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Conference Program
 
Antimicrobial Peptides
Discovery, Function and Application
February 24 - March 1, 2013
Four Points Sheraton / Holiday Inn Express
Ventura, CA

Related Meeting Information
The Antimicrobial Peptides Gordon Research Conference was held in conjunction with the Antimicrobial Peptides Gordon Research Seminar. Please refer to the Antimicrobial Peptides GRS web page for more information.

Antimicrobial peptides (AMPs) are host-defense molecules produced by all living organisms, including bacteria, fungi, plants, invertebrates, and vertebrates. The peptides exhibit potent cytotoxic activity against all microbes, including bacteria, fungi, viruses, and parasites. There is now evidence in humans and other mammals that these peptides represent a key component of host defense at epithelial surfaces, the barrier between the external environment and the interior milieu, interacting with both symbionts and pathogens. Members of these large families also have activities far beyond being directly antimicrobial, including immunity, wound healing, fertility, and as ligands for numerous receptors leading to the induction of a variety of signaling pathways. Furthermore, significant research has been carried out to develop these naturally occurring peptides as therapeutic agents against microbial infections.

The 2013 Gordon Conference on Antimicrobial Peptides will present the latest research on the biology and activities of AMPs with emphasis on their roles in host defense against all forms of microbial pathogens. The Conference will feature a wide range of topics, such as structure/function analysis, regulation of expression, mechanisms of action, microbial avoidance strategies, human disease associations and model systems, and the development of antimicrobial peptides and their mimetics as therapeutics. Invited speakers represent a diverse variety of scientific disciplines, including biochemistry, molecular genetics, microbiology, animal and plant biology, structural biology, medicine, innate immunity, signaling, and drug development. The Conference will bring together a collection of investigators who are at the forefront of their field, and will provide opportunities for junior scientists and graduate students to present their work in poster format and exchange ideas with leaders in the field. Some abstracts and poster presenters will be selected for short talks. The collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an avenue for scientists from different disciplines to brainstorm and promotes cross-disciplinary collaborations in the various research areas represented.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Presentations
Discussion Leaders: Gill Diamond (UMDNJ) and Nita Salzman (Medical College of Wisconsin)
7:40 pm - 7:50 pmYoung Investigator Presentation Winner: Jennifer Bartlett (University of Iowa)
"Chronic otitis media in a PLUNC-deficient mouse model"
7:50 pm - 8:05 pmDiscussion
8:00 pm - 8:50 pmJules Hoffmann (University of Strasbourg)
"The Antimicrobial Defense of Drosophila: a Paradigm for Innate Immunity"
9:00 pm - 9:10 pmDiscussion
9:00 pm - 9:20 pmJean-Marc Reichhart
"Akirins, new players in NF-κB-dependent immune responses"
9:20 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmAMPs: Conservation of Antibacterial Host Defense
Discussion Leaders: William Shafer (Emory University) and Manuela Raffatellu (UC Irvine)
9:00 am - 9:20 amAnn Jerse (USUHS)
"Induction of antimicrobial peptide (AP) expression during experimental gonococcal genital tract infection and mechanisms by which Neisseria gonorrheae (Gc) evades AP-mediated killing"
9:20 am - 9:35 amDiscussion
9:35 am - 9:55 amDelphine Destoumieux-Garzon (University of Montpellier)
"Antimicrobial strategies in molluscan host-pathogen interactions"
9:55 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:00 amMarialuisa Mangoni (La Sapienza University)
"Fighting microbial infections: membrane-active peptides isolated from amphibian skin"
11:00 am - 11:15 amDiscussion
11:15 am - 11:35 amSteven Gross (UC Irvine)
"Lipid-droplet bound histones: a new pathway in innate immunity?"
11:35 am - 11:50 amDiscussion
Selected Poster Presentations
11:50 am - 11:55 amMartina Kalle (Lund University)
"Proteolytic activation transforms heparin cofactor II into a host defense molecule"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:05 pmKaoutar El Mounadi (Donald Danforth Plant Science Center)
"Deciphering structure-activity relationships of the plant defensin MtDef4"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:15 pmVanessa Nienhouse (Loyola University Chicago)
"Antimicrobial Peptide Production In The Urinary Tract Is Influenced By The Resident Bladder Microbiota: Implications For Identification Of Individuals At-Risk For Urinary Tract Infection (UTI)"
12:15 pm - 12:20 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmAMPs as Antivirals
Discussion Leaders: Robert Lehrer (UCLA) and Aaron Weinberg (Case Western Reserve University)
7:30 pm - 7:50 pmDonald Davidson (MRC Edinburgh)
"The antiviral properties of cathelicidins against pathogenic respiratory viruses"
7:50 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmKevan Hartshorn (Boston University)
"Antimicrobial peptides in respiratory viral infection"
8:25 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmJason Smith (University of Washington)
"Defensins in Enteric Viral Infection"
9:00 pm - 9:10 pmDiscussion
Selected Poster Presentations
9:10 pm - 9:15 pmLisa Ryan (Public Health Research Institute)
"Viral Induction of Human Beta Defensin-1 in Plasmacytoid Dendritic Cells and Monocytes and Its Regulation by IRF7 and PU.1"
9:15 pm - 9:20 pmDiscussion
9:20 pm - 9:25 pmKrishnakumari Viswanatha (CSIR - Centre for Cellular and Molecular Biology)
"Effect of N-Terminal Fatty Acylation on Biological Activities of Bovine β-Defensin-2 Analogs"
9:25 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHost Defense Against Fungi and Parasites
Discussion Leaders: Marilyn Anderson (Latrobe University) and Jayne Raper (Hunter College CUNY)
9:00 am - 9:20 amKarin Thevissen (K. U. Leuven)
"Antifungal Mode of Action of Plant Defensins"
9:20 am - 9:35 amDiscussion
9:35 am - 9:55 amGeorge Dimopoulos (Johns Hopkins University)
"Utilization of the mosquito gut microbiota and innate immune system for malaria and dengue control"
9:55 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:00 amDominique Buzoni-Gatel (University of Tours)
"Mucosal Immunity and Toxoplasma gondii infection"
11:00 am - 11:15 amDiscussion
11:15 am - 11:35 amDoron Greenbaum (University of Pennsylvania)
"Platelet factor 4 host defense activity against Plasmodium falciparum and its translation to nonpeptidic mimics as a new class of antimalarials"
11:35 am - 11:50 amDiscussion
Selected Poster Presentations
11:50 am - 11:55 amYazan Akkam (University of Arkansas)
"Analysis of Retro and Retroenantio analogs of Histatin 5"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:05 pmAnita Marinelli (Henry M. Jackson Foundation / USUHS)
"Role of Secretory Leukocyte Protease Inhibitor during Neisseria gonorrhoeae infection"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:15 pmAnna De Breij (Leiden University Medical Center)
"Next generation peptides based on OP-145, a synthetic derivative of the human cathelicidin LL-37, with improved antimicrobial, antibiofilm and immunomodulatory activities"
12:15 pm - 12:20 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmThe Wheel is Turning: Cyclic AMPs
Discussion Leaders: Henk Haagsman (Utrecht) and Anne Ulrich (Karlsruhe Institute of Technology)
7:30 pm - 7:50 pmMichael Seslsted (USC)
"How to make a cyclic defensin and what it's good for"
7:50 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmDavid Craik (Queensland University)
"Cyclotide structure and function: role of membrane binding and permeation"
8:25 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmMarina Rautenbach (University of Stellenbosch)
"Cyclic antimicrobial peptides as fungicides to combat fungal pathogens in agriculture"
9:00 pm - 9:10 pmDiscussion
Selected Poster Presentations
9:10 pm - 9:15 pmMiriam Wilmes (University of Bonn)
"Theta-defensins induce autolysis in staphylococci"
9:15 pm - 9:20 pmDiscussion
9:20 pm - 9:25 pmBjoern Schroeder (IKP Stuttgart)
"A net is not enough: Reducing environment modulates antibiotic activity of human alpha-defensin 6"
9:25 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAMPs at the Interface
Discussion Leaders: Andre Ouellette (USC) and Kim Brogden (University of Iowa)
9:00 am - 9:20 amPaula Watnick (Boston Children's Hospital)
"The role of antimicrobial peptides and epithelial renewal in Drosophila melanogaster tolerance of intestinal Vibrio cholerae infection"
9:20 am - 9:35 amDiscussion
9:35 am - 9:55 amPeter Di (University of Pittsburgh)
"Multifunctional roles of the PLUNC proteins, antimicrobial activity and beyond"
9:55 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:00 amOle Sorrensen (Lund University)
"Injury and AMP expression"
11:00 am - 11:15 amDiscussion
11:15 am - 11:35 amElizabeth Nolan (MIT)
"Bioinorganic Perspectives on Host Defense Peptides"
11:35 am - 11:50 amDiscussion
11:50 am - 12:10 pmMichael McAlpine (Princeton)
"Biointerfaced AMP-Nanosensors"
12:10 pm - 12:25 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmAntimicrobial and Beyond
Discussion Leaders: Yvonne Chan (University of Pittsburgh) and Tomas Ganz (UCLA)
7:30 pm - 7:50 pmGlenn Millhauser (UC Santa Cruz)
"How molecular features of the defensin family control receptor interactions"
7:50 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmTed Tollner (UC Davis)
"DEFB126, at the interface of fertility and innate immunity"
8:25 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmJulia Dorin (MRC Edinburgh)
"Chromosome 8 defensin function in vivo"
9:00 pm - 9:10 pmDiscussion
Selected Poster Presentations
9:10 pm - 9:15 pmJia Sun (Karolinska Institutet)
"The antimicrobial peptide LL-37 induces synthesis and release of cysteinyl-leukotrienes from human eosinophils - implications for asthma"
9:15 pm - 9:20 pmDiscussion
9:20 pm - 9:25 pmThomas Hehlgans (University of Regensburg)
"Mouse beta-defensin14 (Defb14) promotes tumor growth by inducing angiogenesis in a CCR6-dependent manner"
9:25 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
9:00 am - 12:30 pmAMPs and Immunity
Discussion Leaders: Charles Bevins (UC Davis) and Katherine Radek (Loyola University)
9:00 am - 9:20 amBernard Charroux (Marseilles)
"Regulation of tissue specific Antimicrobial Peptides expression in Drosophila"
9:20 am - 9:35 amDiscussion
9:35 am - 9:55 amEd Stange (Robert Bosch Krankenhaus)
"Stem cells and defense in inflammatory bowel diseases"
9:55 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:00 amAgnes Lehuen (INSERM, Paris)
"Role of antimicrobial peptide in type 1 diabetes l"
11:00 am - 11:15 amDiscussion
11:15 am - 11:35 amVolker Gerdts (University of Saskatchewan)
"Peptides as Components of Advanced Adjuvants"
11:35 am - 11:50 amDiscussion
Selected Poster Presentations
11:50 am - 11:55 amLingjuan Zhang (University of California, San Diego)
"Adipose tissue participates in host defense against bacterial infection by secreting cathelicidin"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:05 pmGimano Amatngalim (Leiden University Medical Center)
"Whole volatile cigarette smoke modulates the expression of antimicrobial proteins and peptides by mucociliary differentiated airway epithelial cells"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:15 pmKim Brogden (The University of IowA)
"Histatin 5 binds to Porphyromonas gingivalis hemagglutinin B (HagB) and attenuates HagB-induced chemokine responses in human myeloid dendritic cells"
12:15 pm - 12:20 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNovel Technologies and Applications for AMPs
Discussion Leaders: Wuyuan Lu (University of Maryland) and Michael Zasloff (Georgetown)
7:30 pm - 7:50 pmPieter Dorrestein (USCSD)
"Imaging MS to identify molecules in bacteria-bacteria interactions"
7:50 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmMarvin Whiteley (University of Texas)
"Bacterial lobster traps as a tool to study antimicrobial resistance"
8:25 pm - 8:40 pmDiscussion
Selected Poster Presentations
8:40 pm - 8:45 pmGregory Johnson (Texas A&M University)
"Photoinactivation of bacteria with the antimicrobial peptide (KLAKLAK)2 conjugated to the photosensitizer eosin Y"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 8:55 pmErica Miraglia (Karolinska Institute)
"Boosting innate immunity: development of a high-throughput cell-based screening assay to identify LL-37 inducers/Identification of novel inducers of AMP expression: results from the screening of a chemical library"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:30 pmHot Corner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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