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Conference Program
 
Mechanisms of Epilepsy & Neuronal Synchronization
Reorganization in the Epileptic Brain
August 19-24, 2012
Waterville Valley Resort
Waterville Valley, NH

The 2012 Gordon Conference on Mechanisms of Epilepsy and Neuronal Synchronization will present cutting edge research on the theme of reorganization in the epileptic brain. The issues will be addressed at multiple levels, from cellular and molecular to circuits and networks. The focus will be on three important and persistent questions in the epilepsy field. What are the mechanisms underlying acute seizures? What progressive changes in brain organization and function lead to the chronic condition of epilepsy? What are the relationships between the mechanisms of epilepsy and the co-morbidities that are frequently encountered in this disorder? These questions will be considered specifically in sessions devoted to epileptogenesis, seizure generation, and developmental epilepsies and their co-morbidities. The issues raised during these sessions, including the reorganization of neural circuits in epilepsy, will be further developed in sessions that focus on exciting new methods of circuit analysis and their application in epilepsy research; mechanisms associated with reorganization of interneurons and alterations in chloride homeostasis; and the reorganization of several ion channels that could suggest targets for therapy. The purpose of the Conference is to bring together specialists from multiple disciplines to discuss the complex issues that arise in the processes of seizure generation and progression. It is expected that the exchange of new ideas will influence the critical next stage of experimental epilepsy research.

The collegial atmosphere of the Conference, with expanded Poster Sessions for all attendees, as well as opportunities for informal gatherings in the afternoons and evenings, will provide opportunities for scientists to brainstorm and promote increased interactions among investigators in diverse areas of basic epilepsy research.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
5:00 pm - 6:00 pmWelcome Reception (Meet and relax before dinner!)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 7:50 pmWelcome by Carolyn Houser (Chair), Jack Parent (Vice Chair) and Scott Baraban (Vice Chair)
7:50 pm - 9:30 pmChallenges for Epilepsy Research
7:50 pm - 8:00 pmDiscussion Leader: David Prince (Stanford University)
"Introduction"
8:00 pm - 8:30 pmDan Lowenstein (U. of California, San Francisco)
"Translational research in epilepsy: The prognosis"
8:30 pm - 8:45 pmDiscussion
8:45 pm - 9:15 pmIstvan Mody (U. of California, Los Angeles)
"The new landscape of research in the epilepsies"
9:15 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEpileptogenesis: Can we prevent it?
9:00 am - 9:30 amDiscussion Leader: Douglas Coulter (Children's Hospital of Pennsylvania)
"Introduction"
9:30 am - 9:55 amTallie Z. Baram (U. of California, Irvine)
"Constructing 'epileptic neurons': A role for epigenetic mechanisms"
9:55 am - 10:05 amDiscussion
10:05 am - 10:15 amNigel Jones (University of Melbourne)
"The enduring effects of early-life stress on limbic epileptogenesis are mediated by HPA axis hyper-reactivity"
10:15 am - 10:20 amDiscussion
10:20 am - 10:55 amGroup Photo / Coffee Break
10:55 am - 11:20 amAsla Pitkänen (U. of Eastern Finland)
"Anti-epileptogenesis after traumatic brain injury"
11:20 am - 11:30 amDiscussion
11:30 am - 11:55 amJames McNamara (Duke University)
"TrkB signaling and epileptogenesis: In search of a magic bullet"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:15 pmJennifer Pearson (U. of Colorado)
"Scavenging of highly reactive gamma-ketoaldehydes attenuates learning and memory deficits in experimental temporal lobe epilepsy"
12:15 pm - 12:25 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSeizure Generation: Where do seizures begin and how do they spread?
7:30 pm - 7:40 pmDiscussion Leader: Christophe Bernard (INSERM, Marseille)
"Introduction"
7:40 pm - 8:05 pmBrian Litt (U. of Pennsylvania)
"Network recruitment in seizure generation"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmGilles Huberfeld (ICM, Paris)
"Transition to seizures in human epileptic tissues"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmSydney Cash (Harvard Medical School)
"Neuron dynamics in human focal epilepsy"
9:15 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCircuit Analysis in Epilepsy with Optogenetics: Lighting up a darkened brain
9:00 am - 9:10 amDiscussion Leader: Helen Scharfman (New York University)
"Introduction"
9:10 am - 9:35 amKarl Deisseroth (Stanford University)
"Recent advances in optogenetics"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amIvan Soltesz (U. of California, Irvine)
"Optogenetic modulation of entorhino-hippocampal circuits in epilepsy"
10:10 am - 10:20 amDiscussion
10:20 am - 10:45 amCoffee Break
10:45 am - 10:55 amFabien Wagner (Brown University)
"Spatiotemporal dynamics of local field potentials and single-unit activity during spontaneous seizures and optically-induced oscillations in a rat model of absence epilepsy"
10:55 am - 11:00 amDiscussion
11:00 am - 11:25 amJohn Huguenard (Stanford University)
"Mechanisms of seizure initiation deduced by optogenetic approaches"
11:25 am - 11:35 amDiscussion
11:35 am - 12:00 pmJin Hyung Lee (U. of California, Los Angeles)
"Optogenetic functional magnetic resonance imaging and epilepsy"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmSarah Feldt Muldoon (INSERM, Marseille)
"Synchrony and epilepsy: Uncovering functional network structure in the dentate gyrus"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNetwork Dynamics in Epilepsy: Novel approaches for dissecting functional circuits
7:30 pm - 7:40 pmDiscussion Leader: John Hablitz (U. of Alabama, Birmingham)
"Introduction"
7:40 pm - 8:05 pmEdward Callaway (The Salk Institute, La Jolla)
"Rabies-based tools for elucidating neural circuit structure and function"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmBal Khakh (U. of California, Los Angeles)
"Imaging calcium signals in entire astrocytes and determining their relationship to neuronal activity"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmAndy Trevelyan (Newcastle University)
"The nature of cortical inhibitory restraint in mice and humans"
9:15 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGABA System Reorganization in Epilepsy: How many changes can we find?
9:00 am - 9:10 amDiscussion Leader: Monique Esclapez (INSERM, Marseille)
"Introduction"
9:10 am - 9:35 amGord Fishell (New York University Neuroscience Institute)
"The role of the activity-regulated gene SatB1 in the maturation of cortical interneurons and its relationship to early cortical seizures"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amChris McBain (NIH)
"The role of pentraxins in controlling interneuron glutamate receptor expression, feedforward inhibition and oscillogenesis"
10:10 am - 10:20 amDiscussion
10:20 am - 10:45 amCoffee Break
10:45 am - 10:55 amRobert Hunt (U. of California, San Francisco)
"Progress toward an interneuron-based cell therapy for epilepsy"
10:55 am - 11:00 amDiscussion
11:00 am - 11:25 amPaul Buckmaster (Stanford University)
"Abundant but dysfunctional GABAergic synapses in epilepsy"
11:25 am - 11:35 amDiscussion
11:35 am - 12:00 pmKevin Staley (Massachusetts General Hospital)
"Subcellular chloride distribution, GABA signaling and seizures"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmLeonie Pothmann (U. of Bonn Medical Center)
"Network basis of anticonvulsant drug action"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmMultiple Ways of Altering Excitability in Epilepsy: What can be targeted?
7:30 pm - 7:40 pmDiscussion Leader: Manisha Patel (U. of Colorado)
"Introduction"
7:40 pm - 8:05 pmGary Yellen (Harvard Medical School)
"K(ATP) channels in metabolic control of neuronal excitability"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmDimitri Kullmann (University College London)
"Potassium channel overexpression as a treatment for focal neocortical epilepsy"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmDane Chetkovich (Northwestern U. School of Medicine, Chicago)
"Targeting the trafficking of HCN channels in epilepsy"
9:15 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDevelopmental Epilepsies and Co-Morbidities: Are there common mechanisms?
9:00 am - 9:10 amDiscussion Leader: John Swann (Baylor College of Medicine)
"Introduction"
9:10 am - 9:35 amAmy Brooks-Kayal (U. of Colorado and Children's Hospital Colorado)
"Developmental epilepsy syndromes and questions they raise"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amPeter Crino (U. of Pennsylvania)
"New etiologies for cortical dysplasias"
10:10 am - 10:20 amDiscussion
10:20 am - 10:45 amCoffee Break
10:45 am - 10:55 amChris Dulla (Tufts University)
"Preventing cortical malformations and hyperexcitability with GABApentin"
10:55 am - 11:00 amDiscussion
11:00 am - 11:25 amMassimo Mantegazza (IPMC, CNRS, Nice-Sophia Antipolis, France)
"Nav 1.1 sodium channel dysfunctions in Dravet syndrome and GEFS+"
11:25 am - 11:35 amDiscussion
11:35 am - 12:00 pmFarah Lubin (U. of Alabama, Birmingham)
"Epigenetic mechanisms in epilepsy and epilepsy-related memory dysfunction"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmDavid Auerbach (U. of Michigan)
"A mouse model of Dravet syndrome reveals alterations in cardiac electrophysiology"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmChannel and Transporter Reorganization in the Epileptic Brain: Do the genetics suggest treatment targets?
7:30 pm - 7:40 pmDiscussion Leader: Jaideep Kapur (U. of Virginia)
"Introduction"
7:40 pm - 8:05 pmSamuel Berkovic (U. of Melbourne)
"Glucose transporter mutations in epilepsy"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmRobert Macdonald (Vanderbilt University)
"Altered GABAA receptor biogenesis and function in genetic epilepsies"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmJeffrey Noebels (Baylor College of Medicine)
"Ending happily on a negative note: Voltage-gated chloride channels and epilepsy"
9:15 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

This conference was supported in part by the National Institute of Neurological Disorders and Stroke of the National Institutes of Health under Award Number R13NS078797. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

 
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