The Gordon Research Seminar on Proprotein Processing, Trafficking & Secretion is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.
The 2012 meeting will be the first Gordon Research Seminar on this subject, which will focus on recent research in the cellular and molecular events in the secretory pathway, including post-translational processing, trafficking and secretion of bioactive peptides and other secretory pathway proteins, as well as the significance of these processes to cellular physiology and human disease. This meeting includes interest in protein folding events in the endoplasmic reticulum; post-translational processing steps, including structural, biochemical, proteomic and cellular analyses of proteolysis and peptide-terminal modifications; intra-Golgi and post-Golgi sorting events, including targeting to secretory granules; mechanisms of secretory granule formation and trafficking; and molecular mechanisms of regulated and constitutive secretion. An additional important dimension is on pathologies and diseases whose underlying basis relates to protein processing and/or trafficking (e.g., cancer, diabetes, Alzheimer's, hypercholesterolemia, bacterial toxin activation, viral glycoprotein maturation, and others).
The collegial and inter-disciplinary atmosphere of this Seminar, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an excellent opportunity for young scientists from different disciplines to develop collaborations. The mentorship component of the seminar will present a forum where young scientists can discuss and learn about future job opportunities.
Seed funding for this new Gordon Research Seminar has been provided by the Kenan Institute for Engineering, Technology and Science at North Carolina State University.
|1:00 pm - 5:00 pm||Arrival and Check-in|
|3:30 pm - 3:45 pm||Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair Jonathan Wardman|
|3:45 pm - 4:30 pm||Keynote Lecture|
|3:45 pm - 4:15 pm||Robert Fuller (University of Michigan)|
|4:15 pm - 4:30 pm||Discussion|
|4:30 pm - 6:00 pm||Poster Session I|
|7:30 pm - 9:30 pm||Proprotein Trafficking and Secretion|
|Discussion Leader: Iris Lindberg (University of Maryland School of Medicine) and Michael Helwig (University of Maryland School of Medicine)|
|7:30 pm - 7:50 pm||Elias Blanco (Pontificia Universidad Católic)
"An alpha-helix of CART peptide precursor serves as the sorting signal for the regulated secretory pathway"
|7:50 pm - 8:00 pm||Discussion|
|8:00 pm - 8:20 pm||Xiaoyan Zhang (University Of Michigan)
"Molecular organization and function of the Golgi stacks"
|8:20 pm - 8:30 pm||Discussion|
|8:30 pm - 8:50 pm||Leila Belle (Centre For Cancer Biology)
"Protein Tyrosine Phosphatase Pez - a novel regulator of Protein Trafficking and Secretion"
|8:50 pm - 9:00 pm||Discussion|
|9:00 pm - 9:20 pm||Mathilde Bonnemaison (University Of Connecticut)
"AP-1A is required for PAM-1 inclusion in immature secretory granules in AtT-20 cells"
|9:20 pm - 9:30 pm||Discussion|
|7:30 am - 8:30 am||Breakfast|
|9:00 am - 11:00 am||Proteases and Peptides: Roles in Disease|
|Discussion Leader: John Creemers (KU Leuven) and Jeroen Declercq (KU Leuven)|
|9:00 am - 9:20 am||Frederic Couture (Université De Sherbrooke)
"Role of proprotein convertases (PCs) in prostate cancer"
|9:20 am - 9:30 am||Discussion|
|9:30 am - 9:50 am||Diana Athonvanrangkul (Albert Einstein College Of Medicine)
"Autophagy proteins in POMC neurons are required for a-MSH production and energy balance"
|9:50 am - 10:00 am||Discussion|
|10:00 am - 10:20 am||Woojin Kim (Clinical Research Institute Of Montreal)
"Loss of endothelial furin leads to cardiac malformation and early postnatal death"
|10:20 am - 10:30 am||Discussion|
|10:30 am - 10:50 am||Mark Henderson (National Institute on Drug Abuse)
"KDEL-like sequence ('RTDL') regulates the secretion and surface binding of the neurotrophic factor MANF"
|10:50 am - 11:00 am||Discussion|
|11:00 am - 12:30 pm||Poster Session II|
|Coffee will be served in the poster area from 11:00 am - 11:30 am|
|1:30 pm - 2:30 pm||Mentorship Panel: Career Opportunities for Ph.D.s|
|Discussion Leader: Lloyd Fricker (Albert Einstein College Of Medicine)|
|Panelists: Peter Lyons (Manhattan College), Lakshmi Devi (Mt. Sinai School of Medicine), and Erin Wiswall (Mascoma)
|2:30 pm - 3:00 pm||Evaluation Period|
|Fill out GRS Evaluation Forms|
|3:00 pm||Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm.|