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Conference Program
 
Lysosomes & Endocytosis
June 17-22, 2012
Proctor Academy
Andover, NH
Chair:
Michael Marks

Vice Chair:
Beverly Wendland

Related Meeting Information
The Lysosomes & Endocytosis Gordon Research Conference was held in conjunction with the Lysosomes & Endocytosis Gordon Research Seminar. Please refer to the Lysosomes & Endocytosis GRS web page for more information.

The Gordon Research Conference on Lysosomes and Endocytosis covers recent advances in understanding the function and molecular regulation of the endocytic pathway, lysosomes, and related subcellular organelles. Endosomes and lysosomes play critical roles in the physiology of cells and organisms by serving as the cellular entry point for nutrients, toxins and pathogens and the nexus for intercellular signaling networks. Many inherited and somatic diseases result from defects in endocytic and lysosomal pathways. Some pathogens are destroyed by these pathways, while others subvert their function during infection. Moreover, these pathways play key roles in the stimulation and implementation of immune responses, glucose and lipid metabolism, cell and tissue development, and cancer.

Topics of focus for the 2012 meeting include molecular mechanisms and cell biology of endocytic and degradative pathways, as well as their role in human health and disease. Sessions will cover molecular features of endocytic membrane traffic such as coat formation, membrane tubulation, and cell physiology including endosomal and lysosomal membrane traffic, autophagy and formation and function of specialized lysosome-related organelles. Other sessions will focus on the roles of endocytic pathways in infection and immunity, diabetes and metabolism and development. The conference will continue to feature a session on 'New Directions' in which novel technical and conceptual developments in the field will be discussed.

The meeting will be divided into nine half-day sessions, comprising a mixture of invited speakers and those selected from abstracts. Attendance by under-represented minorities, students, postdoctoral fellows, junior faculty, and faculty from primarily undergraduate institutions is encouraged. If you are a student or postdoctoral researcher, it is very important to identify the principal investigator of your laboratory in your application. This conference is usually oversubscribed, so early application is advised with a suggested deadline of April 2, 2012, after which the conference may be filled. Decisions regarding speaking opportunities for available slots will be made only for abstracts submitted by this date. Applications received after the conference is full will be assigned to a waiting list.

Prior to and in association with the Gordon Research Conference, new in 2012 there will be a Gordon Research Seminar on Lysosomes and Endocytosis, in which students and post-doctoral researchers can present their work to each other and attend instructional seminars prior to the arrival of senior investigators. Interested trainees are encouraged to view the GRS web site and consider attending.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmEndosomes, Lysosomes and Autophagy in Development
Discussion Leader: Lois Weisman (University of Michigan, Ann Arbor, MI, USA)
7:40 pm - 8:00 pmAndrea Ballabio (Telethon Institute of Genetics and Medicine, Napoli, Italy)
"TFEB, a master gene for cellular clearance and energy metabolism"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmLinton Traub (University of Pittsburgh, PA, USA)
"Clathrin-mediated endocytosis in early development"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmHenrik Korswagen (University of Utrecht, The Netherlands)
"A novel SNX3-dependent retromer pathway mediates endosome-to-Golgi retrieval of the Wnt secretion factor Wls"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmJulie Brill (Univ. of Toronto, ON, Canada)
"The PI 4-phosphatase Sac1 is essential for biogenesis of lysosome-related organelles"
9:25 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEndosome Maturation
Discussion Leaders: Mark von Zastrow (University of California, San Francisco, CA, USA) and Christian Ungermann (University of Osnabrück, Osnabrück, Germany)
9:00 am - 9:20 amJuan Bonifacino (National Institutes of Health, Bethesda, MD, USA)
"Mechanisms of polarized sorting in neurons"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amElina Ikonen (University of Helsinki, Finland)
"Post-endocytic trafficking of LDL-cholesterol"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amChristopher Burd (Yale University New Haven, CT, USA)
"Retrograde sorting at the endosome"
10:20 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:20 amMargaret Robinson (University of Cambridge, UK)
"Coats and endosomal traffic"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amDavid Katzmann (Mayo Clinic, Rochester, MN, USA)
"Coordination of Vps4 and ESCRT function"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:15 pmXuefeng Ren (National Institutes of Health, Bethesda, MD, USA)
"Structural basis for Arf1-dependent membrane recruitment of the clathrin adaptor, AP-1"
12:15 pm - 12:25 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmDiabetes and Metabolism
Discussion Leader: Tim McGraw (Cornell University, New York, NY, USA)
7:40 pm - 8:00 pmFrances Brodsky (University of California, San Francisco, CA, USA)
"Diversity of clathrin function"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmDebbie Thurmond (Indiana University, Indianapolis, IN, USA)
"The good and bad of cellular conservation of exocytosis mechanisms for metabolic health and longevity"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmSusanna Keller (University of Virginia, Charlottesville, VA, USA)
"Distinctive roles of Rab GAPs AS160 and Tbc1d1 in GLUT4 trafficking in mouse skeletal muscles and adipocytes"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmVictor Hsu (Harvard Medical School, Boston, MA)
"Regulation of glut4 recycling by insulin through Grp1"
9:25 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmEndocytic Mechanisms
Discussion Leaders: Sandy Schmid (University of Texas Southwestern Medical Center, Dallas, TX, USA) and Alexander Sorkin (University of Pittsburgh, PA, USA)
9:00 am - 9:20 amTom Kirchhausen (Harvard University, Boston, MA, USA)
"Single-molecule biology and visualization of endocytosis"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amJulie Donaldson (National Institutes of Health, Bethesda, MD, USA)
"Clathrin-independent endocytosis: Sorting of cargo proteins after entry"
9:50 am - 10:00 amDiscussion
10:00 am - 10:15 amCostin Antonescu (Ryerson Univ., Toronto, ON, Canada)
"AP-2 ear protein scaffolding domains distinctly regulate multiple facets of clathrin-mediated endocytosis"
10:15 am - 10:25 amDiscussion
10:25 amCoffee Break
10:55 am - 11:15 amRoberto Weigert (National Institutes of Health, Bethesda, MD, USA)
"Dynamics and regulation of endocytic events in live animals"
11:15 am - 11:25 amDiscussion
11:25 am - 11:40 amSanja Sever (Harvard University, Boston, MA)
"Dynamin rings directly regulate the actin cytoskeleton"
11:40 am - 11:50 amDiscussion
11:50 am - 12:10 pmMarino Zerial (Max Planck Institute, Dresden, Germany)
"Multi-scale analysis of liver organization and morphogenesis"
12:10 pm - 12:20 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPhagocytosis and Host-Pathogen Interactions
Discussion Leaders: Pascale Cossart (Institut Pasteur, Paris, France) and Sergio Grinstein (Hospital for Sick Children, Toronto, Canada)
7:40 pm - 8:00 pmCraig Roy (Yale University, New Haven, CT, USA)
"Modulation of host membrane transport by Legionella pneumophila"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmOlivier Neyrolles (CNRS, Toulouse, France)
"Metallobiology of host-pathogen interactions: an intoxicating new insight"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmRaphael Valdivia (Duke University, Durham, NC, USA)
"Chlamydia targets organelles to manipulate innate immunity"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmChristine Becker (Harvard Medical School, Boston, MA, USA)
"Rab39a links caspase-1 activation to phagosome acidification and cellular defense"
9:25 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLysosomes and Lysosome-Related Organelles
Discussion Leaders: Paul Luzio (Cambridge Institute for Medical Research, Cambridge, UK) and Thomas Braulke (University Medical Center Hamburg-Eppendorf, Germany)
9:00 am - 9:20 amVictor Faundez (Emory University, Atlanta, GA, USA)
"Novel insights into BLOC-1 function by proteomic and genetic approaches"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amClare Futter (University College London, London, UK)
"Phagosome processing and interactions with the endocytic pathway in retinal pigment epithelial cells in health and disease"
9:50 am - 10:00 amDiscussion
10:00 am - 10:15 amShawn Ferguson (Yale University, New Haven, CT, USA)
"Eavesdropping on conversations between lysosomes and the nucleus"
10:15 am - 10:25 amDiscussion
10:25 amCoffee Break
10:55 am - 11:15 amJudith Klumperman (University of Utrecht, the Netherlands)
"The role of the mammalian HOPS complex in lysosome biogenesis"
11:15 am - 11:25 amDiscussion
11:25 am - 11:40 amRosa Puertollano-Moro (National Institutes of Health, Bethesda, MD, USA)
"Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes"
11:40 am - 11:50 amDiscussion
11:50 am - 12:10 pmGraça Raposo (Institut Curie, Paris, France)
"Endosome dynamics in the biogenesis of melanosomes"
12:10 pm - 12:20 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmNew Directions
Discussion Leader: Beverly Wendland (Johns Hopkins University, Baltimore, MD, USA)
7:40 pm - 8:00 pmHiroshi Ohno (Riken Institute, Yokohama City, Japan)
"Antigen delivery to the gut immune system through epithelium: M cells vs FAE"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmMara Duncan (Univ. of North Carolina, Chapel Hill, NC, USA)
"Hungry cells can still be picky eaters: Inhibition of autophagy in glucose starved cells"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmMartin Lowe (University of Manchester, Manchester, UK)
"The role of OCRL1 in endocytic membrane traffic"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmAlex Merz (University of Washington, Seattle, WA, USA)
"Titration of Rab 5 signaling in the yeast endosomal system"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmDerek Prosser (Johns Hopkins Univ., Baltimore, MD, USA)
"Many roads from outside to inside: alpha-arrestins contribute to Rho1-mediated clathrin-independent endocytosis in yeast"
9:25 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEndosomes, Lysosomes and Immune Function
Discussion Leaders: Jacques Neefjes (The Netherlands Cancer Institute, Amsterdam, the Netherlands) and Jennifer Stow (University of Queensland, Brisbane, Australia)
9:00 am - 9:20 amGillian Griffiths (Cambridge University, Cambridge, UK)
"Cilia, synapses and secretory lysosomes"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amWillem Stoorvogel (University of Utrecht, Utrecht, the Netherlands)
"Endocytic transport of MHC class II by dendritic cells"
9:50 am - 10:00 amDiscussion
10:00 am - 10:15 amAna-Maria Lennon-Dumenil (Institut Curie, Paris, France)
"Polarized lysosome secretion couples antigen extraction to processing and presentation at the B cell synapse"
10:15 am - 10:25 amDiscussion
10:25 amCoffee Break
10:55 am - 11:15 amGenevieve de Saint Basile (INSERM, Paris, France)
"Further dissection of the mechanisms regulating cytotoxic granule exocytosis"
11:15 am - 11:25 am Discussion
11:25 am - 11:40 amAdriana Mantegazza (University of Pennsylvania, Philadelphia, PA, USA)
"AP-3 facilitates TLR signaling and MHC class II presentation from phagosomes in dendritic cells"
11:40 am - 11:50 amDiscussion
11:50 am - 12:10 pmHidde Ploegh (Whitehead Institute, Cambridge, MA, USA)
"Bacterial toxins as tools to probe the endocytic pathway"
12:10 pm - 12:20 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 8:10 pmEndosome Maturation II
Discussion Leader: Beverly Wendland (Johns Hopkins Univ., Baltimore, MD, USA)
7:30 pm - 7:45 pmLydia Daboussi (Univ. of California, Los Angeles, CA, USA)
"Mechanisms regulating PtdIns(4)phosphate-mediated clathrin adaptor progression at the TGN"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmMike Henne (Cornell University, Ithaca, NY, USA)
"Reconstitution and high-resolution EM imaging of ESCRT assembly and architecture"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 9:30 pmKeynote Lecture (in Honor of Alex Novikoff)
8:10 pm - 8:20 pmIntroduction and History: Mickey Marks
8:20 pm - 9:20 pmFred Maxfield (Cornell University, New York, NY, USA)
"Lysosomal diseases - should we include atherosclerosis and Alzheimer's?"
9:20 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible in part by 1 R13 GM 100570 - 01 from National Institute of General Medical Sciences. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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