Gordon Research Conferences
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Conference Program
 
Oxygen Radicals
February 5-10, 2012
Ventura Beach Marriott
Ventura, CA

The "Oxygen Radicals" conference is designed to provide chemists, biologists, biochemists, cell biologists, clinicians, and other biomedical scientists with state-of-the-art knowledge on reactive oxygen species in the context of human pathophysiology. This encompasses the more traditional areas of oxidative damage and antioxidants, but also incorporates the growing importance of oxidant-mediated redox signaling through the reactions of oxidants with cellular signaling pathways. This research conference is held every two years and fifteen have been held since 1981. These meetings have proven to be extremely productive based on the large number of applicants and the strong post-meeting evaluations. The sessions for the upcoming meeting include: Redox modulation of Cardiovascular Pathology, Novel Detection Strategies for Reactive Oxygen Species, Mass spectrometry: A new view of the redox universe, Mitochondria: A redox organelle, Heme proteins and reactive nitrogen species, Redox processes in Cancer biology. The invited speakers represent current and future leaders in free radical research in pulmonary, cardiovascular disease and inflammation and toxicology. Additionally, there are 11 speaker slots reserved for selected abstract presentations. An honorary lecture at the end of the conference is presented by outstanding long term investigator in the field, and past-president of the Society of Free Radical Biology and Medicine, Professor Victor Darley-Usmar. Two separate poster sessions of two days each are also scheduled.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmNew Signaling Paradigms in Redox Biology
Discussion Leader: Victor Darley-Usmar
7:40 pm - 8:10 pm Bruce Freeman (University of Pittsburgh)
"Redox-derived anti-inflammatory signaling mediators"
8:10 pm - 8:30 pm Discussion
8:30 pm - 9:00 pm Michael Marletta (University of California, Berkeley)
"Building Receptors for Selective Responses to NO and O2: Nature's Way"
9:00 pm - 9:20 pm Discussion
9:20 pm - 9:30 pm General Discussion
9:30 pm - 11:30 pm Reception
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmOxygen Radicals in Cardiovascular Disease
Discussion Leaders: Francisco Schopfer and Mark Gladwin
9:00 am - 9:05 am Announcements and Chair's Introductory Remarks
9:05 am - 9:25 am John Keaney (University of Massachusetts Medical School)
"Redox control of vascular homeostasis"
9:25 am - 9:35 am Discussion
9:35 am - 9:55 am David Gutterman (Medical College Wisconsin)
"Role of Reactive Oxygen Species in Physiological Regulation of the Human Coronary Microcirculation"
9:55 am - 10:05 am Discussion
10:05 am - 10:25 am Richard Cohen (Boston University)
"Oxidative post-translational protein modifications in cardiovascular pathophysiology"
10:25 am - 10:35 am Discussion
10:35 am - 11:05 am Discussion
11:05 am - 11:25 am Stan Hazen (Cleveland Clinic)
"ApoA1 Oxidation and formation of dysfunctional HDL: Structural, functional and clinical studies"
11:25 am - 11:35 am Discussion
11:35 am - 11:55 am Tom McIntyre (Cleveland Clinic)
"Oxidatively Truncated Phospholipids Connect TNFa to Apoptosis"
11:55 am - 12:05 pm Discussion
12:05 pm - 12:20 pm Emilia Kansanan (University of Eastern Finland)
12:20 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmProbes for Detection of ROS
Discussion Leaders: Ginger Milne and Richard Cohen
7:30 pm - 7:50 pm Christopher Chang (Howard Hughes Medical Institute, Berkeley)
"Molecular imaging approaches to studying peroxide biology in living cells and animals"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Balaraman Kalyanaraman (Medical College Wisconsin)
"Real-time monitoring of ROS/RNS in cells: a dream or reality?"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Tobias Dick (German Cancer Research Center, Heidelberg)
"Novel pathways of regulatory protein thiol oxidation"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:10 pm Maolin Guo (University of Massachusetts)
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:30 pm General Discussion
9:30 pm - 11:30 pm Reception
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMass Spectrometry Applications in Oxygen Radical Research
Discussion Leaders: Tom McIntyre and Stan Hazen
9:00 am - 9:05 am Announcements and Chair's Introductory Remarks
9:05 am - 9:25 am Ginger Milne (Vanderbilt University)
"Quantification of Urinary Eicosanoid Metabolites: Technical Considerations and Clinical Utility"
9:25 am - 9:35 am Discussion
9:35 am - 9:55 am Robert Murphy (University of Colorado, Denver)
"Diversity and Implication of Oxidized Cholesterol Ester Molecular Species in Human Atherosclerotic Plaques"
9:55 am - 10:05 am Discussion
10:05 am - 10:25 am Francisco Schopfer (University of Pittsburgh)
"Formation and signaling of omega-3 fatty acid-derived electrophiles in inflammation"
10:25 am - 10:35 am Discussion
10:35 am - 11:05 am Coffee Break
11:05 am - 11:25 am Harry Ischiropoulos (University of Pennsylvania)
"Structural and functional diversity of protein S-nitrosocysteine residues"
11:25 am - 11:35 am Discussion
11:35 am - 11:55 am Ian Blair (University of Pennsylvania)
"Mitochondrial oxidative stress"
11:55 am - 12:05 pm Discussion
12:05 pm - 12:20 pm Molly Sheehan (University of Pennsylvania School of Medicine)
12:20 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmMitochondria: A redox organelle
Discussion Leaders: Rakesh Patel and Ana Denicola
7:30 pm - 7:50 pm Irfan Rahman (University of Rochester)
"Oxidative stress and epigenetic events in inflammation and pulmonary diseases"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Navdeep Chandel (Northwestern University)
"Mitochondrial ROS regulate signaling"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:45 pm Anne Diers (Medical College of Wisconsin)
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:10 pm Jianhua Zhang (University of Alabama)
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:30 pm General Discussion
9:30 pm - 11:30 pm Reception
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHeme Proteins and Reactive Nitrogen Species
Discussion Leaders: Tony Kettle and Eddie Weitzberg
9:00 am - 9:05 am Announcements and Chair's Introductory Remarks
9:05 am - 9:25 am Eddie Weitzberg (Karolinska Institute, Sweden)
"Dietary nitrate: Nutritional, therapeutic and physiological implications"
9:25 am - 9:35 am Discussion
9:35 am - 9:55 am Rakesh Patel (University of Alabama at Birmingham)
"Modulation of vascular inflammation by the red blood cell"
9:55 am - 10:05 am Discussion
10:05 am - 10:15 amWillem Koppenol (Swiss Federal Institute of Technology)
10:15 am - 10:25 am Discussion
10:25 am - 10:55 am Coffee Break
10:55 am - 11:15 am Mark Gladwin (University of Pittsburgh)
"Functional properties of neuroglobin as a allosteric-redox regulated nitrite reductase"
11:15 am - 11:25 am Discussion
11:25 am - 11:45 am Olivier Boutaud (Vanderbilt University)
"Acetaminophen and hemoprotein redox cycling: new tricks for an old drug"
11:45 am - 11:55 am Discussion
11:55 am - 12:05 pm Michael Davis (Heart Research Institute, Sydney)
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:20 pm Chang Chen (Chinese Academy of Science, Beijing)
12:20 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmCancer
Discussion Leaders: Ian Blair and Navdeep Chandel
7:30 pm - 7:50 pm Greg Thatcher (University of Illinois)
"Targeting quinone-derived ROS to the nucleus: conflicting roles in estrogen carcinogenesis and in cancer therapy"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Daret St. Clair (University of Kentucky)
"Oxidative Stress Mediated Retrograde Signaling"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm J. Andres Melendez (Universtiy of Albany)
"Redox-signaling and control of cellular senescence"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:10 pm Albert Girotti (Medical College of Wisconsin)
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:30 pm General Discussion
9:30 pm - 11:30 pm Reception
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmOxidative Stress and Disease
Discussion Leaders: Bruce Freeman and Andres Melendez
9:00 am - 9:05 am Announcements and Chair's Introductory Remarks
9:05 am - 9:25 am Ana Denicola (University of the Republic, Montevideo)
"On the reactivity of peroxiredoxin with peroxides"
9:25 am - 9:35 am Discussion
9:35 am - 9:55 am Yvonne Jannsen-Heininger (University of Vermont)
"Glutaredoxin controlled cysteine oxidation of the death receptor Fas: Role in tissue fibrosis"
9:55 am - 10:05 am Discussion
10:05 am - 10:15 Ohara Augusto (University of Sao Paulo)
10:15 am - 10:25 am Discussion
10:25 am - 10:55 am Coffee Break
10:55 am - 11:15 am Tony Kettle (University of Otago, New Zealand)
"The Superiority of Superoxide as a Reactive Oxygen Species"
11:15 am - 11:25 am Discussion
11:25 am - 11:40 am Erin Heckler (University of Medicine and Dentistry of New Jersey)
11:40 am - 11:45 am Discussion
11:45 am - 12:00 pm William Willmore (Carleton University
12:00 pm - 12:05 pm Discussion
12:05 pm - 12:20 pm Hang Zhao (NHLBI )
12:20 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Session
Discussion Leaders: Valerie O'Donnell and Neil Hogg
7:30 pm - 8:00 pm Closing Remarks and Keynote Speaker Introduction
8:00 pm - 8:45 pm Keynote Lecture: Victor Darley-Usmar (University of Alabama at Birmingham)
"Putting the Bio into Energetics; The Emerging Role of Mitochondria in Health and Disease"
8:45 pm - 9:15 pm Discussion
9:30 pm - 11:30 pm Reception
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13HL112480-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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