 6:20 pmShort Talk: Brittany Howard (Monash University, Melbourne, Australia)
"Inhibitors of Plasmodium falciparum Phosphodiesterases as Novel Antimalarials"
6:20 pm - 6:25 pmDiscussion
6:25 pm - 6:50 pmGeert Jan Sterk (Mercachem, Nijmegen, NL)
"Selective inhibitors of TbrPDEB1: A novel treatment for African trypanosomiasis"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:25 pmJackie D. Corbin (Vanderbilt University Medical Ctr. Nashville, TN)
"PDE5: regulation associated with conformational change"
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTemporal and Spatial Resolution of Second Messenger Signaling
Discussion Leader: Manuela Zaccolo (University of Oxford, UK)
9:05 am - 9:30 amRichard Marais (Institute of Cancer Research, London, UK)
"From BRAF and RAS signalling to therapeutics in melanoma"
9:30 am - 9:40 amDiscussion
9:40 am - 9:50 amShort Talk: Guillaume Pidoux (University René Descartes, Paris, France)
"The A kinase anchoring protein ezrin interacts with connexin 43 to facilitate protein kinase A control of gap junction communication in trophoblast cell fusion"
9:50 am - 9:55 amDiscussion
9:55 am - 10:20 amJin Zhang (Johns Hopkins University School of Medicine, Baltimore, MD)
"Spatiotemporal Visualization and Manipulation of the cAMP Signaling"
10:20 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:25 amBenjamin Kaupp (Research Centre Caesar, Bonn, DE)
"Sperm chemotaxis - a cGMP-signaling pathway with single-molecule sensitivity"
11:25 am - 11:35 amDiscussion
11:35 am - 11:45 amShort Talk: Eduard Stefan (University of Innsbruck, Innsbruck, Austria)
"Novel insights into evolutionary conserved protein kinase A signaling circuits"
11:45 am - 11:50 amDiscussion
11:50 am - 12:15 pmGeorge S. Baillie (University of Glasgow, UK)
"A novel point of crosstalk between the cAMP and ERK Map kinase signalling pathways"
12:15 pm - 12:25 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmMetabolic Control and Local Second Messenger Signaling
Discussion Leader: TBA
5:35 pm - 6:00 pmSven Enerbäck (Gothenburg University, SE)
"Metabolically active brown adipose tissue in healthy adult humans"
6:00 pm - 6:10 pmDiscussion
6:10 pm - 6:20 pmShort Talk: Jay Chung (NIH, Beshesda, MD)
"Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases"
6:20 pm - 6:25 pmDiscussion
6:25 pm - 6:35 pmShort Talk: Geng Tian (Uppsala University, Uppsala, Sweden)
"Role of phosphodiesterases in the shaping of sub-plasma membrane cAMP oscillations and pulsatile insulin secretion"
6:35 pm - 6:40 pmDiscussion
6:40 pm - 7:05 pmBrian A. Hemmings (Friedrich Miescher Institute for Biomedical Research, Basel, CH)
"Regulation of Epithelial-mesenchymal Transition and Cancer Metastasis by PI3K/PKB Signaling"
7:05 pm - 7:15 pmDiscussion
7:15 pm - 7:25 pmShort Talk: Gary Piazza (University of South Alabama, Mobile, AL)
"A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and beta-catenin transcriptional activity"
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPDE Pharmacology and Cardiovascular Control
Discussion Leader: Marco Conti (UCSF, San Francisco, CA)
9:05 am - 9:30 amDavid A. Kass (Johns Hopkins Hospital, Baltimore, MD)
"Cardiac myocyte stress modulation by PDEs: Multiple players, multiple compartments"
9:30 am - 9:40 amDiscussion
9:40 am - 9:50 amShort Talk: Sergei Rybalkin (University of Washington, Seattle, WA)
"Sildenafil, but not Tadalafil improves cardiac dysfunction in the MDX mouse"
9:50 am - 9:55 amDiscussion
9:55 am - 10:05 amShort Talk: Enrico Patrucco (Technical University, Munich, Germany)
"Differential effects of PDE5 inhibitors on AngII induced cardiac hypertrophy"
10:05 am - 10:10 amDiscussion
10:10 amCoffee Break
10:40 am - 11:05 amEmilio Hirsch (University of Torino, IT)
"cAMP and PIP3 at a crossroad in the heart"
11:05 am - 11:15 amDiscussion
11:15 am - 11:25 amShort Talk: Jan Magnus Aronsen (Oslo University Hospital, Oslo, Norway)
"PDE3A is part of the SERCA2-AKAP18δ macromolecular complex in cardiomyocytes"
11:25 am - 11:30 amDiscussion
11:30 am - 11:55 amDonald Maurice (Queen's University, Kingston, ON, Canada)
"Compartment specific cyclic nucleotide signaling and control of mural cell vascular functions"
11:55 am - 12:05 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 5:30 pmPoster Session
6:00 pm - 7:30 pmKeynote Lecture: Cyclic Nucleotide Signaling by Small G Proteins
Discussion Leader: Donald Maurice (Queen's University, Kingston, ON, Canada)
6:15 pm - 7:15 pmJohannes L. Bos (Utrecht University, NL)
"Epac as spatiotemporal control units in cAMP signaling"
7:15 pm - 7:30 pmDiscussion
7:30 pm - 8:00 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTherapeutic Intervention of Phosphodiesterase Signaling 2
Discussion Leader: Rick H. Cote (University of New Hampshire, Durham, NH)
9:05 am - 9:30 amNicholas Brandon (Psychiatry Research at Pfizer, Cambridge, MA)
"Understanding PDE10A Inhibition for the Treatment of Schizophrenia"
9:30 am - 9:40 amDiscussion
9:40 am - 9:50 amShort Talk: Pierre Vincent (CNRS, Paris, France)
"PDE4 control on cAMP/PKA compartmentation revealed by biosensor imaging in neurons"
9:50 am - 9:55 amDiscussion
9:55 am - 10:20 amLawrence P. Wennogle (Intra-Cellular Therapies Inc, New York, NY)
"Phosphodiesterase 1 Mechanisms Implicated in Disorders of the Central Nervous System"
10:20 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:10 amShort Talk: Jos Prickaerts (Maastricht University, Maastricht, The Netherlands)
"PDE4(D) inhibition as a target for cognition enhancement?"
11:10 am - 11:15 amDiscussion
11:15 am - 11:25 amShort Talk: Robbert Havekes (University of Pennsylvania, Philadelphia, PA)
"The phosphodiesterase isoform 4a5 (PDE4a5) is the critical mediator of hippocampus-dependent cognitive impairments induced by sleep loss"
11:25 am - 11:30 amDiscussion
11:30 am - 11:55 amVahri Beaumont (CHDI Foundation, Los Angeles, CA)
"Opportunities for Huntington's Disease therapeutics and PDE inhibition"
11:55 am - 12:05 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmCyclic Nucleotide Signaling and Pathophysiology
Discussion Leader: Jackie D. Corbin (Vanderbilt Univ Medical Center, Nashville, TN)
5:35 pm - 6:00 pmDoris Koesling (Ruhr University Bochum, DE)
"PDEs involved in NO/cGMP mediated effects"
6:00 pm - 6:10 pmDiscussion
6:10 pm - 6:20 pmShort Talk: Tatiana Vinogradova (NIH, Bethesda, MD)
"Concerted PDE3 and PDE4 Activities Control Local Subsarcolemmal Ca2+ releases To Regulate Basal Spontaneous Firing of Cardiac Pacemaker Cells"
6:20 pm - 6:25 pmDiscussion
6:25 pm - 6:50 pmFinn Olav Levy (University of Oslo, NO)
"PDE-mediated crosstalk between cGMP and cAMP in normal and failing hearts"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:25 pmRodolphe Fischmeister (University of Paris-Sud 11, FR)
"PDE4 and cardiac excitation - contraction coupling"
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture
 
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