Gordon Research Conferences
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Conference Program
 
Drug Resistance
A Multidisciplinary Exploration of Similarities in Drug Resistance in Rapidly Evolving Diseases
July 29 - August 3, 2012
Stonehill College
Easton, MA

The occurrence of drug resistance negatively impacts the lives of millions of patients by limiting the longevity of many of our most potent drugs. In most cases, drug resistance is investigated as a disease specific endeavor, with no centralized, cross-disciplinary network in the world, limiting intellectual progress and breakthroughs. Clinicians and researchers are often unaware of the progress, resources and parallels in other diseases. However, it is increasingly clear that close parallels can often be drawn between resistance seen in one disease state and resistance seen within another. Cross-disciplinary collaboration and discussion are permitting a better understanding of resistance and may soon result in real clinical benefits. The new Gordon Research Conference entitled "Drug Resistance" is devoted to recognizing the parallels among quickly evolving diseases. The goal is to bring the challenge of drug resistance to the forefront of drug design strategies.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff & Conference Chairs
7:40 pm - 9:30 pmThe Drug Resistance Challenge: Setting the Stage
Discussion Leader: John Coffin (The Slacker School of Graduate Biomedical Sciences, Tufts University)
7:40 pm - 8:20 pmJohn Coffin (The Slacker School of Graduate Biomedical Sciences, Tufts University)
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmMarie-Pierre de Bethune (Vice President for External Innovation, Tibotec)
9:15 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDrug Resistance Evolution
Discussion Leader: Bruce Levin (Samuel Candler Dobbs Professor of Biology, Emory University)
9:10 am - 9:50 amLeah Cowen (Assistant Professor and Canada Research Chair in Microbial Genomics & Infectious Disease, University of Toronto)
"Global Analysis of the Evolution and Mechanisms of Fungal Drug Resistance"
9:50 am - 10:05 amDiscussion
10:05 amGroup Photo / Coffee Break
10:35 am - 11:15 amTim Clackson (President of Research and Development and Chief Scientific Officer, Ariad)
"Targeted cancer drugs with no mutation-based resistance - fantasy or reality?"
11:15 am - 11:30 amDiscussion
11:30 am - 12:10 pmJudith Berman (Professor, Genetics, Cell Biology and Development, Genetic Mechanisms of Cancer Program, MICaB program, University of Minnesota)
"Rapid evolution of drug resistance in a eukaryotic pathogen"
12:10 pm - 12:25 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmDrug Resistance Epidemiology
Discussion Leader: Thomas O'Brien (Associate Professor of Medicine, Brigham & Women's Hospital)
7:40 pm - 8:20 pmTBA
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmCristian Tomasetti (Research Fellow, Department of Biostatistics, Harvard School of Public Health)
"The distribution of resistance to targeted therapies in cancer patients"
9:15 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPredicting Drug Resistance
Discussion Leader: Stephen Rich (Associate Professor of Entomology, Department of Plant, Soil & Insect Sciences, University of Massachusetts Amherst)
9:10 am - 9:50 amSally Blower (Professor and Director, The Center for Biomedical Modeling, David Geffen School of Medicine at UCLA)
"Evolutionary dynamics of HIV epidemics: the impact of biomedical prevention strategies and treatment programs on drug resistance"
9:50 am - 10:05 amDiscussion
10:05 amCoffee Break
10:35 am - 11:15 amMichael M. Gottesman (Head, Multidrug Resistance Section, National Cancer Institute Center for Cancer Research)
"Relevance of mechanisms of multidrug resistance in cultured cancer cells to clinical multidrug resistance"
11:15 am - 11:30 amDiscussion
11:30 am - 12:10 pmAmy Anderson (Associate Professor of Medicinal Chemistry, University of Connecticut, Storrs)
"Towards Predicting Antibiotic Resistance Mutations During Compound Development"
12:10 pm - 12:25 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pmLimiting Resistance Emergence
Discussion Leader: Jean Patel (Deputy Director, Center for Disease Control Office of Antimicrobial Resistance)
7:40 pm - 8:20 pmPatrick Tranel (Professor, Molecular Weed Science, University of Illinois at Urbana-Champaign)
"What do weeds teach us about resistance evolution?"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmRoy Kishony (Professor of Systems Biology, Harvard Medical School)
9:15 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDesigning Drugs that Last
Discussion Leader: David Spiegel (Assistant Professor, Chemistry, Yale University)
9:10 am - 9:50 amAndrew Greenstein (Scientist, Gilead Sciences)
"Preexisting drug-resistance mutations reveal unique barriers to resistance for distinct antivirals"
9:50 am - 10:05 amDiscussion
10:05 amCoffee Break
10:35 am - 11:15 amEdward Arnold (Professor Chemistry and Chemical Biology, Rutgers, The State University of New Jersey)
"Structure-Guided Design of Two Anti-AIDS Targeting HIV-1 Reverse Transcriptase: Overcoming Resistance by Strategic Flexibility"
11:15 am - 11:30 amDiscussion
11:30 am - 12:10 pmRobert Siliciano (HHMI Investigator, The Johns Hopkins University School of Medicine)
"Resistance-Proof Regimens for HIV"
12:10 pm - 12:25 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session III
6:00 pmDinner
7:30 pm - 9:30 pmNovel Drug Targets to Avoid Resistance
Discussion Leader: Manuel Navia (Executive-in-Residence Oxford Bioscience Partners, Boston, MA)
7:40 pm - 8:20 pmJuswinder Singh (Founder and CSO Avila Therapeutics, Inc)
"The resurgence of covalent drugs"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmDiana Morales (Post Doctoral Fellow, Roberto Kolter Lab, Harvard Medical School, Boston, MA)
"Controlling biofilm antibiotic resistance by targeting lipid rafts"
9:15 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
9:00 am - 12:30 pmMultidisciplinary Approaches to Tackling Drug Resistance, Part 1
Discussion Leader: Jennifer Leeds (Executive Director, Novartis Institutes for Biomedical Research)
9:10 am - 9:50 amRob Dorit (Associate Professor of Biology, Smith College)
"The promiscuous world of antibiotic resistance genes"
9:50 am - 10:05 amDiscussion
10:05 amCoffee Break
10:35 am - 11:15 amRonald Swanstrom (Professor Biochemistry and Biophysics, University of North Carolina)
"Deep Sequencing With Primer ID To Study the Evolution of Resistance"
11:15 am - 11:30 amDiscussion
11:30 am - 12:10 pmRichard Slayden (Associate Professor and Associate Director, Center for Environmental Medicine, Colorado State University)
"Drug Discovery in Context of the Host: Defining Clinically Relevant Targets & Resistance Mechanisms"
12:10 pm - 12:25 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session IV
6:00 pmDinner
7:30 pm - 9:30 pmMultidisciplinary Approaches to Tackling Drug Resistance, Part 2
Discussion Leader: Ray Schinazi (Professor and Director, Laboratory of Biochemical Engineering, Emory University)
7:40 pm - 8:20 pmSusan Bates (Head, Molecular Therapeutics Section and Senior Investigator, National Cancer Institute Center for Cancer Research)
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmDaria Hazuda (Vice President Worldwide Discovery, Franchise Head for Infectious Diseases, MRL, Merck)
9:15 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible [in part] by 1 R13 AI 100477-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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