The Isotopes in Biological and Chemical Sciences Gordon Research Seminar is a forum for young scientists to present and exchange novel research ideas, form collaborations, and build social networks with scientists of comparable levels of experience. Conferees will be given the unique opportunity to lead discussions, give oral presentations, and participate in poster sessions.
The meeting will focus on experimental and computational research using isotopic probes in the fields of biological, organic, and inorganic chemistry. A session of the conference will involve novel experimental techniques in the application of isotopic analysis.
|2:00 pm - 5:00 pm||Arrival and Check-in|
|3:30 pm - 3:45 pm||Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair|
|3:45 pm - 4:30 pm||Keynote Speaker|
|3:45 pm - 4:15 pm||Vern Schramm (Albert Einstein College of Medicine)
"Isotope effects in binding, catalysis and dynamics"
|4:15 pm - 4:30 pm||Discussion|
|4:30 pm - 6:00 pm||Poster Session I|
|7:30 pm - 9:30 pm||Isotope Effects on Chemical Reactions|
|Discussion Leader: Samae Quijano (Texas A&M University)|
|7:30 pm - 7:50 pm||Anna Pabis (Technical University of Lodz)
"Theoretical Determination Of The Kinetic Isotope Effects For The Oxidative Degradation Of Nitrobenzene Catalyzed By Nitrobenzene Dioxygenase"
|7:50 pm - 8:00 pm||Discussion|
|8:00 pm - 8:20 pm||Ivonne Andujar-de Sanctis (Texas A&M University)
"Structural effects on Newtonian Kinetic Isotope Effects"
|8:20 pm - 8:30 pm||Discussion|
|8:30 pm - 8:50 pm||Kin-Yiu Wong (Rutgers, The State University of New Jersey)
"Characterization of the Reaction Path and Transition States for RNA Transphosphorylation Models from Kinetic Isotope Effects"
|8:50 pm - 9:00 pm||Discussion|
|9:00 pm - 9:20 pm||Pawel Adamczyk (Technical University of Lodz)
"Theoretical Evaluation of Isotopic Fractionation Factors in Oxidation Reactions of Aromatic Pollutants"
|9:20 pm - 9:30 pm||Discussion|
|7:30 am - 8:30 am||Breakfast|
|9:00 am - 11:00 am||Isotope Effects on Enzymatic Reactions|
|Discussion Leader: Tatiana Mishanina (University of Iowa)|
|9:00 am - 9:20 am||John Robbins (Auburn University)
"Solvent and Primary Kinetic Isotope Effects on the Desulfonation Mechanism of the Two-Component Alkanesulfonate Monooxygenase System"
|9:20 am - 9:30 am||Discussion|
|9:30 am - 9:50 am||Daniel Roston (University of Iowa)
"Conformational Distributions at the 'Tunneling Ready State' of H-Transfers"
|9:50 am - 10:00 am||Discussion|
|10:00 am - 10:20 am||Swathi Gannavaram (Georgia State University)
"Kinetic Determination of Redox Potential for Flavin Reduction in D-Arginine Dehydrogenase"
|10:20 am - 10:30 am||Discussion|
|10:30 am - 10:50 am||Muhammad Saeed (University of Iowa)
"Targeting thymidylate synthase activity and folate receptors expression to assess therapeutic response and cancer imaging by positron emission tomography (PET) technique"
|10:50 am - 11:00 am||Discussion|
|11:00 am - 12:30 pm||Poster Session II|
|Coffee will be served in the poster area from 11:00 am - 11:30 am|
|1:30 pm - 2:30 pm||Probing Enzyme Dynamics Using Isotope Effects|
|Discussion Leader: Emannuel Burgos (Albert Einstein College of Medicine)|
|1:30 pm - 1:50 pm||Randy Kipp (Albert Einstein College of Medicine)
"Mass-dependent bond vibrational dynamics influence catalysis by HIV-1 protease"
|1:50 pm - 2:00 pm||Discussion|
|2:00 pm - 2:20 pm||Rafael Da Silva (Albert Einstein College of Medicine)
"Femtosecond dynamics coupled to chemical barrier crossing in a Born-Oppenheimer enzyme"
|2:20 pm - 2:30 pm||Discussion|
|2:30 pm - 3:00 pm||Evaluation Period|
|Fill out GRS Evaluation Forms|
|3:00 pm||Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm.|