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Conference Program
 
Intrinsically Disordered Proteins
July 8-13, 2012
Mount Snow Resort
West Dover, VT

The 2012 Gordon Conference on Intrinsically Disordered Proteins (IDPs) is shaping up to be an exciting and important meeting. The growing recognition of the role of IDPs in complex biological functions makes this an opportune time to bring together scientists in the field to identify the important questions, take stock of current progress, and chart the course for rapid and meaningful progress in the study of conformational heterogeneity and its role in function.

The program features an outstanding and diverse group of scientists at the forefront of research in the IDP field. The meeting will be organized around seven thematic sessions focusing on Transcriptional regulation, Signaling pathways & modules, IDP phase behavior and Molecular recognition, Emerging Technologies for Studying IDPs, IDP quality control and homeostasis, Regulated self-assembly and mis-assembly of IDPs, and IDP targeting, trafficking and processing. The meeting will be bookended by two keynote sessions.

Poster sessions will be organized to encourage active participation from young scientists. The organizers have selected two postdoctoral scientists to give short talks. There will be a poster competition judged by a committee of experts. Two awards will be given to graduate students whose posters are deemed to be the best by the committee. The new location for this conference is scenic, convenient, and promises to be an excellent setting for numerous informal discussions during the conference.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmOpening Keynote Session
Discussion Leader: Madan Babu (MRC-LMB, University of Cambridge)
7:50 pm - 8:20 pm Julie Forman-Kay (University of Toronto, Hospital for Sick Kids)
"Dynamic Complexes of IDPs in the Regulation of Cell Cycle, Translation and Ion Flux"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:42 pm Kim Reynolds (University of Texas Southwestern Medical Center)
"Allosteric control through a heterogeneous spatial architecture within proteins"
8:42 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Jeffrey Kelly (The Scripps Research Institute)
"Enhancing Protein Homeostasis to Ameliorate Degenerative Diseases"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEmerging Technologies for Studying Conformational Heterogeneity
Discussion Leader: Régis Pomès (University of Toronto, Hospital for Sick Kids)
9:05 am - 9:30 am Ashok Deniz (The Scripps Research Institute)
"Structural Biophysics of IDPs at Single Molecule Resolution"
9:30 am - 9:40 am Discussion
9:40 am - 10:05 am Martin Blackledge (Institut de Biologie Structurale, Grenoble)
"Towards a Unified Conformational Understanding of the Dynamics of Intrinsic Disorder from NMR"
10:05 am - 10:15 am Discussion
10:15 am - 10:40 am Group Photo / Coffee Break
10:40 am - 11:05 am Claus Seidel (Heinrich-Heine University, Dusseldorf)
"High-precision FRET to Determine Dynamic Protein Structures and Dissect the Corresponding Inter-Conversion Pathways"
11:05 am - 11:15 am Discussion
11:15 am - 11:40 am Gerhard Hummer (NIDDK, National Institutes of Health)
"Assembling Supramolecular Complexes with Intrinsic Disorder by Simulation and Experiment"
11:40 am - 11:50 am Discussion
11:50 am - 12:15 pm Benjamin Schuler (University of Zurich)
"Dimensions and Dynamics of IDPs from Single Molecule Spectroscopy"
12:15 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPhase Behavior, Molecular Recognition, and Evolution of IDPs
Discussion Leader: Patricia Clark (University of Notre Dame)
7:40 pm - 8:05 pm Kyou-Hoon Han (Korea Research Institute of Bioscience & Biotechnology)
"Understanding the Level of Unstructuredness in IDPs"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:40 pm Sonia Longhi (CNRS & Universities Aix-Marseille I & II)
"Molecular Insights Into the NTAIL-PXD Interaction from Biophysical and In Vitro Evolution Approaches"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm Eugene Shakhnovich (Harvard University)
"Interplay of Protein Biophysics and Cell Homeostasis Determines States of Proteins in Cytoplasm"
9:15 pm - 9:25 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTranscriptional Activation & Regulation
Discussion Leader: Monika Fuxreiter (University of Debrecen, Hungary)
9:10 am - 9:35 am Remy Loris (Vrije Universiteit Brussel)
"Intrinsic Disorder in Bacterial Regulation Mechanisms: Toxin-Antitoxin Modules as a Paradigm"
9:35 am - 9:45 am Discussion
9:45 am - 10:10 am Timothy Lohman (Washington University in St. Louis)
"E. coli SSB - Four Tails of Regulation"
10:10 am - 10:20 am Discussion
10:20 am - 10:45 am Coffee Break
10:45 am - 11:10 am Yaakov Levy (The Weizmann Research Institute)
"Modulating Protein-DNA Interactions by Post-Translational Modifications at Disordered Regions"
11:10 am - 11:20 am Discussion
11:20 am - 11:45 am Jianhan Chen (Kansas State University)
"Mechanisms for Efficient Folding Upon Binding: Residual Structures, Conformational Flexibility and Electrostatics"
11:45 am - 11:55 am Discussion
11:55 am - 12:20 pm Trevor Creamer (University of Kentucky)
"Disordered Activation of Calcineurin"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmIDP Proteolysis & Modifications
Discussion Leader: James Bardwell (University of Michigan)
7:40 pm - 8:05 pm Ursula Jakob (University of Michigan)
"Order out of Disorder - Mechanism of an Intrinsically Disordered Chaperone"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:40 pm Yosef Shaul (The Weizmann Research Institute)
"Mechanisms of Proteasomal Degradation of IDPs"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm Hilal Lashuel (EPFL, Swiss Federal Institute of Technology)
"Elucidating the Role of Post-Translational Modifications in Regulating the Structure, Aggregation and Toxicity of α-synuclein"
9:15 pm - 9:25 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFunctionally Relevant & Disease-Related Self-Assembly
Discussion Leader: Rohit Pappu (Washington University)
9:05 am - 9:35 am Susan Lindquist (MIT, Whitehead Institute)
"The Link Between Environmental Stress and Protein Folding Drives Evolutionary Change"
9:35 am - 9:45 am Discussion
9:45 am - 10:10 am Joel Schneider (NCI, National Institutes of Health)
"Form Follows Function: Architecture of Self Assembled Materials"
10:10 am - 10:20 am Discussion
10:20 am - 10:45 am Coffee Break
10:45 am - 11:10 am David Eliezer (Cornell Weill Medical College)
"Disorder and Order in Neurotransmission, Axonal Development, Parkinson's and Alzheimer's Diseases"
11:10 am - 11:20 am Discussion
11:20 am - 11:45 am Thomas Scheibel (Universitat Bayreuth)
"Bringing Order to Disordered Proteins: The Role of Terminal Domains in Spider Silk Proteins"
11:45 am - 11:55 am Discussion
11:55 am - 12:20 pm Sheena Radford (University of Leeds)
"Molecular dissection of protein misfolding mechanisms"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmTagging, Processing, and Trafficking of IDPs and their Assemblies
Discussion Leader: Peter Tompa (Vrije Universiteit Brussel)
7:30 pm - 7:55 pm Edward Lemke (EMBL)
"From single molecules to supramolecular assemblies - Plasticity of Nup153, a major player in the nuclear pore complex"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:30 pm Yuh Min Chook (University of Texas Southwestern Medical Center)
"The PY-NLS-IDPs in Nucleocytoplasmic Transport"
8:30 pm - 8:40 pm Discussion
8:40 pm - 9:05 pm Andreas Matouschek (Northwestern University)
"The Role of Unstructured Regions in Proteasome Targeting"
9:05 pm - 9:15 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSignaling Pathways
Discussion Leader: Tanja Mittag (St. Jude Children's Research Hospital)
9:10 am - 9:35 am Richard Kriwacki (St. Jude Children's Research Hospital)
"Functional Advantages of Intrinsic Disorder"
9:35 am - 9:45 am Discussion
9:45 am - 10:10 am Michael Rosen (University of Texas Southwestern Medical Center)
"Phase Transitions in the Assembly of Multivalent Signaling Proteins"
10:10 am - 10:20 am Discussion
10:20 am - 10:45 am Coffee Break
10:45 am - 11:10 am Jane Dyson (The Scripps Research Institute)
"Role of Disorder in Signal Transduction by NFκB"
11:10 am - 11:20 am Discussion
11:20 am - 11:45 am Susan Taylor (University of California, San Diego)
"PKA: Dynamic Assembly of Macromolecular Scaffolds"
11:45 am - 11:55 am Discussion
11:55 am - 12:20 pm Rama Ranganathan (University of Texas Southwestern Medical Center)
"Evolutionary Principles of Protein Structure and Function"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmClosing Keynote Session
Discussion Leader: Gary Daughdrill (University of South Florida)
7:50 pm - 8:20 pm Alan Fersht (MRC-LMB, University of Cambridge)
"p53 - Tohuvabohu"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:42 pm Marija Buljan (MRC Laboratory of Molecular Biology, Cambridge)
"Tissue-specific splicing rewires protein interaction networks"
8:42 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Vladimir Uversky (University of South Florida)
"Vivat, Disorder!"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Research reported in this publication was supported by the National Institute Of Neurological Disorders And Stroke of the National Institutes of Health under Award Number R13NS080496. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

 
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