| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Late Breaking Science |
| Discussion Leaders: Jerry Turnbull (University of Liverpool) and Renato Iozzo (Thomas Jefferson) |
| 7:40 pm - 8:20 pm | Dan Leahy (Johns Hopkins University)
"The pervasive role of proteoglycans in hedgehog signaling"
|
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | James Fawcett (Kings College Cambridge)
"Glycosaminoglycans and protein interactions in perineuronal nets - regulation of synaptic plasticity"
|
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Anthony J. Day (University of Manchester)
"Crystal structure of heavy chain 1 (HC1) from human inter-alpha-inhibitor (IaI)"
|
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Biosynthesis and Catabolism |
| Discussion Leaders: Lena Kjellén (Uppsala University) and Marion Kusche-Gullberg (University of Bergen) |
| 9:00 am - 9:35 am | Hinke Multhaupt (University of Copenhagen)
"Specific localization of HS and CS biosynthesis enzymes within the Golgi compartment"
|
| 9:35 am - 9:50 am | Discussion |
| 9:50 am | Coffee Break |
| 10:20 am - 10:40 am | Paul DeAngelis (University of Oklahoma Medical Center)
"Domain structures in HS glycosaminoglycans"
|
| 10:40 am - 10:50 am | Discussion |
| 10:50 am - 11:25 am | Jian Liu (University of North Carolina)
"Recent success of the use of biosynthetic enzymes for the in vitro preparation of glycosaminoglycans and domain structure in HS"
|
| 11:25 am - 11:40 am | Discussion |
| 11:40 am - 12:00 pm | Johan Ledin (University of Uppsala)
"Proteoglycans in zebra fish"
|
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:17 pm | David Vigetti (University of Insubria)
"Role of protein O-GlcNAcylation in the control of glycosaminoglycan synthesis in human smooth muscle cells"
|
| 12:17 pm - 12:20 pm | Discussion |
| 12:20 pm - 12:27 pm | Joanne Tobacman (University of Illinois at Chicago)
"Transcriptional effects of arylsulfatase B mediated through changes in chondroitin-4-sulfation and nuclear galectin-3" |
| 12:27 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Developmental Biology |
| Discussion Leaders: Joe Yost (University of Utah) and Hiroshi Nakato (University of Minnesota) |
| 7:30 pm - 8:10 pm | Bradley Olwin (University of Colorado)
"Syndecan-3 in muscular development, regeneration, and disease"
|
| 8:10 pm - 8:30 pm | Discussion |
| 8:30 pm - 9:10 pm | Christine B. Kern (Medical University of South Carolina)
"Extracellular matrix (ECM) during cardiovascular development"
|
| 9:10 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Structure/Analysis/Glycomics |
| Discussion Leaders: Barbara Mulloy (National Institute for Biological Standards and Control) and Joseph Zaia (Boston University) |
| 9:00 am - 9:35 am | Jon Amster (University of Georgia)
"Advances in mass spectrometry allowing for the sequencing of intact glycosaminoglycan chains"
|
| 9:35 am - 9:50 am | Discussion |
| 9:50 am | Coffee Break |
| 10:20 am - 10:55 am | Cindy Larive (University of California, Riverside)
"NMR for the analysis of glycosaminoglycans"
|
| 10:55 am - 11:10 am | Discussion |
| 11:10 am - 11:30 am | Matt Nugent (Boston University Medical School)
"Computational studies on proteoglycans"
|
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 12:00 pm | Kazuyuki Sugahara (Hokkaido University)
"Characterization of a receptor for glycosaminoglycans that mediate experimental lung
metastasis"
|
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:17 pm | Xiaofeng Shi (Boston University School of Medicine)
"Characterization of incorporation of 34S into glycosaminoglycan chains by sulfotransferases"
|
| 12:17 pm - 12:20 pm | Discussion |
| 12:20 pm - 12:27 pm | Jeremy E. Turnbull (University of Liverpool)
"Synthesis of a targeted library of heparan sulfate hexa- to dodeca-saccharides as inhibitors of β-secretase: potential therapeutics for Alzheimer's disease"
|
| 12:27 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Signaling and the Interactome |
| Discussion Leaders: Pascal Zimmerman (Katholieke Universiteit) and David Fernig (University of Liverpool) |
| 7:30 pm - 7:55 pm | Alan Rapraeger (University of Wisconsin)
"Syndecan-coupled signaling complexes and their disruption by synstatins"
|
| 7:55 pm - 8:05 pm | Discussion |
| 8:30 pm - 8:40 pm | A. Radu Aricescu (University of Oxford)
"Proteoglycan-specific molecular switch for cell surface signaling"
|
| 8:40 pm - 9:30 pm | Discussion |
| 8:40 pm - 9:30 pm | Guido David (Catholic University of Leuven)
"Syndecan-syntenin-Alix regulate the biogenesis of exosomes"
|
| 8:40 pm - 9:30 pm | Discussion |
| 8:40 pm - 9:30 pm | Mary Cowman (Polytechnic Institute of New York University)
"Hyaluronan Interactions with Proteins: Binding vs. Repulsive Crowding"
|
| 8:40 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Cancer |
| Discussion Leaders: Ralph Sanderson (University of Alabama at Birmingham) and Alan Rapraeger (University of Wisconsin) |
| 9:00 am - 9:30 am | Steve Pals (University of Amsterdam)
"HS PGs in cancer"
|
| 9:30 am - 9:45 am | Discussion |
| 9:45 am - 10:05 am | Michael Elkin (Hadassah-Hebrew University Medical Center)
"Heparanase and cancer"
|
| 10:05 am - 10:15 am | Discussion |
| 10:15 am | Coffee Break |
| 10:45 am - 11:15 am | Nikos Karamanos (University of Patras)
"Glycosaminoglycans in cancer and therapeutics"
|
| 11:15 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Joanna Phillips (UCSF)
"HSulf in gliomas"
|
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:07 pm | Juliana Dreyfuss (Federal University of Sao Paulo - UNIFESP)
"Paracrine regulation of endothelial cells on tumor biology: proteoglycans as key players"
|
| 12:07 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:17 pm | John Couchman (University of Copenhagen)
"Syndecan-4 and its heparan sulfate are regulators of invadopodia function and breast carcinoma invasion"
|
| 12:17 pm - 12:20 pm | Discussion |
| 12:20 pm - 12:27 pm | Angélica Gomes (Lawence Berkeley National Laboratory)
"Shedding light on the role of heparanase during mammary ductal branching morphogenesis"
|
| 12:27 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
| 7:30 pm - 9:30 pm | Neural, Muscular and Skeletal Diseases |
| Discussion Leaders: Yu Yamaguchi (Sanford-Burnham Medical Research Institute) and Dick Heinegard (Lund University) |
| 7:30 pm - 8:00 pm | Laurie McCauley (University of Michigan)
"Knockout mice show proteoglycan 4 is involved in skeletal formation"
|
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:30 pm | Alan Grodzinsky (MIT)
"Aggrecan structural differences over age as well as on interactions using AFM and other techniques"
|
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:00 pm | Yu Yamaguchi (Sanford-Burnham Medical Research Institute)
"Proteoglycans in autism and epileptic seizures of Has KO mice"
|
| 9:00 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:17 pm | Linda Troeberg (Kennedy Institute of Rheumatology)
"Sulfated glycosaminoglycans of the cartilage extracellular matrix can regulate the levels and activity of the chondroprotective metalloproteinase inhibitor, TIMP-3"
|
| 9:17 pm - 9:20 pm | Discussion |
| 9:20 pm - 9:27 pm | Anders Malmström (Lund University)
"Dermatan sulfate epimerase 1 and 2 and double 1/2 deficient mice as models to study the functions of dermatan sulfate in the body"
|
| 9:27 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Stem Cells and Regenerative Medicine |
| Discussion Leaders: Lola Reid (University of North Carolina) and Jennifer Elisseeff (Johns Hopkins University) |
| 9:00 am - 9:30 am | Cathy Merry (University of Manchester)
"Stem cell glyco-niche"
|
| 9:30 am - 9:45 am | Discussion |
| 9:45 am - 10:05 am | Bruce Caterson (University of Cardiff)
"CS/DS Glycosaminoglycan expression in the Stem/Progenitor cell niche"
|
| 10:05 am - 10:15 am | Discussion |
| 10:15 am | Coffee Break |
| 10:45 am - 11:15 am | Xingbin Ai (Boston University Medical School)
"Heparin sulfate sulfs in the regulation of stem cell function and aging"
|
| 11:15 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Alison Nairn (University of Georgia)
"Stem cell glycosaminoglycanomics"
|
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:07 pm | Addolorata Pisconti (University of Colorado at Boulder)
"Syndecan-3 defines the muscle stem cell niche and its role in controlling muscle regenerative potential"
|
| 12:07 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:17 pm | Donna Tillotson (University of Manchester)
"Glyconanotubes to direct stem cell behavior"
|
| 12:17 pm - 12:20 pm | Discussion |
| 12:20 pm - 12:27 pm | Lianchun Wang (University of Georgia)
"Heparan sulfate facilitates FGF and BMP signaling to drive mesoderm differentiation of mouse embryonic stem cells"
|
| 12:27 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Poster Awards
Leader: Nick Shworak (Conference Vice Chair)
|
| 7:40 pm - 9:30 pm | Cardiovascular and Inflammation |
| Discussion Leaders: Nick Shworak (Dartmouth Medical School) and Pyong Park (Harvard Medical School) |
| 7:40 pm - 8:05 pm | Paul Noble (Duke University)
"Role of hyaluronan and syndecans in immune modulation in chronic lung disease"
|
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:40 pm | Renato Iozzo (Thomas Jefferson)
"Endorepelin in angiogenesis - a new anti-angiogenic mechanism-dual receptor antagonism"
|
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:05 pm | David Birk (University of South Florida)
"SLRPs in matrix assembly"
|
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Liliana Schaefer (University of Frankfurt)
"Proteoglycans in innate immunity"
|
| 9:25 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |