Gordon Research Conferences
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Conference Program
 
Synaptic Transmission
July 29 - August 3, 2012
Waterville Valley Resort
Waterville Valley, NH
Chair:
Felix E. Schweizer

Vice Chair:
Peter Jonas

The synapse serves as the basic signaling unit of the nervous system. Information transfer at the synapse, called synaptic transmission underlies every aspect of brain function and is relevant to most neurological diseases, as well as mental illness and drug addiction. The communication between neurons is a highly complex, dynamically regulated process and a comprehensive understanding of such a process requires a multidisciplinary approach and the complementary use of cutting-edge techniques. The Gordon Research Conference on Synaptic Transmission, established in 1998, highly successful and widely attended since then, has developed into the quintessential biannual meeting covering all aspects of synaptic communication.

The 2012 Conference will present major recent advances on a wide range of topics related to synaptic transmission including vesicle fusion, structure function relationships, novel forms of plasticity and integration of synaptic function into neuronal networks. The Conference will bring together a diverse group of investigators who are at the forefront of their field, and will provide ample opportunities for junior scientists and graduate students to present their work in poster format and exchange ideas with world-class leaders in the field. Some poster presenters will be selected for short talks. In addition, keynote lectures will be delivered by two outstanding scientists whose work on synapses and networks is both highly influential and complementary. Past participants have lauded this GRC for the high quality of unpublished data being presented and for the collegial and interactive atmosphere where scientists at all levels felt welcome to join in the discussion of recent advances in synaptic physiology.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmSynaptic Transmission: from Molecules to Mechanisms and Circuits
Discussion Leader: Felix Schweizer (UCLA)
7:40 pm - 8:20 pmJames E. Rothman (Yale University)
"Structural and Biochemical Mechanisms of Synchronous Neurotransmitter Release"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmEve Marder (Brandeis University)
"Modulation of Synaptic Transmission and Circuit Dynamics"
9:15 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCalcium Channels, Domains and Sensors
9:00 am - 9:05 amDiscussion Leader: Richard W. Tsien (New York University)
"Introductory Remarks"
9:05 am - 9:30 amStephen M. Smith (Oregon Health Science University)
"Differential regulation of transmitter release by calcium"
9:30 am - 9:45 amDiscussion
9:45 am - 10:10 amTobias Moser (University of Goettingen, Germany)
"Synaptic Ca2+ Signaling in Hair Cells: Organization, Coupling to Exocytosis and Heterogeneity"
10:10 am - 10:25 amDiscussion
10:25 am - 11:10 amGroup Photo / Coffee Break
11:10 am - 11:35 amElise Stanley (Toronto Western Research Institute)
"The sandwich synapse"
11:35 am - 11:50 amDiscussion
11:50 am - 12:15 pmEdwin Chapman (University of Wisconsin, Madison)
"Trafficking and function of synaptotagmin isoforms in neurons"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmVesicle Fusion and Fusion Pores
7:30 pm - 7:35 pm Discussion Leader: Cesare Montecucco (University of Paduva, Italy)
"Introductory remarks"
7:35 pm - 8:00 pmVitaly Klyatchko (Washington University, St. Louis)
"Nanoscale-resolution imaging of synaptic vesicle dynamics revelas a role for myosin II in vesicle recycling"
8:00 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmRobert Zorec (University of Ljubljana, Slovenia)
"Unitary exocytotic events and fusion pore regulation"
8:40 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmManfred Lindau (Cornell University)
"How could SNAREs open the fusion pore?"
9:20 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSynaptic Diversity: Ribbon Synapses
9:00 am - 9:05 amDiscussion Leader: Tobias Moser (University of Goettingen, Germany)
"Introductory Remarks"
9:05 am - 9:30 amTeresa Nicolson (Oregon Hearing Research Center, Oregon Health and Sciences University)
"Calcium regulation of ribbon synaptogenesis"
9:30 am - 9:45 amDiscussion
9:45 am - 10:10 amMarlies Knipper (University of Tuebingen, Germany)
"It is more difficult to retrieve the barrel than to shoot: the exo/endo dispute of inner hair cells"
10:10 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:20 amHenrique von Gersdorff (OHSU, Vollum Institute)
"Multivesicular release at auditory synapses: coordinated vs. compound exocytosis"
11:20 am - 11:35 amDiscussion
11:35 am - 11:50 amMark Rutherford (University of Goettingen, Germany)
"Fine-timing control of spike generation in the cochlea by a powerful unitary synapse"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:15 pmSamuel Young (MPI Florida)
"Overexpression of Munc13-1 and ubMunc13-2 results in increases in initial release probabilities but differential effects on RRP size and steady state cycling at a large CNS synapse"
12:15 pm - 12:25 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSynaptic Structure
7:30 pm - 7:35 pm Discussion Leader: Maria Bykhovskaia (Universidad central del Caribe, San Juan, Puerto Rico)
"Introductory remarks"
7:35 pm - 8:00 pmKristen M. Harris (University of Texas, Austin)
"Dendritic Spines, Perisynaptic Astroglia and the Developmental Onset of Hippocampal L-LTP"
8:00 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmAntoine Triller (Ecole Normale Superieure, Paris, France)
"Plasticity at Inhibitory Synapses: microstructure and molecular dynamic"
8:40 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmErik Jorgensen (University of Utah)
"Synaptic vesicle endocytosis: Revisiting Heuser and Reese in the 21st century"
9:20 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDiversity of Synaptic Plasticity
9:00 am - 9:05 amDiscussion Leader: Felix E. Schweizer (UCLA)
"Introductory Remarks"
9:05 am - 9:30 amPablo Castillo (Albert Einstein College of Medicine)
"Activity-dependent synaptic plasticity expressed by NMDA receptors"
9:30 am - 9:45 amDiscussion
9:45 am - 10:10 amNicholas C. Spitzer (UCSD)
"Activity-dependent neurotransmitter respecification: plasticity of synaptic transmission"
10:10 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:20 amCatherine S. Wolley (Northwestern University)
"Sex-Specific Synaptic Modulation in the Hippocampus"
11:20 am - 11:35 amDiscussion
11:35 am - 11:50 amAnnalisa Scimemi (NIH/NINDS)
"A small number of Ca2+ channels shapes transmitter release and short-term plasticity at excitatory hippocampal synapses"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:15 pmJason Rothman
"Estimates of vesicle diffusion and active=zone supply rates at creellar mossy fiber terminals using FRAP and 3D reaction-diffusion simulations"
12:15 pm - 12:25 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmPostsynaptic Signaling and Receptor Trafficking
7:30 pm - 7:35 pm Discussion Leader: Jane Sullivan (University of Washington)
"Introductory remarks"
7:35 pm - 8:00 pmBenjamin Nahir (Oregon Health and Science University)
"Activation of NMDARs at parallel fiber-molecular interneuron synapses in the cerebellum"
8:00 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmIsabel Pérez-Otaño (CIMA, University of Navarra, Spain)
"Reactivation of juvenile NMDA receptors triggers synapse loss and cognitive deficits"
8:40 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmSeth Grant (University of Edinburgh)
"Postsynaptic complexity"
9:20 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSynaptic Basis of Brain Disorders
9:00 am - 9:05 amDiscussion Leader: Kamran Khodkhah (Albert Einstein College of Medicine)
"Introductory Remarks"
9:05 am - 9:30 amMaria Spillantini (University of Cambridge, United Kingdom)
"Synaptic dysfunction: the beginning of Parkinson's disease"
9:30 am - 9:45 amDiscussion
9:45 am - 10:10 amLisa Monteggia (UT Southwestern)
"A synaptic basis for rapid antidepressant action"
10:10 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:20 amJane Sullivan (University of Washington)
"Synapse dysfunction in Alzheimer's disease - is Akt to blame?"
11:20 am - 11:35 amDiscussion
11:35 am - 11:50 amVeronika Zsiros (Nation Institute of Mental Health, Bethesda)
"Cellular insights into the mechanism of synchrony impairment in schizophrenia"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:15 pmAryn Gittis (Gladstone Insitute, UCSF)
"Behavioral and circuit-level effects of striatal fast-spiking interneurons"
12:15 pm - 12:25 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSynaptic Transmission in Microcircuits
7:30 pm - 7:35 pm Discussion Leader: Peter Jonas (Institute for Science and Technology, Vienna, Austria)
"Introductory remarks"
7:35 pm - 8:00 pmRichard W. Tsien (New York University)
"Oxytocin modulation of hippocampal circuit function"
8:00 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmMathew Larkum (Humbolt University of Berlin, Germany)
"NMDA spikes in vivo"
8:40 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmCarl Petersen (University of Lausanne, Switzerland)
"In vivo measurement of synaptic transmission between identified neurons in layer 2/3 mouse barrel cortex"
9:20 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Research reported in this publication was supported by the National Institute Of Neurological Disorders And Stroke of the National Institutes of Health under Award Number R13NS079092. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

 
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