Gordon Research Conferences
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Conference Program
 
Molecular Basis of Microbial One-Carbon Metabolism
August 5-10, 2012
Bates College
Lewiston, ME
Chair:
Julia Vorholt

Vice Chair:
Thomas E. Hanson

Related Meeting Information
The Molecular Basis of Microbial One-Carbon Metabolism Gordon Research Conference was held in conjunction with the Molecular Basis of Microbial One-Carbon Metabolism Gordon-Kenan Research Seminar. Please refer to the Molecular Basis of Microbial One-Carbon Metabolism GKRS web page for more information.

One-carbon (C1) compounds play a central role in microbial metabolism. C1 compounds include methane, carbon monoxide, carbon dioxide, and methanol as well as coenzyme-bound one-carbon compounds. They are of broad global importance because several of these (e.g., methane) are important energy sources, some (e.g., carbon dioxide and methane) are potent greenhouse gases, and others (e.g., dichloromethane) are xenobiotics. C1 compounds are central in pathways of energy metabolism and carbon fixation by microorganisms and many are of industrial interest. The 2012 Gordon Conference will present and discuss cutting-edge research in the field of microbial metabolism of C1 compounds. The conference will feature the roles and application of C1 metabolism in natural and synthetic systems at scales from molecules to ecosystems. The conference will stress molecular aspects of the unique metabolism exhibited by autotrophic bacteria, methanogens, methylotrophs, aerobic and anaerobic methanotrophs, and acetogens. Complementary perspectives will be provided by leading scientists in biochemistry, general microbiology, molecular biology, ecology, systems- and synthetic biology.

The Conference will bring together investigators who are at the forefront of their field, and will provide opportunities for junior scientists and graduate students to present their work in poster format and exchange ideas with leaders in the field. In addition, some poster presenters will be selected to give short talks in the different sessions. The collegial atmosphere of this Conference, with extensive discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an ideal setting for scientists from different disciplines to exchange ideas, brainstorm and discuss cross-disciplinary collaborations.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmFrontiers in carbon dioxide fixation and origin of life
7:40 pm - 7:50 pmDiscussion Leader: Thomas E. Hanson (University of Delaware, USA)
7:50 pm - 8:30 pmKeynote Lecture: Georg Fuchs (University of Freiburg, Germany)
"Alternative CO2 fixation pathways - in search for a rationale"
8:30 pm - 8:45 pmDiscussion
8:45 pm - 9:15 pmWilliam Martin (University of Düsseldorf, Germany)
"Bringing rocks to life: The early evolution of biological energy conservation"
9:15 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEnzyme structure and mechanism
9:00 am - 9:10 amDiscussion Leader: Rolf Thauer (Max-Planck-Institute for terrestrial Microbiology, Marburg, Germany)
9:10 am - 9:35 amCatherine Drennan (MIT, Boston, USA)
"Juggling carbon: B12-dependent methyltransferase complexes caught in the act"
9:35 am - 9:45 amDiscussion
9:45 am - 10:05 amPoster Talk: Kai Schuchmann (Goethe University Frankfurt, Germany)
"An electron bifurcating hydrogenase in the acetogenic bacterium Acetobacterium woodii"
10:05 am - 10:15 amDiscussion
10:15 amCoffee Break
10:45 am - 11:10 amSquire Booker (Pennsylvania State University, USA)
"New strategies for methylation of sp2-hybridized carbon centers"
11:10 am - 11:20 amDiscussion
11:20 am - 11:45 amAmy Rosenzweig (Northwestern University, Evanston, USA)
"New insights into particulate methane monooxygenase"
11:45 am - 11:55 amDiscussion
11:55 am - 12:20 pmRuss Hille (University of California, Riverside, USA)
"The reaction of Mo/Cu-containing CO dehydrogenase with CO and H2"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNickel enzymes
7:30 pm - 7:40 pmDiscussion Leader: Evert Duin (Auburn University, USA)
7:40 pm - 8:05 pmStephen W. Ragsdale (University of Michigan, Ann Arbor, USA)
"Playing with substrates, light, and temperature to capture intermediates in the mechanisms of Nickel-dependent redox enzymes"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmSeigo Shima (Max-Planck-Institute for terrestrial Microbiology, Marburg, Germany)
"Hydrogenases from methanogenic archaea"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmOliver Lenz (Humboldt University Berlin, Germany)
"H2 conversion in air involves a novel cofactor with high structural flexibility"
9:15 pm - 9:25 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNovel reactions and pathways
9:00 am - 9:10 amDiscussion Leader: Ivan Berg (University of Freiburg, Germany)
9:10 am - 9:35 amMike Jetten (Radboud University Nijmegen, The Netherlands)
"New enzymes and metabolisms involved in C1 conversion"
9:35 am - 9:45 amDiscussion
9:45 am - 10:05 amPoster Talk: Yoko Chiba (University of Tokyo, Japan)
"A novel phosphoserine phosphatase to produce C1 precursors discovered in Hydrogenobacter"
10:05 am - 10:15 amDiscussion
10:15 amGroup Photo / Coffee Break
10:45 am - 11:10 amSung Gyun Kang (University of Science and Technology, Daejeon, Korea)
"One-carbon metabolism in a hyperthermophilic archaeon, Thermococcus onnurineus NA1"
11:10 am - 11:20 amDiscussion
11:20 am - 11:45 amWilliam Whitman (University of Georgia, Athens, USA)
"Pathway of methanethiol formation from dimethylsulfoniopropionate"
11:45 am - 11:55 amDiscussion
11:55 am - 12:20 pmJoseph Krzycki (Ohio State University, Columbus, USA)
"Biosynthesis of pyrrolysine, the 'one-carbon' amino acid"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMethanotrophs in oxic environments
7:30 pm - 7:40 pmDiscussion Leader: Nicole Dubilier (Max-Planck-Institute for marine Microbiology, Bremen, Germany)
7:40 pm - 8:05 pmColin Murrell (University of East Anglia, UK)
"Carbon metabolism in facultative methanotrophs"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmJeremy Semrau (University of Michigan, Ann Arbor, USA)
"The copper switch in methanotrophs: What is the role of methanobactin?"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmMarina Kalyuzhnaya (University of Washington, Seattle, USA)
"Global molecular analysis of methane oxidation: from a single cell to an ecosystem"
9:15 pm - 9:25 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMicrobial metabolism in anoxic environments
9:00 am - 9:10 amDiscussion Leader: Harold Drake (University of Bayreuth, Germany)
9:10 am - 9:35 amRon Oremland (US Geological Survey, Menlo Park, USA)
"Acetylene fermentation: Relevance to primordial biogeochemistry and the search for life in the outer solar system"
9:35 am - 9:45 amDiscussion
9:45 am - 10:05 amPoster Talk: Yahai Lu (China Agricultural University, Beijing, China)
"Ecological and genomic features of rice cluster I methanogens"
10:05 am - 10:15 amDiscussion
10:15 amCoffee Break
10:45 am - 11:10 amBernhard Schink (University of Konstanz, Germany)
"Syntrophic fatty acid oxidation in methanogenic degradation"
11:10 am - 11:20 amDiscussion
11:20 am - 11:45 amVicky Orphan (California Institute of Technology, Pasadena, USA)
"Metabolic versatility and structural diversity of multi-celled anaerobic methane-oxidizing consortia"
11:45 am - 11:55 amDiscussion
11:55 am - 12:20 pmSamantha Joye (University of Georgia, Athens, USA)
"Decoupling of anaerobic oxidation of methane and sulfate reduction at high methane concentration and high pressure"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmSystems perspectives
7:30 pm - 7:40 pmDiscussion Leader: Chris Marx (Harvard University, Boston, USA)
7:40 pm - 8:05 pmWilliam Metcalf (University of Illinois, Urbana, USA)
"Synthesis of methylphosphonic acid by marine microbes: a source of methane in the aerobic ocean"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmKathleen Scott (University of South Florida, Tampa, USA)
"How *do* you get that belly full of bicarbonate? Molecular mechanism of carbon concentration by a deep sea vent chemolithoauthotroph"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmDaniel Segrè (Boston University, USA)
"Mathematical models of metabolism in Methylobacterium extorquens: evolution, epistasis and symbiosis"
9:15 pm - 9:25 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmChemical and Synthetic Biology
9:00 am - 9:10 amDiscussion Leader: Sean Elliott (Boston University, USA)
9:10 am - 9:50 amKeynote Lecture: Pamela Silver (Harvard University, Boston, USA)
"Modularity and design of carbon fixation"
9:50 am - 10:05 amDiscussion
10:05 amCoffee Break
10:35 am - 10:55 amPoster Talk: Jan Zarzycki (DOE Joint Genome Institute, Walnut Creek, USA)
"Engineering a bypass to overcome the loss of carbon due to photorespiration in Cyanobacteria and plants"
10:55 am - 11:05 amDiscussion
11:05 am - 11:30 amTobias Erb (ETH Zürich, Switzerland)
"Understanding and engineering a reductive carboxylase"
11:30 am - 11:40 amDiscussion
11:40 am - 12:05 pmLance Seefeldt (Utah State University, Logan, USA)
"CO2 reduction to CH4 catalyzed by nitrogenase"
12:05 pm - 12:15 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmApplied systems
7:30 pm - 7:40 pmDiscussion Leader: Volker Müller (Goethe University Frankfurt, Germany)
7:40 pm - 8:05 pmAlfons Stams (University of Wageningen, The Netherlands)
"C1 compounds in thermophilic sulfur biotechnology"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:35 pmPoster Talk: Aaron Appel (Pacific Northwest National Laboratory, Richland, USA)
"Crudely imitating elegance: functional mimics for CO2 reduction and formate oxidation"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 9:10 pmMichael Köpke (LanzaTech, Auckland, New Zealand)
"Production of fuels and chemicals from industrial waste gases"
9:10 pm - 9:20 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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