Gordon Research Conferences
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Conference Program
 
Neural Development
August 12-17, 2012
Salve Regina University
Newport, RI
Chair:
Franck Polleux

Vice Chair:
Fiona Doetsch

The 2012 Gordon Conference on Neural Development in Newport, Rhode Island, will bring together a unique and international group of scientists with the common research goal of exploring the molecular, cellular and functional basis of brain development. Invited speakers will present cutting-edge research on topics ranging from brain patterning, neural stem cells, cell fate specification, neuronal migration and polarity, synaptic development, circuit development to new insights into human brain development and evolution. Each talk will be followed by discussions in which students and postdocs are especially encouraged to participate. The meeting will highlight the diversity of experimental approaches and model systems (e.g. mammals, zebrafish, C. elegans, Drosophila) that have led to major breakthroughs in the field. Recent technical achievements in molecular genetics and in vivo imaging relevant to research in neural development will be discussed extensively. Poster sessions and informal gatherings will provide additional opportunities for informal interactions among junior and senior researchers, and foster collaborations and further discussion. Some short talks by participants will be selected from the poster abstracts. Informal mentoring workshops for students, postdoctoral fellows and junior faculty will also be held on issues such as funding, obtaining independent positions, and publishing. Members of underrepresented minority groups are especially encouraged to attend.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKEYNOTE LECTURES
Discussion Leader: Franck Polleux
7:40 pm - 8:20 pm Huda Zoghbi (Baylor Medical College, HHMI)
"What I have learned about Neurodevelopment Studying Humans and Model Organisms"
8:20 pm - 8:35 pm Discussion
8:35 pm - 9:15 pm David Ginty (Johns Hopkins University, HHMI)
"The development and organization of neurons that underlie the sense of touch"
9:15 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNEUROGENESIS AND BRAIN PATTERNING
Discussion Leader: Fiona Doetsch
9:00 am - 9:20 am Wieland Huttner (Max Planck Institute Dresden)
"Neural stem and progenitor cells and the evolution of the cerebral cortex"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Songhai Shi (Sloan Kettering Institute NY)
"Lineage-dependent functional development of the neocortex"
9:50 am - 10:00 am Discussion
10:00 am - 10:30 am Group Photo / Coffee Break
10:30 am - 10:50 am Andrea Brand (MRC Univ. Cambridge, UK)
"Nutrient control of neural stem cells"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Kenneth Campbell (Cincinnati Children's Research Foundation)
"Spatial and temporal roles of Gsx genes in the specification of telencephalic cell fates"
11:20 am - 11:30 am Discussion
11:30 am - 11:45 am Maria Lehtinen (Children's Hospital at Harvard)
"Instructive cues for neural stem cells in the cerebrospinal fluid"
11:45 am - 11:50 am Discussion
11:50 am - 12:05 pm Santos Franco (The Scripps Research Institute)
"A Lineage of Radial Glial Cells Fated to Generate Upper Layer Neurons"
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm Zhen Huang (Univ. Wisconsin)
"Radial Glia regulate nascent brain vascular network stabilization via inhibition of Wnt signaling"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 1
6:00 pmDinner
7:30 pm - 9:30 pmCELL TYPE SPECIFICATION
Discussion Leader: Andrea Brand
7:30 pm - 7:50 pm Marc Freeman (Univ. Mass. - HHMI)
"Neuron-glia signaling during astrocyte development"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Paola Arlotta (Harvard Med. School)
"Molecular development of projection neuron subtypes in the neocortex"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Hynek Wichterle (Columbia Univ.)
"Transcriptional logic of motor neuron programming"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Soo-Kyung Lee (Oregon Health Medical)
"Gene networks governing cholinergic neuronal identity in vertebrate CNS"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNEURAL STEM CELLS
Discussion Leader: Hynek Wichterle
9:00 am - 9:20 am Yoshiki Sasai (Riken Kobe, Japan)
"Self-organization of neural structures in 3D ES cell culture"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Stewart Anderson (Cornell Univ.)
"Studying synaptogenesis onto and by human forebrain GABAergic interneurons"
9:50 am - 10:00 am Discussion
10:00 am - 10:30 am Coffee Break
10:30 am - 10:50 am Pierre Vanderhaeghen (ULB/IRIBHM)
"Mechanisms of specification of cortical neurons, from mouse to man"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Guo-li Ming (Johns Hopkins Univ.)
"Regulation of neuronal development by risk genes for mental disorders, from mice to humans"
11:20 am - 11:30 am Discussion
11:30 am - 11:45 am Yutaka Yoshida (Cincinnati Children's Research Foundation)
"Molecular mechanisms underlying circuit development in the spinal cord"
11:45 am - 11:50 am Discussion
11:50 am - 12:05 pm Yasushi Nakagawa (Univ. Minnesota)
"Afferent control of neocortical development in mice"
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm Bassem Hassan (VIB Leuven)
"Stochastic mechanisms in the generation of stereotyped brain maps"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 2
6:00 pmDinner
7:30 pm - 9:30 pmNEURONAL MIGRATION AND MORPHOGENESIS
Discussion Leader: Marc Freeman
7:30 pm - 7:50 pm Oscar Marin (Alicante, Spain)
"Mechanisms of neuronal migration in the cerebral cortex"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Francois Guillemot (MRC Mill Hill, UK)
"Transcriptional and post-transcriptional regulation of neurogenesis in the adult hippocampus"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Kang Shen (Stanford Univ. HHMI)
"Cellular and molecular mechanisms for synaptic partner selection in vivo"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:15 pm Goichi Miyoshi (NYU)
"Prox1 regulates the migration and maturation of caudal ganglionic eminence-derived cortical interneurons"
9:15 pm - 9:20 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmWIRING THE NERVOUS SYSTEM I
Discussion Leader: Guo-li Ming
9:00 am - 9:20 am Maya Shelly (Stony Brook NY)
"Molecular mechanisms underlying neuronal polarization"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am William Harris (Cambridge Univ. UK)
"The polarization of neurons in the zebrafish retina"
9:50 am - 10:00 am Discussion
10:00 am - 10:30 am Coffee Break
10:30 am - 10:50 am Dietmar Schmucker (VIB Leuven)
"Novel molecular pathways underlying specificity of axon branching and connectivity in CNS development"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Christine Holt (Cambridge UK)
"Role of axonal translation in patterning visual connections"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am Artur Kania (McGill University)
"Netrin-ephrin synergy in motor axon guidance"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pm Wes Grueber (Columbia Univ.)
"Dendritic morphogenesis in Drosophila"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 3
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmWIRING THE NERVOUS SYSTEM II
Chair: Cagla Eroglu
7:30 pm - 7:50 pm Josh Sanes (Harvard Univ.)
"Laminar and lateral specificity in the retina"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Linda Van Aelst (CSHL)
"Rho regulators in neuronal development and disease"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Andrew Huberman (UCSD)
"Wiring visual circuits to perform specific functions"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Alex Kolodkin (Johns Hopkins Univ., HHMI)
"Molecular mechanisms underlying the establishment of neural connectivity"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSYNAPTOGENESIS AND CIRCUIT FORMATION
Discussion Leader: Kang Shen
9:00 am - 9:20 am Silvia Arber (FMI Basel)
"Organizational principles of antagonistic motor circuits"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Kim McAllister (UC Davis)
"Novel roles for immune molecules in cortical development"
9:50 am - 10:00 am Discussion
10:00 am - 10:30 am Coffee Break
10:30 am - 10:50 am Cagla Eroglu (Duke University)
"How do astrocytes control synaptic development?"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Joshua Corbin (Children's National Med. Center, Washington DC)
"Embryonic patterning mechanisms for the establishment of limbic system circuitry and innate behaviors"
11:20 am - 11:30 am Discussion
11:30 am - 11:45 am Julien Spatazza (College de France, Paris- France)
"Otx2 homeoprotein transcrition factor regulates plasticity in the adult mouse visual cortex"
11:45 am - 11:50 am Discussion
11:50 am - 12:05 pm Dorothy Schafer (Harvard Medical School)
"Microglia and the complement cascade: Shaping neural circuits in the developing brain"
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm Tudor Badea (NIH)
"Molecular Genetics of Retinal Ganglion Cell Type Differentiation"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 4
6:00 pmDinner
7:30 pm - 9:30 pmHUMAN BRAIN EVOLUTION
Discussion Leader: Pierre Vanderhaeghen
7:30 pm - 7:50 pm Evan Eichler (Univ. Washington, HHMI)
"Genome structural variation, neurocognitive disease and evolution"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:15 pm Kaumudi Joshi (The Scripps Research Institute)
"Role of human-specific gene duplications during brain development"
8:15 pm - 8:20 pm Discussion
8:20 pm - 8:35 pm Kenneth Kwan (Yale University)
"Species-Dependent Post-transcriptional Regulation in the Developing Neocortex"
8:35 pm - 8:40 pm Discussion
8:40 pm - 9:00 pm Arnold Kriegstein (UCSF)
"New insights into neural stem and progenitor cells in human cortical development and evolution"
9:00 pm - 9:10 pm Discussion
9:10 pm - 9:20 pm Concluding Remarks
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

The project described was supported by Grant Number R13NS078923 from the National Institute of Neurological Disorders And Stroke. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Neurological Disorders And Stroke or the National Institutes of Health.

 
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