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Isotopes in Biological and Chemical Sciences
Gordon Research Conference

Centennial Celebration of the Discovery of Stable Isotopes

Dates

February 5-10, 2012

Location

Hotel Galvez
Galveston, TX

Organizers

Chair:
Vernon E. Anderson

Vice Chair:
Amnon Kohen

Meeting Description

The “Isotopes” GRC will celebrate the centennial of the identification of stable isotopes. Over the past 50+ years this conference has emphasized the use of isotopic labels in the study of inorganic, organic and biochemical reaction mechanisms. In more recent years the conference has come to recognize the importance of isotopes in the biomedical sciences. This includes applications of isotopes in medicine, in the determination of protein structure and dynamics; and, the use of isotopic probes in studies on enzymatic reaction mechanisms.

The 2012 conference will have a session honoring Jacob Bigeleisen, the organizer of the inaugural GRC on Isotopes (1954), who provided a theory of isotope effects on reaction rates whose application has been applied to fields as disparate as uranium separation, environmental chemistry, biogeochemistry as well as the elucidation of organic and enzymatic reaction mechanisms, which remain a primary focus of this GRC. Individual sessions focusing on the biological reactions that lead to isotope fractionation in the environment and in geology are scheduled. A special session on isotope effects on metallo enzymes is planned. Throughout the conference computational methods and their application for comparison to and interpretation of experimental effects is a focus. Finally, the Thursday evening session will feature “Isotopes at the Frontiers of Science”.

This conference is very interested in providing younger scientists with a forum in which to present their work. A Gordon Research Seminar for graduate students and post-docs is scheduled for the preceding weekend. Poster presentations are strongly encouraged and several oral presentations will be selected from the among poster presenters.

Related Meeting

This GRC was held in conjunction with the "Isotopes in Biological and Chemical Sciences" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Meeting Program

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmStable Isotopes Since 1912: Session in Honor of Jacob Bigeleisen
Discussion Leader: Vernon Anderson (NIGMS)
7:40 pm - 8:20 pm Kevin Downard (School of Molecular Bioscience, University of Sydney)
"The Story of Isotopes Retold - Stable Isotopes Discovered with Aston's Mass Spectrograph"
8:20 pm - 8:35 pm Discussion
8:35 pm - 9:15 pm Aleck van Hook (Department of Chemistry, University of Tennessee)
"Jacob Bigeleisen: Contributions to Isotope Science: Reminiscences"
9:15 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmIsotope Effects in Biogeochemistry and Pollutant Dynamics
Discussion Leader: Thomas Hofstetter (Institute for Biogeochemistry, ETH Zürich)
9:00 am - 9:35 amMartin Elsner (Institute of Groundwater Ecology, Helmholtz Zentrum München)
"Compound-specific isotope analysis: towards mechanistic isotope effect studies in the environment"
9:35 am - 9:45 amDiscussion
9:45 am - 10:20 amDaniel Hunkeler (University of Neuchâtel, Institute of Geology and Hydrogeology, Neuchatel, Switzerland)
"Carbon and chlorine isotope effects during degradation of chlorinated hydrocarbons: Mechanistic insights and environmental application"
10:20 am - 10:30 amDiscussion
10:30 amCoffee Break
10:50 am - 11:25 amAlex Sessions (Division of Geological and Planetary Sciences, California Institute of Technology)
"The correlation of hydrogen isotope abundances and central metabolism in bacteria"
11:25 am - 11:40 amDiscussion
11:40 am - 12:15 pmKaren Casciotti (Department of Environmental Earth System Science, Stanford)
"Isotopic fractionation in the marine nitrogen cycle"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 1
6:00 pmDinner
7:30 pm - 9:30 pmIsotope Effects on Chemical Reactions
Discussion Leader: Poul Erik Hansen (Department of Science, Systems and Models, Roskilde University)
7:30 pm - 8:10 pm Hans Limbach (Institut für Chemie und Biochemie, Freie Universitaet Berlin)
"Temperature independent vs. temperature dependent kinetic isotope effects on hydrogen transfer reactions"
8:10 pm - 8:30 pm Discussion
8:30 pm - 9:10 pm Ron Kluger (Chemistry, University of Toronto)
"Isotope Effects and Hydrolytic Decarboxylation"
9:10 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmIsotope Effects in Biogeochemistry
Discussion Leader: Martin Elsner (Institute of Groundwater Ecology, Helmholtz Zentrum München)
9:00 am - 9:40 am Edwin Schauble (Dept. of Earth and Space Sciences University of California, Los Angeles)
"Reconstructing ancient environments from isotope records in fossils"
9:40 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 11:10 am Laura Wasylenki (Department of Geological Sciences, Indiana University)
"A mechanistic look at how changes in coordination chemistry drive metal isotope effects"
11:10 am - 11:30 am Discussion
11:30 am - 12:10 pm David Johnston (Dept. of Earth and Planetary Sciences Harvard University)
"Sulfate reducing bacteria as the storytellers of Earth history"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 1
6:00 pmDinner
7:30 pm - 9:30 pmIsotope Effects on Enzyme Reactions
Discussion Leader: Hung-Wen Liu (College of Pharmacy, University of Texas at Austin)
7:30 pm - 8:10 pm Mark Ruszczycky (College of Pharmacy, University of Texas at Austin)
"Radical-Mediated Dehydrogenation of an Alcohol: Mechanistic Insights from the Radical-SAM Enzyme DesII"
8:10 pm - 8:30 pm Discussion
8:30 pm - 9:10 pm W.W. Cleland (Biochemistry, University of Wisconsin)
"Use of heavy atom isotope effects to study enzyme mechanisms"
9:10 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmIsotopes in Medicine
Discussion Leader: Andrew Murkin (Department of Chemistry, SUNY, Buffalo)
9:00 am - 9:40 am Catherine Clarke (Department of Chemistry and Biochemistry, UCLA)
"Toxicity of polyunsaturated fatty acids (PUFA) autoxidation is ameliorated by the presence of small amounts of isotope reinforced PUFAs"
9:40 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 11:10 am Stephen Previs (Merck)
"Can high-resolution mass spectrometry enhance studies of biochemical flux?"
11:10 am - 11:30 am Discussion
11:30 am - 12:10 pm Kevin Downard (School of Molecular Bioscience, University of Sydney)
"New Applications in Radical Probe Mass Spectrometry for the Footprinting of Protein Complexes"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 1
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmIsotope Effects on Enzyme Reactions
Discussion Leader: Michael Harris (Department of Biochemistry, Case Western Reserve University)
7:30 pm - 8:10 pm Tom Meek (Glaxo Smith Kline)
"Solvent Isotope Effects in Pre-Steady-State & Steady-State Kinetics to Elucidate Substrate Dependence on the Rate-Limiting Steps of Cathepsin C"
8:10 pm - 8:30 pm Discussion
8:30 pm - 9:10 pm Joseph Piccirilli (University of Chicago)
"Synthesis of Nucleotide Analogues Bearing Heavy Atom Isotope Labels and Their Application to Base- and Ribozyme-Catalyzed RNA Cleavage"
9:10 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmIsotope Effects on H Atom Abstraction
Discussion Leader: Nigel Richards (Department of Chemistry, University of Florida)
9:00 am - 9:40 am Neil Marsh (Chemistry, University of Michigan)
"Using isotopes to investigate the mechanisms of hydrocarbon-forming enzymes"
9:40 am - 10:00 amDiscussion
10:00 am Coffee Break
10:30 am - 11:10 am Martin Bollinger (Chemistry, Biochemistry and Molecular Biology, Penn State)
"The Novel, Cryptically Redox Monooxygenation Reaction Catalyzed by Cyanobacterial Aldehyde Decarbonylase and Evidence Against the Proposed Dioxygen-Independent Pathway"
11:10 am - 11:30 am Discussion
11:30 am - 12:10 pm Anthony Sauve (Department of Pharmacology, Weill Cornell Medical College)
"Isotope Effects on Reactions, Regulation and Activation of Sirtuins"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 2
6:00 pmDinner
7:30 pm - 9:30 pmIsotope Effects by Computation
Discussion Leader: Piotr Paneth (Chemistry, Technical University of Lodz)
7:30 pm - 8:10 pm Steven Schwartz (Einstein College of Medicine)
"Kinetic Isotope effects writ large: The Born Oppenheimer Enzyme and short timescale motions in PNP"
8:10 pm - 8:30 pm Discussion
8:30 pm - 9:10 pm Richard Robins (Interdisciplinary Chemistry, Université de Nantes)
"Isotope Effects on H-C and C-N Bond Fissions: can they help us understand reaction flexibility of enzyme active sites?"
9:10 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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