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Glycolipid and Sphingolipid Biology
Gordon Research Conference

Dates

April 22-27, 2012

Location

Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy

Organizers

Chair:
Yasuyuki Igarashi

Vice Chair:
Walter M. Holleran

Meeting Description

The Gordon Research Conference on Glycolipid and Sphingolipid Biology, the twelfth in this series, promises to be an exciting and instructive meeting on the cutting edge of the field. Important areas of focus will include: novel imaging technologies for glyco/sphingolipidology. role of these lipids in membrane microdomain and membrane dynamics, regulation of the enzymes of glycolipid and sphingolipid metabolism, lipidomics and identification of novel lipids with novel functions, roles of bioactive sphingolipids in signal transduction, gene regulation, and in diseases such as neurodegeneration, metabolic syndromes, diabetes, skin health and cancer. In addition the meeting will cover exciting new developments in cross relations between sphingolipid and glycolipid, model organisms and knockout mouse models, glyco/sphingolipid nutrition, drug development and translational sciences.

With the help of all attendees, we'll try to cover the significant developments and the different perspectives in the field. In addition to invited presentations by leaders in the field, exciting abstracts will be selected for oral presentation, and stimulating posters will be selected for presentation as part of a “hot topics” session. We will have ample discussion after each talk, during the poster sessions, and during afternoon walks on the old cities of Toscana.

Contributors

Meeting Program

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmMicrodomain and Membrane Dynamics
Discussion Leaders: Sandro Sonnino (University of Milan, Italy) & Toshihide Kobayashi (Riken, Japan)
7:40 pm - 7:45 pmIntroduction by Discussion Leaders
7:45 pm - 8:05 pmToyoshi Fujimoto (Nagoya University, Japan)
"Nanoscale observation of membrane lipids by electron microscopy"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:30 pmManuel Prieto (IST, Portugal)
"Ceramide platform and microdomain function"
8:30 pm - 8:35 pmDiscussion
8:35 pm - 8:55 pmVerana Gobel (Harvard Medical School, USA)
"A role of sphingolipid biosynthesis in membrane polarity in C. elegans"
8:55 pm - 9:05 pmDiscussion
9:05 pm - 9:20 pmAlessandro Prinetti (University of Milan, Italy)
"Regulation of caveolin-dependent signaling complexes by gangliosides"
9:20 pm - 9:30 pmDiscussion and Session Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHot Topics in Sphingolipid Metabolism
Discussion Leaders: Yusuf Hannun (Stony Brook Cancer Center, USA) & Toshiro Okazaki (Kanazawa medical School, Japan)
9:00 am - 9:10 amIntroduction by Discussion leaders
9:10 am - 9:30 amRichard L. Proia and Mari Kono (NIH, USA)
"Imaging S1P1 receptor signaling in vivo"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amFrancoise Roelants (UC Berkeley, USA)
"A complex protein kinase network regulates sphingolipid-glycerolipid homeostasis"
10:00 am - 10:10 amDiscussion
10:10 amGroup Photo / Coffee Break
10:40 am - 11:00 amJoost Holthius (Utrecht University, Netherlands)
"Control of mitochondrial apoptosis by a putative ceramide sensor in the ER"
11:00 am - 11:10 amDiscussion
11:10 am - 11:30 amDimitri Krainc and Joe Mazzulli (Harvard Medical School, USA)
"Glucocerebrosidase and lysosomal diseases"
11:30 am - 11:40 amDiscussion
11:40 am - 11:55 amFelix Wieland (Heidelberg University, Germany)
"Membrane Lipids as Cofactors for Membrane Proteins?"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:15 pmRoger Sandhoff (German Cancer Research Center, Germany)
"Physiological functions of CerS3 in skin barrier development and spermatogenesis"
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmSession Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session (Odd-Numbered Posters to be presented)
5:30 pm - 7:30 pmGlyco/Sphingo Lipidomics
Discussion Leader: James Shayman (University of Michigan, USA)
5:30 pm - 5:35 pmIntroduction by Discussion Leader
5:35 pm - 5:55 pmAl Merrill (Geogia Institute of Technology, USA)
"Welcome to the sphingolipidome, and get ready for more surprises"
5:55 pm - 6:05 pmDiscussion
6:05 pm - 6:25 pmJohn Yu (Academia Sinica, Taiwan)
"Stem Cells and Cancer from the perspective of glycomics analysis"
6:25 pm - 6:35 pmDiscussion
6:35 pm - 6:55 pmYasuroh Shinohara (Hokkaido University, Japan)
"Qualitative cellular glycomics of glycosphingolipids and other classes of complex carbohydrates as cellular descriptors"
6:55 pm - 7:05 pmDiscussion
7:05 pm - 7:20 pmAkemi Suzuki (Tokai University, Japan)
"Structural Analysis of Glycosphingolipids by LC-MS"
7:20 pm - 7:25 pmDiscussion
7:25 pm - 7:30 pmSession Discussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNew Functions of S1P and Application
Discussion Leaders: Tim Hla (Medical College Cornell University, USA) & Nigel Pyne (University of Strathclyde, UK)
9:00 am - 9:10 amIntroduction by Discussion Leaders
9:10 am - 9:30 amSarah Spiegel (Virginia Commonwealth University School of Medicine, USA)
"Sphingosine-1-Phosphate: the TRAFfic regulator of NF-kB"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amMasaru Ishii (Osaka University, Japan)
"Roles of S1P in osteoclast regulation and bone physiology"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amJody Rosenblatt (University of Utah, USA)
"S1P signals epithelial cell extrusion to control homeostatic cell numbers"
10:30 am - 10:40 amDiscussion
10:40 amCoffee Break
11:00 am - 11:20 amTsuyoshi Nishi (Osaka University, Japan)
"Analysis of physiological function of the sphingosine 1-phosphate transporter in mice"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amNigel Pyne (University of Strathclyde, UK)
"Sphingosine 1-phosphate and cancer"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmBesim Ogretmen (Medical University of South Carolina, USA)
"Communication between host organism and cancer cells is transduced by systemic sphingosine 1-phosphate to regulate lung metastasis"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmSession Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session (Even-Numbered Posters to be presented)
5:30 pm - 7:30 pmNovel Glycolipids with Novel Function
Discussion Leaders: Akemi Suzuki (Tokai University, Japan) & Yu-Teh Li (Tulane University, USA)
5:30 pm - 5:35 pmIntroduction by Discussion Leaders
5:35 pm - 5:55 pmYoshio Hirabayashi (Brain Science Institute Riken, Japan)
"A novel bioactive lipid, phosphatidylglucoside: from structure to functions in the developing brain"
5:55 pm - 6:05 pmDiscussion
6:05 pm - 6:25 pmMitchell Kronenberg (La Jolla Institute, USA)
"Novel glycolipid stimulating NKT cells"
6:25 pm - 6:35 pmDiscussion
6:35 pm - 6:50 pmYuki Ito (Yamaguchi University, Japan)
"Pathological and immunological functions of cholesteryl alpha-glucosides in Helicobacter pylori-associated inflammation"
6:50 pm - 6:55 pmDiscussion
6:55 pm - 7:15 pmTeymuras Kurzchalia (MaxPlank Institute, Germany)
"Discovery of two novel classes of glycolipids in C.elegans and investigation of their role in the functioning of the organism"
7:15 pm - 7:30 pmDiscussion and Session Discussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSphingolipid Metabolism and Pathology
Discussion Leaders: Richard Kolesnick (Sloan-Kettering Cancer Center, USA) & Kentaroh Hanada (National Institute of Infectious Disease, Japan)
9:00 am - 9:10 amIntroduction by Discussion leaders
9:10 am - 9:30 amTony Futerman (Weizmann Institute, Israel)
"Ceramide synthases in pathology"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amErich Gulbins (University of Duisburg-Essen, Germany)
"Ceramide in cystic fibrosis and Pseudomonas aeruginosa infections"
10:00 am - 10:10 amDiscussion
10:10 amCoffee Break
10:30 am - 10:50 amAkio Kihara (Hokkaido University, Japan)
"The complete sphingosine 1-phosphate metabolic pathway involves the Sjögren-Larsson syndrome gene"
10:50 am - 11:00 am Discussion
11:00 am - 11:15 amNathalie Andrieu-Abadie (Cancer Research Center of Toulouse, France)
"Role of sphingosine-1-phosphate in melanoma-stroma interactions"
11:15 am - 11:20 amDiscussion
11:20 am - 11:35 amMark Kester (Penn State University College of Medicine, USA)
"Sphingolipid-based nanotechnologies for the treatment of acute myeloid leukemias"
11:35 am - 11:40 amDiscussion
11:40 am - 11:55 amSusumu Mitsutake (Hokkaido University, Japan)
"SMS2 is implicated as a novel regulator of lipid microdomain structure and function"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:15 pmDerek Sieburth (University of Southern California, USA)
"Regulation of synapse structure and function by sphingosine kinase in C. elegans"
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmSession Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session (All Posters to be open for discussion)
5:30 pm - 7:30 pmDiabetes and Metabolic Syndrome
Discussion Leader: Konrad Sandhoff (Bonn University, Germany)
5:30 pm - 5:35 pmIntroduction by Discussion Leader
5:35 pm - 5:55 pmJin-ichi Inokuchi (Tohoku Pharmaceutical University, Japan)
"Ganglioside GM3 participates in the pathogenesis of metabolic syndrome"
5:55 pm - 6:05 pmDiscussion
6:05 pm - 6:25 pmXian-Cheng Jiang (State University of New York, USA)
"Reduced Serine-palmitoyltransferase activity in macrophages alleviates atherosclerosis"
6:25 pm - 6:35 pmDiscussion
6:35 pm - 6:55 pmPingsheng Liu (Chinese Academy of Science, China)
"Proteomics reveals lipid droplets as a conserved multifunctional organelle from bacteria to human"
6:55 pm - 7:05 pmDiscussion
7:05 pm - 7:20 pmLinkang Zhou (Tsinghua University, China)
"Cidea Promotes Hepatic Steatosis by Sensing Dietary Fatty Acids"
7:20 pm - 7:30 pmDiscussion and Session Discussion
7:30 pm - 8:00 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGlycolipid Metabolism and Pathology
Discussion Leaders: Hugo Maccioni (Ciudad University, Argentina) & Koichi Furukawa (Nagoya University, Japan)
9:00 am - 9:10 amIntroduction by Discussion Leaders
9:10 am - 9:30 amSen-tiroh Hakomori (University of Washington, USA)
"Functional role of specific glycosphingolipids in epithelial-mesenchymal transition process defining tumor progression"
9:30 am - 9:40 amDiscussion
9:40 am - 9:55 amHugo Maccioni (Ciudad University, Argentina)
"Regulation of glycolipid synthesis in Golgi Apparatus"
9:55 am - 10:00 am Discussion
10:00 am - 10:15 amRhoderick Brown (University of Minnesota, USA)
"Glycolipid Transfer Protein (GLTP) Superfamily: Emerging New Members and Transcriptional Regulation by Sphingolipid Metabolites"
10:15 am - 10:20 amDiscussion
10:20 amCoffee Break
10:40 am - 11:00 amJohannes Aerts (Academic Medical Center Amsterdam, Netherlands)
"Lipid and protein biomarkers for sphingolipidoses"
11:00 am - 11:10 amDiscussion
11:10 am - 11:30 amHiroshi Kiyono (University of Tokyo, Japan)
"Role of glycolipid/S1P in the regulation of mucosal immunity"
11:30 am - 11:40 amDiscussion
11:40 am - 11:55 amMassimo Aureli (University of Milan, Italy)
"Plasma membrane associated glycohydrolases"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:15 pmJulian Prendergast (Johns Hopkins University)
"Ganglioside interacting proteins - bridging the gap between myelin associated glycoprotein (MAG) and RhoA"
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmSession Discussion
12:30 pmLunch
1:30 pm - 5:30 pmFree Time / Optional Excursion
5:30 pm - 7:30 pmModel Animals/Plants/Microbes in Sphingolipid Biology
Discussion Leader: Makoto Itoh (Kyusyu University, Japan)
5:30 pm - 5:35 pmIntroduction by Discussion Leader
5:35 pm - 5:55 pmHoward Riezman (University of Geneva, Switzerland)
"Lipid homeostasis and function in model systems"
5:55 pm - 6:05 pmDiscussion
6:05 pm - 6:20 pmRobert Dickson (University of Kentucky College of Medicine, USA)
"Down-regulation of sphingolipid synthesis in yeast increases chronological lifespan"
6:20 pm - 6:25 pmDiscussion
6:25 pm - 6:45 pmUsha Acharya (University of Massachusetts Medical School, Worcester USA)
"Intersection of sphingolipid and intermediary metabolism - insights from drosophila"
6:45 pm - 6:55 pmDiscussion
6:55 pm - 7:15 pmLina Obeid (Stony Brook University, USA)
"Bioactive sphingolipids in cancer: lessons from mice"
7:15 pm - 7:30 pmDiscussion and Session Discussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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