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Angiogenesis
August 4-9, 2013
Salve Regina University
Newport, RI
Chair:
Raghu Kalluri

Vice Chair:
Holger Gerhardt
Application Deadline
Applications for this meeting must be submitted by July 7, 2013. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.
Related Meeting Information
The Angiogenesis Gordon Research Conference will be held in conjunction with the Angiogenesis Gordon Research Seminar. Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Please refer to the Angiogenesis GRS web page for more information.

The 2013 Angiogenesis Gordon Conference will present the latest research on the basic and translational biology of angiogenesis and its functional role in embryonic/organ development and disease states with specific emphasis on cancer progression/metastasis. Mechanistic concepts and molecular details in vascular biology, blood vessel formation, growth, and regression will be covered. Angiogenesis contributes to the emergence and progression of cancer in a complex manner and unraveling the molecular details will have a significant impact on current and future drug development. We also need to determine the composite consequence of angiogenesis inhibition in the setting of cancer in order to provide optimal information to aid therapy development in the clinic. Angiogenesis research will provide better biomarkers to predict and monitor anti-angiogenesis therapy in our patients. This conference is being designed to address the most vital areas pertinent to angiogenesis, seeking to stimulate interactions among the experts and importantly provide invaluable educational opportunity for graduate students, post-doctoral fellows and junior investigators.

Contributors
SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:35 pmWelcome / Introductory Comments by GRC Site Staff
7:35 pm - 9:30 pmKeynote Lectures
Discussion Leader: Raghu Kalluri (MD Anderson Cancer Center, Houston)
7:35 pm - 7:58 pmJoseph Schlessinger (Yale, New Haven)
7:58 pm - 8:03 pmDiscussion
8:03 pm - 8:26 pmGregg Semenza (Johns Hopkins, Baltimore)
"Control of Tumor Vascularization and Vascular Modulation by Hypoxia-Inducible Factor 1"
8:26 pm - 8:31 pmDiscussion
8:31 pm - 8:54 pmWilliam Kaelin (Dana Farber Cancer Institute, Boston)
"The VHL Tumor Suppressor: Insights into Oxygen Sensing and Cancer Metabolism"
8:54 pm - 8:59 pmDiscussion
8:59 pm - 9:22 pmJames D. Watson (Cold Spring Harbor Laboratory, New York)
9:22 pm - 9:27 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHypoxia, Metabolism and Angiogenesis
Discussion Leader: TBA
9:00 am - 9:20 amCeleste Simon (UPenn, Philadelphia)
"Hypoxia, Angiogenesis, and Colorectal Cancer"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amPeter Carmeliet (VIB, Leuven, Belgium)
"Control of vascular branching by endothelial cell metabolism"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amGroup Photo / Coffee Break
10:30 am - 10:50 amKari Alitalo (University of Helsinki, Finland)
"Combinatorial Targeting of Angiogenic Pathways"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amZoltan Arany (Beth Israel Deacons Medical Center, Boston)
"PGC-1alpha and angiogenesis"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amShort Talk - selected from abstract: Debabrata Mukhopadhyay
"Neuropilin-1 maintains mitochondrial homeostasis in cardiac and vascular smooth muscle cells"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amShort Talk - selected from abstract: Andreas Moller (Australia)
"The Siah2 ubiquitin ligase is important for tumor neo-angiogenesis"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShort Talk - selected from abstract: Patrik Andersson (Karolinska Institutet, Sweden)
"Collaborative interplay between FGF-2 and VEGF-C promotes lymphangiogenesis and metastasis"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmTBA (selected from abstracts)
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmEndothelial receptor signaling and Angiogenesis
7:30 pm - 7:40 pmDiscussion Leader: Rakesh Jain (Massachusetts General Hospital, Boston)
"Introduction"
7:40 pm - 8:00 pmChenghua Gu (Harvard Medical School, Boston)
"Developmental cross-talk between nervous and vascular systems"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:20 pmShort Talk - selected from abstract: Jessica Reinardy (Duke University)
"The role of Akt-mediated phosphorylation of Tie1 on endothelial gene expression"
8:20 pm - 8:25 pmDiscussion
8:25 pm - 8:45 pmLena Cleasson-Welch (Uppsala, Sweden)
"VEGF signaling at endothelial junctions"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:05 pmShort Talk - selected from abstract: Polena Helena (France)
"Targeted therapies in Renal cell carcinoma: effects on VE-Cadherin tyrosine phosphorylation and cleavage"
9:05 pm - 9:15 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDevelopmental Angiogenesis, Remodeling and Adaptation
9:00 am - 9:10 amDiscussion Leader: Michael Simons (Yale, Connecticut)
"Introduction"
9:10 am - 9:30 amHolger Gerhardt (London, Cancer Research, UK)
"Branch or expand? Pattern generation in vascular networks"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amChrister Betsholtz (Uppsala, Sweden)
"New Insights into the Role of PDGF's in the CNS vasculature"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amCoffee Break
10:30 am - 10:40 amShort Talk - selected from abstract: Sarah De Val (Oxford, UK)
"SoxF and Notch directly control arterial identify through combined gene activation"
10:40 am - 10:45 amDiscussion
10:45 am - 10:55 amShort Talk - selected from abstract: Stefania Nicoli (Yale)
"miRNA in angiogenesis regulation"
10:55 am - 11:00 amDiscussion
11:00 am - 11:20 amAnne Eichmann (Yale, New Haven)
"Guidance of vascular patterning"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amRalf Adams (Muenster, Germany)
"Control of blood vessel remodeling and stability"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmRichard Lang (Cincinnati)
"Regulation of vascular development in the eye by a light response pathway"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmImmune System and Angiogenesis
Discussion Leader: Gabriele Bergers
7:30 pm - 7:50 pmMax Mazzone (VIB, Leuven, Belgium)
"Macrophages in hypoxic tumor niches: should they stay or should they go?"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmJohn Condeelis (Albert Einstein College of Medicine, New York)
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmMichele De Palma (EPFL, Lausanne)
"Targeting angiogenesis in the inflammatory tumor microenvironment"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmGabriele Bergers (UCSF)
"Pleiothrophic implications of innate immune cells in tumor progression and resistance"
9:20 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEndothelial and tissue heterogeneity and Angiogenesis
Discussion Leader: Shahin Rafii (New York)
9:00 am - 9:20 amDavid Cheresh (San Diego)
"MicroRNA regulated pathways in angiogenesis and disease"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amBjorn Olsen (Harvard, Boston)
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:40 amShort Talk - selected from abstract: Mariona Graupera (Barcelona)
"Dynamic PTEN levels are key to develop blood vessels"
10:40 am - 10:45 amDiscussion
10:45 am - 10:55 amShort Talk - selected from abstract: Michael Potente (Frankfurt, Germany)
10:55 am - 11:00 amDiscussion
11:00 am - 11:20 amValerie Weaver (UCSF)
"Tissue tension reprograms the tissue to metastasis"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amTBA
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmShahin Rafii (Cornell, NY)
"Molecular determinants of vascular angiocrine heterogeneity in organ maintenance and regeneration"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmVascular Biology and Endothelial Plasticity and Mechanisms of Angiogenesis
7:30 pm - 7:40 pmDiscussion Leader: Eli Keshet (Jerusalem, Israel)
"Introduction"
7:40 pm - 8:00 pmRenata Pasqualini and Wadih Arap (MD Anderson Cancer Center, Houston)
"Ligand-directed vascular targeting in transnational medicine"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:20 pmShort Talk - selected from abstract: Masataka Majima (Japan)
"Microsomal prostaglandin E synthase-1 as a regulator of angiogenesis"
8:20 pm - 8:25 pmDiscussion
8:25 pm - 8:35 pmShort Talk - selected from abstract: Wiebke Herzog (University of Meunster, Germany)
"Lumen Ensheathment: Novel Developmental Priciples of Vessel Formation in the Zebrafish"
8:35 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmElisabetta Dejana (Milan, Italy)
"Endothelial to mesenchymal transition contributes to the development of cerebral cavernous malformations"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pmGeneral Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMechanics and Mechanisms of Angiogenesis Inhibitors
9:00 am - 9:10 amDiscussion Leader: Donald McDonald (UCSF)
"Introduction"
9:10 am - 9:20 amDouglas Hanahan (ISREC, Switzerland)
"Mechanisms of Adaptive/Evasive Resistance to Anti-angiogenic Therapy"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amNapoleone Ferrara (UCSD, San Diego)
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:40 amShort Talk - selected from abstract: Andrew Reynolds (ICR, London, UK)
"Vascular co-option in liver metastases mediates resistance to VEGF-targeted therapy"
10:40 am - 10:45 amDiscussion
10:45 am - 10:55 amTBA (selected from abstracts)
10:55 am - 11:00 amDiscussion
11:00 am - 11:20 amHellmut Augustin (Heidelberg, Germany)
"Angiocrine signaling and adjuvant tumor therapy: Role of Ang/Tie system"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amTBA (selected from abstracts)
11:40 am - 11:45 amDiscussion
11:45 am - 12:05 pmTBA
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pmClinical Translation of Angiogenesis Knowledge
Discussion Leader: TBA
7:30 pm - 7:45 pmLaura Benjamin (New York)
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:10 pmChad May (Pfizer, New York)
"Targeting the tumor vasculature with antibody drug conjugates"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmGavin Thurston (Regeneron, New York)
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmTBA
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmTBA
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pmGeneral Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture
Last Updated: May 16, 2013
 
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