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Signaling by Adhesion Receptors
Gordon Research Conference

Dates

June 24-29, 2012

Location

Colby College
Waterville, ME

Organizers

Chair:
Martin Schwartz

Vice Chair:
Martin J. Humphries

Meeting Description

The 2012 Signaling by Adhesion Receptors Gordon Conference will cover recent research on mechanisms and consequences of signal transduction by cell-matrix and cell-cell adhesion receptors. The goal is to integrate and extend current knowledge about the structure and biochemistry, cell biology, and whole organism biology of integrins, cadherins and other adhesion receptors. Topics will include signaling to growth, survival and cytoskeletal pathways; mechanotransduction; novel signaling pathways; and system biology approaches. The program is designed to encourage integration of these different areas with the goal of promoting major new cross-disciplinary insights. Training of junior scientists is a key goal of the meeting and the program has multiple opportunities for junior scientists to present their work and engage colleagues. There will be three poster sessions and substantial time is reserved in the main sessions for short talks to be chosen from submitted abstracts. Additionally, the GRC is preceded by a Gordon Research Seminar entitled Frontiers in Cell Adhesion and Signaling. This conference is organized by the trainees and provides a two-day program exclusively for student and postdoctoral trainees. An important aspect of the GRC program is that all meals are taken together and substantial unscheduled time is provided to further promote interaction and collaboration between the various fields represented at the meeting. The entire program is therefore designed to provide extraordinary opportunities for learning and for developing relationships and collaborations.

Related Meeting

This GRC was held in conjunction with the "Signaling by Adhesion Receptors" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:00 pmKeynote Presentation
7:40 pm - 8:40 pmMina Bissell (Lawrence Berkeley Laboratory)
"Extracellular matrix remodeling and regulation in breast morphogenesis and cancer"
8:40 pm - 9:00 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmIntegrin Signaling to the Cytoskeleton and Cell Migration
Discussion Leader: Gaudenz Danuser (Harvard Medical School)
9:00 am - 9:30 amGaudenz Danuser (Harvard Medical School)
"Coordination of leading edge activities in cell motility"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amDavid Calderwood (Yale University)
"Integrin cytoplasmic domain interactions"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amGroup Photo / Coffee Break
10:50 am - 11:20 amMark Ginsberg (UCSD)
"Regulation of Rho GTPases by integrins"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amAdam Simpson (Yale)
"Direct activation of Arg by integrins"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmDorit Hanien (Burnham)
"High resolution analysis of focal adhesion structure"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmGhaffar Muharram (Turko, Finland)
"A novel signalling nexus involving Met, integrins and tensins regulates carcinoma cell migration and proliferation"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmCadherin Signaling to the Cytoskeleton
Discussion Leader: Alpha Yap (Inst. for Molecular Bioscience, Queensland Bioscience Precinct)
7:30 pm - 8:00 pmAlpha Yap (Inst. for Molecular Bioscience, Queensland Bioscience Precinct)
"Myosin in cadherin-dependent junction formation"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmKarl Matter (UCL)
"Regulation of Rho GTPases by cadherins"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmJessica Maiers (University of Iowa)
"αCatenin Couples The Assembly of Tight Junctions to Adherens Junctions"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmIlse Timmerman (Sanquin Institute, Amsterdam)
"The GEF Trio regulates endothelial adherens junctions through the small GTPase Rac1"
9:25 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCadherin Signaling in Growth and Differentiation
Discussion Leader: Elaine Fuchs (Sloan Kettering Memorial)
9:00 am - 9:30 amElaine Fuchs (Sloan Kettering Memorial)
"Cadherins in skin development and cancer"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amDenise Montell (Johns Hopkins)
"Cadherins as migration receptors"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:20 amDietmar Vestweber (Max Planck Institute for Molecular Biomedicine, Germany)
"Signaling by VE-cadherin"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amKeely Mui (University of Pennsylvania)
"Stiffness-induced expression of N-cadherin is essential for FAK-mediated cell cycling"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmBrian Coon (Yale)
"VE-cadherin molecular interactions in fluid shear stress signaling"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmSarita Sastry (University of Texas)
"PTP-PEST targets a novel tyrosine in p120ctn to control epithelial cell motility and Rho GTPase signaling"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pmIntegrin Signaling in Growth, Differentiation and Survival
Discussion Leader: Valerie Weaver (UCSF)
7:30 pm - 8:00 pmValerie Weaver (UCSF)
"Signaling in 3 Dimensions"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmEun-Gook Kim (Korea)
"Survival signaling through the paxillin complex"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmLester Lau (University Illinois at Chicago)
"Control of senescence through CCN proteins"
9:20 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMechanotransduction by Cell Adhesion Receptors
Discussion Leader: Clare Waterman (NIH)
9:00 am - 9:30 amClare Waterman (NIH)
"Force-dependent adhesion and cytoskeletal dynamics"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amMichael Sheetz (Columbia)
"Talin in rigidity sensing"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:20 amJohan deRooij (Utrecht, Netherlands)
"Cadherin-dependent force sensing"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amVincent Fiore (Georgia Tech)
"Force-mediated synergistic binding between syndecan-4 and β1 integrin"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmBigyam Bista (MIT)
"Adhesion-GPCRs in Breast Cancer Progression and Metastasis"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmTorsten Shoneberg (University of Leipzig)
"G protein coupling of adhesion receptors"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmSignaling by other Adhesion Receptors
Discussion Leader: Michael Simons (Yale University)
7:30 pm - 8:00 pmMichael Simons (Yale University)
"Signaling by syndecan 4 in vascular development and angiogenesis"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmEleni Tzima (UNC Chapel Hill)
"Signaling by PECAM-1 in atherosclerosis and artery remodeling"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmErik Sahai (CRUK London)
"Discoidin Domain receptor 1 in cell motility and cancer"
9:20 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmThe Hippo/Yap Pathway
Discussion Leader: Barry Gumbiner (University of Virginia)
9:00 am - 9:30 amBarry Gumbiner (University of Virginia)
"Cadherin regulation of the Hippo pathway"
9:30 am - 9:40 amDiscussion
9:40 am - 9:55 amSergey Tryanovsky (Northwestern University)
"Actin-binding domain of alpha-catenin provides cadherin clusters with extra strength and guides their movement"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amYu Shi (Nanyang Technical University, Singapore)
"NCAM Potentiates Invasion and Metastasis of Melanoma Cells through CAMP Dependent Protein Kinase and Phosphatidylinositol 3-Kinase Pathways"
10:15 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:20 amStephan Piccolo (University of Padua, Milan, Italy)
"Mechanotransduction through the YAP/TAZ pathway"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amJohn Lamar (MIT)
"Roles for YAP and the Hippo Pathway during tumor progression and metastasis"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmFumihiko Nakamura (Brigham and Womens Hospital)
"Visualizing filamin A's integrin-binding site activation in living cells"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmKoen van den Dries (Nijmegen)
"Podosomes by high-resolution bioimaging: actin pillars with guy ropes"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session III
6:00 pmDinner
7:30 pm - 9:30 pmSystems Biology Approaches to Adhesion Receptor Biology
Discussion Leader: Martin Humphries (University of Manchester)
7:30 pm - 8:00 pmMartin Humphries (University of Manchester)
"Mass spectral analysis of integrin interactions"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmAlexander Bershadsky (Weizmann Institute)
"siRNA screens for determinants of rigidity sensing"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmJoan Brugge (Harvard)
"Screening approaches for identifying migration and invasion genes"
9:20 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible [in part] by 1 R13 AI 100533 - 01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

Funding for this conference was made possible (in part) by 5R13CA133995-03 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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