Gordon Research Conferences
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Conference Program
 
Stereochemistry
July 29 - August 3, 2012
Salve Regina University
Newport, RI

Stereochemistry defines the spatial arrangement of atoms in space and provides chemical perspicuity. This special topic in chemistry is key to our ability to design and prepare innovative molecular architectures to serve as new catalysts, new materials and new therapeutics. As such, these tools guide us to understand stereochemical interactions enabling an iteration of understanding. These same precepts allow us to rationalize the chemistry of biology and biologically active compounds. Although our fundamental understanding of stereochemistry may reduce to phenomena on the molecular scale, its practical aspects extrapolate to ton-scale production and sustainable technologies. The daunting task to cover this topic in one conference is a 40 year tradition of the Stereochemistry GRC, which has been a leading venue for scientists to discuss issues of structure, property and synthesis. The Gordon Research Conference on Stereochemistry provides a unique forum for the discussion of current discoveries and intellectual advances pertaining to this most relevant, timely topic. The speaker selection in each of these disciplines emphasizes the very latest in mechanistic and structural aspects of chemistry and biology with stereochemistry at its core.

The 2012 meeting will focus on highly topical areas of stereochemistry. A plenary program of 29 speakers and 9 moderators will form the basis for the conference. There will be also 2 poster sessions with associated "chalk-talks" for new independent researchers. An open atmosphere for informal discussion events in the afternoon and late evening will be fostered.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmStereoselective Synthesis
Discussion Leader: Helma Wennemers (ETH Zurich)
7:40 pm - 8:25 pmYoshito Kishi (Harvard University)
"Natural Product Synthesis"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 9:20 pmTohru Fukuyama (University of Tokyo)
"Synthetic Studies on Heterocyclic Natural Products"
9:20 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAsymmetric Synthesis
Discussion Leader: Anita Mattson (Ohio State University)
9:00 am - 9:35 amJay Siegel (University of Zürich)
"Aromatic Architectures"
9:35 am - 9:45 amDiscussion
9:45 am - 10:20 amRichmond Sarpong (University of California, Berkeley)
"Synthetic Studies Inspired by Complex Alkaloids"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amGroup Photo / Coffee Break
11:00 am - 11:35 amVy Dong (UC Irvine)
"Stereoselective Strategies for C-H Bond Functionalization"
11:35 am - 11:45 amDiscussion
11:45 am - 12:20 pmDawei Ma (Shanghai Institute of Organic Chemistry)
"Asymmetric Synthesis of Bioactive Molecules using Organocatalysts"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmStereochemistry in Process R&D
Discussion Leader: John Ragan (Pfizer)
7:30 pm - 8:00 pmIan Davies (Merck Research Laboratories)
"What can Steve Jobs Teach us About Stereocontrol?"
8:00 pm - 8:05 pmDiscussion
8:05 pm - 8:35 pmSèbastien Lemaire (Janssen Pharmaceutica)
"New C-Glycosylation Methodology in the Synthesis of Important Therapeutics"
8:35 pm - 8:40 pmDiscussion
8:40 pm - 9:25 pmTobias Ritter (Harvard)
9:25 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStereoselective Catalysis
Discussion Leader: Jon Antilla (Univ. South Florida)
9:00 am - 9:35 amScott Miller (Yale University)
"Stereochemical Aspects of Catalytic Natural Product Modifications"
9:35 am - 9:45 amDiscussion
9:45 am - 10:20 amPavel Kocovsky (University of Glasgow)
"Organocatalytic Synthesis of Homoallylic Alcohols and their Stereocontrolled Functionalization"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:35 amElizabeth Jarvo (University of California, Irvine)
"Stereospecific Nickel-Catalyzed Cross-Coupling Reactions"
11:35 am - 11:45 amDiscussion
11:45 am - 12:20 pmMatthew Gaunt (University of Cambridge)
"New Copper-Catalyzed Reactions"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMaterials and Stereochemistry
Discussion Leader: Paul Floreancig (University of Pittsburgh)
7:30 pm - 8:15 pmRobert Grubbs (Nobel Laureate, California Institute of Technology)
"Selective metathesis catalysts for the synthesis of molecules and materials"
8:15 pm - 8:20 pmDiscussion
8:20 pm - 8:50 pmDavid Amabilino (Institut de Ciència de Materials de Barcelona)
"Stereochemistry in nanometer scale aggregates"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:25 pmHeather Maynard (UCLA)
"Selective Polymer Conjugations to Enhance Stabilization of Biologic Drugs"
9:25 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBiocatalysis and Enzymology
Discussion Leader: Lopa Desai (Bristol-Myers Squibb)
9:00 am - 9:35 amManfred Reetz (Max Planck Institute)
"Laboratory Evolution of Stereoselective Enzymes: A Prolific Source of Catalysts for Asymmetric Reactions"
9:35 am - 9:45 amDiscussion
9:45 am - 10:20 amNikki Pohl (Iowa State University)
"Carbohydrates"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:35 amDaniel Mink (DSM)
"Synthesis of statins by enzymatic C-C bond formation"
11:35 am - 11:45 amDiscussion
11:45 am - 12:20 pmChristina Grozinger (Penn State University)
"Genomics of Chemical Communication in Social Insects"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmMedicinal Stereochemistry
Discussion Leader: Scott May (Eli Lilly & Company)
7:30 pm - 8:15 pmSteven Ley (University of Cambridge)
"New Tools for Molecule Makers"
8:15 pm - 8:20 pmDiscussion
8:20 pm - 8:50 pmJacquelyn Gervay-Hague (University of California, Davis)
"Chemically Defined Macromolecular Constructs and Glycolipid Adjuvants in Vaccine Design"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:25 pmPunit Seth (Isis Pharmaceuticals)
"Stereochemistry of nucleoside building blocks can modulate the biophysical and biological properties of modified oligonucleotides"
9:25 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStereoselective Synthesis
Discussion Leader: Kai Rossen (Sanofi-Aventis)
9:00 am - 9:35 amCraig Forsyth (The Ohio State University)
"Stereocontrol in Natural Products Total Synthesis"
9:35 am - 9:45 amDiscussion
9:45 am - 10:20 amJonathan Reeves (Boehringer Ingelheim)
"New Strategies for Chiral Amine Synthesis"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:35 amGeorge Moniz (Eisai Pharmaceuticals)
"Synthesis of Biologically Active Chiral Molecules"
11:35 am - 11:45 amDiscussion
11:45 am - 12:20 pmJon Rainier (University of Utah)
"Targeting Heterocycles at 4700 Feet above Sea Level"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmStereoselective Catalysis
Discussion Leader: Joel Hawkins (Pfizer)
7:30 pm - 8:15 pmScott Denmark (University of Illinois, Urbana-Champaign)
"Understanding Asymmetric Phase Transfer Catalysis Through Chemoinformatics"
8:15 pm - 8:25 pmDiscussion
8:25 pm - 9:10 pmEi-ichi Negishi (Nobel Laureate, Purdue University)
"Zr-Catalyzed Asymmetric Carboalumination of Alkenes (ZACA)"
9:10 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmClosing remarks (Chairs and Future Chairs)
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

This activity is supported by an educational donation provided by Amgen.

 
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