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Endothelial Cell Phenotypes in Health & Disease
July 29 - August 3, 2012
Renaissance Tuscany Il Ciocco Resort
Lucca (Barga), Italy
Chair:
Susan Quaggin

Vice Chair:
S. Ananth Karumanchi
Related Meeting Information
The Endothelial Cell Phenotypes in Health & Disease Gordon Research Conference was held in conjunction with the Endothelial Cell Phenotypes in Health & Disease Gordon-Kenan Research Seminar. Please refer to the Endothelial Cell Phenotypes in Health & Disease GKRS web page for more information.

Alterations of endothelial cells and the vasculature play a central role in the pathogenesis of a broad spectrum of diseases from diabetes to cancer. This GRC will bring together leading researchers from a variety of disciplines with shared interest in the endothelium, providing new insights and perspectives that are moving the field. Attendees will have the opportunity to establish new collaborations and research directions while gaining exposure to cutting edge research in the field of endothelial biology. Although basic research remains a central component, a strong translational focus and emphasis on the heterogeneity of endothelial cell types are unique to this GRC.

Contributors
SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmHypoxia and the Endothelium
7:40 pm - 8:20 pmKeynote Speaker: Gregg Semenza (Johns Hopkins University School of Medicine, Baltimore, MD, USA)
"Hypoxia and the Endothelium"
8:20 pm - 8:40 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmThe Endothelium in Development
Discussion Leader: Victoria L. Bautch (University of North Carolina at Chapel Hill, NC, USA)
9:00 am - 9:40 amKeynote Speaker: Kari Alitalo (Hartman Institute, University of Helsinki, Helsinki, Finland)
"Endothelial Tie's, Rejuvenated at 20"
9:40 am - 10:00 amDiscussion
10:00 amGroup Photo / Coffee Break
10:30 am - 10:55 amAnne Eichmann (Yale School Of Medicine, New Haven, CT, USA)
"Semaphorins and Patterning of the Vasculature"
10:55 am - 11:10 amDiscussion
11:10 am - 11:35 amVictoria L. Bautch (University of North Carolina at Chapel Hill, Chapel Hill, NC, USA)
"Centrosomes and Blood Vessels: Three is a Crowd"
11:35 am - 11:50 amDiscussion
11:50 am - 12:15 pmEli Keshet (The Hebrew University-Hadassah Medical School, Jerusalem, Israel)
"Manipulating the vascular stem cell niche"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmExtrinsic Cues That Modulate Endothelial Behaviour
Discussion Leader: Christer Betsholtz (Karolinska Institute, Stockholm, Sweden)
5:30 pm - 5:55 pmChristiana Ruhrberg (Institute of Ophthalmology, London, UK)
"Macrophages and the Endothelium"
5:55 pm - 6:10 pmDiscussion
6:10 pm - 6:35 pmChrister Betsholtz (Karolinska Institute, Stockholm, Sweden)
"Tip Cells and Gradients"
6:35 pm - 6:50 pmDiscussion
6:50 pm - 7:15 pmRalf H. Adams (Max Planck Institute for Molecular Biomedicine, Munster, Germany)
"Cross Talk form Mural Cells to Endothelial cells"
7:15 pm - 7:30 pmDiscussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDiseases of the Endothelium
Discussion Leader: Ananth Karumanchi (Harvard Medical School, Boston, MA, USA)
9:00 am - 9:25 amMartin Friedlander (The Scripps Research Institute, La Jolla, CA, USA)
"Retinal Vasculature"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 amDean Li (University of Utah School of Medicine, Salt Lake City, UT, USA)
"Cytokines and vascular stability"
10:05 am - 10:20 amDiscussion
10:20 amCoffee Break
10:50 am - 11:15 amRadu V. Stan (Dartmouth Medical School, Lebanon, NH, USA)
"The Fenestrated Vascular Endothelial Phenotype and Disease"
11:15 am - 11:30 amDiscussion
11:30 am - 11:55 amJens Titze (University Hospital, Erlangen, Germany)
"Lymphatic control of local electrolyte clearance"
11:55 am - 12:10 pmDiscussion
12:10 pm - 12:20 pmZoltan Arany (Beth Israel Deaconess & Harvard Medical School)
"Cardiac angiogenic imbalance leads to peri-partum cardiomyopathy"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmThe Future of Endothelial Biology: Bioengineering, Progenitor Cells and Nano Technology
Discussion Leader: Andras Nagy (Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada)
5:30 pm - 5:55 pmMervin Yoder (Indiana University School of Medicine, Indianapolis, Indiana, USA)
"Endothelial Progenitors"
5:55 pm - 6:10 pmDiscussion
6:10 pm - 6:35 pmShahin Rafii (Weill Cornell Medical College, New York, NY, USA)
"Molecular determinants of vascular heterogeneity and their instructive contributions to organ regeneration"
6:35 pm - 6:50 pmDiscussion
6:50 pm - 7:15 pmAndras Nagy (Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Canada)
"Adipose vessel density is a key determinant of metabolic homeostasis"
7:15 pm - 7:30 pmDiscussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSignaling and the Endothelium
Discussion Leader: Elisabetta Dejana (IFOM-IEO, University of Milan, Milan, Italy)
9:00 am - 9:25 amTatiana Byzova (Lerner Research Institute, Cleveland, OH, USA)
"Integrins, Kindlins and Vascular Disease"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 amHellmut Augustin (German Cancer Research Center, Heidelberg, Germany)
"Non-Traditional Roles in the Vasculature"
10:05 am - 10:20 amDiscussion
10:20 amCoffee Break
10:50 am - 11:15 amElisabetta Dejana (IFOM-IEO, University of Milan, Milan, Italy)
"Junctions and Vessel Function"
11:15 am - 11:30 amDiscussion
11:30 am - 11:55 amMichael Simons (Yale School of Medicine, New Haven, CT, US)
"Micro RNAs in Endothelial Function"
11:55 am - 12:10 pmDiscussion
12:10 pm - 12:20 pmJing Jin (Samuel Lunenfeld Research Institute, Mount Sinai Hospital)
"Soluble FLT1 regulates pericyte and glomerular barrier function"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmTargeted Therapeutics and the Endothelium
Discussion Leader: Dontscho Kerjaschki (Medical University Vienna, Vienna, Austria)
5:30 pm - 6:10 pmKeynote Speaker: Napoleone Ferrara (Genentech Inc, South San Francisco, CA, USA)
"Therapeutic targeting vascular disease"
6:10 pm - 6:30 pmDiscussion
6:30 pm - 6:55 pmKeynote Speaker: Mark Kahn (University of Pennsylvania, Philadelphia, USA)
"Integrins, CCM, Development of the Endothelium"
6:55 pm - 7:10 pmDiscussion
7:10 pm - 8:00 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmModel Systems and the Endothelium
Discussion Leader: Brant M. Weinstein (National Institutes of Health, Bethesda, MD, USA)
9:00 am - 9:50 amRenata Pasqualini and Wadih Arap (University of Texas MD Anderson Cancer Center, Houston, TX, USA)
"Ligand-directed targeting in translational medicine"
9:50 am - 10:20 amDiscussion
10:20 amCoffee Break
10:50 am - 11:15 amBrant M. Weinstein (National Institutes of Health, Bethesda, MD, USA)
"Zebrafish as a Model to Study the Endothelium"
11:15 am - 11:30 amDiscussion
11:30 am - 11:55 amKatie Bentley (Cancer Research, UK)
"Simulation uncovers novel mechanisms in angiogenesis"
11:55 am - 12:10 pmDiscussion
12:10 pm - 12:20 pmRong Wang (University of California at San Francisco)
"Endothelial notch signaling regulates arterial venous programming in health & disease"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmMetabolism, Inflammation, Clotting and the Endothelium
Discussion Leader: Jordan S. Pober (Yale University School of Medicine, New Haven, CT, USA)
5:30 pm - 5:55 pmUlf Eriksson (Karolinska Institute, Stockholm, Sweden)
"Vegfb, Fats and the Vasculature"
5:55 pm - 6:10 pmDiscussion
6:10 pm - 6:35 pmPeter Nawroth (University of Heidelberg, University Hospital Heidelberg, Germany)
"Diabetic Microvascular Disease"
6:35 pm - 6:50 pmDiscussion
6:50 pm - 7:15 pmGeorge L. King (Harvard Medical School, Joslin Diabetes Center, Boston, MA, USA)
"Diabetic Complications"
7:15 pm - 7:30 pmDiscussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture
Funding for this conference was made possible (in part) by 1R13HL115824-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
 
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