Gordon Research Conferences
PI_Conferences PI_Conferences_Past
Conference Program
 
Ion Channels
July 8-13, 2012
Mount Holyoke College
South Hadley, MA

Related Meeting Information
The Ion Channels Gordon Research Conference was held in conjunction with the Ion Channels Gordon-Merck Research Seminar. Please refer to the Ion Channels GMRS web page for more information.

The 16th Gordon Research Conference on Ion Channels will continue the strong tradition of providing a unique venue for the presentation of unpublished, cutting-edge biomedical research focused on the proteins responsible for ion transport. The 2012 scientific program will cover all aspects of ion channel biology, with topics including, but not limited to the structure, function, dynamics, mechanisms of regulation and modulation, protein biogenesis and trafficking and integrated aspects of ion channels in physiological function. Invited Speakers will be selected to ensure a diverse set of topics, channels and presenters. All participants are asked to bring a poster since approximately ten abstracts will be chosen for short talks. We strongly encourage graduate students and post doctoral associates to apply to both the 2012 Ion channels GRC and GRS. In addition, selected abstracts from these "early-career" investigators will be chosen for a "Data Blitz", in which the presenters will have two minutes and a slide to present their key findings that can be further discussed during the GRC poster sessions.

A main goal of the meeting is to stimulate detailed discussions among all attendees, giving rise to new ideas and directions for the field. Interactions are promoted by programming a generous amount of time for discussion sessions and by providing opportunities for informal gatherings at meals and in the afternoons and evenings. The 2012 meeting will be held at Mt. Holyoke College in idyllic Western Massachusetts. Mt. Holyoke College is within easy driving distance from Boston's Logan Airport, and a shuttle bus will provide transportation prior to and at the conclusion of the meeting. Travel awards are available for selected postdoctoral associates, graduate students, and minority participants.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:35 pmWelcome / Introductory Comments by GRC Site Staff
7:35 pm - 7:40 pmChair Welcome: Bill Kobertz
7:40 pm - 9:30 pmData Blitz & Cation Channels
Discussion Leader: Henry Colecraft (Columbia University Medical Center)
7:40 pm - 8:15 pmData Blitz
Rapid-fire Presentations by Post-docs & Graduate Students
8:20 pm - 8:45 pmPaul DeCaen (Harvard Medical School)
"The Structure of NaVRh and Ion Selectivity"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmDavid Yue (John Hopkins University School of Medicine)
"Calcium channel modulation involves calmodulin on the move"
9:20 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
8:45 amGroup Photo
9:00 am - 12:30 pmLigand-Dependent Gating
Discussion Leader: Francis Ashcroft (University of Oxford)
9:00 am - 9:25 amGabriela Popescu (University at Buffalo Medical School)
"NMDA Receptor Gating: Kinetics and Mechanism"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amMark Mayer (NIH, NICHD)
"Structure and assembly of heteromeric kainate receptors"
10:00 am - 10:10 amDiscussion
10:10 amCoffee Break
10:40 am - 11:05 amDavid MacLean (University of Texas, Houston Medical School)
"Conformational Dynamics in Ionotropic Glutamate Receptors"
11:05 am - 11:15 amDiscussion
11:15 am - 11:40 amMichael Francis (UMass Medical School)
"Genetic analysis of a simple neural circuit using ionotropic AChR gating mutants"
11:40 am - 11:50 amDiscussion
11:50 am - 12:05 pmHarley Kurata (University of British Columbia)
"Transduction and catalysis of ligand-dependent gating in KATP channels"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmAndrew Plested (Leibniz Institüt für Molekulare Pharmakologie, Berlin, Germany)
"Glutamate Receptors Rock!"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmProtons and Anions
Discussion Leader: Michael Pusch (Istituto di Biofisica, Genova, Italy)
7:30 pm - 8:00 pmEmily Liman (University of Southern California)
"Proton Channels in Taste Transduction"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmMerritt Maduke (Stanford University School of Medicine)
"CLC Channels and Antiporters"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmYuriy Kirichok (UCSF)
"How Brown Fat Makes Heat: Mechanism of Thermogenic Proton Leak across the Inner Mitochondrial Membrane"
9:20 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSodium Channels
9:00 am - 9:05 amDiscussion Leader: Dick Horn (Thomas Jefferson University)
9:05 am - 9:30 amTodd Scheuer (University of Washington)
"Structure and Function of Voltage-gated Sodium Channels at Atomic Resolution"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amCecilia Canessa (Yale University)
"ASIC1 Channels Some Aspects of Structure-Function, but not certain yet"
10:05 am - 10:15 amDiscussion
10:15 amCoffee Break
10:45 am - 11:10 amTed Cummins (Indiana University School of Medicine)
"Harnessing Gating Pore Currents to Explore the Pharmacology of Voltage-gated Sodium Channels"
11:10 am - 11:20 amDiscussion
11:20 am - 11:45 amBonnie Wallace (University of London, Birkbeck College)
"The Open Conformation of a Voltage-Gated Sodium Channel"
11:45 am - 11:55 amDiscussion
11:55 am - 12:20 pmLori Isom (University of Michigan Medical School)
"Role of sodium channel beta 1 subunits in inherited pediatric epilepsy"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGating (Other)
Discussion Leader: Chris Miller (Brandeis University, HHMI)
7:30 pm - 8:00 pmChris Ahern (University of British Columbia)
"Taking a Synthetic Approach to Channel Inactivation Mechanisms"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmEduardo Perozo (University of Chicago)
"Structural rearrangements in Voltage Sensing Domains"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmTom Middendorf (University of Texas at Austin)
"Calcium-activated Potassium Channels"
9:20 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPermeation, Dynamics and Inactivation
Discussion Leader: Clay Armstrong (University of Pennsylvania)
9:00 am - 9:25 amBenoît Roux (University of Chicago)
"Recovery from slow inactivation"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amCrina Nimigean (Weill Cornell Medical College)
"Inactivation Gate Location in MthK Potassium Channels"
10:00 am - 10:10 amDiscussion
10:10 amCoffee Break
10:35 am - 11:00 amWonpil Im (University of Kansas)
"Ion Channel Brownian Dynamics: Approximate, Yet Still Useful Approach"
11:00 am - 11:10 amDiscussion
11:10 am - 11:25 amTzyh-Chang Hwang (University of Missouri-Columbia)
"Non-integral stoichiometry in CFTR gating: Seeing is believing!"
11:25 am - 11:30 amDiscussion
11:30 am - 11:45 amVera Moiseenkova-Bell (Case Western Reserve University)
"Structural insights into the dynamics of the TRPA1 activation mechanism"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmRandy Stockbridge (Brandeis University)
"Fluoride transport in a strange subclass of CLC's"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmMorten Jensen (DE Shaw Research LLC)
"A mechanistic model of voltage-gating in potassium channels based on long-timescale simulations"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmDrug Targets
Discussion Leader: Andrea Brüggemann (Nanion Technologies)
7:30 pm - 8:00 pmSteve Brohawn (Rockefeller University)
"Structural and Functional Studies of the Lipid- and Mechano-sensitive K2P TRAAK"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmGail Robertson (University of Wisconsin School of Medicine)
"Composition and Gating in hERG and Related Channels"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmSteve Hess (Evotec)
"P2X3 and P2X2/3 Channel Drug Discovery"
9:20 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
9:00 am - 12:30 pmPotassium Channels
Discussion Leader: Cathy Morris (Ottawa Hospital Research Institute)
9:00 am - 9:25 amNicole Schmitt (University of Copenhagen)
"The Cardiac IKs Complex and Molecular Determinants of its Localization"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amPaul Slesinger (The Salk Institute for Biological Studies)
"Gating of GIRK Channels: The Trifecta of G proteins, Alcohol and PIP2"
10:00 am - 10:10 amDiscussion
10:10 amCoffee Break
10:40 am - 11:05 amBlanche Schwappach (University of Göttingen Medical School)
"Electrical Fine Tuning of Cardiac Myocytes by Differential Cell Surface Expression of Ion Channels"
11:05 am - 11:15 amDiscussion
11:15 am - 11:40 amStephen Tucker (University of Oxford)
"Mechanisms of Kir Channel Gating"
11:40 am - 11:50 amDiscussion
11:50 am - 12:05 pmAnna Moroni (University of Milan, Italy)
"How to make a voltage-gated ion channel"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmAnastasios Tzingounis (University of Connecticut)
"Mapping SK channels in Living Neurons using Single Molecule AFM"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMixed Calcium Signals
Discussion Leader: Daniel Minor (UCSF)
7:30 pm - 8:00 pmEitan Reuveny (Weizmann Institute of Science)
"SARAF Inactivates the Store Operated Calcium Entry Machinery to Prevent Excess Calcium Refilling"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmAnna Greka (Harvard Medical School)
"TRPCs and Calcium Signaling in Glomerular Podocytes: New Targets for Kidney Disease?"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmIlya Bezprozvanny (UT Southwestern Medical Center)
"Presenilins Function as ER Calcium Leak Channels - Implications for Alzheimer's Disease Pathogenesis"
9:20 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Research reported in this publication was supported by the National Institute of Neurological Disorders and Stroke of the National Institutes of Health under Award Number R13NS080275. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

 
© 2014 Gordon Research Conferences Search | Contact | Terms of Use | Privacy Policy | Follow us: Facebook Twitter