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Phosphorylation & G-Protein Mediated Signaling Networks
Gordon-Merck Research Seminar
Novel Mechanisms and Therapeutic Approaches in GPCR and Kinase Signaling
June 9-10, 2012
University of New England
Biddeford, ME
Chair:
Angeline M. Lyon

Associate Chair:
Benita Sjogren
Related Meeting Information
The Phosphorylation & G-Protein Mediated Signaling Networks Gordon-Merck Research Seminar was held in conjunction with the Phosphorylation & G-Protein Mediated Signaling Networks Gordon Research Conference. Please refer to the Phosphorylation & G-Protein Mediated Signaling Networks GRC web page for more information.

The Gordon Research Seminar on Phosphorylation & G-Protein Mediated Signaling Networks is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is to foster discussions in novel mechanisms of GPCR signaling, advances in canonical protein kinase and G-protein signaling networks, and translational pharmacology. These topics will provide attendees with an overview of the most recent advances in signaling prior to the Phosphorylation & G-Protein Mediated Signaling Gordon Research Conference.

Contributors
SATURDAY
1:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Lecture
3:45 pm - 4:15 pmT. Kendall Harden (University of North Carolina at Chapel Hill, USA)
"Mechanisms of the Gq/Phospholipase C-β Signaling Complex"
4:15 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmNovel GPCR Signaling Mechanisms
Discussion Leaders: Carmen W. Dessauer (University of Texas-Houston Medical School, USA) and Elena Borroni (Instituto Clinico Humanitas, University of Milan, Italy)
7:30 pm - 7:50 pmJasmin Leschner (Ludwig-Maximilians-Universität, Germany)
"Role of β-arrestin 1 and 2 in bradykinin B2 receptor regulation and signaling"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmJillian Hurst (University of North Carolina at Chapel Hill, USA)
"Dynamic ubiquitination of the MAP2K Ste7 determines the strength and specificity of signaling in the yeast pheromone pathway"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmStephanie Dusaban (University of California, San Diego, USA)
"The role of phospholipase c-epsilon in COX-2 expression and inflammation"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmDivya Prasanna Kumar (Virginia Commonwealth University, USA)
"Activation of transmembrane bile acid receptor TGR5 stimulates both insulin gene transcription and insulin release in pancreatic β Cells"
9:20 pm - 9:30 pmDiscussion
SUNDAY
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amAdvances in Canonical Kinase and G Protein Signaling
Discussion Leaders: Jin Zhang (The Johns Hopkins University, USA) and Kristoff Homan (University of Michigan, USA)
9:00 am - 9:20 amJesse Zalatan (University of California, San Francisco, USA)
"Conformational control of the Ste5 scaffold protein insulates against MAP kinase misactivation"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amRebecca Plimpton (Brigham Young University, USA)
"Structures of the Gβ-CCT and PhLP1-Gβ-CCT complexes reveal a molecular mechanism for G protein β subunit folding and βγ dimer assembly"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amYong Li (University of Texas-Houston Medical School, USA)
"The A-kinase anchoring protein Yotiao facilitates complex formation between type 9 adenylyl and the IKs potassium channel in heart"
10:20 am - 10:30 amDiscussion
10:30 am - 10:50 amEkaterina Posokhova (The Scripps Research Institute, USA)
"RGS6 regulates heart rate variability in isolated hearts"
10:50 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session II
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmTranslational Pharmacology
Discussion Leaders: Alan V. Smrcka (University of Rochester, NY, USA) and Jiaxiao Shen (University of Cambridge, United Kingdom)
1:30 pm - 1:50 pmMichael Lee (Massachusetts Institute of Technology, USA)
"Sequential exposure to anti-cancer drugs enhances cell death by dynamic re-wiring of apoptotic signaling networks"
1:50 pm - 2:00 pmDiscussion
2:00 pm - 2:20 pmSusann Björk (University of Turku, Finland)
"α2-adrenoceptor elicited vascular smooth muscle cell contraction - discerning the intracellular pathways involved"
2:20 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill out GRS Evaluation Forms
3:00 pmGordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm.
 
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