Gordon Research Conferences
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Conference Program
 
Transglutaminases in Human Disease Processes
July 15-20, 2012
Davidson College
Davidson, NC
Chair:
Kapil Mehta

Vice Chair:
Mauro Piacentini

Transglutaminases are a family of structurally and functionally related proteins that are widely distributed in all living organisms. There has been a recent surge in findings supporting that dysregulated expression and function of transglutaminases contribute to pathological conditions, such as cancer metastasis, tissue fibrosis, celiac disease, neurodegenerative disorders, and diseases related to defective assembly of the stratum corneum of the skin. The 2nd Gordon Conference on "Transglutaminases in Human Disease Processes" will focus on this rapidly expanding field. The meeting will cover cutting-edge research on the biology of transglutaminases and their role in health and disease processes. Sessions will cover recent advances relating to the following topics:

  • Transglutaminases in growth, development, and differentiation
  • Transglutaminases as regulators of cell survival and cell death modalities
  • Transglutaminases in cancer development and metastasis processes
  • Transglutaminases and cell signal transduction
  • Transglutaminases in physiological and pathological inflammation
  • Transglutaminases in celiac, neurodegeneration, and cardiovascular disease
  • Transglutaminases-induced matrix remodeling in health and disease
  • Transglutaminases as therapeutic targets
  • Transglutaminases as a tool for biotechnology

Major focus of this conference is to bring together an international group of experts and new investigators working in this rapidly expanding field with a goal of presenting and discussing the most recent advances in the field. Each talk will be structured to include ample time for discussion. Discussion will cover key issues of current relevance to the field and the implications of the work for future development of this area. Particular attention will be dedicated to fostering open informal debate among attendees during all the meeting. In particular, this conference is designed to provide an opportunity for young investigators to participate and interact with established experts in the field.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmOpening comments and Keynote lecture
7:40 pm - 8:00 pmWelcome Address from Conference Chair Kapil Mehta and Vice Chair Mauro Piacentini
8:00 pm - 8:45 pmKeynote Lecture: Peter Davies (Texas A&M University, Houston, USA)
"Transglutaminases - the past and next decade"
8:45 pm - 9:00 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmTransglutaminases and Celiac Disease
9:00 am - 9:15 amDiscussion Leader: Laszlo Fesus (University of Debrecen, Hungary)
"Celiac disease - an overview"
9:15 am - 9:45 amLudwig Sollid (University of Oslo, Norway)
"Transglutaminase 2 as a driving force in the immune reaction leading to celiac disease"
9:45 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:55 amIlma Korponay-Szabo (Univ. of Debrecen, Hungary)
"Compartmentalization of transglutaminase 2 and antigenicity in celiac disease"
10:55 am - 11:05 amDiscussion
11:05 am - 11:30 amKatri Lindfors (Tampere University, Finland)
"Biological effects of celiac disease antibodies"
11:30 am - 11:40 amDiscussion
11:40 am - 12:00 pmJeff Keillor (University of Ottawa, Canada)
"Selective TG2 inhibitors"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmKiyotaka Hitomi (Nagoya University, Japan)
"Substrate peptides for Transglutaminases"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTransglutaminases in Neurological disorders
7:30 pm - 7:45 pmDiscussion Leader: Mauro Piacentini (University of Rome, Italy)
"Implications of TG2 expression in neurological disorders - an overview"
7:45 pm - 8:10 pmNancy Muma (Kansas, USA)
"Targeting Calmodulin to alter Transglutaminase in Huntington's disease"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmAnne-Marie Van Dam (Amsterdam, Netherlands)
"Tissue Transglutaminase in experimental Multiple Sclerosis: a double-edged sword?"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmRay Truant (Ontario, Canada)
"A New Role for TG2 Hyperactivity at the Cytoskeleton and Stress Response in Neurodegeneration in Huntington's disease"
9:20 pm - 9:30 pmDiscussion
9:30 pmChair's Reception
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTransglutaminases in Cancer
9:00 am - 9:15 amDiscussion Leader: Richard Cerione (New York, USA)
"Novel roles for tissue transglutaminase in cancer progression"
9:15 am - 9:45 amDaniela Matei (Indiana, USA)
"Extra- and intracellular TG2 in Ovarian Cancer Metastasis"
9:45 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:00 amRichard Eckert (Univ. of Maryland, Baltimore, USA)
"A TG1 interacting tumor suppressor"
11:00 am - 11:10 amDiscussion
11:10 am - 11:40 amSoichi Kojima (REIKEN Science Institute, Japan)
"Essential role of TG2 in tumor angiogenesis"
11:40 am - 11:50 amDiscussion
11:50 am - 12:20 pmR.J. Ablin (Tucson, USA)
"The Antithetical Role of TGs in Insemination, Pregnancy and Malignancy"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTransglutaminases in inflammation
7:30 pm - 7:45 pmDiscussion Leader: Barry Fanburg (Tufts Medical Center, Boston, USA)
"Transamidation (Serotonylation) of Fibronectin in Pulmonary Hypertension"
7:45 pm - 8:10 pmKevin D. Brown (University of Florida, Gainesville, USA)
"Constitutive and DNA Damage-Induced Transglutaminase 2 Expression is Controlled by ATM / NF-kappaB Signaling"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmDong-Sup Lee (Seoul, Korea)
"Epithelial transglutaminase 2 in pulmonary inflammation and fibrosis"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmTristan Croll (Queensland University, Australia)
"The dynamics of transglutaminases: what is the data trying to tell us"
9:20 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTransglutaminases in Cornea, Skin, and Bone
9:00 am - 9:15 amDiscussion Leader: Mari T. Kaartinen (McGill University, Canada)
"Transglutaminases, matrix stabilization and mesenchymal stem cell differentiation"
9:15 am - 9:45 amLaszlo Muszbek (University of Debrecen, Hungary)
"Factor XIII in Tears and Cornea"
9:45 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:00 amKiyofumi Yamanishi (Hyogo College of Medicine, Japan)
"The phenotype of transglutaminase-1 deficiency"
11:00 am - 11:10 amDiscussion
11:10 am - 11:40 amLaurence J. Meyer (Univ. of Utah, UT)
"The role of Epidermal Transglutaminase (TG3) in the pathogenesis of Dermatitis Herpetiformis"
11:40 am - 11:50 amDiscussion
11:50 am - 12:20 pmStephanie Watts (Michigan State University, USA)
"Smooth muscle Transglutaminase: a different frontier"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmTransglutaminases as Transcription regulators
7:30 pm - 7:45 pmDiscussion Leader: Alexey Belkin (Univ. of Maryland, Baltimore, USA)
7:45 pm - 8:10 pmRajiv R. Ratan (Cornell Medical Research Institute, USA)
"Transglutaminase in the nucleus: novel targets for an old enzyme"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmGail Johnson (University of Rochester, USA)
"Friend and Foe: The role of transglutaminase 2 in ischemic cell death"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmKapil Mehta (UT M.D. Anderson Cancer Center, Houston, USA)
"The ugly side of TG2-regulated transcription"
9:20 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTransglutaminases - the Clinical perspective
9:00 am - 9:15 amDiscussion Leader: Martin Griffin (Aston University, UK)
"Transglutaminases - novel therapeutic targets in the treatment of human disease"
9:15 am - 9:45 amTimothy S. Johnson (University of Sheffield, UK)
"Specific targeting of Transglutaminase 2 as an anti-fibrotic therapy in chronic kidney disease"
9:45 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:00 amBei Sha Tang (Central South University, China)
"The role of transglutaminases in spinocerebellar ataxia: genetics and pathology"
11:00 am - 11:10 amDiscussion
11:10 am - 11:40 amAkitada Ichinose (Yamagata University, Japan)
"Molecular and clinical approach to autoimmune hemorrhaphilia FXIII"
11:40 am - 11:50 amDiscussion
11:50 am - 12:20 pmLouis Tong (National Eye Center, Singapore)
"Critical involvement of TG2 in human corneal epithelial migration, biomechanics and in vivo findings of a paxillin dependent mechanism"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNews from the Posters
7:30 pm - 7:35 pmDiscussion Leaders: Elisabetta Verderio (Nottingham Trent Univ, UK) and Siiri Iismaa (Univ of New South Wales, Australia)
7:35 pm - 9:30 pmShort Presentations (Selected from posters)
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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