The Gordon Research Seminar on Microbial Toxins & Pathogenicity is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas. A primary goal of the GRS is to allow trainees to hone critical career skills and build lifelong collegial associations in a comfortable scientific setting. Coinciding with the Microbial Toxins & Pathogenicity Gordon Research Conference, the GRS will prepare attendees for the format of the larger GRC and ideally promote a higher level of participation throughout the subsequent conference.
The focus of this meeting is Frontiers of Microbial Pathogenesis. Speaker sessions will highlight pioneering approaches to the study of host-microbe interactions and mechanisms of virulence. The conference will explore areas including but not limited to toxin structure and function, virulence gene regulation, subversion of cellular processes by pathogens, and activation and avoidance of innate immune mechanisms. The two-day program will include seminars by 10-12 invited speakers, poster sessions by the participants, and opportunities for social interaction. Discussion leaders for the seminar sessions will also be chosen from the abstracts. Attendees who will not be giving an oral presentation are expected to present a poster on their work. Those attendees invited to present a seminar or serve as a discussion leader should also plan to present a poster at the GRS.
|1:00 pm - 5:00 pm||Arrival and Check-in|
|3:30 pm - 3:45 pm||Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair: Zachary Dalebroux (University of Washington)|
|3:45 pm - 4:30 pm||Host-Pathogen Interactions|
|Discussion Leader: Aimee Richard (University of Pennsylvania)|
|3:45 pm - 4:15 pm ||Andrew Olive (Harvard Medical School)|
"Chlamydia trachomatis-mediated alterations in host protein stability are required for bacterial growth"
|4:15 pm - 4:30 pm ||Discussion|
|4:30 pm - 6:00 pm||Poster Session I: Toxin Action and the Host Response to Infection|
|7:30 pm - 9:30 pm||Mechanisms of Toxin Action|
|Discussion Leader: Francis Alonzo (NYU School of Medicine)|
|7:30 pm - 7:50 pm ||David Anderson (Medical College of Wisconsin)|
"ExoU and Ubiquitin: A Model System for Bacterial-Host Protein Interaction and Effector Folding"
|7:50 pm - 8:00 pm ||Discussion|
|8:00 pm - 8:20 pm ||Ladislav Bumba (Institute of Microbiology - Czech Republic)
"Structural basis for RTX protein folding upon secretion through the Type I secretion system"
|8:20 pm - 8:30 pm ||Discussion|
|8:30 pm - 8:50 pm ||Andrew McCluskey (Harvard Medical School)|
"Changing the receptor specificity of anthrax toxin"
|8:50 pm - 9:00 pm ||Discussion|
|9:00 pm - 9:20 pm ||Doris LaRock (University of Washington)|
"A Salmonella Typhimurium translocated glycerophospholipid: cholesterol acyltransferase promotes virulence by binding to the RhoA switch regions"
|9:20 pm - 9:30 pm ||Discussion|
|7:30 am - 8:30 am||Breakfast|
|9:00 am - 11:00 am||Immunity and the Host Response to Infection|
|Discussion Leader: Chris LaRock (University of Washington)|
|9:00 am - 9:20 am ||Dara Burdette (University of California-Berkeley)|
"A Mechanism for the Innate Immune Sensing of Cyclic Dinucleotides"
|9:20 am - 9:30 am ||Discussion|
|9:30 am - 9:50 am ||Lisa Maudsdotter (Stockholm University-Sweden)|
"Lactobacilli inhibit adherence of pathogenic bacteria to host cells by interfering with host cell calcium signaling"
|9:50 am - 10:00 am ||Discussion|
|10:00 am - 10:20 am ||Kerri-Lynn Sheahan (Tufts University)|
"Host Cell Contribution to Type III Secretion in Yersinia pseudotuberculosis"
|10:20 am - 10:30 am ||Discussion|
|10:30 am - 10:50 am ||Sarah Clark (University of Pennsylvania)|
"Phosphorylcholine allows for evasion of bactericidal antibody by Haemophilus influenzae"
|10:50 am - 11:00 am ||Discussion|
|11:00 am - 12:30 pm||Poster Session II: Virulence Mechanisms of Bacterial Pathogens|
|Coffee will be served in the poster area from 11:00 am - 11:30 am|
|1:30 pm - 2:40 pm||Regulatory Mechanisms of Bacterial Pathogens|
|Discussion Leader: Edward Geisinger (Tufts University)|
|1:30 pm - 1:50 pm ||Jeffrey Mellin (CIRAD - France)
"A Cobalamin riboswitch regulates a long antisense RNA in Listeria monocytogenes"
|1:50 pm - 2:00 pm ||Discussion|
|2:00 pm - 2:20 pm ||Joseph Boll (University of Texas Southwestern)|
"Involvement of the Flagellar MS- and C-Rings in the Regulatory Cascade that Influences Flagellar Gene Expression in Campylobacter jejuni"
|2:20 pm - 2:30 pm ||Discussion|
|2:30 pm - 2:40 pm ||Concluding Remarks: Zachary Dalebroux (University of Washington) and Aimee Richard (University of Pennsylvania)|
|2:40 pm - 3:00 pm||Evaluation Period|
|Fill out GRS Evaluation Forms|
|3:00 pm||Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm.|
Funding for this conference was made possible [in part] by 1 R13 AI 100311-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.