Gordon Research Conferences
PI_Conferences PI_Conferences_Past
Conference Program
 
Amygdala in Health & Disease
July 28 - August 2, 2013
Stonehill College
Easton, MA
Chair:
Sumantra Chattarji

Vice Chair:
Sheena Josselyn

Related Meeting Information
The Amygdala in Health & Disease Gordon Research Conference was held in conjunction with the Amygdala in Health & Disease Gordon-Kenan Research Seminar. Please refer to the Amygdala in Health & Disease GKRS web page for more information.

Interest in the amygdala, a brain structure known to play a pivotal role in emotional processes, has increased considerably in recent years. Rapid progress has been made in elucidating the cellular and molecular plasticity mechanisms involved in the acquisition and expression of conditioned fear using animal models. Notably, some of these same plasticity mechanisms can become maladaptive and lead to disease. Indeed, a growing body of clinical evidence implicates the amygdala in a range of affective disorders, including anxiety, depression, phobia, post-traumatic stress disorder, and autism. There is also growing appreciation that the amygdala plays a critical role in appetitive behaviors, and amygdala dysfunction has been implicated in drug and alcohol addiction.

The 2013 Gordon Research Conference on the "Amygdala in Health and Disease" will feature the latest findings from internationally renowned basic and clinical researchers in this exciting field of neuroscience. We will focus on research investigating the role of the amygdala in both normal and pathological emotional processes spanning multiple levels of neural organization - from molecular and cellular mechanisms at one end, to circuits, networks and behavior at the other. Reflecting recent progress in the field, we will also consider functional interactions between the amygdala and other brain structures, such as the hippocampus, prefrontal cortex, striatum, and nucleus accumbens that are implicated in the formation and extinction of aversive and appetitive memories. The collegial and interactive atmosphere of this conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an avenue for scientists from different disciplines to brainstorm and promotes cross-disciplinary collaborations in the various research areas represented. Notably, the 2013 conference will be preceded by a Gordon Research Seminar that will feature young scientists, who are already involved in, or are interested in exploring, this exciting area of research.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmThe Amygdala and Emotion: looking back to look ahead
Discussion Leader: Kerry Ressler (Emory University, USA)
7:40 pm - 8:05 pm Joseph Ledoux (New York University, USA)
"Coming to Terms with Fear"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:40 pm Michael Fanselow (University of California, Los Angeles, USA)
"Stress-enhanced fear learning is mediated by neuroendocrine influences on the amygdala"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:05 pm Marissa Maheu (McGill University, Canada)
"Transcript-specific regulation of GDNF receptor by microRNAs alters downstream signaling: Implications for BLA functioning in depression"
9:05 pm - 9:10 pm Discussion
9:10 pm - 9:25 pm Jun-Hyeong Cho (McLean Hospital, Harvard, USA)
"Synaptic Encoding of Fear Extinction in mPFC-amygdala Circuits"
9:25 pm - 9:30 pm Discussion
9:30 pm - 11:30 pm Informal Social
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAmygdala Function & Connectivity in Humans & Non-human Primates
Discussion Leader: Elizabeth Phelps (New York University, USA)
9:00 am - 9:25 am John O'Doherty (Caltech, USA)
"The role of the human amygdala in encoding value and uncertainty: insights from high-resolution computational fMRI"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am Raffael Kalisch (University Medical Center, Hamburg, Germany)
"Single dose of L-DOPA makes extinction memories context-independent and prevents the return of fear"
10:00 am - 10:10 am Discussion
10:00 am - 10:40 am Group Photo / Coffee Break
10:40 am - 11:05 am Sonia Bishop (University of California, Berkeley, USA)
"Role of the amygdala versus frontal cortex in human trait anxiety"
11:05 am - 11:15 am Discussion
11:15 am - 11:40 am Angela Roberts (Cambridge University, UK)
"Negative emotion and its regulation: contribution of the prefrontal cortex, amygdala & serotonin"
11:40 am - 11:50 am Discussion
11:50 am - 12:15 pm Daniel Salzman (Columbia University, USA)
"Cognitive signals in the amygdala"
12:15 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmModulation of fear across scales: from humans to rodents and back
Discussion Leader: Kay Tye (MIT, USA)
7:30 pm - 7:55 pm Elizabeth Phelps (New York University, USA)
"Preventing the return of fear: Reconsolidation and control"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:25 pm Rony Paz (Weizmann Institute, Israel)
"Optimal generalization in the primate amygdala"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:55 pm Donald Rainnie (Emory University, USA)
"Stress modulation of principal neuron excitability"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:25 pm Kerry Ressler (Emory University, USA)
"Understanding molecular pathways involved in fear: convergent genomic approaches from mice to humans"
9:25 pm - 9:30 pm Discussion
9:30 pm - 11:30 pm Informal Social
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRegulation of fear: circuit and network interactions
Discussion Leader: Denis Pare (Rutgers University, USA)
9:00 am - 9:25 am Gregory Quirk (University of Puerto Rico, Puerto Rico)
"Recruitment of prefrontal-thalamic circuits in expression of fear"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am Pankaj Sah (Queensland Brain Institute, Australia)
"Intrinsic circuitry of the prefrontal cortex and amygdala"
10:00 am - 10:10 am Discussion
10:10 am - 10:30 am Coffee Break
10:30 am - 10:55 am Alexei Morozov (Virginia Tech, USA)
"Prefrontal-amygdala circuit and behavior following vicarious pain"
10:55 am - 11:00 am Discussion
11:00 am - 11:25 am Kay Tye (MIT, USA)
"Distinct function of basolateral amygdala neurons based on projection target"
11:25 am - 11:35 am Discussion
11:35 am - 12:00 pm Cornelius Gross (EMBL, Italy)
"Circuits controlling predator and social fear"
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:15 pm Hot Topic: Gleb Shumyatsky (Rutgers University, USA)
"Learning-dependent changes in dynamic microtubules are essential for contextual fear memory"
12:15 pm - 12:20 pm Discussion
12:20 pm - 12:25 pm Hot Topic: Ayako Watabe (Jikei University School of Medicine, Japan)
"Involvement of Nociceptive Amygdala in Fear Learning"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time / Optional Excursion
4:00 pm - 6:00 pmPoster Session I (continued)
6:00 pmDinner
7:30 pm - 9:30 pmFormation and Extinction of Aversive Memories
Discussion Leader: Gregory Quirk (Univ. of Puerto Rico)
7:30 pm - 7:55 pm Stephen Maren (Texas A&M University, USA)
"Nature and causes of the immediate extinction deficit"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:25 pm Andrew Holmes (NIH/NIAAA, USA)
"Genetically driven variation in fear extinction"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:55 pm Robert Pawlak (University of Exeter, UK)
"Control of anxiety and fear by extracellular proteolysis in the amygdala"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:25 pm Cyril Herry (INSERM, France)
"Prefrontal parvalbumin-expressing interneurons control fear expression"
9:25 pm - 9:30 pm Discussion
9:30 pm - 11:30 pm Informal Social
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmReinforcement Learning, Appetitive Behavior and Addiction
Discussion Leader: John O'Doherty (Caltech, USA)
9:00 am - 9:25 am Jay Gottfried (Northwestern University, USA)
"Olfactory insights into amygdala function"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am Bernard Balleine (University of Sydney, Australia)
"Amygdala-striatal interactions in action control"
10:00 am - 10:10 am Discussion
10:10 am Coffee Break
10:25 am - 10:50 am Geoff Schoenbaum (NIDA/NIH, USA)
"By hook or by crook - what different methods of extinction tell us about amygdalar and orbitofrontal function of relevance to addiction"
10:50 am - 11:00 am Discussion
11:00 am - 11:25 am Joshua Johansen (Riken Brain Science Institute, Japan)
"Teaching the amygdala to fear"
11:25 am - 11:35 am Discussion
11:35 am - 12:00 pm Sheena Josselyn (Hospital for Sick Children Research Institute, Canada)
"Erasing cocaine memories"
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:15 pm Hot Topic: Dorothee Bentz (Mt. Sinai, NY, USA)
"Effects of rapamycin on fear memory reconsolidation in humans"
12:15 pm - 12:20 pm Discussion
12:20 pm - 12:25 pm Hot Topic: Peter Rudebeck (NIMH, USA)
"Effects of amygdala lesions on value coding in orbital and medial prefrontal cortex"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pmDevelopment of the Amygdala and Fear Regulation
Discussion Leader: Sheena Josselyn (Hospital for Sick Children Research Institute, Canada)
7:30 pm - 7:55 pm Regina Sullivan (New York University, USA)
"Ontogeny of attachment and fear: amygdala and emergence of PFC connectivity"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:25 pm Joshua Corbin (Children's National Medical Center, USA)
"Developmental mechanisms for constructing the amygdala"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:55 pm Shubha Tole (TIFR, India)
"A migrating stream of cells to the accessory olfactory bulb suggests an evolutionary link with the amygdala"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:25 pm Yann Humeau (IINS, France)
"Differential vulnerability of amygdala excitatory synapses to an ID mutation and consequences on fear memory formation and expression"
9:25 pm - 9:30 pm Discussion
9:30 pm - 11:30 pm Informal Social
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
9:00 am - 12:30 pmInhibitory circuits in the amygdala: structure and function
Discussion Leader: Pankaj Sah (Queensland Brain Institute, Australia)
9:00 am - 9:25 am Andreas Lüthi (FMI, Switzerland)
"Role of defined inhibitory circuits in fear conditioning"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am Francesco Ferraguti (Innsbruck Medical University, Austria)
"Novel insight into fear-mediated structural plasticity at GABAergic synapses of the amygdala"
10:00 am - 10:10 am Discussion
10:10 am Coffee Break
10:40 am - 11:05 am Marco Capogna (Oxford University, UK)
"Hippocampal and somatosensory inputs to the basolateral amygdala: role of identified GABAergic neurons"
11:05 am - 11:15 am Discussion
11:15 am - 11:40 am Hans-Christian Pape (Westfaelische Wilhelms University, Germany)
"GABAergic mechanisms in the (extended) amygdala: a novel view on endocannabinoid modulation"
11:40 am - 12:00 pm Discussion
12:00 pm - 12:05 pm Hot Topic: Matt Hill (University of Calgary, Canada)
"CRH signaling drives anandamide hydrolysis in the amygdala to promote anxiety"
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:15 pm Hot Topic: Bridget Callaghan (University of New South Wales, Australia)
"Experience-dependent alteration of the excitation-inhibition balance in emotion learning circuits: Maternal-separation regulates the expression of GAD protein in the infant hippocampus"
12:15 pm - 12:20 pm Discussion
12:20 pm - 12:25 pm Hot Topic: Jesse Gray (Harvard, USA)
"The genome as a signal processing machine, and its relevance to mapping memory traces"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II (continued)
6:00 pmDinner
7:30 pm - 9:30 pmRole of the Extended Amygdala in Fear and Anxiety
Discussion Leader: Andreas Lüthi (FMI, Switzerland)
7:30 pm - 7:55 pm Denis Pare (Rutgers University, USA)
"Physiological organization of the bed nucleus of the stria terminalis"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:25 pm Elizabeth Bauer (Barnard College, USA)
"The extended amygdala mediates the effects of acute SSRIs on fear conditioning"
8:25 pm - 8:35 pm Discussion
8:35 pm - 9:00 pm Bo Li (CSHL, USA)
"Experience-dependent modification of central amygdala fear circuits"
9:00 pm - 9:05 pm Discussion
9:05 pm - 9:25 pm Ron Stoop (University of Lausanne, Switzerland)
"In vitro and in vivo effects of oxytocin and vasopressin signaling in the amygdala"
9:25 pm - 9:30 pm Discussion
9:30 pm - 11:30 pm Informal Social
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
© 2014 Gordon Research Conferences Search | Contact | Terms of Use | Privacy Policy | Follow us: Facebook Twitter