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Conference Program
 
Aging, Biology of
August 11-16, 2013
Renaissance Tuscany Il Ciocco Resort
Lucca (Barga), Italy

Related Meeting Information
The Aging, Biology of Gordon Research Conference was held in conjunction with the Aging, Biology of Gordon Research Seminar. Please refer to the Aging, Biology of GRS web page for more information.

The 2013 Gordon Research Conference (GRC) on Biology of Aging aims to highlight new developments towards elucidating the mechanisms underlying homeostasis maintenance and breakdown at the molecular, cellular, tissue and organismal level. Aging is intimately linked with a marked decrease of homeostatic potential, in organisms as diverse as the single-celled yeast and humans. Loss of molecular, cellular, tissue and organismal homeostasis emerges as a universal common denominator of the aging process and can have devastating consequences relevant to longevity and the well-being and healthspan of humans. Comprehensive understanding of these mechanisms is of fundamental importance for successful implementation of intervention strategies targeting the decline or loss of homeostasis as manifested in numerous age-associated disorders and during aging, diminishing quality of life in the elderly. The conference will provide a highly interactive forum to discuss the current state-of-the-art in the field by combining the latest concepts, emerging in diverse models systems including yeast, worms, flies, mice and humans. The preceding Gordon Research Seminar (GRS) aims to introduce the next generation of basic scientists to key elements of modern aging research and acquaint them with the concept of homeostasis, thus preparing them for full participation in the GRC to follow.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmCellular Senescence, Aging, and Age-related Diseases
7:40 pm - 7:45 pmDiscussion Leaders: Pankaj Kapahi (The Buck Institute for Research on Aging) and Nektarios Tavernarakis (Foundation for Research & Technology-Hellas, University of Crete Medical School)
7:45 pm - 8:15 pmJudith Campisi (The Buck Institute for Research on Aging)
"Cellular Senescence: Yin and Yang"
8:15 pm - 8:25 pmDiscussion
8:25 pm - 8:55 pmJames Kirkland (Mayo Clinic, Robert and Arlene Kogod Center on Aging)
"Aging and Adipose Tissue Cellular Senescence"
8:55 pm - 9:05 pmDiscussion
9:05 pm - 9:25 pmFelipe Sierra (National Institute on Aging (NIA), National Institutes of Health (NIH))
"Geroscience, a trans-NIH initiative on aging and disease"
9:25 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCircadian Clocks
9:00 am - 9:15 amDiscussion Leader: Jadwiga Giebultowicz (Oregon State University)
9:15 am - 9:45 amAmita Sehgal (HHMI, University of Pennsylvania)
"Circadian rhythms and aging"
9:45 am - 9:55 amDiscussion
9:55 am - 10:10 amGroup Photo / Coffee Break
10:10 am - 10:40 amPaolo Sassone-Corsi (University of California, Irvine)
"Epigenetics, Metabolism and the Circadian Clock"
10:40 am - 10:50 amDiscussion
10:50 am - 11:20 amSalvador Anzar-Benitah (ICREA Research Professor, Center for Genomic Regulation (CRG))
"Spatiotemporal regulation of epidermal stem cell function by circadian rhythms: impact on homeostasis and aging"
11:20 am - 11:30 amDiscussion
11:30 am - 12:00 pmLeonard Guarente (Massachusttes Institute of Technology)
"Sirtuins and Aging"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:18 pmTBA (Short Talk)
12:18 pm - 12:20 pmDiscussion
12:20 pm - 12:28 pmTBA (Short Talk)
12:28 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmStem Cells
5:30 pm - 5:45 pmDiscussion Leader: Leanne Jones (University of California, Los Angeles)
5:45 pm - 6:15 pmAmy Wagers (Harvard University)
"Systemic regulation of aging phenotypes in mammalian tissues"
6:15 pm - 6:25 pmDiscussion
6:25 pm - 6:55 pmAnne Brunet (Stanford University)
"Epigenetic regulation of aging"
6:55 pm - 7:05 pmDiscussion
7:05 pm - 7:13 pmTBA (Short Talk)
7:13 pm - 7:15 pmDiscussion
7:15 pm - 7:23 pmTBA (Short Talk)
7:23 pm - 7:25 pmDiscussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMitochondria and Fat Metabolism
9:00 am - 9:15 amDiscussion Leader: Siu Sylvia Lee (Cornell University)
9:15 am - 9:45 amEric Verdin (Gladstone Institutes, UCSF)
"Mitochondria intermediate metabolism and aging"
9:45 am - 9:55 amDiscussion
9:55 am - 10:10 amCoffee Break
10:10 am - 10:40 amSean Curran (University of Southern California)
"Novel roles for mitochondrial SKN-1/Nrf in metabolic homeostasis"
10:40 am - 10:50 amDiscussion
10:50 am - 11:20 amMichael Ristow (ETH Zurich, Switzerland, Swiss Federal Institute of Technology)
"Mitohormesis: How increased ROS formation promotes healthspan"
11:20 am - 11:30 amDiscussion
11:30 am - 12:00 pmRolf Bodmer (Sanford-Burnham Medical Research Institute)
"Cardiac aging and diabetic cardiomyopathy models in Drosophila"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:18 pmTBA (Short Talk)
12:18 pm - 12:20 pmDiscussion
12:20 pm - 12:28 pmTBA (Short Talk)
12:28 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmNeuronal and Endocrine Signaling and Aging
5:30 pm - 5:45 pmDiscussion Leader: Matt Gill (The Scripps Research Institute - Scripps Florida)
5:45 pm - 6:15 pmColeen Murphy (Princeton University)
"Post-Mating Somatic Collapse"
6:15 pm - 6:25 pmDiscussion
6:25 pm - 6:55 pmAdam Antebi (Max Planck Institute for Biology of Ageing, Baylor College of Medicine)
"Regulation of longevity by the reproductive system"
6:55 pm - 7:05 pmDiscussion
7:05 pm - 7:13 pmTBA (Short Talk)
7:13 pm - 7:15 pmDiscussion
7:15 pm - 7:23 pmTBA (Short Talk)
7:23 pm - 7:25 pmDiscussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMuscle/Exercise
9:00 am - 9:15 amDiscussion Leader: Simon Melov (The Buck Institute for Research on Aging)
9:15 am - 9:45 amMark Tarnapolsky (McMaster University Medical Center)
"Exercise and mitochondrial function in human and murine aging"
9:45 am - 9:55 amDiscussion
9:55 am - 10:10 amCoffee Break
10:10 am - 10:40 amBente Pedersen (Center of Inflammation and Metabolism)
"Muscle, exercise and metabolism: Skeletal muscle as a secretory organ"
10:40 am - 10:50 amDiscussion
10:50 am - 11:20 amBill Evans (GlaxoSmithKline, Duke University)
"Resistance Exercise: Age associated adaptive responses to muscle damage"
11:20 am - 11:30 amDiscussion
11:30 am - 12:00 pmShin-Ichiro Imai (Washington University School of Medicine)
"Understanding the Mechanism of Mammalian Aging and Longevity: The Intertissue Communication Mediated by NAMPT/NAD/SIRT1"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:18 pmTBA (Short Talk)
12:18 pm - 12:20 pmDiscussion
12:20 pm - 12:28 pmTBA (Short Talk)
12:28 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmGut Function, Microbes and Aging
5:30 pm - 5:45 pmDiscussion Leader: David Walker (University of California, Los Angeles)
5:45 pm - 6:10 pmPeter Hunt (University of California, San Francisco)
"Gut Epithelial Barrier Dysfunction and Chronic Morbidities of Aging in Treated HIV Infection"
6:10 pm - 6:20 pmDiscussion
6:20 pm - 6:45 pmDavid Gems (University College London)
"Ageing in C. elegans: Damage or hyperfunction"
6:45 pm - 6:55 pmDiscussion
6:55 pm - 7:20 pmGary Ruvkun (Harvard University)
"Eukaryotic pathways that surveil conserved proteins for inhibition by microbial toxins and couple to detoxification, defense, and longevity"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
9:00 am - 12:30 pmProteostasis/Autophagy
9:00 am - 9:15 amDiscussion Leader: Thomas Nystrom (University of Gothenburg)
9:15 am - 9:45 amAndy Dillin (HHMI - University of California Berkeley)
"Humoral control of proteostasis and aging"
9:45 am - 9:55 amDiscussion
9:55 am - 10:10 amCoffee Break
10:10 am - 10:40 amAna Maria Cuervo (Albert Einstein College of Medicine)
"Selective autophagy and the metabolic disbalance in aging"
10:40 am - 10:50 amDiscussion
10:50 am - 11:20 amThorsten Hoppe (University of Cologne, Institute for Genetics and CECAD)
"Myosin assembly in muscle development and age-dependent muscle degeneration"
11:20 am - 11:30 amDiscussion
11:30 am - 12:00 pmShu-Bing Qian (Cornell University)
"Nutrient Signaling in Protein Homeostasis: an Increase in Quantity at the Expense of Quality"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:18 pmTBA (Short Talk)
12:18 pm - 12:20 pmDiscussion
12:20 pm - 12:28 pmTBA (Short Talk)
12:28 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmSystems Biology
5:30 pm - 5:45 pmDiscussion Leaders: John Sedivy (Brown University) & Yousin Suh (Albert Einstein College of Medicine)
5:45 pm - 6:10 pmTom Kirkwood (Newcastle University)
"Systems biology of metabolism and aging"
6:10 pm - 6:20 pmDiscussion
6:20 pm - 6:45 pmDaniel Promislow (University of Washington)
"Diet restriction and the fly metabolome: A systems biology perspective"
6:45 pm - 6:55 pmDiscussion
6:55 pm - 7:20 pmJing-Dong Jackie Han (CAS-Max Planck Partner Institute for Computational Biology, Shanghai)
"Systems biology of aging: New tricks to the old problem"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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