Gordon Research Conferences
PI_Conferences PI_Conferences_Past
Conference Program
 
Barriers of the CNS
Bridging Barriers to Treat CNS Disease
June 17-22, 2012
Colby-Sawyer College
New London, NH

Related Meeting Information
The Barriers of the CNS Gordon Research Conference was held in conjunction with the Barriers of the CNS Gordon Research Seminar. Please refer to the Barriers of the CNS GRS web page for more information.

The Barriers of the Central Nervous System (CNS) are a system of regulatory interfaces between the blood and the brain that are essential to brain function and have major impact on the course and treatment of many CNS diseases. The 2012 Barriers of the CNS Gordon Research Conference will present the latest, cutting edge research on the cellular and molecular mechanisms that comprise the CNS barriers and will explore state-of-the-art strategies for imaging barrier function and improving drug delivery for the treatment of human disease. The Conference will feature a wide range of sessions, including Barrier Structure and Function, Barrier Permeability and Signalling, Barrier Transporters, Drug Delivery, Barrier Alterations in Disease, Angiogenesis and Brain Tumors, Barrier Imaging, and Other Barrier Systems. Invited speakers will present of a variety of topics, ranging from biochemistry, molecular genetics, structural biology, and to disease pathophysiology, imaging, oncology, pharmaceutical sciences, and clinical therapy. The Conference will bring together a broad range of clinical and basic scientists who are at the forefront of Barriers research, and will provide opportunities for junior scientists and graduate students to present their work in poster format and exchange ideas with leaders in the field. The collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an ideal avenue for scientists from different disciplines to brainstorm and promotes cross-disciplinary collaborations in the various research areas represented in the Barriers of the CNS field.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Presentation: Barrier Modeling
Discussion Leader: Quentin Smith (Texas Tech UHSC, Amarillo, TX)
7:40 pm - 7:50 pmWelcome
7:50 pm - 8:25 pmTetsuya Terasaki (Tohuko University, Sendai, Japan)
"Blood-Brain Barrier Pharmacoproteomics (PPx): Challenge for the Discovery of New Barrier Function in Humans"
8:25 pm - 8:40 pmDiscussion
8:40 pm - 9:15 pmDamir Janigro (Cleveland Clinic, Cleveland, OH)
"Inflammatory Events Initiate and Result from BBB Failure"
9:15 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBarrier Structure and Function
Discussion Leaders: Richard Keep (University of Michigan, Ann Arbor, MI), Karen Mark (South College, Knoxville, TN)
9:00 am - 9:20 amLester Drewes (University of Minnesota, Duluth, MN)
"Acute Regulation of MCT1 Function in Brain Endothelial Cells by cAMP Dependent Vesicular Trafficking"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amGraham K. Farrington (Biogenidec Corporation, Weston, MA)
"Receptor-Mediated Transcytosis: Ins and Outs of the Blood Brain Barrier Transport"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:50 amUlrich Bickel (Texas Tech UHSC, Amarillo, TX)
"T-Cell Receptor Mimics as Novel Tools for Brain Targeting"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amFarida Sohrabji (Texas A&M HSC, College Station, TX)
"Age and Sex Differences in the Blood Brain Barrier: Implications for Stroke"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amJoseph Nicolazzo (Monash U, Victoria Australia)
"The Impact of Systemic Inflammation and Bacterial Infection on the Blood-Brain Barrier Transport of Colistin"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:30 pmDiscussion Leader Wrap-Up
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmBarrier Permeability and Signaling
Discussion Leaders: Pierre-Olivier Couraud (INSERM, France), Joan Abbott (Kings College, London, UK)
7:30 pm - 7:50 pmRichard Daneman (UCSF Department of Anatomy, San Francisco, CA)
"Molecular Mechanisms of Blood-Brain Barrier Formation"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmStefan Liebner (Goethe University, Frankfurt, Germany)
"Molecular Regulation of Endothelial Barrier Function at the Blood-Brain Barrier"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmWeihong Pan (Pennington Biomedical Research Center, Baton Rouge, LA)
"BBB Cytokine Signaling - from Cell Biology to Behavior"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmAlex Avdeef (in-ADME Research, Boston, MA)
"Barrier Permeability and Various In Vitro Models for Predicting It"
9:20 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBarrier Imaging
Discussion Leaders: M Waleed Gaber (Baylor University, Houston, TX) and Paul Lockman (Texas Tech UHSC, Amarillo, TX)
9:00 am - 9:20 amTavakere Nagaraja (Henry Ford Health System, Detroit, MI)
"Localization and Quantification of BBB Dysfunction and Implications to Treatments"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amBill Rooney (Oregon HSU, Portland, OR)
"Quantitative MRI of BBB Permeability in Neuroinflammation"
9:50 am - 10:00 amDiscussion
10:00 amGroup Photo / Coffee Break
10:30 am - 10:50 amKullervo Hynynen (University of Toronto, Canada)
"MRI-Guided and Monitored Local BBB Disruption by Focused Ultrasound for Targeted Drug Delivery"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amStina Syvänen (University of Leiden, Netherlands)
"The Search for a Reliable PET Tracer for Imaging of P-glycoprotein Function at the Blood-Brain Barrier"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amKarunya Kandimalla (University of Minnesota, Minneapolis, MN)
"Traffic Jam at the Blood Brain Barrier Promotes Greater Accumulation of Alzheimer's Disease Amyloid Beta Proteins in the Cerebral Vasculature"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:30 pmDiscussion Leader Wrap-Up
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmOther Barrier Systems
Discussion Leaders: Hazel Jones (Kings College, London, UK) and Tom Abbruscato (Texas Tech UHSC, Amarillo, TX)
7:30 pm - 7:50 pmRobert Thorne (University of Wisconsin, Madison, WI)
"Barriers to Diffusion in the Extracellular Spaces of the Living Brain"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmChris Campos (NIEHS, Research Triangle Park, NC)
"ABC Transporter Function and Regulation at the Blood-Spinal Cord Barrier"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmKen-Ichi Hosoya (University of Toyama, Toyama, Japan)
"The Inner Blood-Retinal Barrier in Retinal Drug Delivery"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmJean-Francois Ghersi-Egea (INSERM, France)
"Neuroprotective Mechanisms Associated With the Blood-CSF Barrier in the Developing Brain"
9:20 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBarrier Transporters
Discussion Leaders: David Miller (NIEHS, Research Triangle Park, NC) and Tom Raub (Lilly Research Labs, Indianapolis, IN)
9:00 am - 9:20 amJean-Michel Scherrmann (INSERM, Paris, France)
"The Ah Receptor as a Target Modulating Drug Metabolism Enzymes and ABC Transporters in hCMEC/D3 Cells"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amElizabeth Hopper-Borge (Fox Chase Cancer Center, Philadelphia, PA)
"Abcc10 (MRP7) as a Breast Cancer Treatment Resistance Factor"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:50 amIan Simpson (Penn State, State College, PA)
"Transport of Glucose Across the BBB Revisited"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amAnika Hartz (University of Minnesota, Duluth, MN)
"Blood-Brain Barrier P-glycoprotein: A New Therapeutic Target in Alzheimer's Disease?"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amAnne Mahringer (University of Heidelberg, Heidelberg, Germany)
"Interaction between Alpha-Synuclein and P-Glycoprotein at the BBB"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmPatrick Ronaldson (University of Arizona, Tucson, AZ)
"Targeting Organic Anion Transporting Polypeptide 1a4 (Oatp1a4) at the Blood-Brain Barrier for Optimization of CNS Drug Delivery"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pmDrug Delivery
Discussion Leaders: Margaretta Hammarlund-Udenaes (Uppsala University, Uppsala, Sweden), David Smith (University of Michigan, Ann Arbor, MI)
7:30 pm - 7:50 pmAlexander Kabanov (University of Nebraska, Omaha, NE)
"Nanomedicines for Protein Delivery to the Brain"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmJean Lachowicz (Angiochem, Montreal, Canada)
"Successfully Accessing the Brain using EPiC Technology"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmLi Di (Pfizer, Groton, CT)
"Overcoming Blood Brain Barrier Challenges in CNS Drug Discovery"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmMaxime Culot (University of Artois, France)
"Assessing the Free Brain/Free Plasma Ratio In Vitro in Early Drug Discovery"
9:20 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
9:00 am - 12:30 pmBarrier Alterations in Disease
Discussion Leader: Damir Janigro (Cleveland Clinic, Cleveland, OH) and David Begley (Kings College, London, UK)
9:00 am - 9:20 amTom Davis (University of Arizona, Tucson, AZ)
"P-glycoprotein Trafficking at the BBB altered by Peripheral Inflammatory Pain"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amJim Connor (Penn State, College Station, PA)
"Mechanisms of Iron Uptake into the Brain and their Regulation--a New Concept for the BBB"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:50 amMaria A Deli (Hungarian Academy of Sciences, Szeged, Hungary)
"Blood-Brain Barrier in Pancreatitis"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amGreg Bix (University of Kentucky, Lexington, KY)
"Enter the Matrix: Perlecan Domain V as a Novel Stroke Therapy"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amReina Bendayan (University of Toronto, Toronto CA)
"In Vivo Model of HIV-1 Associated Neuro-Inflammation: Potential Therapeutic Approaches"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:30 pmDiscussion Leader Wrap-Up
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pmBrain Tumors
Discussion Leader: Gert Fricker (University of Heidelberg, Heidelberg, Germany)
7:30 pm - 7:50 pmBill Elmquist (University of Minnesota, Minneapolis, MN)
"Molecularly-Targeted Therapy for Primary and Metastatic Brain Tumors"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmOlaf Van Tellingen (Netherlands Cancer Institute, Amsterdam, NL)
"Chemotherapeutic Drug Delivery for the Treatment of Brain Tumors"
8:20 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmClinton Stewart (St. Jude Children's Research Hospital)
"CNS Drug Penetration in Murine Models of Pediatric Brain Tumors: Getting Past the Barriers"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pmOverall Discussion
Quentin Smith and Margaretta Hammarlund-Udenaes
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

The project described was supported by Grant Number R13NS079109 from the National Institute Of Neurological Disorders And Stroke. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute Of Neurological Disorders And Stroke or the National Institutes of Health.

 
© 2014 Gordon Research Conferences Search | Contact | Terms of Use | Privacy Policy | Follow us: Facebook Twitter