The 2012 Gordon Research Conference on Protein Folding Dynamics will bring together experimentalists and theoreticians to discuss basic issues in protein folding dynamics and their role in a number of applications. It has become increasingly clear that understanding the basic aspects of Protein Folding Dynamics is crucial in describing virtually all processes ranging from transcription to motility of motors and diseases related to misfolding. In order to solve the fundamental problems protein folding and dynamics it has been recognized that a multifaceted approach that incorporates developments in singe molecule methods, advances in theory and simulations, and the more traditional techniques such as NMR and ensemble methods is needed. Recent advances both in theory and experiments now demand a more quantitative approach in this vital area of research, and have made it necessary for discussions between theorists and experimentalists. To explore the most recent exciting developments the conference will bring together diverse background to assemble in a forum that will encourage open discussions. The meeting will bring together scientists with expertise in chemistry, physics, and biology to share the latest developments in theory and experiments. The Gordon Research Conference in Protein Folding Dynamics was established specifically to bring experiment and theory together to explore advances in the field. The program will cover a range of topics, not restricted to, in vitro and in vivo folding, protein aggregation, and functional role of protein dynamics with implications for transcription and molecular motors. The conference will strive to encourage interactions between junior scientists and graduate students by including a few of them to present their work through abstract-selected presentations and posters. Graduate students and post-doctoral fellows are encouraged to attend the accompanying Gordon Research Seminar in Protein Folding Dynamics which will include an overview of the field as well as an opportunity to present research results.