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Conference Program
 
Drug Carriers in Medicine & Biology
Translational Drug Carriers: From Design and Understanding Mechanism of Action to Clinical Use
August 12-17, 2012
Waterville Valley Resort
Waterville Valley, NH

The 2012 Gordon Conference on Drug Carriers in Medicine and Biology is a well established forum with three decades of history, focused on the principles and means for improvement of pharmacotherapy and diagnostics of human maladies employing advanced drug delivery systems. It will bring together an exciting multi-disciplinary group of prominent academic and pharmaceutical/biotechnology researchers working to develop and implement such new medical and experimental interventions. The conference will feature integrated sessions that bring together cutting-edge advances in intracellular drug delivery, biotherapeutics including protein and nucleic acid drugs, nanotechnology and nanomedicine, polymer- lipid- and cell-based carriers, carriers for targeted therapeutics, vascular and CNS targeting, vaccine delivery. Themes to be explored include molecular and cellular targets for drug delivery and action, siRNA and other nucleic acid therapeutic and delivery platforms, drug transport across biological and cellular barriers, defining biological factors modulating drug delivery and effects and enabling experimental and translational approaches for pre-clinical and clinical development. The conference provides a dynamic, diverse and collegial environment for collaboratively identifying current barriers and interdisciplinary solutions to pressing medical needs, and facilitates the informal mixing of an international group of researchers, junior and senior scientists, as well as academic, industrial and regulatory viewpoints. The conference is also noted for its lively poster sessions and selected short talks from poster presenters. The wonderful resort setting at the Waterville Valley Resort will provide many opportunities for informal discussions and outdoor recreation activities as part of the conference registration. We recommend early application to the Drug Carriers in Medicine and Biology GRC as attendance is limited, and welcome applications from junior scientists to attend and present their research findings. A number of travel awards will be made based on submitted poster abstracts.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmVascular delivery, targets and barriers
Discussion Leader: Silvia Muro (University of Maryland)
7:40 pm - 8:10 pm Jan Schnitzer (Proteogenomics Research Institute for Systems Medicine)
"Vascular targeting via caveolar pathways"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:50 pm Grietje Molema (University of Groningen)
"Carriers for anti-inflammatory vascular interventions - therapeutics and tools for endothelial biology"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Shad Thaxton (Northwestern University)
"Biomimetric High Density Lipoprotein (HDL) Nanoparticles for Nucleic Acid Delivery"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTranslational studies, clinical trials and combination therapies
Discussion Leader: David Scheinberg (Memorial Sloan-Kettering Cancer Center)
9:00 am - 9:30 am Lawrence Mayer (Celator Pharmaceuticals)
"Challenges and Opportunities for Developing Drug Carrier-Based Combination Chemotherapy Formulations"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 am Ruth Duncan (University of Cardiff)
"Bioresponsive/biodegradable polymer therapeutics for cancer and tissue repair"
10:15 am - 10:30 am Discussion
10:30 am - 11:00 am Group Photo / Coffee Break
11:00 am - 11:30 am Paula Hammond (Massachusetts Institute of Technology)
"Nanodevices for cellular drug delivery and controlled release"
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pm Sonke Svenson (Cerulean Pharma Inc)
"Nanopharmaceuticals in Drug Delivery: Phase 2 Candidate Camptothecin-CDP (CRLX101) and Preclinical Candidate siRNA-PNP"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmLocal, pulmonary, GI and CNS delivery: barriers, transporters, devices
Discussion Leader: Patrick Stayton (University of Washington)
7:30 pm - 8:00 pm Krystof Bankiewicz (University of California San Francisco)
"Delivery of drugs, genes and imaging probes to the CNS"
8:00 pm - 8:15 pm Discussion
8:15 pm - 8:45 pm Randy Mrsny (University of Bath)
"Permeation of barriers for GI and pulmonary drug delivery"
8:45 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Vikash Chauhan (Harvard Medical School)
"Overcoming tumor delivery barriers"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEmerging technologies, materials, carriers and mechanisms
Discussion Leader: Sasha Kabanov (University of Nebraska)
9:00 am - 9:30 am Omid Farokhzad (Harvard University)
"New generations of targeted nanocarriers"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 am Gabriel Lopez (University of Texas MD Anderson Cancer Center)
"Monocytes and Macrophages: friends or foes... or both"
10:15 am - 10:30 am Discussion
10:30 am - 10:45 am Coffee Break
10:45 am - 11:15 am Debra Auguste (Harvard University)
"A Personalized Approach to Targeting Metastatic Breast Cancers"
11:15 am - 11:30 am Discussion
11:30 am - 11:50 am Efrosini Kokkoli (University of Minnesota)
"Peptide-targeted nanodevices for drug delivery"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pm Tyrone Porter (Boston University)
"Ultrasound-assisted drug delivery systems"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmNatural carriers (cells, proteins and peptides)
Discussion Leaders: Philip Low (Purdue University) and William Zamboni (Univesrity of North Carolina)
7:30 pm - 8:00 pm Catherine Bollard (Baylor College of Medicine)
"Cellular therapies: stem cells, modulation of immune response"
8:00 pm - 8:15 pm Discussion
8:15 pm - 8:45 pm Mauro Magnani (University of Urbino)
"Drug delivery by red blood cells"
8:45 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Jennifer R. Cochran (Stanford University)
"Engineered protein-based targeted therapeutics and probes"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCarriers for delivery of biologicals including vaccines and antigens
Discussion Leader: Jennifer Cochran (Stanford University)
9:00 am - 9:30 am Nathalie Garcon (Global Adjuvant Center for Vaccines at GlaxoSmithKline)
"Design of better vaccines: translational perspectives"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 am Tarek Fahmy (Yale University)
"Carriers for drug delivery antigens and probes to immune system"
10:15 am - 10:30 am Discussion
10:30 am - 10:45 am Coffee Break
10:45 am - 11:15 am Derek O'Hagan (Novartis Vaccines and Diagnostics)
"New Generation of Vaccine Adjuvants"
11:15 am - 11:30 am Discussion
11:30 am - 11:50 am Sam Lai (University of North Carolina)
"PEG coatings and their interactions with immune cells and antibodies"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pm Karyn O'Neil (Centyrex, Johnson & Johnson)
"Exploiting the Biophysical Properties of Centyrins for Novel Therapeutics"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmLatest news and young voices
Discussion Leaders: Heather D. Maynard (University of California Los Angeles) and Paul A. Burke (Burke Bioventures LLC)
TBA (six short 10 minute talks with 5 minutes discussion selected from the posters)
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmIntracellular delivery, trafficking and cellular barriers
Discussion Leader: Jan Schnitzer (Proteogenomics Research Institute for Systems Medicine)
9:00 am - 9:50 am Keynote Speaker: Chad Mirkin (Northwestern University)
"Emerging materials for intracellular delivery"
9:50 am - 10:10 am Discussion
10:10 am - 10:40 am Renata Pasqualini and Wadih Arap (University of Texas MD Anderson Cancer Center)
"Decoding vascular zip codes for treatment of human diseases"
10:40 am - 10:55 am Discussion
10:55 am - 11:10 am Coffee Break
11:10 am - 11:40 am Hamid Ghandehari (University of Utah)
"Nanocarriers for intracellular and transcellular drug delivery"
11:40 am - 11:55 am Discussion
11:55 am - 12:20 pm Silvia Muro (University of Maryland)
"Endosomal delivery via adhesion molecules"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pmBiological response to delivered drugs and genes
Discussion Leader: Leaf Huang (University of North Carolina)
7:30 pm - 8:00 pm William Zamboni (University of North Carolina)
"Profiling the biological factors modulating drug delivery in preclinical animal models and in patients"
8:00 pm - 8:15 pm Discussion
8:15 pm - 8:45 pm Carol H. Miao (Seattle Children's Hopsital)
"Modulation of non-viral gene therapy for hemophilia"
8:45 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Joy Yu (Genentech)
"Crossing the blood-brain barrier: transcytosis of a therapeutic antibody"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13EB015810-01 from the National Institute of Biomedical Imaging and Bioengineering. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement.

 
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