The Gordon Research Seminar on Ion Channels is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.
The focus of this meeting is on the structure, function and biophysics of ion channels, transporters, and receptors that mediate cellular ion transport, encompassing areas of research from atomic structure and molecular interactions (e.g. protein-protein, or protein-lipid interactions) to cellular functions and whole animal studies. The Ion Channels GRS will give undergraduates, graduate students and post-docs working in the ion channel field the opportunity to present and discuss their data and career experiences with their peers from top laboratories from around the globe and an opportunity to discuss future career options with mentors from academia, industry, government and the media.
Seed funding for this new Gordon Research Seminar has been provided by Merck Research Laboratories.
|1:00 pm - 5:00 pm||Arrival and Check-in|
|3:30 pm - 3:40 pm||Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair|
|3:40 pm - 4:30 pm||Intracellular roles of ion channels and transporters|
|Discussion Leader: Merritt Maduke (Stanford University School of Medicine)|
|3:40 pm - 4:00 pm ||Lilia Leisle (MDC/FMP Berlin)|
"ClC-7 is a slowly voltage-gated 2Cl-/1H+-exchanger"
|4:00 pm - 4:05 pm ||Discussion|
|4:05 pm - 4:25 pm ||Stefanie Weinert (MDC Berlin)|
"Biological advantage of Cl- transport coupled to H+ gradient over a simple chloride channel for endosomal/lysosomal physiology"
|4:25 pm - 4:30 pm ||Discussion|
|4:30 pm - 6:00 pm||Poster Session I|
|7:30 pm - 9:30 pm||Lipid modulation of ion channel function|
|Discussion Leader: Andrea Bruggemann (Nanion Technologies GMBH)|
|7:30 pm - 7:50 pm ||Shizhen Wang (Washington University School of Medicine)|
"Inter-subunit interactions determine PIP2 sensitivity of KirBac1.1"
|7:50 pm - 8:00 pm ||Discussion|
|8:00 pm - 8:20 pm ||Mark Zaydman (Washington University School of Medicine)|
"PIP2 potentiates voltage-dependent gating by coupling voltage-sensor activation and pore opening in Kv7.1"
|8:20 pm - 8:30 pm ||Discussion|
|8:30 pm - 8:50 pm ||Helgi Ingolfsson (University of Groningen)|
"Changes in membrane protein function through drug/amphiphile effects on membrane properties"
|8:50 pm - 9:00 pm ||Discussion|
|9:00 pm - 9:20 pm ||Amy Eastwood (Stanford University)|
"Models of Mechanotransduction Channel Activation"
|9:20 pm - 9:30 pm ||Discussion|
|7:30 am - 8:30 am||Breakfast|
|9:00 am - 11:00 am||Ion channel regulatory proteins|
|Discussion Leader: Shai Silberberg (National Institute of Health - NINDS)|
|9:00 am - 9:20 am ||Ademuyiwa Aromolaran (Columbia University)|
"Illuminating Trafficking of KCNQ1/KCNE1 Channels In Heart"
|9:20 am - 9:30 am ||Discussion|
|9:30 am - 9:50 am ||Elke Bocksteins (University of Antwerp)|
"The silent K+ channel subunit Kv6.4 induces hyperpolarized gating charge movement in Kv2.1/Kv6.4 heterotetrameric channels"
|9:50 am - 10:00 am ||Discussion|
|10:00 am - 10:20 am ||Jenny Li (University of British Columbia)|
"Essential Aspartate Anchor for ATP-sensitive potassium channels Gating"
|10:20 am - 10:30 am ||Discussion|
|10:30 am - 10:50 am ||Amanda Lewis (Northwestern University)|
"Interaction between fast inactivation, DIVS4 movement, and open-channel block in expressed sodium channels"
|10:50 am - 11:00 am ||Discussion|
|11:00 am - 12:30 pm||Poster Session II|
|Coffee will be served in the poster area from 11:00 am - 11:30 am|
|1:30 pm - 2:30 pm||High resolution approaches for ion channel structure|
|Discussion Leader: Lesley Anson (Nature Communications)|
|1:30 pm - 1:50 pm ||Qufei Li (University of Chicago)|
"Structural Basis of Lipid-driven Conformational Transitions In The KvAP Voltage Sensing Domain"
|1:50 pm - 2:00 pm ||Discussion|
|2:00 pm - 2:20 pm ||Jun Liao (UT Southwestern Medical Center)|
"Structural Insight into the Ion-Exchange Mechanism of the Sodium/Calcium Exchanger"
|2:20 pm - 2:30 pm ||Discussion|
|2:30 pm - 3:00 pm||Evaluation Period|
|Fill out GRS Evaluation Forms|
|3:00 pm||Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm.|