Gordon Research Conferences
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Conference Program
 
Hemostasis
July 22-27, 2012
Waterville Valley Resort
Waterville Valley, NH

Related Meeting Information
The Hemostasis Gordon Research Conference was held in conjunction with the Hemostasis Gordon Research Seminar. Please refer to the Hemostasis GRS web page for more information.

Dysregulated hemostasis is a major cause of human disease and death. The Gordon Research Conference on Hemostasis is considered the premiere small format meeting on the topics of blood coagulation, platelet biology, anticoagulant pathways and associated diseases. First organized by hemostasis pioneers Earl W. Davie and Oscar Ratnoff in 1973, the meeting was held yearly until 1992 and biennially since then. The Hemostasis Gordon Conference brings together scientists interested in the biology, biochemistry and genetics of platelets and coagulation proteins, physicians involved in the treatment of bleeding and thrombotic diseases and investigators from small and large pharmaceutical companies developing new therapies for the diseases of hemostasis. The Hemostasis Gordon Conference enjoys an international reputation for being the forum at which cutting-edge research is presented and major advances in the field are unveiled.

The next conference will be held on July 22-27, 2012 at the Waterville Valley Conference Center, Waterville Valley, New Hampshire. The site is regarded as a top venue providing comfortable meeting and housing facilities in an inviting location. This Conference Center, surrounded by the White Mountain National Forest provides over 15,000 square feet of flexible, highly functional space. Recreational facilities include ready access to biking, hiking, golf, tennis, boating, chair-lift rides, an athletic center and the Waterville Valley Arts Center. All accommodations, dining hall, poster areas and meeting rooms are accessible to handicapped persons. Waterville Valley is two hours north of Boston and a bit more than an hour from Manchester, New Hampshire. Travel to the site is convenient for attendees from the US and overseas alike.

It is the goal of the conference organizers that nearly every person attending the conference participates either as a speaker, discussion leader, or poster presenter. At Waterville Valley, the venue for the 2012 Conference, there is space available for 30-40 posters per session, and four poster sessions will be scheduled. The conference Vice-Chair, Andrew Weyrich, will be responsible for organizing the posters into sessions that are related to the meeting agenda and for the selection of top posters for presentation as a series of short talks in a Hot Topics session.

Afternoons will be open for informal discussion among attendees and leisure activities aimed at fostering further interactions and intellectual exchange - traditionally a central feature of all Gordon Conferences. Poster sessions will be held before dinner on four of the five days. These sessions provide a dedicated, informal forum for interaction between junior and more senior scientists in the field.

All applicants who are not invited speakers are encouraged to submit an abstract for presentation at one of the four poster sessions (Monday-Thursday) and for consideration to be chosen for a short oral presentation at the Hot Topics session on Wednesday evening.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmIntroductory Comments by GRC Site Staff
7:40 pm - 7:55 pmWelcome and Overview (Organizers)
8:00 pm - 9:30 pmThrombosis and Hemostasis: Historical Perspectives
8:00 pm - 8:05 pmDiscussion Leader: Charles Esmon (OMRF)
8:05 pm - 8:35 pmJoel Bennett (University of Pennsylvania)
"Adventures and misadventures in chasing the mechanism of platelet aggregation"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 9:15 pmDarrel Stafford (University of North Carolina-Chapel Hill)
"The vitamin K cycle: Retrospective and Prospective"
9:15 pm - 9:25 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmInflammation/Infection and Coagulation
9:00 am - 9:05 amDiscussion Leader: Susan Smyth (University of Kentucky)
9:05 am - 9:30 amPiet Gros (Utrecht University)
"Structural Biology of the Complement System"
9:30 am - 9:45 amDiscussion
9:45 am - 10:10 amPaul Kubes (University of Calgary)
"Imaging the host-pathogen interaction in the vasculature"
10:10 am - 10:25 amDiscussion
10:25 am - 11:05 amGroup Photo / Coffee Break
11:05 am - 11:30 amJo Ann Trejo (University of California-San Diego)
"Cytoprotective signaling by activated protein C"
11:30 am - 11:45 amDiscussion
11:45 am - 12:10 pmJerry Ware (University of Arkansas for Medical Sciences)
"The platelet-inflammatory axis in rheumatoid arthritis"
12:10 pm - 12:25 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session A
6:00 pmDinner
7:30 pm - 9:30 pmThrombus Formation and its Dissolution
7:30 pm - 7:35 pmDiscussion Leader: José Lopez (Puget Sound Blood Center)
7:35 pm - 8:00 pmJames Whisstock (Monash University)
"The X-ray crystal structure of full length human plasminogen"
8:00 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmJohn Weisel (University of Pennsylvania)
"Thrombus Composition and Properties"
8:40 pm - 8:55 pmDiscussion
8:55 pm - 9:05 pmShort Talk: Paul Bock (Vanderbilt University)
"Staphylocoagulase shows promiscuity in conformational activation of prothrombin"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmPatricia Liaw (McMaster University)
"Cell-free DNA in coagulation, sepsis, and cancer"
9:25 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmReceptors and Signaling
9:00 am - 9:05 amDiscussion Leader: Skip Brass (University of Pennsylvania)
9:05 am - 9:30 amRenhao Li (Emory University)
"Organization and structure of GPIb-IX complex"
9:30 am - 9:45 amDiscussion
9:45 am - 10:10 amMark Ginsberg (University of California-San Diego)
"Two Modes of Integrin Activation Form A Binary Switch in Adhesion Maturation"
10:10 am - 10:25 amDiscussion
10:25 am - 10:50 amCoffee Break
10:50 am - 11:15 amCharles Abrams (University of Pennsylvania)
"Phosphoinositides and platelet biology"
11:15 am - 11:30 amDiscussion
11:30 am - 11:55 amSergio Grinstein (Hospital for Sick Children, Toronto)
"Tracking immunoreceptors at the single-molecule level: how does receptor mobility affect activation?"
11:55 am - 12:10 pmDiscussion
12:10 pm - 12:25 pmShort Talk: Valder Arruda (Children's Hospital of Philadelphia)
"Zymogen Protein C and Tumor Progression"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session B
6:00 pmDinner
7:30 pm - 9:30 pmBlood/Vessel Wall Interface
7:30 pm - 7:35 pmDiscussion Leader: Leslie Parise (UNC-Chapel Hill)
7:35 pm - 8:00 pmJaime Grutzendler (Yale University)
"Imaging microvascular occlusion and recanalization"
8:00 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmRobert Flaumenhaft (Harvard)
"Targeting vascular PDI with small molecules"
8:40 pm - 8:55 pmDiscussion
8:55 pm - 9:05 pmShort Talk: Rafal Pawlinski (University of North Carolina-Chapel Hill)
"Role of Tissue Factor in the Pathology of Sickle Cell Disease"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmRodger McEver (OMRF)
"Regulation of Cell Adhesion to the Vessel Wall"
9:25 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDefective Hemostasis
9:00 am - 9:05 amDiscussion Leader: James Morrissey (University of Illinois, Champaign-Urbana)
9:05 am - 9:30 amRodney Camire (University of Pennsylvania)
"Zymogen-Like Proteases for the Treatment of Coagulation Defects"
9:30 am - 9:45 amDiscussion
9:45 am - 10:10 amAlfica Sehgal (Alnylam Pharmaceuticals)
"RNAi mediated intervention of coagulation pathway for treatment of hemophilia"
10:10 am - 10:25 amDiscussion
10:25 am - 10:50 amCoffee Break
10:50 am - 11:15 amWalter Kahr (Hospital for Sick Children, Toronto)
"Molecular Basis of Platelet Granule Defects"
11:15 am - 11:30 amDiscussion
11:30 am - 11:55 amBruce Sullenger (Duke University Medical Center)
"Inhibition of thrombosis with aptamers and nucleic acid binding polymers"
11:55 am - 12:10 pmDiscussion
12:10 pm - 12:25 pmShort Talk: Shekhar Kumar (Children's Hospital of Philadelphia)
"Structures of Snake Venom Factor V: Evolution of a Hemostatic Cofactor to a Potent Toxin"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session C
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmHot Topics
Discussion Leader: Andrew Weyrich (University of Utah)
7:30 pm - 7:40 pmYing Zheng (University of Washington)
"In vitro microvessels for the study of angiogenesis and thrombosis"
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmMatthew Bunce (Children's Hospital of Philadelphia)
"Autoinhibitory B-domain fragments reveal the mechanism by which factor V function is suppressed"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmRenata Grozovsky (Brigham and Women's Hospital/Harvard Medical School)
"Clearance of desialylated platelets by the hepatic asialoglycoprotein receptor regulates TPO homeostasis in vivo"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmKaren De Ceunynck (Catholic University of Leuven)
"Single molecule visualization of ADAMTS13 enzymes on EC-anchored VWF strings"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmYiming Wang (University of Toronto)
"Plasma fibronectin is a supportive factor for hemostasis and a regulator of thrombosis: Evidence for fibrin-dependent and independent pathways"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmSang Min (University of Pennsylvania)
"The regulation of intracellular trafficking of platelet granules by PIKFyve, a phopholipid kinase that synthesizes PtdIns(3,5)P2"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmJonathan Thon (Brigham and Women's Hospital/Harvard Medical School)
"T-granules function as a mediator of innate immunity in platelets"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmYacine Boulaftali (University of North Carolina at Chapel Hill)
"A novel method for the adoptive transfer of platelets into thrombocytopenic mice for studying the specific role of platelets in the maintenance of vascular integrity during inflammation"
9:25 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRegulation of Thrombus Formation
9:00 am - 9:05 amDiscussion Leader: Barbara Furie (Harvard)
9:05 am - 9:30 amJim Huntington (Cambridge University)
"Structure of prothrombinase from Pseudonaja textilis venom"
9:30 am - 9:45 amDiscussion
9:45 am - 10:10 amWolfgang Bergmeier (University of North Carolina-Chapel Hill)
"Platelet activation in thrombosis and hemostasis: a RAP-sody in cell biology"
10:10 am - 10:25 amDiscussion
10:25 am - 10:50 amCoffee Break
10:50 am - 11:15 amEvan Sadler (Washington University in Saint Louis)
"How ADAMTS13 recognizes von Willebrand factor"
11:15 am - 11:30 amDiscussion
11:30 am - 11:55 amJorge DiPaola (University of Colorado)
"Genomic approaches to dissect platelet and coagulation disorders"
11:55 am - 12:10 pmDiscussion
12:10 pm - 12:25 pmShort Talk: Timothy Stalker (University of Pennsylvania)
"Hierarchical organization in the hemostatic response and its relationship to the platelet signaling network"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMembranes/Microparticles/Atherothrombosis
7:30 pm - 7:35 pmDiscussion Leader: Nigel Mackman (University of North Carolina-Chapel Hill)
7:35 pm - 8:00 pmRoy Silverstein (Medical College of Wisconsin)
"Platelets and Lipoproteins"
8:00 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmWolfram Ruf (Scripps)
"Tissue factor, microparticles and the P2X7 receptor"
8:40 pm - 8:55 pmDiscussion
8:55 pm - 9:05 pmShort Talk: Jonathan Gibbins (University of Reading)
"Minding the gaps ... and channels in platelet function"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmAndrew Kim (University of California-San Francisco)
"TMEM16F Regulates Phosphatidylserine Exposure"
9:25 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13HL115804-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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