Gordon Research Conferences
PI_Conferences PI_Conferences_Past
Conference Program
 
Mammary Gland Biology
June 10-15, 2012
Renaissance Tuscany Il Ciocco Resort
Lucca (Barga), Italy

Related Meeting Information
The Mammary Gland Biology Gordon Research Conference was held in conjunction with the Mammary Gland Biology Gordon Research Seminar. Please refer to the Mammary Gland Biology GRS web page for more information.

Mammary gland biology is driven by an interest both in the biology of the normal gland and in breast disease. The 2012 GRC Mammary Gland Biology meeting will concentrate on how on understanding normal breast biology drives our understanding of breast pathophysiology. Scientific sessions will focus on cutting edge research directed at the basics of mammary gland biology - the developmental cycle of proliferation, differentiation, lactation and involution. Speakers will also examine how our improving knowledge in these areas is driving a better understanding of breast cancer biology. The conference will include leaders in the field as invited speakers as well as selecting speakers for short talks from submitted abstracts. The 2012 GRC will be preceded by the first Mammary Gland Gordon Research Seminar and post-graduate students and junior post-docs are encouraged to apply for both meetings. The Mammary Gland Biology GRC has a tradition of good interaction across all levels of seniority, from the newest student to the most senior professor, and we look forward to continuing that at Il Ciocco in 2012.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 7:50 pmWelcome and Introduction by the Meeting Chairs: Matt Smalley (Chair), Terri Wood and John Wysolmerski (Co-Vice Chairs)
7:50 pm - 9:30 pmINTRODUCTORY ADDRESS - DRIVING TRANSLATIONAL RESEARCH WITH BASIC BIOLOGY
7:50 pm - 8:45 pmAlan Ashworth (The Institute of Cancer Research, London)
"Harnessing Genetic Dependencies In Cancer Therapy"
8:45 pm - 9:00 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTHE CELLULAR ORIGINS OF BREAST CANCER
9:00 am - 9:10 amDiscussion Leader: Yi Li (Baylor College of Medicine, Houston)
9:10 am - 9:35 amEldad Zacksenhaus (University Health Network, Toronto)
"Tumor-initiating cell derived-prognostic signatures and therapeutics using subtype-specific mouse models of breast cancer"
9:35 am - 9:50 amDiscussion
9:50 am - 10:15 amJose Moreira (Institute of Cancer Biology, Copenhagen)
"Addressing the cellular hierarchy of the breast by proteomics"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amGroup Photo / Coffee Break
11:00 am - 11:25 amAlexandra Pietersen (National Cancer Centre, Singapore)
"Wip1: a lineage-specific oncogene for Her2+ breast cancer?"
11:25 am - 11:40 amDiscussion
11:40 am - 11:55 amShort Talk: Mimmi Ballard (UCSC)
"The Role of Slit Signaling in Asymmetric Self-Renewal of Mammary Stem Cells"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:20 pmShort Talk: Aurelie Chiche (Institut Curie)
"Role of p53 in mammary development and tumorigenesis"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session I
5:30 pm - 7:25 pmPRE-PUBERTAL DEVELOPMENT
5:30 pm - 5:40 pmDiscussion Leader: Beatrice Howard (The Institute of Cancer Research, London)
5:40 pm - 6:05 pmMarja Mikkola (University of Helsinki)
"Regulation of embryonic mammary gland development by the ectodysplasin/NF-kappaB pathway"
6:05 pm - 6:20 pmDiscussion
6:20 pm - 6:45 pmAnn Ramsdell (University of South Carolina)
"Mammary Gland Laterality: Has Embryonic Patterning Left One Side More Susceptible to Neoplastic Development?"
6:45 pm - 7:00 pmDiscussion
7:00 pm - 7:15 pmShort Talk: Maisam Makerem (Terry Fox Laboratory, BCCRC)
"Differences in primitive mammary epithelial cell properties determined from in vivo and in vitro analyses of fetal and adult cells"
7:15 pm - 7:25 pmDiscussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCELLULAR INTERACTIONS, DIFFERENTIATION AND BREAST CANCER
9:00 am - 9:10 amDiscussion Leader: Keith Brennan (University of Manchester)
9:10 am - 9:35 amPatrick Derksen (UMC Utrecht)
"Context-dependent roles for p120-catenin in metastatic breast cancer"
9:35 am - 9:50 amDiscussion
9:50 am - 10:15 amKristina Trujillo (University of New Mexico)
"Breast Carcinogenesis: Stochastic multistep evolution, selection of naturally occurring wound healing populations, or both?"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amWalid Khaled (Wellcome Trust Sanger Institute)
"The role of hematopoietic transcription regulators in mammary stem cells and breast cancer"
11:25 am - 11:40 amDiscussion
11:40 am - 11:55 amShort Talk: Lisa Arendt (Tufts University)
"Obesity-like adipose stroma promotes angiogenesis in a humanized mouse model of breast cancer"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:20 pmShort Talk: Eliah Shamir (Johns Hopkins University School of Medicine)
"Regulation of mammary epithelial dissemination"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session II
5:30 pm - 7:30 pmPOST-PUBERTAL DEVELOPMENT
5:30 pm - 5:40 pmDiscussion Leader: Rob Clarke (Paterson Institute for Cancer Research, Manchester)
5:40 pm - 6:05 pmPaul Lu (Paterson Institute for Cancer Research, Manchester)
"Role of the stromal microenvironment in cell fate reprogramming and lineage differentiation"
6:05 pm - 6:20 pmDiscussion
6:20 pm - 6:45 pmIsabelle Miletich (Guy's Hospital, London)
"Coordination of epithelial branching and lumen formation during salivary gland development"
6:45 pm - 7:00 pmDiscussion
7:00 pm - 7:15 pmShort Talk: Bhopal Mohapatra (University of Nebraska Medical Center)
"The role of Cbl family ubiquity ligases in mammary gland development"
7:15 pm - 7:25 pmDiscussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPREGNANCY
9:00 am - 9:10 amDiscussion Leader: Terri Wood (New Jersey Medical School)
9:10 am - 9:35 amMohamed Bentires-Alj (Friedrich Miescher Institute for Biomedical Research, Basel)
"Changes in signalling molecules upon pregnancy"
9:35 am - 9:50 amDiscussion
9:50 am - 10:15 amGertraud Robinson (NIDDK/NIH)
"Role of histone methylation in preparing for lactation"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amJoe Jerry (UMass, Amherst)
"Parity: Changing the balance of survival and surveillance"
11:25 am - 11:40 amDiscussion
11:40 am - 11:55 amShort Talk: Renee Van Amerongen (Netherlands Cancer Institute)
"Developmental stage and time dictate the fate of Wnt/beta-catenin responsive stem cells in the mammary gland"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:20 pmShort Talk: Leena Baker (University of Toronto)
"The polarity protein Scribble is required for alveolar differentiation of mammary epithelial cells"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session III
5:30 pm - 7:25 pmLACTATION AND INVOLUTION I
5:30 pm - 5:40 pmDiscussion Leader: John Wysolmerski (Yale University)
5:40 pm - 6:05 pmEvelyne Meyer (University of Ghent)
"Intraductal inoculation of the lactating murine mammary gland: what can be learned from applications with this model?"
6:05 pm - 6:20 pmDiscussion
6:20 pm - 6:45 pmMike Lewis (Baylor College of Medicine)
"...So what's a mesenchymal cell like you doing in a parenchyma like this?"
6:45 pm - 7:00 pmDiscussion
7:00 pm - 7:15 pmShort Talk: Rosa Zaragoza (Incliva Research Foundation)
"Activated calpains cleave lysosomal membrane proteins triggering cathepsins release and thus regulating mammary gland remodelling"
7:15 pm - 7:25 pmDiscussion
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
9:00 am - 12:30 pmLACTATION AND INVOLUTION II
9:00 am - 9:10 amDiscussion Leader: Christine Watson (University of Cambridge)
9:10 am - 9:35 amRosa Serra (University of Alabama at Birmingham)
"Wnt5a and Cx43 regulate milk ejection"
9:35 am - 9:50 amDiscussion
9:50 am - 10:15 amRichard Clarkson (Cardiff University)
"Extrinsic cell death in mammary involution, tumour surveillance and therapy"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amSara Pensa (University of Cambridge)
"Stat3 transcriptional targets and their role in lysosomal mediated cell death"
11:25 am - 11:40 amDiscussion
11:40 am - 11:55 amShort Talk: Laura Hernandez (University of Wisconsin)
"5-Hydroxtryptophan Induces Mammary Gland PTHrP During the Transition Period"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:20 pmShort Talk: Traci Lyons (University of Colorado Anschutz Medical Center)
"Postpartum mammary gland involution drives COX-2 dependent lymphangiogenesis and lymphatic vessel invasion in a model of postpartum breast cancer"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session IV
5:30 pm - 7:30 pmKEYNOTE ADDRESS
5:30 pm - 5:40 pmIntroduction: Matt Smalley
5:40 pm - 6:40 pmCathrin Brisken (ISREC, Lausanne)
"How hormones orchestrate mammary gland development"
6:40 pm - 7:00 pmDiscussion
7:00 pm - 7:05 pmFinal comments and hand over to Chair for 2013
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 5R13CA150225-03 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
© 2014 Gordon Research Conferences Search | Contact | Terms of Use | Privacy Policy | Follow us: Facebook Twitter