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Conference Program
 
Fibroblast Growth Factors in Development & Disease
May 13-18, 2012
Les Diablerets Conference Center
Les Diablerets, Switzerland

Related Meeting Information
The Fibroblast Growth Factors in Development & Disease Gordon Research Conference was held in conjunction with the Fibroblast Growth Factors in Development & Disease Gordon Research Seminar. Please refer to the Fibroblast Growth Factors in Development & Disease GRS web page for more information.

The Fibroblast growth factors (FGFs) comprise a large family of growth and differentiation factors with essential functions in development, metabolism, and repair of various tissues and organs. Dysregulation of FGF signaling is associated with a wide variety of human diseases, including several developmental/genetic diseases, metabolic disorders, and malignancies. This conference will encompass the most recent and timely research in this highly diverse field, and promote interdisciplinary interactions between scientists, clinicians and colleagues from industry studying all aspects of FGF biology. Topics will cover Biochemistry of the FGF signaling complex and control of downstream signaling pathways and their impact on cell biology, physiology, endocrinology, development, pharmacology, pathology and regeneration/repair.

In addition to presentations by invited speakers, abstracts will be selected for shorter oral presentations for each session, ensuring that the program includes a breadth of exciting new topics emerging in the period just preceding the conference.

Strong emphasis will be placed on presentation of unpublished data and extended discussion times tackling the cutting edge of the field. Poster sessions will also be given high priority. Applications will be accepted from a diverse mix of established investigators, junior PIs, postdocs and graduate students. There will also be a satellite GRS meeting for postdocs and graduate students prior to the main GRC.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote and Emerging/Hot Topics
Discussion Leader: Sabine Werner (ETH Zürich, Switzerland)
7:40 pm - 7:55 pmDuncan Sparrow (Victor Chang Cardiac Research Centre, Syndey, Australia)
"A mechanism for gene-environment interaction in the etiology of congenital scoliosis"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:20 pmZamal Ahmed (M D Anderson Cancer Centre, Houston, USA)
"Grb2 controls phosphorylation of FGF receptor by regulating kinase and Shp2 phosphatase activity"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmKeynote: Michael Brand (Technische Universität Dresden, Germany)
"Biophysical aspects of Fgf8 signaling in vivo"
9:10 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFGFs, FGFRs and the extracellular environment
Discussion Leader: David Ornitz (Washington University School of Medicine, USA)
9:00 am - 9:25 amMoosa Mohammadi (New York University School of Medicine, USA)
"A Novel Mode of FGF Receptor Dimerization"
9:25 am - 9:35 amDiscussion
9:35 am - 9:45 amEllen Haugsten (The Norwegian Radiumhospital, Oslo, Norway)
"Clathrin- and dynamin-independent endocytosis of FGFR3 - implications for signaling"
9:45 am - 9:50 amDiscussion
9:50 am - 10:00 amChiara Francavilla (University of Copenhagen(NNF CPR), Denmark)
"Proteomic characterization of the molecular switch underlying FGFR2IIIb recycling"
10:00 am - 10:05 amDiscussion
10:05 amCoffee Break
10:35 am - 10:45 amDiego Garcia-Gonzalez (Hospital Nacional de Parapléjicos, Spain)
"Anosmin-1 over-expression produces impaired olfactory function and congruent neuroanatomical changes in mice"
10:45 am - 10:50 amDiscussion
10:50 am - 11:00 amToru Imamura (Biomedical Research Institute, AIST, Tsukuba, Japan)
"Sulfated Glycosaminoglycans Are Required for Specific and Sensitive Fibroblast Growth Factor (FGF) 19 Signaling"
11:00 am - 11:05 amDiscussion
11:05 am - 11:30 amDavid Fernig (Liverpool University, UK)
"Exploring the Matrix with FGFs"
11:30 am - 11:40 amDiscussion
12:30 pmGroup Photo / Lunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session I
5:30 pm - 7:30 pmFGF signaling pathways
Discussion Leader: David Fernig (Liverpool University, UK)
5:30 pm - 5:55 pmMichael Tsang (University of Pittsburgh, USA)
"Chemical approaches to dissecting the role of FGF signaling in heart development and regeneration"
5:55 pm - 6:05 pmDiscussion
6:05 pm - 6:15 pm Catherine Degnin (Shriners Research Center, Portland, USA)
"FGFR3 in the nucleus: mechanisms to generate the unexpected"
6:15 pm - 6:20 pmDiscussion
6:20 pm - 6:30 pmPavel Krejci (Masaryk University Brno, Czech Republic & Cedars-Sinai Medical Center, Los Angeles, USA)
"Fibroblast growth factor upregulates Wnt/beta-catenin signaling via Erk MAP kinase/Lrp6 pathway"
6:30 pm - 6:35 pmDiscussion
6:35 pm - 6:45 pmFrederick Tan (California Institute of Technology, Pasadena, California, USA)
"FGF/Erk MAP kinase signaling targets Nanog mRNA for degradation"
6:45 pm - 6:50 pmDiscussion
6:50 pm - 7:15 pmXin Zhang (Indiana University School of Medicine, USA)
"Genetic analysis of FGF signaling in eye development"
7:15 pm - 7:25 pmDiscussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEndocrine FGFs
Discussion Leader: Nobuyuki Itoh (Kyoto University, Japan)
9:00 am - 9:25 amSteven Kliewer (UT Southwestern Medical Center, USA)
"Metabolic Actions of Endocrine FGFs 15/19 and 21"
9:25 am - 9:35 amDiscussion
9:35 am - 9:45 amChristian Faul (University of Miami Miller School of Medicine, USA)
"Fibroblast Growth Factor 23 induces Left Ventricular Hypertrophy"
9:45 am - 9:50 amDiscussion
9:50 am - 10:00 amTarja Kinnunen (University of Liverpool, UK)
"Control of metabolic physiology by FGFR/Klotho signalling is evolutionarily conserved"
10:00 am - 10:05 amDiscussion
10:05 amCoffee Break
10:35 am - 11:00 amAlexei Kharitonenkov (Lilly Research Laboratories, USA)
"Novel approaches to target FGF21 pathway"
11:00 am - 11:10 amDiscussion
11:10 am - 11:20 amJunichiro Sonoda (Genentech, Inc., South San Francisco, USA)
"Antibody based approach to study the role of FGFR1 in adult mice"
11:20 am - 11:25 amDiscussion
11:25 am - 11:50 amYang Li (Amgen, Inc., USA)
"Novel approaches to targeting the FGF21 pathway"
11:50 am - 12:00 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session I (continued)
5:30 pm - 7:30 pmFGFs in genetic disease, humans and models
Discussion Leader: Fen Wang (Texas A&M Health Science Center, USA)
5:30 pm - 5:55 pmMarja Hurley (University of Connecticut, USA)
"Nuclear Isoforms and Bone Matrix Mineralization"
5:55 pm - 6:05 pmDiscussion
6:05 pm - 6:15 pm Rachel Liao (Harvard Graduate School of Arts and Sciences, USA)
"FGFR2 and FGFR3 as therapeutic targets in squamous cell lung carcinoma"
6:15 pm - 6:20 pmDiscussion
6:20 pm - 6:30 pmSachiko Iseki (Tokyo Medical and Dental University, Japan)
"Opposing effects of FGF18 and FGF2 on developing cranial bones by different influences on Fgfr, Twist1 and Bmp expression"
6:30 pm - 6:35 pmDiscussion
6:35 pm - 6:45 pmIrma Thesleff (Institute of Biotechnology, University of Helsinki, Finland)
"Stem cells expressing Sox2 and regulated by FGFs contribute to all epithelial cell lineages in teeth"
6:45 pm - 6:50 pmDiscussion
6:50 pm - 7:15 pmNelly Pitteloud (Université de Lausanne, Switzerland)
"FGF21: a link between metabolism and reproduction"
7:15 pm - 7:25 pmDiscussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFGFs in growth control and cancer
Discussion Leader: Marja Hurley (University of Connecticut, USA)
9:00 am - 9:25 amTomoko Iwata (Glasgow University, UK)
"Bladder cancer and the FGF signalling network"
9:25 am - 9:35 amDiscussion
9:35 am - 9:45 amRichard Grose (Barts Cancer Institute, Queen Mary University London, London, UK)
"FGFR1 cleavage and nuclear translocation regulates breast cancer cell behavior"
9:45 am - 9:50 amDiscussion
9:50 am - 10:00 amElaine Kilgour (AstraZeneca Oncology Innovative Medicines, Macclesfield, UK)
"AZD4547, a potent and selective FGF-receptor inhibitor, induces tumour regressions in human primary explant models of FGF-receptor amplified gastric cancer and squamous NSCLC"
10:00 am - 10:05 amDiscussion
10:05 amCoffee Break
10:35 am - 11:00 amPamela Pollock (Queensland University of Technology, Australia)
"FGFR inhibition and the issues of intrinsic and acquired resistance"
11:00 am - 11:10 amDiscussion
11:10 am - 11:20 amFen Wang (Texas A&M Health Science Center, Houston, TX, USA)
"FGF signaling in prostate stem cells and prostate cancer"
11:20 am - 11:25 amDiscussion
11:25 am - 11:50 amAna Costa-Pereira (Imperial College London, UK)
"JAKs and STATs in FGF-2-mediated drug resistance"
11:50 am - 12:00 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session II
5:30 pm - 7:30 pmFGFs and organization of development
Discussion Leader: Irma Thesleff (University of Helsinki, Finland)
5:30 pm - 5:55 pmMark Lewandoski (NCI-Frederick, NIH, USA)
"Diverse roles of Fibroblast Growth Factor signaling during somitogenesis and axis extension"
5:55 pm - 6:05 pmDiscussion
6:05 pm - 6:15 pm Matt Hoffman (NIDCR, NIH, Bethesda,USA)
"The self-renewal of epithelial progenitors during organogenesis requires Kit and Fgfr2b signaling"
6:15 pm - 6:20 pmDiscussion
6:20 pm - 6:30 pmRaj Ladher (RIKEN CDB, Kobe, Japan)
"Fibroblast Growth Factor Receptor 1 (FGFR1) controls intraflagellar transport in inner ear hair cell kinocilia"
6:30 pm - 6:35 pmDiscussion
6:35 pm - 6:45 pmSunday Oladipupo (Washington University School of Medicine, USA)
"FGF Receptor signaling is dispensable for normal vascular development, but is required for vascular response to injury and tumorigenesis"
6:45 pm - 6:50 pmDiscussion
6:50 pm - 7:15 pmSaverio Bellusci (Justus-Liebig-Universität, Germany)
"Role of FGF signaling in mesenchymal lineage commitment during lung development and after injury"
7:15 pm - 7:25 pmDiscussion
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
9:00 am - 12:30 pmFGFs in the nervous system
Discussion Leader: Saverio Bellusci (Justus-Liebig-Universität, Germany)
9:00 am - 9:25 amAlbert Basson (King's College London, UK)
"The importance of regulating FGF signals during development of the cerebellum"
9:25 am - 9:35 amDiscussion
9:35 am - 9:45 amIng-Ming Chiu (National Health Research Institutes, Miaoli, Taiwan)
"Expression pattern of GFP driven by FGF1 promoter in F1B-GFP transgenic mice"
9:45 am - 9:50 amDiscussion
9:50 am - 10:00 amSophie Thompson (University of Liverpool, UK)
"Remodelling of heparan sulfate by 6-O-sulfatases regulates fibroblast growth factor induced astrocytosis and glial cell boundary formation"
10:00 am - 10:05 amDiscussion
10:05 amCoffee Break
10:35 am - 11:00 amHisashi Umemori (University of Michigan, USA)
"FGF and Synapse Formation"
11:00 am - 11:10 amDiscussion
11:10 am - 11:20 amOlga Baron (Hannover Medical School, Hannover, Germany)
"Contributory regulation of ventral mesencephalic dopaminergic neuron development by FGF-2"
11:20 am - 11:25 amDiscussion
11:25 am - 11:50 amDavid Ornitz (Washington University School of Medicine, USA)
"In vivo regulation of progenitor cell lineages by the FGF9/16/20 family"
11:50 am - 12:00 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session II (continued)
5:30 pm - 7:30 pmFGF signaling in repair, regeneration and therapeutics
Discussion Leader: Brad Olwin (University of Colorado, USA)
5:30 pm - 5:50 pmSabine Werner (ETH Zürich, Switzerland)
"Mechanisms of FGF action in repair of epithelial tissues"
5:50 pm - 6:00 pmDiscussion
6:00 pm - 6:20 pmStijn De Langhe (National Jewish Health, USA)
"Lung stem cells and their niche"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:40 pmLars Klimaschewski (Medical University Innsbruck, Innsbruck, Austria)
"FGF-dependent signaling in sensory neurons: Novel approaches to accelerate peripheral axon regeneration"
6:40 pm - 6:45 pmDiscussion
6:45 pm - 6:55 pmSimon Woehrle (Novartis Institutes for BioMedical Research, Basel, Switzerland)
"FGFR inhibitors as a targeted therapy for FGF23-related hypophosphatemia disorders"
6:55 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmChristoph Ladel (Merck Serono Research, Germany)
"FGF18 as specific growth factor for cartilage repair in preclinical and clinical cartilage disorders"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by Grant 1 R13 HD072647-01 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices or organizations imply endorsement by the U.S. Government.

 
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