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Conference Program
 
Reprogramming Cell Fate
February 26 - March 2, 2012
Hotel Galvez
Galveston, TX

The 2012 Gordon Conference on "Reprogramming Cell Fate" will present cutting-edge research on the molecular and cellular aspects of reprogramming to pluripotency and lineage conversion and applications of reprogrammed cells. Somatic cell nuclear transfer (or cloning) showed that somatic nuclei can be reprogrammed to a primitive state to generate new embryos. Many groups focus on the mechanisms by which the donor nucleus is reprogrammed in the recipient ovum to understand pluripotency. Recently, it was shown that forced expression of key transcription factors that are important for maintaining pluripotent stem cells can cause somatic cells to be reprogrammed to a pluripotent state. Now known as induced pluripotency, this method has tremendous potential to be applied for patient-specific stem cell therapies and disease studies and thus garners extraordinary attention. More recently, several groups have shown that expression of various combinations of transcription factors can reprogram somatic cells directly to alternative somatic fates directly, without passing through a pluripotent intermediate. In the future, it will be important to reveal opportunities and limits of each of these reprogramming processes. Before any of these methods are applied in clinical settings, it is vital that the basic issues surrounding these various types of reprogrammed cells are settled. As these newly reprogrammed cells have only recently been generated, relatively little is known about their origins, their epigenetic state, their differentiation potential etc. This conference therefore is an ideal setting for discourse on not only mechanisms of reprogramming, but a detailed examination of reprogrammed cells, their developmental and functional potential, and the relevance of reprogramming to natural phenomena, and their clinical potential.

Our 2012 conference will be the first Gordon Conference on this topic and will be held at the beautiful Hotel Galvez. The Conference will bring together a collection of investigators who are at the forefront of the field, and will provide opportunities for junior scientists and graduate students to present their work in poster format and exchange ideas with leaders in the field. Some poster presenters will be selected for short talks. We hope that a collegial atmosphere, with defined discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, will provide an avenue for scientists from different disciplines to brainstorm and promote cross-disciplinary collaborations in the various research areas represented.

Confirmed speakers include Sir John Gurdon, Alex Meissner, Stephen Tapscott, Oliver Hobert, Hans Scholer, Joanna Wysocka, Marius Wernig, Andras Nagy, Lorenz Studer, Mick Bhatia, Jose Silva, Magdalena Goetz, Duanqing Pei, Ken Zaret, Azim Surani, Ricardo Dolmetsch, Ihor Lemischka, Hanna Mikkola, Joe Wu, Dino Morvinski, Flaminia Talos, Shila Mekhoubad, Jianlong Wang and Rupa Sridharan.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmIdentifying Mediators of Reprogramming
Discussion Leader: Kathrin Plath (UCLA)
7:40 pm - 8:20 pmSir John Gurdon (Gurdon Insitute)
"Reprogramming of mammalian nuclei in amphibian oocytes"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmJoanna Wysocka (Stanford University)
"Cross-talk between chromatin and cis-regulatory elements in pluripotency"
9:15 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmReprogramming the Germ Line
Discussion Leader: Ken Zaret (UPenn)
9:00 am - 9:40 amHans Scholer (Max Planck Institute)
"Induction of pluripotency by OCT4"
9:40 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 11:10 amAzim Surani (Gurdon Institute)
"Germ line, stem cells and reprogramming"
11:10 am - 11:30 amDiscussion
11:30 am - 12:10 pmOliver Hobert (Columbia University)
"Direct conversion of germ cells into specific neuron types"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGenetic/Epigenetic Mechanisms of Reprogramming
Discussion Leader: Ihor Lemischka (Mt. Sinai School of Medicine)
7:30 pm - 8:10 pmKen Zaret (University of Pennsylvania)
"Parameters affecting the initial genome occupancy by pluripotency factors in human somatic cells"
8:10 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmAlex Meissner (Harvard University)
"DNA methylation dynamics in stem cells and development"
9:10 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDirect Reprogramming Between Somatic Cell States
Discussion Leader: Bill Lowry (UCLA)
9:00 am - 9:40 amStephen Tapscott (Fred Hutchinson Cancer Research Center)
"Common and distinct mechanisms for myogenic and neurogenic conversion"
9:40 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 11:10 amHanna Mikkola (UCLA)
"Uncovering latent cardiogenic potential in hemogenic endothelium and endocardium"
11:10 am - 11:30 amDiscussion
11:30 am - 12:10 pmMick Bhatia (McMaster Stem Cell and Cancer Research Institute)
"Programming human hematopoietic progenitors"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMore Direct Reprogramming Between Somatic Cell States
Discussion Leader: Lorenz Studer (Sloan Kettering Memorial Cancer Institute)
7:30 pm - 8:10 pmMarius Wernig (Stanford University)
"Making neurons by crossing major lineage boundaries"
8:10 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmMagdalena Goetz (Ludwig-Maximilians-University Munich)
"A core program of neurogenesis and its role in direct neuronal reprogramming"
9:10 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmModeling Human Disease With Reprogrammed Cells
Discussion Leader: Andras Nagy (Samuel Lunenfeld Research Institute)
9:00 am - 9:40 amLorenz Studer (Memorial Sloan Kettering)
9:40 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 11:10 amRicardo Dolmetsch (Stanford University)
11:10 am - 11:30 amDiscussion
11:30 am - 12:10 pmJoe Wu (Stanford)
"Cardiac iPSCs for Modeling Disease Mechanism, Drug Screening, and Cell Therapy"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmReprogramming and Dedifferentiation in Cancer
Discussion Leader: Danqing Pei (GIBH)
7:30 pm - 8:10 pmDino Morvinski (The Salk Institute, Verma Lab)
"Glioblastomas can originate by reprogramming of differentiated cells in the brain"
8:10 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmShort Talk: Flaminia Talos (Columbia University)
"Directed differentiation and transdifferentiation to prostate epithelia"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmShort Talk: Shila Mekhoubad (Harvard Stem Cell Institute)
"Erosion of Dosage Compensation Impacts Human iPS Cell Disease Modeling"
9:20 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMolecular Mechanisms of Pluripotency and Reprogramming - I
Discussion Leader: Konrad Hochedlinger (Harvard University)
9:00 am - 9:40 amAndras Nagy (Samuel Lunenfeld Research Institute)
"Reprogramomics"
9:40 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 11:10 amDuanqing Pei (GIBH)
"Reprogramming through vitamin C and histone modification enzymes"
11:10 am - 11:30 amDiscussion
11:30 am - 12:10 pmIhor Lemischka (Mt. Sinai Medical School)
"Pluripotency, Etc."
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMolecular Mechanisms of Pluripotency and Reprogramming - II
Discussion Leader: Thomas Zwacka (Baylor College of Medicine)
7:30 pm - 8:10 pmJose Silva (University of Cambridge)
"Reprogramming mechanisms of Oct4 and Nanog"
8:10 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmShort Talk: Jianlong Wang (Mt. Sinai School of Medicine)
"Reprogramming Logic from the Oct4/Nanog Interactome"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmShort Talk: Rupa Sridharan (University of Wisconsin-Madison)
"Histone methylation changes, identified by mass spectrometry, improve reprogramming efficiency"
9:20 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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