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Molecular Mechanisms in Lymphatic Function & Disease
March 4-9, 2012
Ventura Beach Marriott
Ventura, CA
Chair:
Guillermo C. Oliver

Vice Chair:
Melody Swartz

The lymphatic vascular system is essential for lipid absorption, fluid homeostasis, and immune surveillance. Malfunctions of the lymphatic system can lead to congenital or inherited disorders such as lymphedema, a disfiguring and disabling disorder that is caused by imbalance in lymph absorption and often characterized by swelling of the extremities.

Our understanding of the genes and mechanisms controlling the formation of the lymphatic vasculature has improved a great deal during the last decade. The availability of molecular markers and animal models with various degrees of lymphatic defects has been instrumental to the progress in this field. Also, work in the last few years had led to a better understanding of the functional roles of this vascular system in health and disease. Furthermore, recent work has also unraveled additional functional roles of the lymphatic vasculature in fat metabolism, obesity, inflammation, tumor lymphangiogenesis, and the regulation of salt storage in hypertension.

The 2012 Gordon Conference on Molecular Mechanisms in Lymphatic Function & Disease will bring together an outstanding group of basic and clinically-oriented interdisciplinary scientists to discuss their latest progress in a wide range of topics in this rapidly advancing field of research. The program contains sessions about lymphatic vascular development, lymphatics and inflammation, lymphangiogenesis and cancer, lymphatic-related diseases such as obesity, hypertension, immune suppression, congenital and secondary lymphedema, and therapeutic approaches. The goal is to discuss new insights into the cellular and molecular mechanisms mediating lymphatic development and function, and the design of new interventions against pathological conditions affecting the lymphatic vascular system.

The Conference will bring together investigators who are at the forefront of their field, and will provide opportunities for junior scientists and graduate students to present their work in poster format and exchange ideas with leaders in the field. Some poster presenters will be selected for short talks. This conference is intended to provide a unique format for the exchange of ideas and information, to discuss the latest research findings and technical advances in a collegial atmosphere.

Contributors
SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmDEVELOPMENTAL (LYMPH)ANGIOGENESIS
Discussion Leader: Guillermo Oliver (St. Jude Children's Res. Hospital, Memphis, TN)
7:40 pm - 8:00 pmRong Wang (University California San Francisco, USA)
"Molecular programing of mammalian arterial venous specification"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmStephan Schulte-Merker (Hubrecht Institute, Utrecht, The Netherlands)
"Lymphangiogenesis in fish and mice: comparing genes, comparing processes"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmMark Kahn (University of Pennsylvania, Philadelphia, USA)
"Signaling pathways in lymphatic development"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmShort Talk: Johnathan Astin (The University of Auckland, New Zeland)
"lyve1 expression reveals novel lymphatic vessels and new mechanisms for lymphatic development in zebrafish"
9:20 pm - 9:25 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMOLECULAR REGULATORS OF LYMPHANGIOGENESIS
Discussion Leader: Kathleen Caron (The University of North Carolina at Chapel Hill, USA)
9:00 am - 9:20 amPeter Carmeliet (Vesalius Research Center, Leuven, Belgium)
"Metabolism and vessel growth"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amNatasha Harvey (Center for Cancer Biology, Adelaide, Australia)
"Defining signals that control morphogenesis of the lymphatic vasculature in the mouse embryo"
9:50 am - 10:00 amDiscussion
10:00 amGroup Photo / Coffee Break
10:30 am - 10:50 amHolger Gerhardt (London Research Institute, UK)
"Pattern formation in (blood)-vascular networks"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amSatish Srinivasan (St. Jude Children's Research Hospital, Memphis, USA)
"Molecular mechanisms of lymphatic valve development"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amTatiana Petrova (University of Lausanne, Switzerland)
"Transcriptional regulation of lymphatic valve morphogenesis"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShort Talk: Taija Makinen (Cancer Research Institute, UK)
"Planar cell polarity signaling regulates lymphatic valve development"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmShort Talk: Young-Sup Yoon (Emory University, Atlanta, USA)
"Lymphatic neovascularization by lymphatic endothelial lineage cells differentiated from human pluripotent stem cells"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I (Last names A to G inclusive)
6:00 pmDinner
7:30 pm - 9:30 pmMORPHOGENESIS OF THE LYMPHATIC VASCULAR NETWORK
Discussion Leader: Mark Kahn (University of Pennsylvania, Philadelphia, USA)
7:30 pm - 7:50 pmEckhard Lammert (Institute of Metabolic Physiology, Dusseldorf, Germany)
"Mechanoinduction of lymph vessel expansion"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmWalter Murfee (Tulane University, New Orleans, USA)
"Identifying lymphatic/blood endothelial cell dynamics during microvascular network growth"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmYulong He (Nanjing University, Nanjing, China)
"Molecular regulation of lymphatic network formation and remodeling in development"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmMichael Detmar (Swiss Federal Institute of Technology, Zurich, Switzerland)
"Molecular pathways mediating lymphatic vessel growth and development"
9:20 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLYMPHATIC TRANSPORT AND FLOW
Discussion Leader: Melody Swartz (Swiss Federal Institute of Technology, Lausanne, Switzerland)
9:00 am - 9:20 amDavid Zawieja (Texas A&M Health Science Center, Temple, Texas, USA)
"Molecular mechanisms of the flow mediated regulation of lymph transport"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amVirginia Huxley (University of Missouri, Columbia, USA)
"Natriuretic peptide modulation of lymphatic exchange: coupling of barrier and contractile function?"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:50 amAgnes Noel (University of Liege, Belgium)
"How do lymphatics deal with an interstitial environment?"
10:50 am - 11:00 amDiscussion
11:00 am - 11:10 amShort Talk: Risuke Mizuno (The University of Tokyo, Japan)
"High concentration of salt dysfunctions lymphatic activity through Na+-K+-ATPase-dependent mechanisms"
11:10 am - 11:15 amDiscussion
11:15 am - 11:25 amShort Talk: Witold Kilarski (Swiss Federal Institute of Technology, Lausanne, Switzerland)
"A novel intravital imaging method of dermal lymphatic function reveals differential regulation of fluid vs. cell transport in acute inflammation"
11:25 am - 11:30 amDiscussion
11:30 am - 11:50 amKari Alitalo (University of Helsinki, Finland)
"VEGF-C/D/VEGFR-3: From structures to functional insights"
11:50 am - 12:00 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II (Last names H to M inclusive)
6:00 pmDinner
7:30 pm - 9:30 pmLYMPHANGIOGENESIS IN CANCER
Discussion Leader: Michael Detmar (Swiss Federal Institute of Technology, Zurich, Switzerland)
7:30 pm - 7:50 pmMelody Swartz (Swiss Federal Institute of Technology, Lausanne, Switzerland)
"Lymphatic transport in regulating immunological tolerance"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmMihaela Skobe (Mount Sinai, New York, USA)
"Role of lymphatic endothelium in cancer metastasis"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmDontscho Kerjaschki (University of Vienna, Austria)
"Initial steps of lymphatic metastasis"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:00 pmShort Talk: Alanna Ruddell (Fred Hutchinson Cancer Research Center, USA)
"B lymphocytes promote lymphogenous metastasis of lymphoma and melanoma"
9:00 pm - 9:05 pmDiscussion
9:05 pm - 9:25 pmLena Claesson-Welsh (Uppsala University, Uppsala, Sweden)
"VEGFR2 signaling in the regulation of vascular permeability"
9:25 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLYMPHATIC REGULATION OF INFLAMMATION
Discussion Leader: David Jackson (University of Oxford, UK)
9:00 am - 9:20 amAlberto Mantovani (Istituto Clinico Humanitas, Milan, Italy)
"Selective expression and function of the chemokine decoy and scavenger receptor D6 in lymphatic endothelium"
9:20 am - 9:30 amDiscussion
9:30 am - 9:40 amShort Talk: Steven Proulx (Swiss Federal Institute of Technology, Zurich, Switzerland)
"Non-invasive longitudinal imaging of collecting lymphatic vessel function and metastatic spread of murine melanoma"
9:40 am - 9:45 amDiscussion
9:45 am - 9:55 amShort Talk: Masataka Majima (Kitasato University, Japan)
"Prostanoids as regulators of pathological lymphangiogenesis"
9:55 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:50 amSirpa Jalkanen (Institute for Molecular Medicine, Turku, Finland)
"Lymphocyte trafficking within lymphatics - shared mechanisms with cancer cells?"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amCornelia Halin-Winter (Swiss Federal Institute of Technology, Zurich, Switzerland)
"Impact of inflammation on lymphatic vessel phenotype and function"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amShort Talk: Veronique Angeli (National University of Singapore Korea)
"Neutrophils - unexpected key players in driving lymphangiogenesis and resolution of inflammation"
11:40 am - 11:45 amDiscussion
11:45 am - 12:05 pmPierre-Yves von der Weid (University of Calgary, Alberta, Canada)
"Mesenteric lymphatic vessel dysfunction in intestinal inflammation-mechanism and importance for IBD pathogenesis"
12:05 pm - 12:15 pmDiscussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:30 pm - 9:30 pmLYMPHATICS AND IMMUNITY
Discussion Leader: Alberto Mantovani (Istituto Clinico Humanitas, Milan, Italy)
7:30 pm - 7:50 pmNancy Ruddle (Yale University School of Medicine, New Haven, USA)
"Visualizing the Immune Response"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmMichael Carroll (Immune Disease Institute, Harvard, USA)
"B cell acquisition of antigen in draining lymph nodes"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmGou-Young Koh (Biomedical Center, Daejeon, Korea)
"Regulation of Lymphangiogenesis by Immune Cells"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmShort Talk: Sophia Ran (Southern Illinois University, USA)
"Modeling macrophage transdifferentiation into lymphatic endothelial progenitors"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk: Louise Johnson (University of Oxford, UK)
"A novel role for the chemokine CX3CL1 (Fractalkine) in promoting DC trafficking through the lymphatics to the lymph node in inflammation"
9:25 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
9:00 am - 12:30 pmLYMPHATICS AND DISEASE
Discussion Leader: Peter Mortimer (St George's, University of London, UK)
9:00 am - 9:20 amDonald McDonald (University of California San Francisco, USA)
"Plasticity of lymphatics in health and disease"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amStanley Rockson (Stanford University, California, USA)
"Diagnosis and Treatment of Human Lymphedema: Translation from the Animal Model"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:50 amEva-Sevick Muraca (The Brown Foundation, Texas, USA)
"Near-Infrared Fluorescence Lymphatic Imaging Discovery in Translation"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amSteve Jeffery (St George's Hospital Medical School, London, England)
"Phenotyping and gene identification in human primary lymphoedema"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amJayakrishna Ambati (University of Kentucky College of Medicine, Lexington, USA)
"The function of soluble VEGFR-2 in the retina"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShort Talk: Fusa Ogata (The University of Tokyo, Japan)
"Smooth muscle phenotypic modulation plays an important role in lymphatic vessel remodeling in lymphedema"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmShort Talk: Sidney Levy (Peter Maccallum Cancer Center, Australia)
"New models of secondary lymphoedema, a common complication of cancer surgery"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session III (Last names N to Z)
6:00 pmDinner
7:30 pm - 9:30 pmNEW DIRECTIONS: LYMPHATICS AND METABOLISM
Discussion Leader: Donald McDonald (University of California San Francisco, USA)
7:30 pm - 7:50 pmGwendalyn Randolph (Washington University School of Medicine, St. Louis, USA)
"Lymphatic vessel and immune cell interactions regulate adipocyte phenotype"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmShort Talk: Catherine Martel (Washington University in St. Louis, MO, USA)
"Reverse cholesterol transport relies on a functional lymphatic network"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:35 pmChris Porter (Monash Institute of Pharmaceutical Sciences, Victoria, Australia)
"Exploring the interface between lipid and drug transport in the intestinal lymphatics"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmShort Talk: Eser Tolunay (National Institutes of Health, Bethesda, USA)
"NIH update on lymphatic research"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:30 pmGeneral discussion of future directions in lymphatic research
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture
 
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