Gordon Research Conferences
PI_Conferences PI_Conferences_Past
Conference Program
 
Signal Transduction by Engineered Extracellular Matrices
July 8-13, 2012
University of New England
Biddeford, ME
Chair:
Karen Hirschi

Vice Chair:
Jason A. Burdick

Related Meeting Information
The Signal Transduction by Engineered Extracellular Matrices Gordon Research Conference was held in conjunction with the Signal Transduction by Engineered Extracellular Matrices Gordon Research Seminar. Please refer to the Signal Transduction by Engineered Extracellular Matrices GRS web page for more information.

The Gordon Research Conference (GRC) on Signal Transduction By Engineered Extracellular Matrices was established in 2000 and has become the premier meeting at the intersection of bioengineering and stem cell biology. The 2012 meeting, to be held July 8-13 at the University of New England in Biddeford, ME, highlights another important dimension - applications of stem cell/engineered matrix constructs to human clinical therapy. The main objective of the conference will be to share the newest knowledge from research on: the development and regulation of cellular microenvironments; the control of cell function by engineered microenvironments; dynamic tracking of cell fate in vivo; and application of such insights to the development and optimization of human clinical therapies for tissue repair and regeneration. This meeting necessarily brings together researchers in diverse fields of stem cell and developmental biology, chemistry, bioimaging and engineering for both the understanding of cellular function and how this can be harnessed for the repair and replacement of tissues lost or damaged due to disease or injury. Lively discussion sessions will include well-established leaders in the field, as well as emerging young investigators. The meeting also includes highly interactive poster sessions, and some poster presenters will be selected for short talks. The collegial atmosphere of the Conference affords ample opportunity for informal gatherings in the afternoons and evenings, which provides an avenue for scientists from different disciplines in both industry and academia to brainstorm, network and establish new cross-disciplinary collaborations in this dynamic area of research at the interface of biology and engineering.

As initiated in 2010, the main Conference in 2012 will be preceded by a weekend meeting planned by and for pre-doctoral and post-doctoral trainees. This pre-meeting, the Gordon Research Seminar (GRS), provides a forum for future leaders in this growing interdisciplinary field to present their work in talks and posters in a highly interactive environment that fosters creativity and collaboration.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session
Discussion Leader: Karen Hirschi (Yale University)
7:40 pm - 8:20 pmDavid Cheresh (University of California, San Diego)
"Integrin Signaling in Angiogenesis and Cancer"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmChristopher Chen (University of Pennsylvania)
"Engineering Cellular Responses"
9:15 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEngineering Adhesion and Signaling
9:00 am - 9:10 amDiscussion Leader: Cynthia Reinhart-King (Cornell University)
9:15 am - 9:45 amCatherine Picart (Grenoble)
"Engineering Adhesion and Signaling by Multifunctional Polyelectrolyte Multilayer Films"
9:45 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 11:00 amAndrés J. García (Georgia Institute for Technology)
"Exploiting Cell Adhesive Forces for Biomedical Applications"
11:00 am - 11:15 amDiscussion
11:15 am - 11:45 amMargaret Gardel (University of Chicago)
"Regulation of Focal Adhesions by the Actin Cytoskeleton"
11:45 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmThomas Barker (Georgia Institute for Technology & Emory University)
"Regulation of TGFβ Mechanoactivation and Cell Phenotype Through Orthogonal Biochemical and Mechanical Signals"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmPoster Blitzes (from Session I)
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmCellular Mechanotransduction
Discussion Leader: Robert Mauck (University of Pennsylvania)
7:30 pm - 8:00 pmMartin Schwartz (Yale University)
"Signaling and Mechanotransduction by Cell Adhesion Receptors"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmValerie Weaver (University of California, San Francisco)
"Force-dependent Reprogramming of the Tissue Regulates Tumor Aggression and Metastasis"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmNing Wang (University of Illinois)
"Mechanics and Mechanotransduction of Adherent Cells"
9:20 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm3D Matrices
9:00 am - 9:10 amDiscussion Leader: Andrew Putnam (University of Michigan)
9:15 am - 9:45 amMathias Lutholf (École Polytechnique Fédérale de Lausanne)
"Hydrogel Technologies for Systems-level Analysis of Stem Cell Fate"
9:45 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 11:00 amSarah Heilshorn (Stanford University)
"Genetic Engineering of 3D Matrices"
11:00 am - 11:15 amDiscussion
11:15 am - 11:45 amElliot Botvinick (University of California, Irvine)
"Physical Measurement and Modulation of Stiffness in 3D"
11:45 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmTatiana Segura (University of California, Los Angeles)
"Engineering VEGF Presentation for Therapeutic Angiogenesis"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmPoster Blitzes (from Session I)
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmMatrix Remodeling
Discussion Leader: Johanna Temenoff (Georgia Tech & Emory University)
7:30 pm - 8:00 pmViola Vogel (ETH Zurich)
"Mechanical Signaling by Extracellular Matrix"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmGeorge Davis (University of Missouri)
"Hematopoietic Stem Cell Cytokines Stimulate Human Vascular Tube Morphogenesis in 3D Matrices"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmSharon Gerecht (Johns Hopkins University)
"Controlling Cell-material Interactions for Vascular Assembly"
9:20 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEngineering Stem Cell Niches
9:00 am - 9:10 amDiscussion Leader: David Schaffer (University of California, Berkeley)
9:15 am - 9:45 amTodd C. McDevitt (Georgia Tech & Emory University)
"Engineering 3D Stem Cell Environments Inside-out & Outside-in: which way do we go?"
9:45 am - 10:00 amDiscussion
10:00 amGroup Photo / Coffee Break
10:30 am - 11:00 amKam Leong (Duke University)
"Stem Cell Response to Topographical Cues"
11:00 am - 11:15 amDiscussion
11:15 am - 11:45 amAdam Engler (University of California, San Diego)
"Stem Cell Instructive Scaffolds via Interface Engineering"
11:45 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmHaoqian Chen (Columbia University)
"Optical Manipulation and Quantification of T-lymphocyte Activation"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmPoster Blitzes (from Session II)
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmEngineering Tissue Function
Discussion Leader: William Murphy (University of Wisconsin)
7:30 pm - 8:00 pmGordana Vunjak-Novakovic (Columbia University)
"Native Matrix as a Template for Engineering Functional Cardiac and Bone Tissues"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmDavid Mooney (Harvard University)
"Biomaterials Design Based on ECM Mechanics - Going Beyond Elastic Modulus"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmLinda Griffith (Massachusetts Institute of Technology)
"EGF Receptor Family Gymnastics: Easy as 1, 2, 3"
9:20 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTissue Patterning
9:00 am - 9:10 amDiscussion Leader: Jason Burdick (University of Pennsylvania)
9:15 am - 9:45 amShulamit Levenberg (Technion Israel Institute of Technology)
"Vascular Patterning in Engineered Tissues and its Effect on Tissue Integration"
9:45 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 11:00 amLance Davidson (University of Pittsburgh)
"The Physical Mechanics of Morphogenesis: stiffness, force, and feedback"
11:00 am - 11:15 amDiscussion
11:15 am - 11:45 amKate Bentley (London Research Institute, Cancer Research UK)
"Computer Simulation Uncovers New Signaling Dynamics in Vascular Patterning"
11:45 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShelly Peyton (University of Massachusetts, Amherst)
"Breast Cancer Metastasis and Tissue Tropism in Enmgineered Materials"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmPoster Blitzes (from Session II)
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pmImaging and Quantification of Tissue Formation
Discussion Leader: Charles Little (University of Kansas Medical Center)
7:30 pm - 8:00 pmBrenda Rongish (University of Kansas Medical Center)
"Dynamic Imaging of Cell and Tissue Motion During Avian Heart Morphogenesis"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmMichael Modo (University of Pittsburgh)
"Non-invasive Imaging of Transplanted Cells and Biomaterials"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmVictoria Bautch (University of North Carolina)
"Watching Blood Vessels Form: Lessons from Live Imaging"
9:20 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13HL115803-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
© 2014 Gordon Research Conferences Search | Contact | Terms of Use | Privacy Policy | Follow us: Facebook Twitter