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Barriers of the CNS
Gordon Research Seminar
June 16-17, 2012
Colby-Sawyer College
New London, NH
Chair:
Rajendar K. Mittapalli
Related Meeting Information
The Barriers of the CNS Gordon Research Seminar was held in conjunction with the Barriers of the CNS Gordon Research Conference. Please refer to the Barriers of the CNS GRC web page for more information.

The Gordon Research Seminar on Barriers of the CNS is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is to encourage young scientists, students, and post-docs from the CNS Barriers field as well as other related disciplines to present their latest findings and novel methods for input and discussion with experts with a broad array of knowledge and skills. The collegial atmosphere of this meeting is expected to provide an opportunity for budding scientists from different disciplines to brainstorm and promote the highest level of positive input and critical analysis to promote the advancement in the field.

Contributors
SATURDAY
1:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Lecture
3:45 pm - 4:15 pmThomas P Davis (University of Arizona, Tucson, Arizona)
"The Blood Brain Barrier: Target or Obstacle for Drug Delivery to the Brain"
4:15 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmBlood Brain Barrier: Transporters and Drug Delivery
Discussion Leaders: Ulrich Bickel (Texas Tech University Health Sciences Center, Amarillo, TX, USA) and Anika Hartz (University of Minnesota, Duluth, MN, USA)
7:30 pm - 7:50 pmXiaobin Zhang (University of Wisconsin, Madison, WI, USA)
"Searching for antibodies having brain drug delivery potential"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmDevika S. Manickam (University of Nebraska Medical Center, Omaha, NE, USA)
"Well-defined Antioxidant Nanozymes for Treatment of Ischemic Brain Injury"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmMuhammad Sadiq (Uppsala University, Uppsala, Sweden)
"Oxymorphone pharmacokinetic-pharmacodynamic relationship and blood-brain barrier transport studied with microdialysis"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmRamaKrishna Samala (Texas Tech University Health Sciences Center, Amarillo, TX, USA)
"Vinorelbine Distribution to Brain Metastases of Breast Cancer and Factor Affecting In vivo Efficacy"
9:20 pm - 9:30 pmDiscussion
SUNDAY
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amBlood-Brain Barrier Signaling, Disease, and Imaging: Session I
Discussion Leaders: Weihong Pan (Penington Biomedical Research Center, USA) and Robert G. Thorne (University of Wisconsin, Madison, WI, USA)
9:00 am - 9:20 amHannah Wilson (University of Wisconsin, Madison, WI, USA)
"Stem Cell-Based Modeling of the Blood-Brain Barrier"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amEduard Urich (FA.Hoffmann-La Roche Ltd. Switzerland)
"Transcriptional profiling of 2D human brain endothelial cells and a 3D setup of the neurovascular unit"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amSripad Ram (University Of Texas Southwestern Medical Center, Texas, USA)
"3D single molecule imaging of macromolecular transport at blood-CNS barriers using multifocal plane microscopy"
10:00 am - 10:20 amDiscussion
10:30 am - 10:50 amOlga Huber (University of Heidelberg, Heidelberg, Germany)
"Exploring the expression pattern of human P-glycoprotein by applying super-resolution fluorescence microscopy"
10:50 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session II
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmBlood-Brain Barrier Signaling, Disease, and Imaging: Session II
Discussion Leaders: Weihong Pan (Penington Biomedical Research Center, USA) and Robert G. Thorne (University of Wisconsin, Madison, USA)
1:30 pm - 1:50 pmAna Moreira (Center For Neuroscience And Cell Biology, Portugal)
"Modulation of GLUT-1 Expression at Blood-Brain Barrier by Estrogens: a Mechanism to overcome Hot Flashes in Menopause?"
1:50 pm - 2:00 pmDiscussion
2:00 pm - 2:20 pmAileen Marcelo (Marshall University, Huntington, WV, USA)
"The Role and Regulation of Vascular Endothelial Growth Factor (VEGF) at the Blood-Brain Barrier (BBB) in a Rat Model of Diabetes"
2:20 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill out GRS Evaluation Forms
3:00 pmGordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm.
The project described was supported by Grant Number R13NS079109 from the National Institute Of Neurological Disorders And Stroke. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute Of Neurological Disorders And Stroke or the National Institutes of Health.
 
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