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Ligand Recognition & Molecular Gating
January 15-20, 2012
Four Points Sheraton / Holiday Inn Express
Ventura, CA
Chair:
Kenton J. Swartz

Vice Chair:
Dirk Jan Slotboom

The goal of 2012 Ligand Recognition and Molecular Gating GRC will be to foster research into the structure and operational mechanisms of membrane proteins involved in cellular signaling throughout biology. A focus of the meeting will be on ion channels, ion and small molecule transporters, and G protein coupled receptors. The emphasis will be on bringing together work at structural and functional levels to understand the mechanisms of gating or activation by ligands, and associated dynamic conformational changes. The poster sessions are critical elements of the conference, and all participants are asked to submit abstracts and bring posters - providing opportunities for people at different stages in their careers to meet, mix, learn and establish new interdisciplinary collaborations. We especially encourage graduate students and postdoctoral fellows to attend. The organizers will select additional speakers to give short talks, and these will be chosen based on the submitted abstracts.

Contributors
SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 8:50 pmSensory ion channels
Discussion Leader: Rick Aldrich (UT Austin)
7:40 pm - 8:05 pmBill Zagotta (University of Washington, Seattle)
"EAG-family channels: New twists on an old theme"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmRachelle Gaudet (Harvard University)
"Structural determinants of TRPV channel activation and desensitization"
8:40 pm - 8:50 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmCation channels and transport proteins
Discussion Leader: Bill Zagotta (University of Washington, Seattle)
9:00 am - 9:25 amCrina Nimigean (Cornell University)
"MthK channel gates probed with quaternary ammonium blockers"
9:25 am - 9:35 amDiscussion
9:35 am - 9:50 amPhilip Fowler (Oxford University)
"Potassium channels are frustrated"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:55 amRod MacKinnon (Rockefeller University)
"Gating mechanisms of potassium channels"
10:55 am - 11:05 amDiscussion
11:05 am - 11:30 amMing Zhou (Columbia University)
"Structure and function of a bacterial potassium transporter, TrkH"
11:30 am - 11:40 amDiscussion
11:40 am - 11:55 amJian Payandeh (Genentech)
"Crystal structure of a voltage-gated sodium channel"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:20 pmJana Kusch (University Hopsital Jena)
"How subunits cooperate in homotetrameric HCN2 channels upon cAMP-induced activation"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:15 pmβ-Adrenergic receptors
Discussion Leader: Gebhard Schertler (Paul Scherrer Institut)
7:30 pm - 7:55 pmChris Tate (MRC Laboratory of Molecular Biology)
"Comparison of agonist-bound structures of the β1-adrenoceptor and adenosine A2A receptors"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmRoger Sunahara (University of Michigan)
"Insights into the mechanism for receptor-mediated nucleotide exchange on heterotrimeric G proteins gleaned from the crystal structure of the β2AR-Gs complex"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pm Brian Kobilka (Stanford University)
"The dynamic process of GPCR activation: insights from the human β2 adrenoceptor"
9:05 pm - 9:15 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTransport assemblies and mechanisms
Discussion Leader: Dirk Slotboom (University of Groningen)
9:00 am - 9:25 amJue Chen (Purdue University)
"Structural studies of the E. coli maltose transporter"
9:25 am - 9:35 amDiscussion
9:35 am - 9:50 amEnrica Bordignon (ETH Zurich)
"ABC transporters: structural investigation by electron paramagnetic resonance"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:55 amNicholas Noinaj (NIH)
"Structural basis for iron piracy by pathogenic Neisseria"
10:55 am - 11:05 amDiscussion
11:05 am - 11:30 amGabriel Waksman (University College London)
"Mechanism of a pilus assembly and secretion nano machine at the outer membrane of bacterial pathogens"
11:30 am - 11:40 amDiscussion
11:40 am - 11:55 amHarini Krishnamurthy (Vollum Institute)
"Structures of intermediate states of the transport cycle of LeuT"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:20 pmKelli Kazmier (Vanderbilt University)
"Mechanistic diversity within the LeuT fold"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:15 pmNew approaches to membrane protein structure and mechanism
Discussion Leader: Susan Buchanan (NIH)
7:30 pm - 7:55 pmCarol Robinson (Oxford University)
"Mass Spectrometry of Membrane Protein Complexes - lipid and small molecule binding revealed"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmAntoine van Oijen (University of Groningen)
"Single-molecule approaches to study channels and transporters"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmPetra Fromme (Arizona State University)
"Femtosecond nanocrystallography of membrane proteins: towards molecular movies of biomolecules at work"
9:05 pm - 9:15 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLigand-gated ion channels
Discussion Leader: Rod MacKinnon (Rockefeller University)
9:00 am - 9:25 amMark Mayer (NIH)
"Structure and assembly of heteromeric glutamate receptor ion channels"
9:25 am - 9:35 amDiscussion
9:35 am - 9:50 amRene Frank (Cambridge University)
"Endogenous post-synaptic glutamate receptor complexes"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:55 amHiro Furukawa (Cold Spring Harbor Laboratories)
"Structural dissection of NMDA receptor pharmacology"
10:55 am - 11:05 amDiscussion
11:05 am - 11:30 amEric Gouaux (Vollum Institute)
"Mechanism of ATP binding and activation of P2X receptors"
11:30 am - 11:40 amDiscussion
11:40 am - 11:55 amMatt Whorton (Rockefeller University)
"Structure of a G-protein activated inward rectifier potassium channel"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:20 pmIwan Zimmermann (University of Zurich)
"Ligand activation of the prokaryotic pentameric ligand-gated ion channel ELIC"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:05 pmTransport Mechanisms
Discussion Leader: Hassane Mchaourab (Vanderbilt University)
7:30 pm - 7:55 pmOlga Boudker (Cornell University)
"Sodium coupled aspartate transporter: the energetics of the transport cycle"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmInga Hanelt (University of Groningen)
"Monitoring substrate induced dynamics of GltPH by EPR and tryptophan fluorescence measurements"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 8:55 pmTim Rasmussen (University of Aberdeen)
"Activation and complex regulation of the Kef potassium efflux system during protection of bacteria against toxic electrophiles"
8:55 pm - 9:05 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmG-protein coupled receptors
Discussion Leader: Reinhard Grisshammer (NIH)
9:00 am - 9:25 amGebhard Schertler (Paul Scherrer Institut)
"A structural view of constitutive activation of GPCRs"
9:25 am - 9:35 amDiscussion
9:35 am - 9:50 amXavier Deupi (Paul Scherrer Institut)
"Ligand binding pathways in β-adrenergic receptors"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:55 amVadim Cherezov (Scripps Research Institute)
"Structural diversity of G-protein coupled receptors"
10:55 am - 11:05 amDiscussion
11:05 am - 11:30 amTakuya Kobayashi (Kyoto University)
"Molecular basis of antihistamine specificity against the human histamine H1 receptor"
11:30 am - 11:40 amDiscussion
11:40 am - 11:55 amHideaki Kato (University of Tokyo)
"Crystal structure of channelrhodopsin, a light-gated cation channel"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:20 pmManuela Ambrosio (University of Würzburg)
"Activation of α2A-adrenergic receptor under non-equilibrium conditions"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:15 pmDulcis in fundo
Discussion Leader: Kenton Swartz (NIH)
7:30 pm - 7:55 pmOsamu Nureki (University of Tokyo)
"Structure of complexes of multidrug exporter and screened cyclic peptides for structure-based inhibitor design"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmChristine Ziegler (Max Planck Institute for Biophysics)
"Potassium-induced regulatory crosstalk in the trimeric betaine transporter BetP"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmTom Walz (Harvard University)
"Using 2D crystals of AQP0 to investigate lipid-protein interactions"
9:05 pm - 9:15 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture
The project described was supported by Grant Number R13NS077584 from the National Institute Of Neurological Disorders And Stroke. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute Of Neurological Disorders And Stroke or the National Institutes of Health.
 
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