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Muscle: Excitation-Contraction Coupling
Gordon Research Conference

Dates

June 3-8, 2012

Location

Les Diablerets Conference Center
Les Diablerets, Switzerland

Organizers

Chairs:
Francesco Zorzato & Paul D. Allen

Vice Chair:
Robert T. Dirksen

Meeting Description

The 2012 Gordon Conference on Muscle: Excitation/Contraction Coupling will present results of the latest research on the intricate processes that link excitation to contraction in skeletal and cardiac muscle as well as the disorders that result from their malfunction. The conference will emphasize the many multi-disciplinary approaches used to study this process, including structural biology, electron microscopy, biochemistry, biophysics, molecular genetics, cell physiology, and animal studies.

Invited speakers will discuss and evaluate critically new findings on (1) the structure of the molecular machinery underlying excitation-contraction coupling, (2) the rapid calcium signaling important for excitation-contraction coupling as well as the slower calcium signals that are important for regulating other processes in striated muscle, (3) the effects of human disease-causing mutations, fatigue and aging on excitation-contraction coupling (4) the roles of both the primary players and the accessory proteins of the triad junction in excitation-contraction coupling, (5) the role of calcium signaling in adaptation, and disease progression, and (6) the development and implementation of new methods to probe muscle excitation-contraction coupling and signaling.

In addition to the invited speakers, the organizing committee will select several poster presenters to give short talks during the formal sessions. The conference will stimulate discussions and will provide a forum that will give young and established investigators the opportunity to meet and interact and exchange their opinions on various topics of the meeting. By bridging basic science, translational and clinical studies related to the mechanism of muscle diseases, this meeting will foster new research directions and scientific collaborations moving the field forward into the future.

Contributors

Meeting Program

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmStructure and function of the calcium release unit
Discussion Leader: C. Franzini-Armostrong (Philadelphia, U.S.A.)
7:40 pm - 7:50 pmClara Franzini Armstrong: Introduction
7:50 pm - 8:10 pmJames D. Fessenden (Boston, U.S.A.)
"FRET-based structural measurements of full-length RyR1 expressed in cells"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:40 pmFilip Van Petegem (Vancouver, Canada)
"Crystallographic insights into the Ryanodine Receptor in native and diseased states"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:10 pmSimona Boncompagni (Chieti, Italy)
"Reciprocal positioning of CRU and mitochondria in vertebrate skeletal muscle: evolution and age dependence"
9:10 pm - 9:20 pmDiscussion
9:20 pm - 9:25 pmIsuru Jayasinghe (Brisbane, Australia)
"Three-dimensional analysis of ultrastructure and dynamic properties of the transverse tubular system in living mammalian and amphibian skeletal muscle fibres"
9:25 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSignal transduction via ryanodine receptor, dihydropiridine receptor
Discussion Leader: Bernhard Flucher (Innsbruck, Austria)
9:00 am - 9:10 amBernhard Flucher: Introduction
9:10 am - 9:30 amKurt Beam (Denver, U.S.A.)
"Where is the voltage sensor for EC coupling: Cav1.1 mutations strongly altering L-type channel gating affect EC coupling modestly or not at all"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amErick Hernandez-Ochoa (Baltimore, U.S.A.)
"S100A1 and Calmodulin modulation of voltage activated Ca2+ release"
10:00 am - 10:10 am Discussion
10:10 amCoffee Break
10:40 am - 11:00 amPeter Braubach (Ulm, Germany)
"Skeletal muscle alteration in poly-Q disease"
11:00 am - 11:10 amDiscussion
11:10 am - 11:30 amVincent Jacquemond (Lyon, France)
"Regulation of E-C coupling in voltage-clamped mammalian muscle fibers: role of phosphoinositides"
11:30 am - 11:40 amDiscussion
11:40 am - 12:00 pmManfred Grabner (Innsbruck, Austria)
"New insights into structure-function relationship of the DHPRβ1a subunit in skeletal muscle excitation-contraction coupling"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmPetronel Tuluc (Innsbruck, Austria)
"A single amino acid residue determines the characteristic Cav1.1 gating properties"
12:20 pm - 12:30 pm Discussion
12:30 pmGroup Photo / Lunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmSignaling via accessory proteins
Discussion Leader: Laszlo Csernoch (Debrecen, Hungary)
5:30 pm - 5:40 pmLaszlo Csernoch: Introduction
5:40 pm - 6:00 pmHiroshi Takeshima (Kyoto, Japan)
"TRIC channels supporting physiological Ca2+ release"
6:00 pm - 6:10 pmDiscussion
6:10 pm - 6:30 pmGraham Lamb (Latrobe, Australia)
"SR proteins involved in Ca2+ storage and release"
6:30 pm - 6:40 pmDiscussion
6:40 pm - 7:00 pmIsabelle Marty (Grenoble, France)
"Triadin and the calcium release complex"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:20 pmNicole Beard (Canberra, Australia)
"In vitro characterization of interactions between junctin and ryanodine receptor (RyR1/ RyR2)"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCardiac RyR in health and disease
Discussion Leader: Wayne Chen (Calgary, Canada)
9:00 am - 9:10 amWayne Chen: Introduction
9:10 am - 9:30 amAna Gomez (Montpellier, France)
"Calcium handling dysfunction in heart rythm anomalies"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amSpyros Zissimopoulos (Cardiff, U.K.)
"Arrhythmogenic interactions of the cardiac ryanodine receptor"
10:00 am - 10:10 am Discussion
10:10 amCoffee Break
10:40 am - 11:00 amAndriy Belevych (Columbus, U.S.A.)
"Refractoriness of intracellular Ca2+ release and arrhythmogenesis"
11:00 am - 11:10 amDiscussion
11:10 am - 11:30 amRebecca Sitsapesan (Bristol, UK)
"RyR2 gating control by FK-binding proteins and phosphorylation"
11:30 am - 11:40 amDiscussion
11:40 am - 12:00 pmSilvia Priori (Pavia, Italy)
"Arrhythmias in genetically mediated abnormalities of Ca++ regulation in the heart"
12:00 pm - 12.10 pmDiscussion
12:10 pm - 12:20 pmMarcel Egger (Bern, Switzerland)
"Calcium Release Events evoked by Photorelease of InsP3 in Mouse Atrial Myocytes"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmCardiac EC coupling
Discussion Leader: Hector Valdivia (Winsconsin, U.S.A.)
5:30 pm - 5:40 pmHector Valdivia: Introduction
5:40 pm - 6:00 pmKarin Sipido (Leuven, Belgium)
"Synchrony of sarcoplasmic reticulum calcium release in cardiac myocytes"
6:00 pm - 6:10 pmDiscussion
6:10 pm - 6:30 pmNina Ullrich (Bern, Switzerland)
"PKA-phosphorylation of RyR2: β-stimulation for better synchronization"
6:30 pm - 6:40 pmDiscussion
6:40 pm - 7:00 pmHenry M. Colecraft (New York, U.S.A.)
"Molecular regulation of cardiac L-type calcium channels"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:20 pmDirk Gillespie (Chicago, U.S.A.)
"Pernicious attrition: A novel inter-RyR CICR termination mechanism"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMuscle fatigue, ageing and repair
Discussion Leader: Christopher W. Ward (Baltimore, U.S.A.)
9:00 am - 9:10 amChristopher W. Ward: Introduction
9:10 am - 9:30 amOsvaldo Delbono (Winston-Salem, U.S.A)
"Role of Nuclear Troponin T in Aging Skeletal Muscle"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amJianjie Ma (Piscataway, U.S.A.)
"Elucidating the molecular mechanism for cell membrane repair and its application in muscle diseases"
10:00 am - 10:10 am Discussion
10:10 amCoffee Break
10:40 am - 11:00 amHakan Westerblad (Stockholm, Sweden)
"Ca2+, mitochondria and fatigue"
11:00 am - 11:10 amDiscussion
11:10 am - 11:30 amOliver Friedrick (Erlanger, Germany)
"Second harmonic generation microscopy: a novel quantitative morphometry approach to monitor tissue remodeling in dystrophic mdx muscle during aging"
11:30 am - 11:40 amDiscussion
11:40 am - 12:00 pmDavid Allen (Sydney, Australia)
"Mechanisms of muscle fatigue in blood-perfused mouse muscle"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmMariana Casas (Santiago, Chile)
"Cav1.1 controls frequency-dependent molecular events implicated in adult skeletal muscle plasticity"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmRyanodine receptor calcium release channel regulation: the RNS/ROS connection
Discussion Leader: Gerhard Meissner (Chapel Hill, U.S.A.)
5:30 pm - 5:40 pmGerhard Meissner: Introduction
5:40 pm - 6:00 pmPaulina Donoso (Santiago, Chile)
"Redox modulation of cardiac RyR2 activity"
6:00 pm - 6:10 pmDiscussion
6:10 pm - 6:30 pmIsaac N. Pessah (Davis, U.S.A.)
"Regulation of ryanodine receptors by reactive lipid species"
6:30 pm - 6:40 pmDiscussion
6:40 pm - 7:00 pmGeorge G. Rodney (Houston, U.S.A.)
"Site specific detection of ROS generation in skeletal muscle"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:20 pmBenjamin Prosser (Baltimore, U.S.A.)
"Stretch-dependent 'X-ROS' signaling in heart"
7:20 pm - 7:30 pmDiscussion
7:30 pm - 8:00 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmExcitation Contraction coupling macromolecular complex related disorders: from molecules to clinical trials
Discussion Leader: Francesco Muntoni (London U.K.)
9:00 am - 9:10 amFrancesco Muntoni (London U.K.): Introduction
9:10 am - 9:30 amBjorn C. Knollmann (Nashville, U.S.A.)
"The Calcium Release Unit as Therapeutic Target in Arrhythmia - from Mice to Man"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amDaniel Andersson (Stockholm, Sweden)
"Role of leaky ryanodine receptors in sarcopenia and muscular dystrophy"
10:00 am - 10:10 am Discussion
10:10 amCoffee Break
10:40 am - 11:00 amHeinz Jungbluth (London, U.K.)
"Beyond Central Core Disease and Malignant Hyperthermia - the expanding spectrum of RYR1-related disorders"
11:00 am - 11:10 amDiscussion
11:10 am - 11:30 amSteve Cannon (Dallas, U.S.A.)
"Hypokalemic Periodic Paralysis in a Mouse with the CaV1.1-R528H Mutation"
11:30 am - 11:40 amDiscussion
11:40 am - 12:00 pmSusan Hamilton (Houston, U.S.A.)
"The Role of Ca2+ influx via CaV1.1 in Muscle function"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmDerek Laver (Newcastle, Australia)
"Regulation Of Human Ryr2 By Intracellular Ca2+ and Mg2+"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmRound table: New tools to probe signaling in striated muscle
Discussion Leader: Eduardo Rios (Chicago, U.S.A.)
5:30 pm - 5:50 pmEduardo Rios (Chicago, U.S.A.)
"Insights on E-C coupling from novel tools for measuring [Ca2+] in cytosol and organelles"
5:50 pm - 6:00 pmDiscussion
6:00 pm - 6:20 pmHeping (Peace) Cheng (Beijing, China)
"Mitochondrial superoxide flashes in heart and skeletal muscles"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmJulio Vergara (Los Angeles, U.S.A.)
"Functional expression of transgenic proteins in adult skeletal muscle fibers"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmPhillip Sasse (Bonn, Germany)
"Exciting Light: Optogenetics in Muscle Physiology"
7:30 pm - 7:30 pmDiscussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by (I1 R13AR062438-01) from NIAMS. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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